Validation of CoaBC as a Bactericidal Target in the Coenzyme A Pathway of Mycobacterium tuberculosis

ACS Infectious Diseases

Volumn 2, Issue 12, 2016, Pages 958-968

  Evans, Joanna C ^a   Trujillo, Carolina ^b   Wang, Zhe ^b   Eoh, Hyungjin ^b,d   Ehrt, Sabine ^b   Schnappinger, Dirk ^b   Boshoff, Helena I M ^c   Rhee, Kyu Y ^b   Barry, Clifton E ^a,c   Mizrahi, Valerie ^a  

^a UNIVERSITY OF CAPE TOWN   (South Africa)

^b WEILL CORNELL MEDICAL COLLEGE   (United States)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^d UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

CoA; CoaBC; drug discovery; pantetheine; tuberculosis

Indexed keywords

BACTERIAL PROTEIN; COABC PROTEIN; COAD PROTEIN; COAE PROTEIN; COENZYME A; PANB PROTEIN; PANC PROTEIN; PANTETHEINE; PANTETHINE; UNCLASSIFIED DRUG; ENZYME INHIBITOR; PEPTIDE SYNTHASE; TUBERCULOSTATIC AGENT;

ACUTE DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL GROWTH; BACTERICIDAL ACTIVITY; BACTERIOSTASIS; BACTERIUM MUTANT; CHRONIC DISEASE; CONTROLLED STUDY; FEMALE; GENE SILENCING; IN VITRO STUDY; IN VIVO STUDY; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PERSISTENT INFECTION; PRIORITY JOURNAL; TUBERCULOSIS; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; GENETICS; HUMAN; METABOLISM; MICROBIOLOGY;

ANIMALS; ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; COENZYME A; ENZYME INHIBITORS; FEMALE; HUMANS; MICE; MICE, INBRED C57BL; MYCOBACTERIUM TUBERCULOSIS; PEPTIDE SYNTHASES; TUBERCULOSIS;

EID: 85003506455     PISSN: None     EISSN: 23738227     Source Type: Journal    
DOI: 10.1021/acsinfecdis.6b00150     Document Type: Article

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