AcpM, the meromycolate extension Acyl carrier protein of mycobacterium tuberculosis, is activated by the 4′-phosphopantetheinyl transferase PptT, a potential target of the multistep mycolic acid biosynthesis

Biochemistry

Volumn 54, Issue 14, 2015, Pages 2360-2371

  Zimhony, Oren ^a   Schwarz, Alon ^b   Raitses Gurevich, Maria ^b   Peleg, Yoav ^c   Dym, Orly ^c   Albeck, Shira ^c   Burstein, Yigal ^d   Shakked, Zippora ^b  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b Department of Structural Biology ^*  (Israel)

^c Israel Structural Proteomics Center   (Israel)

^d WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; BIOSYNTHESIS; CATALYST ACTIVITY; CHEMICAL ACTIVATION; KETONES; MASS SPECTROMETRY; PROTEINS;

ACYL CARRIER PROTEINS; MASS SPECTROMETRY ANALYSIS; MYCOBACTERIAL CELLS; MYCOBACTERIUM TUBERCULOSIS; MYCOLIC ACID BIOSYNTHESIS; NONRIBOSOMAL PEPTIDE; POLYKETIDE SYNTHASES; STRUCTURAL MODELING;

FATTY ACIDS;

4' PHOSPHOPANTETHEINE TRANSFERASE; ACPM PROTEIN; ACYL CARRIER PROTEIN; ARGININE; BACTERIAL PROTEIN; COENZYME A; FATTY ACID SYNTHASE; HYBRID PROTEIN; MONOMER; MYCOLIC ACID; NONRIBOSOMAL PEPTIDE SYNTHETASE; POLYKETIDE SYNTHASE; SYNTHETASE; TRANSFERASE; UNCLASSIFIED DRUG; ACPM PROTEIN, MYCOBACTERIUM TUBERCULOSIS; CARRIER PROTEIN; HOLO-(ACYL-CARRIER-PROTEIN) SYNTHASE; PEPTIDE SYNTHASE; PHOSPHOPANTETHEINYL TRANSFERASE; PHOSPHOTRANSFERASE; PROTEIN BINDING; RECOMBINANT PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; COVALENT BOND; CRYSTAL STRUCTURE; ELECTROPHORETIC MOBILITY; ELECTROSPRAY MASS SPECTROMETRY; ENZYMATIC ASSAY; ENZYME ACTIVATION; FATTY ACID SYNTHESIS; GEL PERMEATION CHROMATOGRAPHY; HUMAN; LIMIT OF DETECTION; MOLECULAR WEIGHT; MYCOBACTERIUM AFRICANUM; MYCOBACTERIUM BOVIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PH; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN PURIFICATION; STATIC ELECTRICITY; SURFACE PLASMON RESONANCE; THERMOSTABILITY; CHEMICAL STRUCTURE; CHEMISTRY; ENZYMOLOGY; METABOLISM; MOLECULAR GENETICS;

MYCOBACTERIUM TUBERCULOSIS;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; CARRIER PROTEINS; COENZYME A; ENZYME ACTIVATION; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MYCOBACTERIUM BOVIS; MYCOBACTERIUM TUBERCULOSIS; MYCOLIC ACIDS; PEPTIDE SYNTHASES; PROTEIN BINDING; RECOMBINANT PROTEINS; TRANSFERASES (OTHER SUBSTITUTED PHOSPHATE GROUPS);

EID: 84927722333     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi501444e     Document Type: Article

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