Structure-Guided Discovery of Phenyl-diketo Acids as Potent Inhibitors of M. Tuberculosis Malate Synthase

Chemistry and Biology

Volumn 19, Issue 12, 2012, Pages 1556-1567

  Krieger, Inna V ^a   Freundlich, Joel S ^a,d   Gawandi, Vijay B ^a   Roberts, Justin P ^a   Gawandi, Vidyadhar B ^a   Sun, Qingan ^a   Owen, Joshua L ^a   Fraile, Maria T ^c   Huss, Sofia I ^c   Lavandera, Jose Luis ^c,e   Ioerger, Thomas R ^b   Sacchettini, James C ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

^b Department of Electrical and Computer Engineering   (United States)

^c GLAXOSMITHKLINE   (Spain)

^d RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^e UNIVERSIDAD SAN PABLO CEU   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID; MALATE SYNTHASE; PHENYL DIKETO ACID INHIBITOR; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CRYSTAL STRUCTURE; DRUG EFFICACY; DRUG POTENCY; ENZYME INHIBITION; FEMALE; GENE EXPRESSION; MOUSE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PHARMACODYNAMICS; PRIORITY JOURNAL; TUBERCULOSIS;

ANIMALS; ANTITUBERCULAR AGENTS; DRUG DESIGN; ENZYME INHIBITORS; FEMALE; HUMANS; MALATE SYNTHASE; MICE; MICE, INBRED C57BL; MODELS, MOLECULAR; MYCOBACTERIUM TUBERCULOSIS; TUBERCULOSIS;

MYCOBACTERIUM TUBERCULOSIS;

EID: 84871551094     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2012.09.018     Document Type: Article

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