Assessment of mycobacterium tuberculosis pantothenate kinase vulnerability through target knockdown and mechanistically diverse inhibitors

Antimicrobial Agents and Chemotherapy

Volumn 58, Issue 6, 2014, Pages 3312-3326

  Reddy, B K Kishore ^a   Landge, Sudhir ^a   Ravishankar, Sudha ^a   Patil, Vikas ^a   Shinde, Vikas ^a   Tantry, Subramanyam ^a   Kale, Manoj ^a   Raichurkar, Anandkumar ^a   Menasinakai, Sreenivasaiah ^a   Mudugal, Naina Vinay ^a   Ambady, Anisha ^a   Ghosh, Anirban ^a   Tunduguru, Ragadeepthi ^a   Kaur, Parvinder ^a   Singh, Ragini ^c   Kumar, Naveen ^a   Bharath, Sowmya ^a   Sundaram, Aishwarya ^a   Bhat, Jyothi ^a   Sambandamurthy, Vasan K ^a   Björkelid, Christofer ^b   Jones, T Alwyn ^b   Das, Kaveri ^a   Bandodkar, Balachandra ^a   Malolanarasimhan, Krishnan ^a   Mukherjee, Kakoli ^a   Ramachandran, Vasanthi ^a   more..

^a ASTRAZENECA   (United Kingdom)

^b UPPSALA UNIVERSITY   (Sweden)

^c Monitoring Evaluation Learning and Documentation   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID DERIVATIVE; ENZYME INHIBITOR; PANTOTHENATE KINASE; PIPERAZINE DERIVATIVE; QUINOLONE DERIVATIVE; TRIAZOLE DERIVATIVE; PHOSPHOTRANSFERASE; TUBERCULOSTATIC AGENT;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; BACTERIAL STRAIN; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; ENZYME BINDING; ENZYME INHIBITION; GROWTH INHIBITION; IN VITRO STUDY; IN VIVO STUDY; KINETICS; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STRUCTURE ACTIVITY RELATION; SURVIVAL; SYNTHESIS; WILD TYPE; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; ENZYMOLOGY; GENE SILENCING; GENETICS; HUMAN; MICROBIAL SENSITIVITY TEST; MYCOBACTERIUM BOVIS; PHENOTYPE; PHOSPHORYLATION; PROTEIN CONFORMATION; WESTERN BLOTTING;

ANTITUBERCULAR AGENTS; BLOTTING, WESTERN; ENZYME INHIBITORS; GENE KNOCKDOWN TECHNIQUES; HUMANS; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM BOVIS; MYCOBACTERIUM TUBERCULOSIS; PHENOTYPE; PHOSPHORYLATION; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEIN CONFORMATION; QUINOLONES; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

EID: 84901256348     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00140-14     Document Type: Article

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