Structural and biochemical characterization of compounds inhibiting mycobacterium tuberculosis pantothenate kinase

Journal of Biological Chemistry

Volumn 288, Issue 25, 2013, Pages 18260-18270

  Bjorkelid, Christofer ^a   Bergfors, Terese ^a   Raichurkar, Anand Kumar V ^b   Mukherjee, Kakoli ^b   Malolanarasimhan, Krishnan ^b   Bandodkar, Balachandra ^b   Jones, T Alwyn ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ATP BINDING; BIOCHEMICAL CHARACTERIZATION; M. TUBERCULOSIS; MYCOBACTERIUM TUBERCULOSIS; PANTOTHENATE KINASE; RATE-LIMITING STEPS;

BINDING SITES;

ENZYMES;

ADENOSINE TRIPHOSPHATE; PANTOTHENATE KINASE; PANTOTHENATE KINASE INHIBITOR; PANTOTHENIC ACID; PANTOTHENIC ACID 4' PHOSPHATE; PHOSPHOTRANSFERASE INHIBITOR; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; DRUG CLASSIFICATION; DRUG CONFORMATION; DRUG RESEARCH; DRUG STRUCTURE; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME ENGINEERING; ENZYME INHIBITION; ENZYME INHIBITOR COMPLEX; ENZYME SUBSTRATE COMPLEX; IC 50; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; SEQUENCE ALIGNMENT; THERMOSTABILITY;

COAA; COENZYME A; CRYSTAL STRUCTURE; DRUG DESIGN; ENZYME INHIBITORS; MYCOBACTERIUM TUBERCULOSIS; PANTOTHENATE KINASE;

ADENOSINE TRIPHOSPHATE; AMINO ACID SEQUENCE; BACTERIAL PROTEINS; BINDING SITES; BIOCATALYSIS; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; MYCOBACTERIUM TUBERCULOSIS; PANTOTHENIC ACID; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY;

EID: 84880067081     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.476473     Document Type: Article

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