-
1
-
-
33749362302
-
The history of tuberculosis
-
1 Daniel, T.M., The history of tuberculosis. Respir. Med. 100 (2006), 1862–1870.
-
(2006)
Respir. Med.
, vol.100
, pp. 1862-1870
-
-
Daniel, T.M.1
-
2
-
-
84935892144
-
Global Tuberculosis Report 2015
-
WHO
-
2 WHO, Global Tuberculosis Report 2015., 2015, WHO.
-
(2015)
-
-
WHO1
-
3
-
-
80053459692
-
High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism
-
3 Griffin, J.E., et al. High-resolution phenotypic profiling defines genes essential for mycobacterial growth and cholesterol catabolism. PLoS Pathog., 7, 2011, e1002251.
-
(2011)
PLoS Pathog.
, vol.7
, pp. e1002251
-
-
Griffin, J.E.1
-
4
-
-
20444419421
-
Genome-wide requirements for Mycobacterium tuberculosis adaptation and survival in macrophages
-
4 Rengarajan, J., et al. Genome-wide requirements for Mycobacterium tuberculosis adaptation and survival in macrophages. Proc. Natl. Acad. Sci. U. S. A. 102 (2005), 8327–8332.
-
(2005)
Proc. Natl. Acad. Sci. U. S. A.
, vol.102
, pp. 8327-8332
-
-
Rengarajan, J.1
-
5
-
-
0035940515
-
Comprehensive identification of conditionally essential genes in mycobacteria
-
5 Sassetti, C.M., et al. Comprehensive identification of conditionally essential genes in mycobacteria. Proc. Natl. Acad. Sci. U. S. A. 98 (2001), 12712–12717.
-
(2001)
Proc. Natl. Acad. Sci. U. S. A.
, vol.98
, pp. 12712-12717
-
-
Sassetti, C.M.1
-
6
-
-
0345701347
-
Genes required for mycobacterial growth defined by high density mutagenesis
-
6 Sassetti, C.M., et al. Genes required for mycobacterial growth defined by high density mutagenesis. Mol. Microbiol. 48 (2003), 77–84.
-
(2003)
Mol. Microbiol.
, vol.48
, pp. 77-84
-
-
Sassetti, C.M.1
-
7
-
-
33845903833
-
Drugs for bad bugs: confronting the challenges of antibacterial discovery
-
7 Payne, D.J., et al. Drugs for bad bugs: confronting the challenges of antibacterial discovery. Nat. Rev. Drug Discov. 6 (2007), 29–40.
-
(2007)
Nat. Rev. Drug Discov.
, vol.6
, pp. 29-40
-
-
Payne, D.J.1
-
8
-
-
19944429772
-
A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis
-
8 Andries, K., et al. A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis. Science 307 (2005), 223–227.
-
(2005)
Science
, vol.307
, pp. 223-227
-
-
Andries, K.1
-
9
-
-
33845323336
-
OPC-67683, a nitro-dihydro-imidazooxazole derivative with promising action against tuberculosis in vitro and in mice
-
9 Matsumoto, M., et al. OPC-67683, a nitro-dihydro-imidazooxazole derivative with promising action against tuberculosis in vitro and in mice. PLoS Med., 3, 2006, e466.
-
(2006)
PLoS Med.
, vol.3
, pp. e466
-
-
Matsumoto, M.1
-
10
-
-
84893784333
-
Tuberculosis drug discovery in the post-post-genomic era
-
10 Lechartier, B., et al. Tuberculosis drug discovery in the post-post-genomic era. EMBO Mol. Med. 6 (2014), 158–168.
-
(2014)
EMBO Mol. Med.
, vol.6
, pp. 158-168
-
-
Lechartier, B.1
-
11
-
-
77951883143
-
Genetic requirements for the survival of tubercle bacilli in primates
-
11 Dutta, N.K., et al. Genetic requirements for the survival of tubercle bacilli in primates. J. Infect. Dis. 201 (2010), 1743–1752.
-
(2010)
J. Infect. Dis.
, vol.201
, pp. 1743-1752
-
-
Dutta, N.K.1
-
12
-
-
16244400093
-
Designer arrays for defined mutant analysis to detect genes essential for survival of Mycobacterium tuberculosis in mouse lungs
-
12 Lamichhane, G., et al. Designer arrays for defined mutant analysis to detect genes essential for survival of Mycobacterium tuberculosis in mouse lungs. Infect. Immun. 73 (2005), 2533–2540.
-
(2005)
Infect. Immun.
, vol.73
, pp. 2533-2540
-
-
Lamichhane, G.1
-
13
-
-
34547129074
-
Molecular approaches to target discovery: evaluating targets for antituberculosis drug discovery programmes
-
13 Balganesh, T., Furr, B., Molecular approaches to target discovery: evaluating targets for antituberculosis drug discovery programmes. Infect. Disord. Drug Targets 7 (2007), 120–126.
-
(2007)
Infect. Disord. Drug Targets
, vol.7
, pp. 120-126
-
-
Balganesh, T.1
Furr, B.2
-
14
-
-
84940974566
-
The application of tetracyclineregulated gene expression systems in the validation of novel drug targets in Mycobacterium tuberculosis
-
14 Evans, J.C., Mizrahi, V., The application of tetracyclineregulated gene expression systems in the validation of novel drug targets in Mycobacterium tuberculosis. Front. Microbiol., 6, 2015, 812.
-
(2015)
Front. Microbiol.
, vol.6
, pp. 812
-
-
Evans, J.C.1
Mizrahi, V.2
-
15
-
-
84925240314
-
Regulated expression systems for Mycobacteria and their applications
-
MGM2-0018-2013
-
15 Schnappinger, D., Ehrt, S., Regulated expression systems for Mycobacteria and their applications. Microbiol. Spectr., 2(1), 2014, 10.1128/microbiolspec.MGM2-0018-2013 MGM2-0018-2013.
-
(2014)
Microbiol. Spectr.
, vol.2
, Issue.1
-
-
Schnappinger, D.1
Ehrt, S.2
-
16
-
-
84925270106
-
Construction of conditional knockdown mutants in mycobacteria
-
16 Schnappinger, D., et al. Construction of conditional knockdown mutants in mycobacteria. Methods Mol. Biol. 1285 (2015), 151–175.
-
(2015)
Methods Mol. Biol.
, vol.1285
, pp. 151-175
-
-
Schnappinger, D.1
-
17
-
-
84992170651
-
Investigating essential gene function in Mycobacterium tuberculosis using an efficient CRISPR interference system
-
Published online July 12, 2016.
-
17 Singh, A.K., et al. Investigating essential gene function in Mycobacterium tuberculosis using an efficient CRISPR interference system. Nucleic Acids Res., 2016 Published online July 12, 2016. http://dx.doi.org/10.1093/nar/gkw625.
-
(2016)
Nucleic Acids Res.
-
-
Singh, A.K.1
-
18
-
-
79961085853
-
Identifying vulnerable pathways in Mycobacterium tuberculosis by using a knockdown approach
-
18 Carroll, P., et al. Identifying vulnerable pathways in Mycobacterium tuberculosis by using a knockdown approach. Appl. Environ. Microbiol. 77 (2011), 5040–5043.
-
(2011)
Appl. Environ. Microbiol.
, vol.77
, pp. 5040-5043
-
-
Carroll, P.1
-
19
-
-
84907015388
-
The phosphatidyl-myo-inositol mannosyltransferase PimA is essential for Mycobacterium tuberculosis growth in vitro and in vivo
-
19 Boldrin, F., et al. The phosphatidyl-myo-inositol mannosyltransferase PimA is essential for Mycobacterium tuberculosis growth in vitro and in vivo. J. Bacteriol. 196 (2014), 3441–3451.
-
(2014)
J. Bacteriol.
, vol.196
, pp. 3441-3451
-
-
Boldrin, F.1
-
20
-
-
84897115137
-
Assessing the essentiality of the decaprenyl-phospho-d-arabinofuranose pathway in Mycobacterium tuberculosis using conditional mutants
-
20 Kolly, G.S., et al. Assessing the essentiality of the decaprenyl-phospho-d-arabinofuranose pathway in Mycobacterium tuberculosis using conditional mutants. Mol. Microbiol. 92 (2014), 194–211.
-
(2014)
Mol. Microbiol.
, vol.92
, pp. 194-211
-
-
Kolly, G.S.1
-
21
-
-
84973644310
-
Predictive modeling targets thymidylate synthase ThyX in Mycobacterium tuberculosis
-
21 Djaout, K., et al. Predictive modeling targets thymidylate synthase ThyX in Mycobacterium tuberculosis. Sci. Rep., 6, 2016, 27792.
-
(2016)
Sci. Rep.
, vol.6
, pp. 27792
-
-
Djaout, K.1
-
22
-
-
84921460797
-
The complex mechanism of antimycobacterial action of 5-fluorouracil
-
22 Singh, V., et al. The complex mechanism of antimycobacterial action of 5-fluorouracil. Chem. Biol. 22 (2015), 63–75.
-
(2015)
Chem. Biol.
, vol.22
, pp. 63-75
-
-
Singh, V.1
-
23
-
-
84871764621
-
Identification of novel imidazo[1,2-a]pyridine inhibitors targeting M. tuberculosis QcrB
-
23 Abrahams, K.A., et al. Identification of novel imidazo[1,2-a]pyridine inhibitors targeting M. tuberculosis QcrB. PLoS One, 7, 2012, e52951.
-
(2012)
PLoS One
, vol.7
, pp. e52951
-
-
Abrahams, K.A.1
-
24
-
-
84921470540
-
Target-based identification of whole-cell active inhibitors of biotin biosynthesis in Mycobacterium tuberculosis
-
24 Park, S.W., et al. Target-based identification of whole-cell active inhibitors of biotin biosynthesis in Mycobacterium tuberculosis. Chem. Biol. 22 (2015), 76–86.
-
(2015)
Chem. Biol.
, vol.22
, pp. 76-86
-
-
Park, S.W.1
-
25
-
-
65649096556
-
Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis
-
25 Makarov, V., et al. Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis. Science 324 (2009), 801–804.
-
(2009)
Science
, vol.324
, pp. 801-804
-
-
Makarov, V.1
-
26
-
-
77955074030
-
Development of a repressible mycobacterial promoter system based on two transcriptional repressors
-
26 Boldrin, F., et al. Development of a repressible mycobacterial promoter system based on two transcriptional repressors. Nucleic Acids Res., 38, 2010, e134.
-
(2010)
Nucleic Acids Res.
, vol.38
, pp. e134
-
-
Boldrin, F.1
-
27
-
-
84921908372
-
Rapid cytolysis of Mycobacterium tuberculosis by faropenem, an orally bioavailable beta-lactam antibiotic
-
27 Dhar, N., et al. Rapid cytolysis of Mycobacterium tuberculosis by faropenem, an orally bioavailable beta-lactam antibiotic. Antimicrob. Agents Chemother. 59 (2015), 1308–1319.
-
(2015)
Antimicrob. Agents Chemother.
, vol.59
, pp. 1308-1319
-
-
Dhar, N.1
-
28
-
-
84937148144
-
DprE1 is a vulnerable tuberculosis drug target due to its cell wall localization
-
28 Brecik, M., et al. DprE1 is a vulnerable tuberculosis drug target due to its cell wall localization. ACS Chem. Biol. 10 (2015), 1631–1636.
-
(2015)
ACS Chem. Biol.
, vol.10
, pp. 1631-1636
-
-
Brecik, M.1
-
29
-
-
78649731694
-
Mycobacterium tuberculosis phosphoribosylpyrophosphate synthetase: biochemical features of a crucial enzyme for mycobacterial cell wall biosynthesis
-
29 Lucarelli, A.P., et al. Mycobacterium tuberculosis phosphoribosylpyrophosphate synthetase: biochemical features of a crucial enzyme for mycobacterial cell wall biosynthesis. PLoS One, 5, 2010, e15494.
-
(2010)
PLoS One
, vol.5
, pp. e15494
-
-
Lucarelli, A.P.1
-
30
-
-
0037199999
-
Definition of the first mannosylation step in phosphatidylinositol mannoside synthesis. PimA is essential for growth of mycobacteria
-
30 Kordulakova, J., et al. Definition of the first mannosylation step in phosphatidylinositol mannoside synthesis. PimA is essential for growth of mycobacteria. J. Biol. Chem. 277 (2002), 31335–31344.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 31335-31344
-
-
Kordulakova, J.1
-
31
-
-
84931562524
-
Lead selection and characterization of antitubercular compounds using the Nested Chemical Library
-
31 Sipos, A., et al. Lead selection and characterization of antitubercular compounds using the Nested Chemical Library. Tuberculosis 95:Suppl. 1 (2015), S200–S206.
-
(2015)
Tuberculosis
, vol.95
, pp. S200-S206
-
-
Sipos, A.1
-
32
-
-
84864401215
-
Pathway-selective sensitization of Mycobacterium tuberculosis for target-based whole-cell screening
-
32 Abrahams, G.L., et al. Pathway-selective sensitization of Mycobacterium tuberculosis for target-based whole-cell screening. Chem. Biol. 19 (2012), 844–854.
-
(2012)
Chem. Biol.
, vol.19
, pp. 844-854
-
-
Abrahams, G.L.1
-
33
-
-
79959794071
-
Tuberculosis drugs: new candidates and how to find more
-
33 Sala, C., Hartkoorn, R.C., Tuberculosis drugs: new candidates and how to find more. Fut. Microbiol. 6 (2011), 617–633.
-
(2011)
Fut. Microbiol.
, vol.6
, pp. 617-633
-
-
Sala, C.1
Hartkoorn, R.C.2
-
34
-
-
34247143197
-
Low-oxygen-recovery assay for high-throughput screening of compounds against nonreplicating Mycobacterium tuberculosis
-
34 Cho, S.H., et al. Low-oxygen-recovery assay for high-throughput screening of compounds against nonreplicating Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 51 (2007), 1380–1385.
-
(2007)
Antimicrob. Agents Chemother.
, vol.51
, pp. 1380-1385
-
-
Cho, S.H.1
-
35
-
-
84886571125
-
Identification of novel inhibitors of nonreplicating Mycobacterium tuberculosis using a carbon starvation model
-
35 Grant, S.S., et al. Identification of novel inhibitors of nonreplicating Mycobacterium tuberculosis using a carbon starvation model. ACS Chem. Biol. 8 (2013), 2224–2234.
-
(2013)
ACS Chem. Biol.
, vol.8
, pp. 2224-2234
-
-
Grant, S.S.1
-
36
-
-
84925236491
-
A multi-stress model for high throughput screening against non-replicating Mycobacterium tuberculosis
-
36 Gold, B., et al. A multi-stress model for high throughput screening against non-replicating Mycobacterium tuberculosis. Methods Mol. Biol. 1285 (2015), 293–315.
-
(2015)
Methods Mol. Biol.
, vol.1285
, pp. 293-315
-
-
Gold, B.1
-
37
-
-
0028942364
-
Novel mutation in 16S rRNA associated with streptomycin dependence in Mycobacterium tuberculosis
-
37 Honore, N., et al. Novel mutation in 16S rRNA associated with streptomycin dependence in Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 39 (1995), 769–770.
-
(1995)
Antimicrob. Agents Chemother.
, vol.39
, pp. 769-770
-
-
Honore, N.1
-
38
-
-
77957375205
-
Simple model for testing drugs against nonreplicating Mycobacterium tuberculosis
-
38 Sala, C., et al. Simple model for testing drugs against nonreplicating Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 54 (2010), 4150–4158.
-
(2010)
Antimicrob. Agents Chemother.
, vol.54
, pp. 4150-4158
-
-
Sala, C.1
-
39
-
-
84868007876
-
Streptomycin-starved Mycobacterium tuberculosis 18b, a drug discovery tool for latent tuberculosis
-
39 Zhang, M., et al. Streptomycin-starved Mycobacterium tuberculosis 18b, a drug discovery tool for latent tuberculosis. Antimicrob. Agents Chemother. 56 (2012), 5782–5789.
-
(2012)
Antimicrob. Agents Chemother.
, vol.56
, pp. 5782-5789
-
-
Zhang, M.1
-
40
-
-
73649143180
-
High content screening identifies decaprenyl-phosphoribose 2′ epimerase as a target for intracellular antimycobacterial inhibitors
-
40 Christophe, T., et al. High content screening identifies decaprenyl-phosphoribose 2′ epimerase as a target for intracellular antimycobacterial inhibitors. PLoS Pathog., 5, 2009, e1000645.
-
(2009)
PLoS Pathog.
, vol.5
, pp. e1000645
-
-
Christophe, T.1
-
41
-
-
84924351877
-
Novel inhibitors of cholesterol degradation in Mycobacterium tuberculosis reveal how the bacterium's metabolism is constrained by the intracellular environment
-
41 VanderVen, B.C., et al. Novel inhibitors of cholesterol degradation in Mycobacterium tuberculosis reveal how the bacterium's metabolism is constrained by the intracellular environment. PLoS Pathog., 11, 2015, e1004679.
-
(2015)
PLoS Pathog.
, vol.11
, pp. e1004679
-
-
VanderVen, B.C.1
-
42
-
-
84883824094
-
Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis
-
42 Pethe, K., et al. Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis. Nat. Med. 19 (2013), 1157–1160.
-
(2013)
Nat. Med.
, vol.19
, pp. 1157-1160
-
-
Pethe, K.1
-
43
-
-
79959225741
-
Advent of imidazo[1,2-a]pyridine-3-carboxamides with potent multi- and extended drug resistant antituberculosis activity
-
43 Moraski, G.C., et al. Advent of imidazo[1,2-a]pyridine-3-carboxamides with potent multi- and extended drug resistant antituberculosis activity. ACS Med. Chem. Lett. 2 (2011), 466–470.
-
(2011)
ACS Med. Chem. Lett.
, vol.2
, pp. 466-470
-
-
Moraski, G.C.1
-
44
-
-
84936887451
-
Design, synthesis, and biological evaluation of pyrazolo[1,5-a]pyridine-3-carboxamides as novel antitubercular agents
-
44 Tang, J., et al. Design, synthesis, and biological evaluation of pyrazolo[1,5-a]pyridine-3-carboxamides as novel antitubercular agents. ACS Med. Chem. Lett. 6 (2015), 814–818.
-
(2015)
ACS Med. Chem. Lett.
, vol.6
, pp. 814-818
-
-
Tang, J.1
-
45
-
-
84895732971
-
Identification of host-targeted small molecules that restrict intracellular Mycobacterium tuberculosis growth
-
45 Stanley, S.A., et al. Identification of host-targeted small molecules that restrict intracellular Mycobacterium tuberculosis growth. PLoS Pathog., 10, 2014, e1003946.
-
(2014)
PLoS Pathog.
, vol.10
, pp. e1003946
-
-
Stanley, S.A.1
-
46
-
-
84908058654
-
Anticytolytic screen identifies inhibitors of mycobacterial virulence protein secretion
-
46 Rybniker, J., et al. Anticytolytic screen identifies inhibitors of mycobacterial virulence protein secretion. Cell Host Microbe 16 (2014), 538–548.
-
(2014)
Cell Host Microbe
, vol.16
, pp. 538-548
-
-
Rybniker, J.1
-
47
-
-
84937013006
-
Lansoprazole is an antituberculous prodrug targeting cytochrome bc1
-
47 Rybniker, J., et al. Lansoprazole is an antituberculous prodrug targeting cytochrome bc1. Nat. Commun., 6, 2015, 7659.
-
(2015)
Nat. Commun.
, vol.6
, pp. 7659
-
-
Rybniker, J.1
-
48
-
-
84884505005
-
Identification of new drug targets and resistance mechanisms in Mycobacterium tuberculosis
-
48 Ioerger, T.R., et al. Identification of new drug targets and resistance mechanisms in Mycobacterium tuberculosis. PLoS One, 8, 2013, e75245.
-
(2013)
PLoS One
, vol.8
, pp. e75245
-
-
Ioerger, T.R.1
-
49
-
-
84898619017
-
Cross-resistance between clofazimine and bedaquiline through upregulation of MmpL5 in Mycobacterium tuberculosis
-
49 Hartkoorn, R.C., et al. Cross-resistance between clofazimine and bedaquiline through upregulation of MmpL5 in Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 58 (2014), 2979–2981.
-
(2014)
Antimicrob. Agents Chemother.
, vol.58
, pp. 2979-2981
-
-
Hartkoorn, R.C.1
-
50
-
-
77049136734
-
A new antibiotic, pyridomycin
-
50 Maeda, K., et al. A new antibiotic, pyridomycin. J. Antibiot., 6, 1953, 140.
-
(1953)
J. Antibiot.
, vol.6
, pp. 140
-
-
Maeda, K.1
-
51
-
-
84867067622
-
Towards a new tuberculosis drug: pyridomycin – nature's isoniazid
-
51 Hartkoorn, R.C., et al. Towards a new tuberculosis drug: pyridomycin – nature's isoniazid. EMBO Mol. Med. 4 (2012), 1032–1042.
-
(2012)
EMBO Mol. Med.
, vol.4
, pp. 1032-1042
-
-
Hartkoorn, R.C.1
-
52
-
-
84897108482
-
Pyridomycin bridges the NADH- and substrate-binding pockets of the enoyl reductase InhA
-
52 Hartkoorn, R.C., et al. Pyridomycin bridges the NADH- and substrate-binding pockets of the enoyl reductase InhA. Nat. Chem. Biol. 10 (2014), 96–98.
-
(2014)
Nat. Chem. Biol.
, vol.10
, pp. 96-98
-
-
Hartkoorn, R.C.1
-
53
-
-
84925633527
-
2-Carboxyquinoxalines kill Mycobacterium tuberculosis through noncovalent inhibition of DprE1
-
53 Neres, J., et al. 2-Carboxyquinoxalines kill Mycobacterium tuberculosis through noncovalent inhibition of DprE1. ACS Chem. Biol. 10 (2015), 705–714.
-
(2015)
ACS Chem. Biol.
, vol.10
, pp. 705-714
-
-
Neres, J.1
-
54
-
-
84858677107
-
Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane
-
54 Grzegorzewicz, A.E., et al. Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane. Nat. Chem. Biol. 8 (2012), 334–341.
-
(2012)
Nat. Chem. Biol.
, vol.8
, pp. 334-341
-
-
Grzegorzewicz, A.E.1
-
55
-
-
84863404695
-
SQ109 targets MmpL3, a membrane transporter of trehalose monomycolate involved in mycolic acid donation to the cell wall core of Mycobacterium tuberculosis
-
55 Tahlan, K., et al. SQ109 targets MmpL3, a membrane transporter of trehalose monomycolate involved in mycolic acid donation to the cell wall core of Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 56 (2012), 1797–1809.
-
(2012)
Antimicrob. Agents Chemother.
, vol.56
, pp. 1797-1809
-
-
Tahlan, K.1
-
56
-
-
84878098841
-
Preliminary structure–activity relationships and biological evaluation of novel antitubercular indolecarboxamide derivatives against drug-susceptible and drug-resistant Mycobacterium tuberculosis strains
-
56 Onajole, O.K., et al. Preliminary structure–activity relationships and biological evaluation of novel antitubercular indolecarboxamide derivatives against drug-susceptible and drug-resistant Mycobacterium tuberculosis strains. J. Med. Chem. 56 (2013), 4093–4103.
-
(2013)
J. Med. Chem.
, vol.56
, pp. 4093-4103
-
-
Onajole, O.K.1
-
57
-
-
84891722137
-
Indolcarboxamide is a preclinical candidate for treating multidrug-resistant tuberculosis
-
57 Rao, S.P., et al. Indolcarboxamide is a preclinical candidate for treating multidrug-resistant tuberculosis. Sci. Transl. Med., 5, 2013, 214ra168.
-
(2013)
Sci. Transl. Med.
, vol.5
, pp. 214ra168
-
-
Rao, S.P.1
-
58
-
-
84978648886
-
Indole-2-carboxamide-based MmpL3 inhibitors show exceptional antitubercular activity in an animal model of tuberculosis infection
-
58 Stec, J., et al. Indole-2-carboxamide-based MmpL3 inhibitors show exceptional antitubercular activity in an animal model of tuberculosis infection. J. Med. Chem. 59 (2016), 6232–6247.
-
(2016)
J. Med. Chem.
, vol.59
, pp. 6232-6247
-
-
Stec, J.1
-
59
-
-
84876272210
-
Tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide and N-benzyl-6′,7′-dihydrospiro[piperidine-4,4′-thieno[3,2-c]pyran] analogues with bactericidal efficacy against Mycobacterium tuberculosis targeting MmpL3
-
59 Remuinan, M.J., et al. Tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide and N-benzyl-6′,7′-dihydrospiro[piperidine-4,4′-thieno[3,2-c]pyran] analogues with bactericidal efficacy against Mycobacterium tuberculosis targeting MmpL3. PLoS One, 8, 2013, e60933.
-
(2013)
PLoS One
, vol.8
, pp. e60933
-
-
Remuinan, M.J.1
-
60
-
-
84890954080
-
Indoleamides are active against drug-resistant Mycobacterium tuberculosis
-
60 Lun, S., et al. Indoleamides are active against drug-resistant Mycobacterium tuberculosis. Nat. Commun., 4, 2013, 2907.
-
(2013)
Nat. Commun.
, vol.4
, pp. 2907
-
-
Lun, S.1
-
61
-
-
84455173193
-
MmpL3 is the cellular target of the antitubercular pyrrole derivative BM212
-
61 La Rosa, V., et al. MmpL3 is the cellular target of the antitubercular pyrrole derivative BM212. Antimicrob. Agents Chemother. 56 (2012), 324–331.
-
(2012)
Antimicrob. Agents Chemother.
, vol.56
, pp. 324-331
-
-
La Rosa, V.1
-
62
-
-
84865253965
-
Identification of novel inhibitors of M. tuberculosis growth using whole cell based high-throughput screening
-
62 Stanley, S.A., et al. Identification of novel inhibitors of M. tuberculosis growth using whole cell based high-throughput screening. ACS Chem. Biol. 7 (2012), 1377–1384.
-
(2012)
ACS Chem. Biol.
, vol.7
, pp. 1377-1384
-
-
Stanley, S.A.1
-
63
-
-
84934805597
-
Whole cell screen based identification of spiropiperidines with potent antitubercular properties
-
63 Tantry, S.J., et al. Whole cell screen based identification of spiropiperidines with potent antitubercular properties. Bioorg. Med. Chem. Lett. 25 (2015), 3234–3245.
-
(2015)
Bioorg. Med. Chem. Lett.
, vol.25
, pp. 3234-3245
-
-
Tantry, S.J.1
-
64
-
-
84903527119
-
4-Aminoquinolone piperidine amides: noncovalent inhibitors of DprE1 with long residence time and potent antimycobacterial activity
-
64 Naik, M., et al. 4-Aminoquinolone piperidine amides: noncovalent inhibitors of DprE1 with long residence time and potent antimycobacterial activity. J. Med. Chem. 57 (2014), 5419–5434.
-
(2014)
J. Med. Chem.
, vol.57
, pp. 5419-5434
-
-
Naik, M.1
-
65
-
-
84907555819
-
2-Phenylindole and arylsulphonamide: novel scaffolds bactericidal against Mycobacterium tuberculosis
-
65 Naik, M., et al. 2-Phenylindole and arylsulphonamide: novel scaffolds bactericidal against Mycobacterium tuberculosis. ACS Med. Chem. Lett. 5 (2014), 1005–1009.
-
(2014)
ACS Med. Chem. Lett.
, vol.5
, pp. 1005-1009
-
-
Naik, M.1
-
66
-
-
84983509267
-
Therapeutic potential of the Mycobacterium tuberculosis mycolic acid transporter, MmpL3
-
66 Li, W., et al. Therapeutic potential of the Mycobacterium tuberculosis mycolic acid transporter, MmpL3. Antimicrob. Agents Chemother. 60 (2016), 5198–5207.
-
(2016)
Antimicrob. Agents Chemother.
, vol.60
, pp. 5198-5207
-
-
Li, W.1
-
67
-
-
84908288084
-
Novel insights into the mechanism of inhibition of MmpL3, a target of multiple pharmacophores in Mycobacterium tuberculosis
-
67 Li, W., et al. Novel insights into the mechanism of inhibition of MmpL3, a target of multiple pharmacophores in Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 58 (2014), 6413–6423.
-
(2014)
Antimicrob. Agents Chemother.
, vol.58
, pp. 6413-6423
-
-
Li, W.1
-
68
-
-
84937814208
-
Thiophenecarboxamide derivatives activated by EthA kill Mycobacterium tuberculosis by inhibiting the CTP synthetase PyrG
-
68 Mori, G., et al. Thiophenecarboxamide derivatives activated by EthA kill Mycobacterium tuberculosis by inhibiting the CTP synthetase PyrG. Chem. Biol. 22 (2015), 917–927.
-
(2015)
Chem. Biol.
, vol.22
, pp. 917-927
-
-
Mori, G.1
-
69
-
-
84904554770
-
Rv2466c mediates the activation of TP053 to kill replicating and non-replicating Mycobacterium tuberculosis
-
69 Albesa-Jove, D., et al. Rv2466c mediates the activation of TP053 to kill replicating and non-replicating Mycobacterium tuberculosis. ACS Chem. Biol. 9 (2014), 1567–1575.
-
(2014)
ACS Chem. Biol.
, vol.9
, pp. 1567-1575
-
-
Albesa-Jove, D.1
-
70
-
-
84951753430
-
The redox state regulates the conformation of Rv2466c to activate the antitubercular prodrug TP053
-
70 Albesa-Jove, D., et al. The redox state regulates the conformation of Rv2466c to activate the antitubercular prodrug TP053. J. Biol. Chem. 290 (2015), 31077–31089.
-
(2015)
J. Biol. Chem.
, vol.290
, pp. 31077-31089
-
-
Albesa-Jove, D.1
-
71
-
-
84930647575
-
Antibiotics. Targeting DnaN for tuberculosis therapy using novel griselimycins
-
71 Kling, A., et al. Antibiotics. Targeting DnaN for tuberculosis therapy using novel griselimycins. Science 348 (2015), 1106–1112.
-
(2015)
Science
, vol.348
, pp. 1106-1112
-
-
Kling, A.1
|