-
1
-
-
84893257773
-
-
World Health Organization. World Health Organization, Geneva, Switzerland
-
World Health Organization. 2015. Global tuberculosis report 2015. World Health Organization, Geneva, Switzerland.
-
(2015)
Global Tuberculosis Report
-
-
-
2
-
-
79959794071
-
Tuberculosis drugs: New candidates and how to find more
-
Sala C, Hartkoorn RC. 2011. Tuberculosis drugs: new candidates and how to find more. Future Microbiol 6:617-633. http://dx.doi.org/10.2217/fmb.11.46.
-
(2011)
Future Microbiol
, vol.6
, pp. 617-633
-
-
Sala, C.1
Hartkoorn, R.C.2
-
3
-
-
84880130708
-
Progress in targeting cell envelope biogenesis in Mycobacterium tuberculosis
-
Jackson M, McNeil MR, Brennan PJ. 2013. Progress in targeting cell envelope biogenesis in Mycobacterium tuberculosis. Future Microbiol 8:855-875. http://dx.doi.org/10.2217/fmb.13.52.
-
(2013)
Future Microbiol
, vol.8
, pp. 855-875
-
-
Jackson, M.1
McNeil, M.R.2
Brennan, P.J.3
-
4
-
-
84873811860
-
Fueling open-source drug discovery: 177 Small-molecule leads against tuberculosis
-
Ballell L, Bates RH, Young RJ, Alvarez-Gomez D, Alvarez-Ruiz E, Barroso V, Blanco D, Crespo B, Escribano J, Gonzalez R, Lozano S, Huss S, Santos-Villarejo A, Martin-Plaza JJ, Mendoza A, Rebollo-Lopez MJ, Remuinan-Blanco M, Lavandera JL, Perez-Herran E, Gamo-Benito FJ, Garcia-Bustos JF, Barros D, Castro JP, Cammack N. 2013. Fueling open-source drug discovery: 177 small-molecule leads against tuberculosis. ChemMed- Chem 8:313-321. http://dx.doi.org/10.1002/cmdc.201200428.
-
(2013)
ChemMed- Chem
, vol.8
, pp. 313-321
-
-
Ballell, L.1
Bates, R.H.2
Young, R.J.3
Alvarez-Gomez, D.4
Alvarez-Ruiz, E.5
Barroso, V.6
Blanco, D.7
Crespo, B.8
Escribano, J.9
Gonzalez, R.10
Lozano, S.11
Huss, S.12
Santos-Villarejo, A.13
Martin-Plaza, J.J.14
Mendoza, A.15
Rebollo-Lopez, M.J.16
Remuinan-Blanco, M.17
Lavandera, J.L.18
Perez-Herran, E.19
Gamo-Benito, F.J.20
Garcia-Bustos, J.F.21
Barros, D.22
Castro, J.P.23
Cammack, N.24
more..
-
5
-
-
84858677107
-
Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane
-
Grzegorzewicz AE, Pham H, Gundi VA, Scherman MS, North EJ, Hess T, Jones V, Gruppo V, Born SE, Korduláková J, Chavadi SS, Morisseau C, Lenaerts AJ, Lee RE, McNeil MR, Jackson M. 2012. Inhibition of mycolic acid transport across the Mycobacterium tuberculosis plasma membrane. Nat Chem Biol 8:334-341. http://dx.doi.org/10.1038/nchembio.794.
-
(2012)
Nat Chem Biol
, vol.8
, pp. 334-341
-
-
Grzegorzewicz, A.E.1
Pham, H.2
Gundi, V.A.3
Scherman, M.S.4
North, E.J.5
Hess, T.6
Jones, V.7
Gruppo, V.8
Born, S.E.9
Korduláková, J.10
Chavadi, S.S.11
Morisseau, C.12
Lenaerts, A.J.13
Lee, R.E.14
McNeil, M.R.15
Jackson, M.16
-
6
-
-
84863404695
-
SQ109 targets MmpL3, a membrane transporter of trehalose monomycolate involved in mycolic acid donation to the cell wall core of Mycobacterium tuberculosis
-
Tahlan K, Wilson R, Kastrinsky DB, Arora K, Nair V, Fischer E, Barnes SW, Walker JR, Alland D, Barry CE, III, Boshoff HI. 2012. SQ109 targets MmpL3, a membrane transporter of trehalose monomycolate involved in mycolic acid donation to the cell wall core of Mycobacterium tuberculosis. Antimicrob Agents Chemother 56:1797-1809. http://dx.doi.org/10.1128/AAC.05708-11.
-
(2012)
Antimicrob Agents Chemother
, vol.56
, pp. 1797-1809
-
-
Tahlan, K.1
Wilson, R.2
Kastrinsky, D.B.3
Arora, K.4
Nair, V.5
Fischer, E.6
Barnes, S.W.7
Walker, J.R.8
Alland, D.9
Barry, C.E.10
Boshoff, H.I.11
-
7
-
-
84455173193
-
MmpL3 is the cellular target of the antitubercular pyrrole derivative BM212
-
La Rosa V, Poce G, Canseco JO, Buroni S, Pasca MR, Biava M, Raju RM, Porretta GC, Alfonso S, Battilocchio C, Javid B, Sorrentino F, Ioerger TR, Sacchettini JC, Manetti F, Botta M, De Logu A, Rubin EJ, De Rossi E. 2012. MmpL3 is the cellular target of the antitubercular pyrrole derivative BM212. Antimicrob Agents Chemother 56:324-331. http://dx.doi.org/10.1128/AAC.05270-11.
-
(2012)
Antimicrob Agents Chemother
, vol.56
, pp. 324-331
-
-
La Rosa, V.1
Poce, G.2
Canseco, J.O.3
Buroni, S.4
Pasca, M.R.5
Biava, M.6
Raju, R.M.7
Porretta, G.C.8
Alfonso, S.9
Battilocchio, C.10
Javid, B.11
Sorrentino, F.12
Ioerger, T.R.13
Sacchettini, J.C.14
Manetti, F.15
Botta, M.16
De Logu, A.17
Rubin, E.J.18
De Rossi, E.19
-
8
-
-
84865253965
-
Identification of novel inhibitors of M. Tuberculosis growth using whole cell based high-throughput screening
-
Stanley SA, Grant SS, Kawate T, Iwase N, Shimizu M, Wivagg C, Silvis M, Kazyanskaya E, Aquadro J, Golas A, Fitzgerald M, Dai H, Zhang L, Hung DT. 2012. Identification of novel inhibitors of M. tuberculosis growth using whole cell based high-throughput screening. ACS Chem Biol 7:1377-1384. http://dx.doi.org/10.1021/cb300151m.
-
(2012)
ACS Chem Biol
, vol.7
, pp. 1377-1384
-
-
Stanley, S.A.1
Grant, S.S.2
Kawate, T.3
Iwase, N.4
Shimizu, M.5
Wivagg, C.6
Silvis, M.7
Kazyanskaya, E.8
Aquadro, J.9
Golas, A.10
Fitzgerald, M.11
Dai, H.12
Zhang, L.13
Hung, D.T.14
-
9
-
-
84874297088
-
Improved BM212 MmpL3 inhibitor analogue shows efficacy in acute murine model of tuberculosis infection
-
Poce G, Bates RH, Alfonso S, Cocozza M, Porretta GC, Ballell L, Rullas J, Ortega F, De Logu A, Agus E, La Rosa V, Pasca MR, De Rossi E, Wae B, Franzblau SG, Manetti F, Botta M, Biava M. 2013. Improved BM212 MmpL3 inhibitor analogue shows efficacy in acute murine model of tuberculosis infection. PLoS One 8:e56980. http://dx.doi.org/10.1371/journal.pone.0056980.
-
(2013)
PLoS One
, vol.8
-
-
Poce, G.1
Bates, R.H.2
Alfonso, S.3
Cocozza, M.4
Porretta, G.C.5
Ballell, L.6
Rullas, J.7
Ortega, F.8
De Logu, A.9
Agus, E.10
La Rosa, V.11
Pasca, M.R.12
De Rossi, E.13
Wae, B.14
Franzblau, S.G.15
Manetti, F.16
Botta, M.17
Biava, M.18
-
10
-
-
84876272210
-
Tetrahydropyrazolo[1,5-a]pyrimidine-3- carboxamide and N-benzyl-6′,7′-dihydrospiro[piperidine-4,4′-thieno[3,2-c]pyran] analogues with bactericidal efficacy against Mycobacterium tuberculosis targeting MmpL3
-
Remuinan MJ, Perez-Herran E, Rullas J, Alemparte C, Martinez-Hoyos M, Dow DJ, Afari J, Mehta N, Esquivias J, Jimenez E, Ortega-Muro F, Fraile-Gabaldon MT, Spivey VL, Loman NJ, Pallen MJ, Constantinidou C, Minick DJ, Cacho M, Rebollo-Lopez MJ, Gonzalez C, Sousa V, Angulo-Barturen I, Mendoza-Losana A, Barros D, Besra GS, Ballell L, Cammack N. 2013. Tetrahydropyrazolo[1,5-a]pyrimidine-3- carboxamide and N-benzyl-6′,7′-dihydrospiro[piperidine-4,4′-thieno[3,2-c]pyran] analogues with bactericidal efficacy against Mycobacterium tuberculosis targeting MmpL3. PLoS One 8:e60933. http://dx.doi.org/10.1371/journal.pone.0060933.
-
(2013)
PLoS One
, vol.8
-
-
Remuinan, M.J.1
Perez-Herran, E.2
Rullas, J.3
Alemparte, C.4
Martinez-Hoyos, M.5
Dow, D.J.6
Afari, J.7
Mehta, N.8
Esquivias, J.9
Jimenez, E.10
Ortega-Muro, F.11
Fraile-Gabaldon, M.T.12
Spivey, V.L.13
Loman, N.J.14
Pallen, M.J.15
Constantinidou, C.16
Minick, D.J.17
Cacho, M.18
Rebollo-Lopez, M.J.19
Gonzalez, C.20
Sousa, V.21
Angulo-Barturen, I.22
Mendoza-Losana, A.23
Barros, D.24
Besra, G.S.25
Ballell, L.26
Cammack, N.27
more..
-
11
-
-
84884505005
-
Identification of new drug targets and resistance mechanisms in Mycobacterium tuberculosis
-
Ioerger TR, O'Malley T, Liao R, Guinn KM, Hickey MJ, Mohaideen N, Murphy KC, Boshoff HI, Mizrahi V, Rubin EJ, Sassetti CM, Barry CE, III, Sherman DR, Parish T, Sacchettini JC. 2013. Identification of new drug targets and resistance mechanisms in Mycobacterium tuberculosis. PLoS One 8:e75245. http://dx.doi.org/10.1371/journal.pone.0075245.
-
(2013)
PLoS One
, vol.8
-
-
Ioerger, T.R.1
O'Malley, T.2
Liao, R.3
Guinn, K.M.4
Hickey, M.J.5
Mohaideen, N.6
Murphy, K.C.7
Boshoff, H.I.8
Mizrahi, V.9
Rubin, E.J.10
Sassetti, C.M.11
Barry, C.E.12
Sherman, D.R.13
Parish, T.14
Sacchettini, J.C.15
-
12
-
-
84890954080
-
Indoleamides are active against drug-resistant Mycobacterium tuberculosis
-
Lun S, Guo H, Onajole OK, Pieroni M, Gunosewoyo H, Chen G, Tipparaju SK, Ammerman NC, Kozikowski AP, Bishai WR. 2013. Indoleamides are active against drug-resistant Mycobacterium tuberculosis. Nat Commun 4:2907.
-
(2013)
Nat Commun
, vol.4
, pp. 2907
-
-
Lun, S.1
Guo, H.2
Onajole, O.K.3
Pieroni, M.4
Gunosewoyo, H.5
Chen, G.6
Tipparaju, S.K.7
Ammerman, N.C.8
Kozikowski, A.P.9
Bishai, W.R.10
-
13
-
-
84891722137
-
Indolcarboxamide is a preclinical candidate for treating multidrug-resistant tuberculosis
-
Rao SP, Lakshminarayana SB, Kondreddi RR, Herve M, Camacho LR, Bifani P, Kalapala SK, Jiricek J, Ma NL, Tan BH, Ng SH, Nanjundappa M, Ravindran S, Seah PG, Thayalan P, Lim SH, Lee BH, Goh A, Barnes WS, Chen Z, Gagaring K, Chatterjee AK, Pethe K, Kuhen K, Walker J, Feng G, Babu S, Zhang L, Blasco F, Beer D, Weaver M, Dartois V, Glynne R, Dick T, Smith PW, Diagana TT, Manjunatha UH. 2013. Indolcarboxamide is a preclinical candidate for treating multidrug-resistant tuberculosis. Sci Transl Med 5:214ra168. http://dx.doi.org/10.1126/scitranslmed.3007355.
-
(2013)
Sci Transl Med
, vol.5
-
-
Rao, S.P.1
Lakshminarayana, S.B.2
Kondreddi, R.R.3
Herve, M.4
Camacho, L.R.5
Bifani, P.6
Kalapala, S.K.7
Jiricek, J.8
Ma, N.L.9
Tan, B.H.10
Ng, S.H.11
Nanjundappa, M.12
Ravindran, S.13
Seah, P.G.14
Thayalan, P.15
Lim, S.H.16
Lee, B.H.17
Goh, A.18
Barnes, W.S.19
Chen, Z.20
Gagaring, K.21
Chatterjee, A.K.22
Pethe, K.23
Kuhen, K.24
Walker, J.25
Feng, G.26
Babu, S.27
Zhang, L.28
Blasco, F.29
Beer, D.30
Weaver, M.31
Dartois, V.32
Glynne, R.33
Dick, T.34
Smith, P.W.35
Diagana, T.T.36
Manjunatha, U.H.37
more..
-
14
-
-
84934805597
-
Whole cell screen based identification of spiropiperidines with potent antitubercular properties
-
Tantry SJ, Degiacomi G, Sharma S, Jena LK, Narayan A, Guptha S, Shanbhag G, Menasinakai S, Mallya M, Awasthy D, Balakrishnan G, Kaur P, Bhattacharjee D, Narayan C, Reddy J, Naveen Kumar CN, Shandil R, Boldrin F, Ventura M, Manganelli R, Hartkoorn RC, Cole ST, Panda M, Markad SD, Ramachandran V, Ghorpade SR, Dinesh N. 2015. Whole cell screen based identification of spiropiperidines with potent antitubercular properties. Bioorg Med Chem Lett 25:3234-3245. http://dx.doi.org/10.1016/j.bmcl.2015.05.087.
-
(2015)
Bioorg Med Chem Lett
, vol.25
, pp. 3234-3245
-
-
Tantry, S.J.1
Degiacomi, G.2
Sharma, S.3
Jena, L.K.4
Narayan, A.5
Guptha, S.6
Shanbhag, G.7
Menasinakai, S.8
Mallya, M.9
Awasthy, D.10
Balakrishnan, G.11
Kaur, P.12
Bhattacharjee, D.13
Narayan, C.14
Reddy, J.15
Naveen Kumar, C.N.16
Shandil, R.17
Boldrin, F.18
Ventura, M.19
Manganelli, R.20
Hartkoorn, R.C.21
Cole, S.T.22
Panda, M.23
Markad, S.D.24
Ramachandran, V.25
Ghorpade, S.R.26
Dinesh, N.27
more..
-
15
-
-
41649116701
-
Disclosure of the mycobacterial outer membrane: Cryo-electron tomography and vitreous sections reveal the lipid bilayer structure
-
Hoffmann C, Leis A, Niederweis M, Plitzko JM, Engelhardt H. 2008. Disclosure of the mycobacterial outer membrane: cryo-electron tomography and vitreous sections reveal the lipid bilayer structure. Proc Natl Acad Sci U S A 105:3963-3967. http://dx.doi.org/10.1073/pnas.0709530105.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 3963-3967
-
-
Hoffmann, C.1
Leis, A.2
Niederweis, M.3
Plitzko, J.M.4
Engelhardt, H.5
-
16
-
-
49449107199
-
Direct visualization of the outer membrane of mycobacteria and corynebacteria in their native state
-
Zuber B, Chami M, Houssin C, Dubochet J, Griffiths G, Daffé M. 2008. Direct visualization of the outer membrane of mycobacteria and corynebacteria in their native state. J Bacteriol 190:5672-5680. http://dx.doi.org/10.1128/JB.01919-07.
-
(2008)
J Bacteriol
, vol.190
, pp. 5672-5680
-
-
Zuber, B.1
Chami, M.2
Houssin, C.3
Dubochet, J.4
Griffiths, G.5
Daffé, M.6
-
17
-
-
84908288084
-
Novel insights into the mechanism of inhibition of MmpL3, a target of multiple pharmacophores in Mycobacterium tuberculosis
-
Li W, Upadhyay A, Fontes FL, North EJ, Wang Y, Crans DC, Grzegorzewicz AE, Jones V, Franzblau SG, Lee RE, Crick DC, Jackson M. 2014. Novel insights into the mechanism of inhibition of MmpL3, a target of multiple pharmacophores in Mycobacterium tuberculosis. Antimicrob Agents Chemother 58:6413-6423. http://dx.doi.org/10.1128/AAC.03229-14.
-
(2014)
Antimicrob Agents Chemother
, vol.58
, pp. 6413-6423
-
-
Li, W.1
Upadhyay, A.2
Fontes, F.L.3
North, E.J.4
Wang, Y.5
Crans, D.C.6
Grzegorzewicz, A.E.7
Jones, V.8
Franzblau, S.G.9
Lee, R.E.10
Crick, D.C.11
Jackson, M.12
-
18
-
-
84898408111
-
Multi-target drug discovery for tuberculosis and other infectious diseases
-
Li K, Schurig-Briccio LA, Feng X, Upadhyay A, Pujari V, Lechartier B, Fontes F, Yang H, Rao G, Zhu W, Gulati A, No JH, Cintra G, Bogue S, Liu Y-L, Molohon K, Orlean P, Mitchell DA, Freitas-Junior L, Ren F, Sun H, Jiang T, Li Y, Guo R-T, Cole ST, Gennis RB, Crick DC, Oldfield E. 2014. Multi-target drug discovery for tuberculosis and other infectious diseases. J Med Chem 57:3126-3139. http://dx.doi.org/10.1021/jm500131s.
-
(2014)
J Med Chem
, vol.57
, pp. 3126-3139
-
-
Li, K.1
Schurig-Briccio, L.A.2
Feng, X.3
Upadhyay, A.4
Pujari, V.5
Lechartier, B.6
Fontes, F.7
Yang, H.8
Rao, G.9
Zhu, W.10
Gulati, A.11
No, J.H.12
Cintra, G.13
Bogue, S.14
Liu, Y.-L.15
Molohon, K.16
Orlean, P.17
Mitchell, D.A.18
Freitas, L.19
Ren, F.20
Sun, H.21
Jiang, T.22
Li, Y.23
Guo, R.-T.24
Cole, S.T.25
Gennis, R.B.26
Crick, D.C.27
Oldfield, E.28
more..
-
19
-
-
84864332596
-
Discovery and development of SQ109: A new antitubercular drug with a novel mechanism of action
-
Sacksteder KA, Protopopova M, Barry CE, III, Andries K, Nacy CA. 2012. Discovery and development of SQ109: a new antitubercular drug with a novel mechanism of action. Future Microbiol 7:823-837. http://dx.doi.org/10.2217/fmb.12.56.
-
(2012)
Future Microbiol
, vol.7
, pp. 823-837
-
-
Sacksteder, K.A.1
Protopopova, M.2
Barry, C.E.3
Andries, K.4
Nacy, C.A.5
-
20
-
-
84888113573
-
A genetic strategy to identify targets for the development of drugs that prevent bacterial persistence
-
Kim JH, O'Brien KM, Sharma R, Boshoff HI, Rehren G, Chakraborty S, Wallach JB, Monteleone M, Wilson DJ, Aldrich CC, Barry CE, III, Rhee KY, Ehrt S, Schnappinger D. 2013. A genetic strategy to identify targets for the development of drugs that prevent bacterial persistence. Proc Natl Acad Sci U S A 110:19095-19100. http://dx.doi.org/10.1073/pnas.1315860110.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 19095-19100
-
-
Kim, J.H.1
O'Brien, K.M.2
Sharma, R.3
Boshoff, H.I.4
Rehren, G.5
Chakraborty, S.6
Wallach, J.B.7
Monteleone, M.8
Wilson, D.J.9
Aldrich, C.C.10
Barry, C.E.11
Rhee, K.Y.12
Ehrt, S.13
Schnappinger, D.14
-
21
-
-
84925270106
-
Construction of conditional knockdown mutants in mycobacteria
-
Schnappinger D, O'Brien KM, Ehrt S. 2015. Construction of conditional knockdown mutants in mycobacteria. Methods Mol Biol 1285:151-175. http://dx.doi.org/10.1007/978-1-4939-2450-9-9.
-
(2015)
Methods Mol Biol
, vol.1285
, pp. 151-175
-
-
Schnappinger, D.1
O'Brien, K.M.2
Ehrt, S.3
-
22
-
-
0010191850
-
Gene replacement and transposon delivery using the negative selection marker sacB
-
Jackson M, Camacho LR, Gicquel B, Guilhot C. 2001. Gene replacement and transposon delivery using the negative selection marker sacB. Methods Mol Med 54:59-75.
-
(2001)
Methods Mol Med
, vol.54
, pp. 59-75
-
-
Jackson, M.1
Camacho, L.R.2
Gicquel, B.3
Guilhot, C.4
-
23
-
-
0029976980
-
An in vitro model for sequential study of shiftdown of Mycobacterium tuberculosis through two stages of non-replicating persistence
-
Wayne LG, Hayes LG. 1996. An in vitro model for sequential study of shiftdown of Mycobacterium tuberculosis through two stages of non-replicating persistence. Infect Immun 64:2062-2069.
-
(1996)
Infect Immun
, vol.64
, pp. 2062-2069
-
-
Wayne, L.G.1
Hayes, L.G.2
-
24
-
-
28844499001
-
P-Hydroxybenzoic acid synthesis in Mycobacterium tuberculosis
-
Stadthagen G, Korduláková J, Griffin R, Constant P, Bottova I, Barilone N, Gicquel B, Daffé M, Jackson M. 2005. p-Hydroxybenzoic acid synthesis in Mycobacterium tuberculosis. J Biol Chem 280:40699-40706. http://dx.doi.org/10.1074/jbc.M508332200.
-
(2005)
J Biol Chem
, vol.280
, pp. 40699-40706
-
-
Stadthagen, G.1
Korduláková, J.2
Griffin, R.3
Constant, P.4
Bottova, I.5
Barilone, N.6
Gicquel, B.7
Daffé, M.8
Jackson, M.9
-
25
-
-
0242290941
-
Resazurin microtiter assay plate testing of Mycobacterium tuberculosis susceptibilities to second-line drugs: Rapid, simple, and inexpensive method
-
Martin A, Camacho M, Portaels F, Palomino J-C. 2003. Resazurin microtiter assay plate testing of Mycobacterium tuberculosis susceptibilities to second-line drugs: rapid, simple, and inexpensive method. Antimicrob Agents Chemother 47:3616-3619. http://dx.doi.org/10.1128/AAC.47.11.3616-3619.2003.
-
(2003)
Antimicrob Agents Chemother
, vol.47
, pp. 3616-3619
-
-
Martin, A.1
Camacho, M.2
Portaels, F.3
Palomino, J.-C.4
-
26
-
-
54749149484
-
Animal models of M. tuberculosis infection
-
Chapter 10:Unit 10A.5
-
Orme I, Gonzalez-Juarrero M. 2007. Animal models of M. tuberculosis infection. Curr Protoc Microbiol Chapter 10:Unit 10A.5.
-
(2007)
Curr Protoc Microbiol
-
-
Orme, I.1
Gonzalez-Juarrero, M.2
-
27
-
-
84901654908
-
Inactivation of fructose-1,6- bisphosphate aldolase prevents optimal co-catabolism of glycolytic and gluconeogenic carbon substrates in Mycobacterium tuberculosis
-
Puckett S, Trujillo C, Eoh H, Marrero J, Spencer J, Jackson M, Schnappinger D, Rhee K, Ehrt S. 2014. Inactivation of fructose-1,6- bisphosphate aldolase prevents optimal co-catabolism of glycolytic and gluconeogenic carbon substrates in Mycobacterium tuberculosis. PLoS Pathog 10:e1004144. http://dx.doi.org/10.1371/journal.ppat.1004144.
-
(2014)
PLoS Pathog
, vol.10
-
-
Puckett, S.1
Trujillo, C.2
Eoh, H.3
Marrero, J.4
Spencer, J.5
Jackson, M.6
Schnappinger, D.7
Rhee, K.8
Ehrt, S.9
-
28
-
-
84901228056
-
Mycobacterium tuberculosis proteins involved in mycolic acid synthesis and transport localize dynamically to the old growing pole and septum
-
Carel C, Nukdee K, Cantaloube S, Bonne M, Diagne CT, Laval F, Daffé M, Zerbib D. 2014. Mycobacterium tuberculosis proteins involved in mycolic acid synthesis and transport localize dynamically to the old growing pole and septum. PLoS One 9:e97148. http://dx.doi.org/10.1371/journal.pone.0097148.
-
(2014)
PLoS One
, vol.9
-
-
Carel, C.1
Nukdee, K.2
Cantaloube, S.3
Bonne, M.4
Diagne, C.T.5
Laval, F.6
Daffé, M.7
Zerbib, D.8
-
29
-
-
46249108568
-
Tuberculous granulomas are hypoxic in guinea pigs, rabbits, and nonhuman primates
-
Via LE, Lin PL, Ray SM, Carrillo J, Allen SS, Eum SY, Taylor K, Klein E, Manjunatha U, Gonzales J, Lee EG, Park SK, Raleigh JA, Cho SN, McMurray DN, Flynn JL, Barry CE, III. 2008. Tuberculous granulomas are hypoxic in guinea pigs, rabbits, and nonhuman primates. Infect Immun 76:2333-2340. http://dx.doi.org/10.1128/IAI.01515-07.
-
(2008)
Infect Immun
, vol.76
, pp. 2333-2340
-
-
Via, L.E.1
Lin, P.L.2
Ray, S.M.3
Carrillo, J.4
Allen, S.S.5
Eum, S.Y.6
Taylor, K.7
Klein, E.8
Manjunatha, U.9
Gonzales, J.10
Lee, E.G.11
Park, S.K.12
Raleigh, J.A.13
Cho, S.N.14
McMurray, D.N.15
Flynn, J.L.16
Barry, C.E.17
-
30
-
-
70449705831
-
The spectrum of latent tuberculosis: Rethinking the biology and intervention strategies
-
Barry CE, III, Boshoff HI, Dartois V, Dick T, Ehrt S, Flynn J, Schnappinger D, Wilkinson RJ, Young D. 2009. The spectrum of latent tuberculosis: rethinking the biology and intervention strategies. Nat Rev Microbiol 7:845-855. http://dx.doi.org/10.1038/nrmicro2236.
-
(2009)
Nat Rev Microbiol
, vol.7
, pp. 845-855
-
-
Barry, C.E.1
Boshoff, H.I.2
Dartois, V.3
Dick, T.4
Ehrt, S.5
Flynn, J.6
Schnappinger, D.7
Wilkinson, R.J.8
Young, D.9
-
31
-
-
84860211277
-
Targeting persisters for tuberculosis control
-
Zhang Y, Yew WW, Barer MR. 2012. Targeting persisters for tuberculosis control. Antimicrob Agents Chemother 56:2223-2230. http://dx.doi.org/10.1128/AAC.06288-11.
-
(2012)
Antimicrob Agents Chemother
, vol.56
, pp. 2223-2230
-
-
Zhang, Y.1
Yew, W.W.2
Barer, M.R.3
-
32
-
-
84864401215
-
Pathway-selective sensitization of Mycobacterium tuberculosis for target-based whole-cell screening
-
Abrahams GL, Kumar A, Savvi S, Hung AW, Wen S, Abell C, Barry CE, III, Sherman DR, Boshoff HI, Mizrahi V. 2012. Pathway-selective sensitization of Mycobacterium tuberculosis for target-based whole-cell screening. Chem Biol 19:844-854. http://dx.doi.org/10.1016/j.chembiol.2012.05.020.
-
(2012)
Chem Biol
, vol.19
, pp. 844-854
-
-
Abrahams, G.L.1
Kumar, A.2
Savvi, S.3
Hung, A.W.4
Wen, S.5
Abell, C.6
Barry, C.E.7
Sherman, D.R.8
Boshoff, H.I.9
Mizrahi, V.10
-
33
-
-
84871551094
-
Structure-guided discovery of phenyl-diketo acids as potent inhibitors of M. Tuberculosis malate synthase
-
Krieger IV, Freundlich JS, Gawandi VB, Roberts JP, Gawandi VB, Sun Q, Owen JL, Fraile MT, Huss SI, Lavandera JL, Ioerger TR, Sacchettini JC. 2012. Structure-guided discovery of phenyl-diketo acids as potent inhibitors of M. tuberculosis malate synthase. Chem Biol 19:1556-1567. http://dx.doi.org/10.1016/j.chembiol.2012.09.018.
-
(2012)
Chem Biol
, vol.19
, pp. 1556-1567
-
-
Krieger, I.V.1
Freundlich, J.S.2
Gawandi, V.B.3
Roberts, J.P.4
Gawandi, V.B.5
Sun, Q.6
Owen, J.L.7
Fraile, M.T.8
Huss, S.I.9
Lavandera, J.L.10
Ioerger, T.R.11
Sacchettini, J.C.12
-
34
-
-
84863088810
-
High-throughput screening and sensitized bacteria identify an M. Tuberculosis dihydrofolate reductase inhibitor with whole cell activity
-
Kumar A, Zhang M, Zhu L, Liao RP, Mutai C, Hafsat S, Sherman DR, Wang MW. 2012. High-throughput screening and sensitized bacteria identify an M. tuberculosis dihydrofolate reductase inhibitor with whole cell activity. PLoS One 7:e39961. http://dx.doi.org/10.1371/journal.pone.0039961.
-
(2012)
PLoS One
, vol.7
-
-
Kumar, A.1
Zhang, M.2
Zhu, L.3
Liao, R.P.4
Mutai, C.5
Hafsat, S.6
Sherman, D.R.7
Wang, M.W.8
-
35
-
-
80052588394
-
The structure-activity relationship of urea derivatives as anti-tuberculosis agents
-
Brown JR, North EJ, Hurdle JG, Morisseau C, Scarborough JS, Sun D, Korduláková J, Scherman MS, Jones V, Grzegorzewicz A, Crew RM, Jackson M, McNeil MR, Lee RE. 2011. The structure-activity relationship of urea derivatives as anti-tuberculosis agents. Bioorg Med Chem 19: 5585-5595. http://dx.doi.org/10.1016/j.bmc.2011.07.034.
-
(2011)
Bioorg Med Chem
, vol.19
, pp. 5585-5595
-
-
Brown, J.R.1
North, E.J.2
Hurdle, J.G.3
Morisseau, C.4
Scarborough, J.S.5
Sun, D.6
Korduláková, J.7
Scherman, M.S.8
Jones, V.9
Grzegorzewicz, A.10
Crew, R.M.11
Jackson, M.12
McNeil, M.R.13
Lee, R.E.14
-
36
-
-
19744376797
-
Contribution of the Mycobacterium tuberculosis MmpL protein family to virulence and drug resistance
-
Domenech P, Reed MB, Barry CE, III. 2005. Contribution of the Mycobacterium tuberculosis MmpL protein family to virulence and drug resistance. Infect Immun 73:3492-3501. http://dx.doi.org/10.1128/IAI.73.6.3492-3501.2005.
-
(2005)
Infect Immun
, vol.73
, pp. 3492-3501
-
-
Domenech, P.1
Reed, M.B.2
Barry, C.E.3
-
37
-
-
80053459537
-
Evaluating the sensitivity of Mycobacterium tuberculosis to biotin deprivation using regulated gene expression
-
Park SW, Klotzsche M, Wilson DJ, Boshoff HI, Eoh H, Manjunatha U, Blumenthal A, Rhee KY, Barry CE, III, Aldrich CC, Ehrt S, Schnappinger D. 2011. Evaluating the sensitivity of Mycobacterium tuberculosis to biotin deprivation using regulated gene expression. PLoS Pathog 7:e1002264. http://dx.doi.org/10.1371/journal.ppat.1002264.
-
(2011)
PLoS Pathog
, vol.7
-
-
Park, S.W.1
Klotzsche, M.2
Wilson, D.J.3
Boshoff, H.I.4
Eoh, H.5
Manjunatha, U.6
Blumenthal, A.7
Rhee, K.Y.8
Barry, C.E.9
Aldrich, C.C.10
Ehrt, S.11
Schnappinger, D.12
-
38
-
-
84897115137
-
Assessing the essentiality of the decaprenyl-phospho-D-arabinofuranose pathway in Mycobacterium tuberculosis using conditional mutants
-
Kolly GS, Boldrin F, Sala C, Dhar N, Hartkoorn RC, Ventura M, Serafini A, McKinney JD, Manganelli R, Cole ST. 2014. Assessing the essentiality of the decaprenyl-phospho-D-arabinofuranose pathway in Mycobacterium tuberculosis using conditional mutants. Mol Microbiol 92:194-211. http://dx.doi.org/10.1111/mmi.12546.
-
(2014)
Mol Microbiol
, vol.92
, pp. 194-211
-
-
Kolly, G.S.1
Boldrin, F.2
Sala, C.3
Dhar, N.4
Hartkoorn, R.C.5
Ventura, M.6
Serafini, A.7
McKinney, J.D.8
Manganelli, R.9
Cole, S.T.10
-
39
-
-
84907015388
-
The phosphatidyl-myo-inositol mannosyltransferase PimA is essential for Mycobacterium tuberculosis growth in vitro and in vivo
-
Boldrin F, Ventura M, Degiacomi G, Ravishankar S, Sala C, Svetliková Z, Ambady A, Dhar N, Korduláková J, Zhang M, Serafini A, Vishwas KG, Kolly GS, Kumar N, Palu G, Guerin ME, Mikušová K, Cole ST, Manganelli R. 2014. The phosphatidyl-myo-inositol mannosyltransferase PimA is essential for Mycobacterium tuberculosis growth in vitro and in vivo. J Bacteriol 196:3441-3451. http://dx.doi.org/10.1128/JB.01346-13.
-
(2014)
J Bacteriol
, vol.196
, pp. 3441-3451
-
-
Boldrin, F.1
Ventura, M.2
Degiacomi, G.3
Ravishankar, S.4
Sala, C.5
Svetliková, Z.6
Ambady, A.7
Dhar, N.8
Korduláková, J.9
Zhang, M.10
Serafini, A.11
Vishwas, K.G.12
Kolly, G.S.13
Kumar, N.14
Palu, G.15
Guerin, M.E.16
Mikušová, K.17
Cole, S.T.18
Manganelli, R.19
-
40
-
-
79953175298
-
Discovery and characterization of a unique mycobacterial heme acquisition system
-
Tullius MV, Harmston CA, Owens CP, Chim N, Morse RP, McMath LM, Iniguez A, Kimmey JM, Sawaya MR, Whitelegge JP, Horwitz MA, Goulding CW. 2011. Discovery and characterization of a unique mycobacterial heme acquisition system. Proc Natl Acad Sci U S A 108:5051-5056. http://dx.doi.org/10.1073/pnas.1009516108.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 5051-5056
-
-
Tullius, M.V.1
Harmston, C.A.2
Owens, C.P.3
Chim, N.4
Morse, R.P.5
McMath, L.M.6
Iniguez, A.7
Kimmey, J.M.8
Sawaya, M.R.9
Whitelegge, J.P.10
Horwitz, M.A.11
Goulding, C.W.12
-
41
-
-
84881232776
-
The Mycobacterium tuberculosis secreted protein Rv0203 transfers heme to membrane proteins MmpL3 and MmpL11
-
Owens CP, Chim N, Graves AB, Harmston CA, Iniguez A, Contreras H, Liptak MD, Goulding CW. 2013. The Mycobacterium tuberculosis secreted protein Rv0203 transfers heme to membrane proteins MmpL3 and MmpL11. J Biol Chem 288:21714-21728. http://dx.doi.org/10.1074/jbc.M113.453076.
-
(2013)
J Biol Chem
, vol.288
, pp. 21714-21728
-
-
Owens, C.P.1
Chim, N.2
Graves, A.B.3
Harmston, C.A.4
Iniguez, A.5
Contreras, H.6
Liptak, M.D.7
Goulding, C.W.8
-
42
-
-
0036270739
-
Evaluation of a nutrient starvation model of Mycobacterium tuberculosis persistence by gene and protein expression profiling
-
Betts JC, Lukey PT, Robb LC, McAdam RA, Duncan K. 2002. Evaluation of a nutrient starvation model of Mycobacterium tuberculosis persistence by gene and protein expression profiling. Mol Microbiol 43:717-731. http://dx.doi.org/10.1046/j.1365-2958.2002.02779.x.
-
(2002)
Mol Microbiol
, vol.43
, pp. 717-731
-
-
Betts, J.C.1
Lukey, P.T.2
Robb, L.C.3
McAdam, R.A.4
Duncan, K.5
-
43
-
-
3042750016
-
Mycobacterium tuberculosis gene expression during environmental conditions associated with latency
-
Edinb
-
Voskuil MI. 2004. Mycobacterium tuberculosis gene expression during environmental conditions associated with latency. Tuberculosis (Edinb) 84:138-143. http://dx.doi.org/10.1016/j.tube.2003.12.008.
-
(2004)
Tuberculosis
, vol.84
, pp. 138-143
-
-
Voskuil, M.I.1
-
44
-
-
84923172431
-
Heterogeneity in tuberculosis pathology, microenvironments and therapeutic responses
-
Lenaerts A, Barry CE, III, Dartois V. 2015. Heterogeneity in tuberculosis pathology, microenvironments and therapeutic responses. Immunol Rev 264:288-307. http://dx.doi.org/10.1111/imr.12252.
-
(2015)
Immunol Rev
, vol.264
, pp. 288-307
-
-
Lenaerts, A.1
Barry, C.E.2
Dartois, V.3
|