Thiophenecarboxamide Derivatives Activated by EthA Kill Mycobacterium tuberculosis by Inhibiting the CTP Synthetase PyrG

Chemistry and Biology

Volumn 22, Issue 7, 2015, Pages 917-927

  Mori, Giorgia ^a   Chiarelli, Laurent R ^a   Esposito, Marta ^a   Makarov, Vadim ^b   Bellinzoni, Marco ^c   Hartkoorn, Ruben C ^d   Degiacomi, Giulia ^e   Boldrin, Francesca ^e   Ekins, Sean ^f   De jesus lopes ribeiro, Ana Luisa ^a,l   Marino, Leonardo B ^g,h   Centárová, Ivana ⁱ   Svetlíková, Zuzana ⁱ   Blaško, Jaroslav ⁱ   Kazakova, Elena ^b   Lepioshkin, Alexander ^b   Barilone, Nathalie ^c   Zanoni, Giuseppe ^a   Porta, Alessio ^a   Fondi, Marco ^j   Fani, Renato ^j   Baulard, Alain R ^k   Mikušová, Katarína ⁱ   Alzari, Pedro M ^c   Manganelli, Riccardo ^e   De carvalho, Luiz Pedro S ^g   Riccardi, Giovanna ^a   Cole, Stewart T ^d   Pasca, Maria Rosalia ^a   more..

^a UNIVERSITY OF PAVIA   (Italy)

^b BACH INSTITUTE OF BIOCHEMISTRY   (Russian Federation)

^c INSTITUT PASTEUR   (France)

^d EPFL   (Switzerland)

^e UNIVERSITY OF PADOVA   (Italy)

^f Collaborative Drug Discovery ^*  (United States)

^g THE FRANCIS CRICK INSTITUTE   (United Kingdom)

^h SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

ⁱ Faculty of Natural Sciences   (Slovakia)

^j UNIVERSITY OF FLORENCE   (Italy)

^k INSERM U1019   (France)

^l UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

more..

Author keywords

[No Author keywords available]

Indexed keywords

AMIDE; CTP SYNTHETASE PYRG; CYTIDINE TRIPHOSPHATE SYNTHASE; MONOOXYGENASE ETHA; PYRIMIDINE NUCLEOTIDE; THIOPHENECARBOXAMIDE DERIVATIVE; UNCLASSIFIED DRUG; UNSPECIFIC MONOOXYGENASE; URIDINE TRIPHOSPHATE; [3 PHENYL N[(4 PIPERIDIN 1 YLPHENYL)CARBAMOTHIOYL]PROPANAMIDE]; [5 METHYL N(4 NITROPHENYL)THIOPHENE 2 CARBOXAMIDE]; BACTERIAL PROTEIN; ETHA PROTEIN, MYCOBACTERIUM TUBERCULOSIS; LIGASE; OXIDOREDUCTASE; THIOPHENE DERIVATIVE; TUBERCULOSTATIC AGENT;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DNA SYNTHESIS; ENZYME INHIBITION; GENE MUTATION; MASS SPECTROMETRY; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; RNA SYNTHESIS; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG DESIGN; DRUG EFFECTS; ENZYMOLOGY; HEP-G2 CELL LINE; HIGH THROUGHPUT SCREENING; HUMAN; METABOLIC ACTIVATION; METABOLISM; MICROBIAL SENSITIVITY TEST; MOLECULAR MODEL; MOUSE; PRECLINICAL STUDY; PROCEDURES; PROTEIN CONFORMATION;

MYCOBACTERIUM TUBERCULOSIS;

ACTIVATION, METABOLIC; ANIMALS; ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; CARBON-NITROGEN LIGASES; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; HEP G2 CELLS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MICE; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MYCOBACTERIUM TUBERCULOSIS; OXIDOREDUCTASES; PROTEIN CONFORMATION; THIOPHENES;

EID: 84937814208     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2015.05.016     Document Type: Article

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