Rv2466c mediates the activation of TP053 to kill replicating and non-replicating Mycobacterium tuberculosis

ACS Chemical Biology

Volumn 9, Issue 7, 2014, Pages 1567-1575

  Albesa Jové, David ^a,b   Chiarelli, Laurent R ^c   Makarov, Vadim ^d   Pasca, Maria Rosalia ^c   Urresti, Saioa ^a,b   Mori, Giorgia ^c   Salina, Elena ^d   Vocat, Anthony ^e   Comino, Natalia ^a,b   Mohorko, Elisabeth ^f   Ryabova, Svetlana ^d   Pfieiffer, Bernhard ^f   Lopes Ribeiro, Ana Luisa De Jesus ^c   Rodrigo Unzueta, Ane ^a,b   Tersa, Montse ^a,b   Zanoni, Giuseppe ^c   Buroni, Silvia ^c   Altmann, Karl Heinz ^f   Hartkoorn, Ruben C ^e   Glockshuber, Rudi ^f   Cole, Stewart T ^e   Riccardi, Giovanna ^c   Guerin, Marcelo E ^a,b,g   more..

^a CSIC UPV Unidad de Biofisica UBF   (Spain)

^b UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^c UNIVERSITY OF PAVIA   (Italy)

^d BACH INSTITUTE OF BIOCHEMISTRY   (Russian Federation)

^e EPFL   (Switzerland)

^f ETH ZURICH   (Switzerland)

^g BASQUE FOUNDATION FOR SCIENCE   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

HOMODIMER; PYRIMIDINE DERIVATIVE; THIOREDOXIN; TP 053; TRYPTOPHAN; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG; THIENOPYRIMIDINE;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIUM ISOLATION; BACTERIUM MUTANT; CRYSTAL STRUCTURE; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG SYNTHESIS; GENE MUTATION; GENE OVEREXPRESSION; GROWTH INHIBITION; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; OXIDATIVE STRESS; PHENOTYPE; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; WILD TYPE; BACTERIAL GENE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DESIGN; DRUG EFFECTS; GENETICS; GROWTH, DEVELOPMENT AND AGING; HUMAN; MICROBIAL SENSITIVITY TEST; MULTIDRUG RESISTANCE; MUTATION; TUBERCULOSIS;

ANTITUBERCULAR AGENTS; DRUG DESIGN; DRUG RESISTANCE, MULTIPLE, BACTERIAL; GENES, BACTERIAL; HUMANS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MUTATION; MYCOBACTERIUM TUBERCULOSIS; PYRIMIDINES; TUBERCULOSIS;

EID: 84904554770     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb500149m     Document Type: Article

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