2-carboxyquinoxalines kill mycobacterium tuberculosis through noncovalent inhibition of DprE1

ACS Chemical Biology

Volumn 10, Issue 3, 2015, Pages 705-714

  Neres, João ^a   Hartkoorn, Ruben C ^a   Chiarelli, Laurent R ^b   Gadupudi, Ramakrishna ^c,d   Pasca, Maria Rosalia ^b   Mori, Giorgia ^b   Venturelli, Alberto ^c   Savina, Svetlana ^e   Makarov, Vadim ^e   Kolly, Gaelle S ^e   Molteni, Elisabetta ^e   Binda, Claudia ^b   Dhar, Neeraj ^a   Ferrari, Stefania ^c,d   Brodin, Priscille ^f   Delorme, Vincent ^f   Landry, Valérie ^f   De Jesus Lopes Ribeiro, Ana Luisa ^b   Farina, Davide ^d   Saxena, Puneet ^d   Pojer, Florence ^a   Carta, Antonio ^g   Luciani, Rosaria ^d   Porta, Alessio ^b   Zanoni, Giuseppe ^b   De Rossi, Edda ^b   Costi, Maria Paola ^c,d   Riccardi, Giovanna ^b   Cole, Stewart T ^a   more..

^a EPFL   (Switzerland)

^b UNIVERSITY OF PAVIA   (Italy)

^c Tydock Pharma   (Italy)

^d UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^e BACH INSTITUTE OF BIOCHEMISTRY   (Russian Federation)

^f UNIV LILLE   (France)

^g UNIVERSITY OF SASSARI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

QUINOXALINE DERIVATIVE; ALCOHOL DEHYDROGENASE; BACTERIAL PROTEIN; DPRE1 PROTEIN, MYCOBACTERIUM TUBERCULOSIS; ENZYME INHIBITOR; MOLECULAR LIBRARY; PROTEIN BINDING; RECOMBINANT PROTEIN; TUBERCULOSTATIC AGENT;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACTERICIDAL ACTIVITY; BIOGENESIS; CRYSTAL STRUCTURE; ENZYME ACTIVITY; GROWTH RATE; KINETICS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; STRUCTURE ACTIVITY RELATION; WILD TYPE; X RAY CRYSTALLOGRAPHY; ANTAGONISTS AND INHIBITORS; BINDING SITE; CELL WALL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DEVELOPMENT; DRUG EFFECTS; ENZYMOLOGY; GENE EXPRESSION; GENETICS; GROWTH, DEVELOPMENT AND AGING; HYDROGEN BOND; METABOLISM; MICROBIAL SENSITIVITY TEST; MOLECULAR LIBRARY; MUTATION; PHARMACOLOGY; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; SYNTHESIS;

MYCOBACTERIUM TUBERCULOSIS;

ALCOHOL OXIDOREDUCTASES; ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; BINDING SITES; CELL WALL; CRYSTALLOGRAPHY, X-RAY; DRUG DISCOVERY; ENZYME INHIBITORS; GENE EXPRESSION; HYDROGEN BONDING; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MUTATION; MYCOBACTERIUM TUBERCULOSIS; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; QUINOXALINES; RECOMBINANT PROTEINS; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84925633527     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb5007163     Document Type: Article

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