SCOPUS 정보 검색 플랫폼

Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 16, 2015, Pages 3234-3245

Whole cell screen based identification of spiropiperidines with potent antitubercular properties

(27) Tantry, Subramanyam J a,d Degiacomi, Giulia b Sharma, Sreevalli a Jena, Lalit Kumar a Narayan, Ashwini a Guptha, Supreeth a Shanbhag, Gajanan a,e Menasinakai, Sreenivasaiah a Mallya, Meenakshi a Awasthy, Disha a Balakrishnan, Gayathri a Kaur, Parvinder a Bhattacharjee, Deepa a Narayan, Chandan a,f Reddy, Jitendar a Naveen Kumar, C N a Shandil, Radha a,g Boldrin, Francesca b Ventura, Marcello b Manganelli, Riccardo b more..

a ASTRAZENECA (United Kingdom)

b UNIVERSITY OF PADOVA (Italy)

c EPFL (Switzerland)

d Anthem Biosciences Pvt Ltd (India)

e PI Industries Ltd (India)

f Pohang University of Science and Technology (POSTECH) (South Korea)

g Foundation for Neglected Disease Research (India)

h BMS Research Center (India)

i Hoechst India Limited (India)

Author keywords

Antimycobacterial; Hypoxic conditions; MmpL3; Non replicating phase; ss18b; Whole cell screen

Indexed keywords

1 AMINOBENZOTRIAZOLE; ARABINOGALACTAN; CLOFAZIMINE; ETHAMBUTOL; ISONIAZID; OFLOXACIN; PIPERIDINE DERIVATIVE; POTASSIUM CHANNEL HERG; RIFAMPICIN; STREPTOMYCIN; COLLAGENASE 3; LIPID; SPIRO COMPOUND; TUBERCULOSTATIC AGENT;

ANTIBACTERIAL ACTIVITY; AREA UNDER THE CURVE; ARTICLE; BACTERIAL STRAIN; BACTERICIDAL ACTIVITY; CELL HYPOXIA; CYTOTOXICITY; DRUG DESIGN; DRUG HALF LIFE; DRUG POTENCY; DRUG SCREENING; DRUG SOLUBILITY; DRUG SYNTHESIS; HUMAN; IC50; IN VITRO STUDY; LIPOPHILICITY; LIVER CELL; MAXIMUM PLASMA CONCENTRATION; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PHYSICAL CHEMISTRY; TIME TO MAXIMUM PLASMA CONCENTRATION; WHOLE CELL; WHOLE CELL SCREENING; ANIMAL; ANOXIA; ANTIBIOTIC RESISTANCE; BACTERIAL GENOME; BACTERIUM; BIOSYNTHESIS; CHEMISTRY; DRUG EFFECTS; GENETICS; HIGH THROUGHPUT SCREENING; MICROBIAL SENSITIVITY TEST; MOUSE; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

MYCOBACTERIUM TUBERCULOSIS;

ANIMALS; ANOXIA; ANTITUBERCULAR AGENTS; BACTERIA; DRUG RESISTANCE, BACTERIAL; GENOME, BACTERIAL; HIGH-THROUGHPUT SCREENING ASSAYS; LIPIDS; MATRIX METALLOPROTEINASE 13; MICE; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM TUBERCULOSIS; PIPERIDINES; SPIRO COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84934805597 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2015.05.087 Document Type: Article

Times cited : (35)

References (26)

1
- 77952542701
- N.R. Gandhi, P. Nunn, K. Dheda, H.S. Schaaf, M. Zignol, D. van Soolingen, P. Jensen, and J. Bayona Lancet 375 2010 1830
- (2010) Lancet , vol.375 , pp. 1830
- Gandhi, N.R.¹ Nunn, P.² Dheda, K.³ Schaaf, H.S.⁴ Zignol, M.⁵ Van Soolingen, D.⁶ Jensen, P.⁷ Bayona, J.⁸

2
- 80054020110
- C. Nagaraja, B.L. Shashibhushan, C. Sagar, M. Asif, and P.H. Manjunath J. Postgrad. Med. 57 2011 181
- (2011) J. Postgrad. Med. , vol.57 , pp. 181
- Nagaraja, C.¹ Shashibhushan, B.L.² Sagar, C.³ Asif, M.⁴ Manjunath, P.H.⁵

3
- 85042735990
- L. Fattorini, G. Piccaro, A. Mustazzolu, and F. Giannoni Infect. Dis. 5 2011 e2013072
- (2011) Infect. Dis. , vol.5
- Fattorini, L.¹ Piccaro, G.² Mustazzolu, A.³ Giannoni, F.⁴

4
- 70349638608
- 4th ed. WHO Geneva, Switzerland (WHO/HTM/TB/2009.420)
- World Health Organization Treatment of Tuberculosis: Guidelines 4th ed. 2009 WHO Geneva, Switzerland (WHO/HTM/TB/2009.420)
- (2009) Treatment of Tuberculosis: Guidelines
- World Health Organization¹

5
- 84860380179
- C. Lienhardt, M. Raviglione, M. Spigelman, R. Hafner, E. Jaramillo, M. Hoelscher, A. Zumla, and J. Gheuens J. Infect. Dis. 205 2012 S241
- (2012) J. Infect. Dis. , vol.205 , pp. S241
- Lienhardt, C.¹ Raviglione, M.² Spigelman, M.³ Hafner, R.⁴ Jaramillo, E.⁵ Hoelscher, M.⁶ Zumla, A.⁷ Gheuens, J.⁸

6
- 84877267006
- A. Zumla, P. Nahid, and S.T. Cole Nat. Rev. Drug Disc. 12 2013 388
- (2013) Nat. Rev. Drug Disc. , vol.12 , pp. 388
- Zumla, A.¹ Nahid, P.² Cole, S.T.³

7
- 0034780485
- L.G. Wayne, and C.D. Sohaskey Annu. Rev. Microbiol. 55 2001 139
- (2001) Annu. Rev. Microbiol. , vol.55 , pp. 139
- Wayne, L.G.¹ Sohaskey, C.D.²

8
- 0029976980
- L.G. Wayne, and L.G. Hayes Infect. Immun. 64 1996 2062
- (1996) Infect. Immun. , vol.64 , pp. 2062
- Wayne, L.G.¹ Hayes, L.G.²

9
- 77957375205
- C. Sala, N. Dhar, R.C. Hartkoorn, M. Zhang, Y.H. Ha, P. Schneider, and S.T. Cole Antimicrob. Agents Chemother. 54 2010 4150
- (2010) Antimicrob. Agents Chemother. , vol.54 , pp. 4150
- Sala, C.¹ Dhar, N.² Hartkoorn, R.C.³ Zhang, M.⁴ Ha, Y.H.⁵ Schneider, P.⁶ Cole, S.T.⁷

10
- 84868007876
- M. Zhang, C. Sala, R.C. Hartkoorn, N. Dhar, A. Mendoza-Losana, and S.T. Cole Antimicrob. Agents Chemother. 56 2012 5782
- (2012) Antimicrob. Agents Chemother. , vol.56 , pp. 5782
- Zhang, M.¹ Sala, C.² Hartkoorn, R.C.³ Dhar, N.⁴ Mendoza-Losana, A.⁵ Cole, S.T.⁶

11
- 84863404695
- K. Tahlan, R. Wilson, D.B. Kastrinsky, K. Arora, V. Nair, E. Fischer, S.W. Barnes, J.R. Walker, D. Alland, C.E. Barry 3rd, and H.I. Boshoff Antimicrob. Agents Chemother. 56 2012 1797
- (2012) Antimicrob. Agents Chemother. , vol.56 , pp. 1797
- Tahlan, K.¹ Wilson, R.² Kastrinsky, D.B.³ Arora, K.⁴ Nair, V.⁵ Fischer, E.⁶ Barnes, S.W.⁷ Walker, J.R.⁸ Alland, D.⁹ Barry, C.E.¹⁰ Boshoff, H.I.¹¹

12
- 84858677107
- A.E. Grzegorzewicz, H. Pham, V.A. Gundi, M.S. Scherman, E.J. North, T. Hess, V. Jones, V. Gruppo, S.E. Born, J. Korduláková, S.S. Chavadi, C. Morisseau, A.J. Lenaerts, R.E. Lee, M.R. McNeil, and M. Jackson Nat. Chem. Biol. 8 2012 334
- (2012) Nat. Chem. Biol. , vol.8 , pp. 334
- Grzegorzewicz, A.E.¹ Pham, H.² Gundi, V.A.³ Scherman, M.S.⁴ North, E.J.⁵ Hess, T.⁶ Jones, V.⁷ Gruppo, V.⁸ Born, S.E.⁹ Korduláková, J.¹⁰ Chavadi, S.S.¹¹ Morisseau, C.¹² Lenaerts, A.J.¹³ Lee, R.E.¹⁴ Mcneil, M.R.¹⁵ Jackson, M.¹⁶

13
- 84865253965
- S.A. Stanley, S.S. Grant, T. Kawate, N. Iwase, M. Shimizu, C. Wivagg, M. Silvis, E. Kazyanskaya, J. Aquadro, A. Golas, M. Fitzgerald, H. Dai, L. Zhang, and D.T. Hung ACS Chem. Biol. 7 2012 1377
- (2012) ACS Chem. Biol. , vol.7 , pp. 1377
- Stanley, S.A.¹ Grant, S.S.² Kawate, T.³ Iwase, N.⁴ Shimizu, M.⁵ Wivagg, C.⁶ Silvis, M.⁷ Kazyanskaya, E.⁸ Aquadro, J.⁹ Golas, A.¹⁰ Fitzgerald, M.¹¹ Dai, H.¹² Zhang, L.¹³ Hung, D.T.¹⁴

14
- 84455173193
- V. La Rosa, G. Poce, J.O. Canseco, S. Buroni, M.R. Pasca, M. Biava, R.M. Raju, G.C. Porretta, S. Alfonso, C. Battilocchio, B. Javid, F. Sorrentino, T.R. Ioerger, J.C. Sacchettini, F. Manetti, M. Botta, A. De Logu, E.J. Rubin, and E. De Rossi Antimicrob. Agents Chemother. 56 2012 324
- (2012) Antimicrob. Agents Chemother. , vol.56 , pp. 324
- La Rosa, V.¹ Poce, G.² Canseco, J.O.³ Buroni, S.⁴ Pasca, M.R.⁵ Biava, M.⁶ Raju, R.M.⁷ Porretta, G.C.⁸ Alfonso, S.⁹ Battilocchio, C.¹⁰ Javid, B.¹¹ Sorrentino, F.¹² Ioerger, T.R.¹³ Sacchettini, J.C.¹⁴ Manetti, F.¹⁵ Botta, M.¹⁶ De Logu, A.¹⁷ Rubin, E.J.¹⁸ De Rossi, E.¹⁹

15
- 84876272210
- M.J. Remuiñán, E. Pérez-Herrán, J. Rullás, C. Alemparte, M. Martínez-Hoyos, D.J. Dow, J. Afari, N. Mehta, J. Esquivias, E. Jiménez, F. Ortega-Muro, M.T. Fraile-Gabaldón, V.L. Spivey, N.J. Loman, M.J. Pallen, C. Constantinidou, D.J. Minick, M. Cacho, M.J. Rebollo-López, C. González, V. Sousa, I. Angulo-Barturen, A. Mendoza-Losana, D. Barros, G.S. Besra, L. Ballell, and N. Cammack PLoS One 8 2013 e60933
- (2013) PLoS One , vol.8
- Remuiñán, M.J.¹ Pérez-Herrán, E.² Rullás, J.³ Alemparte, C.⁴ Martínez-Hoyos, M.⁵ Dow, D.J.⁶ Afari, J.⁷ Mehta, N.⁸ Esquivias, J.⁹ Jiménez, E.¹⁰ Ortega-Muro, F.¹¹ Fraile-Gabaldón, M.T.¹² Spivey, V.L.¹³ Loman, N.J.¹⁴ Pallen, M.J.¹⁵ Constantinidou, C.¹⁶ Minick, D.J.¹⁷ Cacho, M.¹⁸ Rebollo-López, M.J.¹⁹ González, C.²⁰ more..

16
- 84891722137
- S.P.S. Rao, S.B. Lakshminarayana, R.R. Kondreddi, M. Herve, L.R. Camacho, P. Bifani, S.K. Kalapala, J. Jiricek, N.L. Ma, B.H. Tan, S.H. Ng, M. Nanjundappa, S. Ravindran, P.G. Seah, P. Thayalan, S.H. Lim, B.H. Lee, A. Goh, W.S. Barnes, Z. Chen, K. Gagaring, A.K. Chatterjee, K. Pethe, K. Kuhen, J. Walker, G. Feng, S. Babu, L. Zhang, F. Blasco, D. Beer, M. Weaver, V. Dartois, R. Glynne, T. Dick, Paul W. Smith, T.T. Diagana, and U.H. Manjunatha Sci. Transl. Med. 5 2012 214ra168
- (2012) Sci. Transl. Med. , vol.5 , pp. 214ra168
- Rao, S.P.S.¹ Lakshminarayana, S.B.² Kondreddi, R.R.³ Herve, M.⁴ Camacho, L.R.⁵ Bifani, P.⁶ Kalapala, S.K.⁷ Jiricek, J.⁸ Ma, N.L.⁹ Tan, B.H.¹⁰ Ng, S.H.¹¹ Nanjundappa, M.¹² Ravindran, S.¹³ Seah, P.G.¹⁴ Thayalan, P.¹⁵ Lim, S.H.¹⁶ Lee, B.H.¹⁷ Goh, A.¹⁸ Barnes, W.S.¹⁹ Chen, Z.²⁰ more..

17
- 84864332596
- K.A. Sacksteder, M. Protopopova, and C. Barry Future Microbiol. 7 2012 823
- (2012) Future Microbiol. , vol.7 , pp. 823
- Sacksteder, K.A.¹ Protopopova, M.² Barry, C.³

18
- 84903527119
- M. Naik, V. Humnabadkar, S.J. Tantry, M. Panda, A. Narayan, S. Guptha, V. Panduga, P. Manjrekar, L.K. Jena, K. Koushik, G. Shanbhag, S. Jatheendranath, M.R. Manjunatha, G. Gorai, C. Bathula, S. Rudrapatna, V. Achar, S. Sharma, A. Ambady, N. Hegde, J. Mahadevaswamy, P. Kaur, V.K. Sambandamurthy, D. Awasthy, C. Narayan, S. Ravishankar, P. Madhavapeddi, J. Reddy, K. Prabhakar, R. Saralaya, M. Chatterji, J. Whiteaker, B. McLaughlin, L.R. Chiarelli, G. Riccardi, M.R. Pasca, C. Binda, J. Neres, N. Dhar, F. Signorino-Gelo, J.D. McKinney, V. Ramachandran, R. Shandil, R. Tommasi, P.S. Iyer, S. Narayanan, V. Hosagrahara, S. Kavanagh, N. Dinesh, and S.R. Ghorpade J. Med. Chem. 57 2014 5419
- (2014) J. Med. Chem. , vol.57 , pp. 5419
- Naik, M.¹ Humnabadkar, V.² Tantry, S.J.³ Panda, M.⁴ Narayan, A.⁵ Guptha, S.⁶ Panduga, V.⁷ Manjrekar, P.⁸ Jena, L.K.⁹ Koushik, K.¹⁰ Shanbhag, G.¹¹ Jatheendranath, S.¹² Manjunatha, M.R.¹³ Gorai, G.¹⁴ Bathula, C.¹⁵ Rudrapatna, S.¹⁶ Achar, V.¹⁷ Sharma, S.¹⁸ Ambady, A.¹⁹ Hegde, N.²⁰ more..

19
- 77957825925
- Y. Uto, Y. Ueno, Y. Kiyotsuka, Y. Miyazawa, H. Kurata, T. Ogata, M. Yamada, T. Deguchi, M. Konishi, T. Takagi, S. Wakimoto, and J. Ohsumi Eur. J. Med. Chem. 45 2010 4788
- (2010) Eur. J. Med. Chem. , vol.45 , pp. 4788
- Uto, Y.¹ Ueno, Y.² Kiyotsuka, Y.³ Miyazawa, Y.⁴ Kurata, H.⁵ Ogata, T.⁶ Yamada, M.⁷ Deguchi, T.⁸ Konishi, M.⁹ Takagi, T.¹⁰ Wakimoto, S.¹¹ Ohsumi, J.¹²

20
- 4644267929
- S.K. Balani, P. Li, J. Nguyen, K. Cardoza, H. Zeng, D. Mu, J. Wu, L. Gan, and F.W. Lee Drug Metab. Dispos. 32 2004 1092
- (2004) Drug Metab. Dispos. , vol.32 , pp. 1092
- Balani, S.K.¹ Li, P.² Nguyen, J.³ Cardoza, K.⁴ Zeng, H.⁵ Mu, D.⁶ Wu, J.⁷ Gan, L.⁸ Lee, F.W.⁹

21
- 19744376797
- P. Domenech, and M.B. Reed Infect. Immun. 73 2005 3492
- (2005) Infect. Immun. , vol.73 , pp. 3492
- Domenech, P.¹ Reed, M.B.²

22
- 80053459692
- J.E. Griffin, J.D. Gawronski, M.A. Dejesus, T.R. Ioerger, B.J. Akerley, and C.M. Sassetti PLoS Pathog. 7 2011 e1002251
- (2011) PLoS Pathog. , vol.7
- Griffin, J.E.¹ Gawronski, J.D.² Dejesus, M.A.³ Ioerger, T.R.⁴ Akerley, B.J.⁵ Sassetti, C.M.⁶

23
- 84884505005
- T.R. Ioerger, T. O'Malley, R. Liao, K.M. Guinn, M.J. Hickey, N. Mohaideen, K.C. Murphy, H.I. Boshoff, V. Mizrahi, E.J. Rubin, C.M. Sassetti, C.E. Barry 3rd, D.R. Sherman, T. Parish, and J.C. Sacchettini PLoS One 8 2013 e75245
- (2013) PLoS One , vol.8
- Ioerger, T.R.¹ O'malley, T.² Liao, R.³ Guinn, K.M.⁴ Hickey, M.J.⁵ Mohaideen, N.⁶ Murphy, K.C.⁷ Boshoff, H.I.⁸ Mizrahi, V.⁹ Rubin, E.J.¹⁰ Sassetti, C.M.¹¹ Barry, C.E.¹² Sherman, D.R.¹³ Parish, T.¹⁴ Sacchettini, J.C.¹⁵

24
- 84894136887
- G.V. Rayasam Expert Opin. Ther. Targets 18 2014 247
- (2014) Expert Opin. Ther. Targets , vol.18 , pp. 247
- Rayasam, G.V.¹

25
- 84860181497
- C. Varela, D. Rittmann, A. Singh, K. Krumbach, K. Bhatt, L. Eggeling, G.S. Besra, and A. Bhatt Chem. Biol. 19 2012 498
- (2012) Chem. Biol. , vol.19 , pp. 498
- Varela, C.¹ Rittmann, D.² Singh, A.³ Krumbach, K.⁴ Bhatt, K.⁵ Eggeling, L.⁶ Besra, G.S.⁷ Bhatt, A.⁸

26
- 84857383238
- C.P. Owens, J. Du, J.H. Dawson, and C.W. Goulding Biochemistry 51 2012 1518
- (2012) Biochemistry , vol.51 , pp. 1518
- Owens, C.P.¹ Du, J.² Dawson, J.H.³ Goulding, C.W.⁴

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.