Target-based identification of whole-cell active inhibitors of biotin biosynthesis in mycobacterium tuberculosis

Chemistry and Biology

Volumn 22, Issue 1, 2015, Pages 76-86

  Park, Sae Woong ^a   Casalena, Dominick E ^b   Wilson, Daniel J ^c   Dai, Ran ^d   Nag, Partha P ^b   Liu, Feng ^d   Boyce, Jim P ^e   Bittker, Joshua A ^b   Schreiber, Stuart L ^b   Finzel, Barry C ^d   Schnappinger, Dirk ^a   Aldrich, Courtney C ^c,d  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^c UNIVERSITY OF MINNESOTA   (United States)

^d UNIVERSITY OF MINNESOTA   (United States)

^e NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOTRANSFERASE INHIBITOR; BIOTIN; BIOTIN INHIBITOR; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG; AMINOTRANSFERASE; BACTERIAL PROTEIN; BIOA PROTEIN, BACTERIA;

ARTICLE; BACTERIAL STRAIN; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; DRUG DESIGN; DRUG IDENTIFICATION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IC50; ISOTHERMAL TITRATION CALORIMETRY; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; WHOLE CELL; ANTAGONISTS AND INHIBITORS; BINDING SITE; BIOSYNTHESIS; CALORIMETRY; CHEMISTRY; DRUG EFFECTS; HYDROGEN BOND; METABOLISM; MICROBIAL SENSITIVITY TEST; MOLECULAR DYNAMICS; PROTEIN TERTIARY STRUCTURE; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

MYCOBACTERIUM TUBERCULOSIS;

ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; BINDING SITES; BIOTIN; CALORIMETRY; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HIGH-THROUGHPUT SCREENING ASSAYS; HYDROGEN BONDING; MICROBIAL SENSITIVITY TESTS; MOLECULAR DYNAMICS SIMULATION; MYCOBACTERIUM TUBERCULOSIS; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSAMINASES;

EID: 84921470540     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2014.11.012     Document Type: Article

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