-
1
-
-
79952284127
-
Hallmarks of cancer: the next generation
-
21376230,.; (): –.
-
Hanahan D, Weinberg RA, Hallmarks of cancer: the next generation. Cell. 2011;144(5):646–74. doi: 10.1016/j.cell.2011.02.01321376230
-
(2011)
Cell
, vol.144
, Issue.5
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
2
-
-
0034614637
-
The hallmarks of cancer
-
10647931,.; (): –.
-
Hanahan D, Weinberg RA, The hallmarks of cancer. Cell. 2000;100(1):57–70. doi: 10.1016/S0092-8674(00)81683-910647931
-
(2000)
Cell
, vol.100
, Issue.1
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
3
-
-
0023279926
-
The inheritance of epigenetic defects
-
3310230,.; (): –.
-
Holliday R, The inheritance of epigenetic defects. Science. 1987;238(4824):163–70. doi: 10.1126/science.33102303310230
-
(1987)
Science
, vol.238
, Issue.4824
, pp. 163-170
-
-
Holliday, R.1
-
4
-
-
40849139208
-
Epigenetics in cancer
-
18337604,.; (): –.
-
Esteller M, Epigenetics in cancer. The New England journal of medicine. 2008;358(11):1148–59. doi: 10.1056/NEJMra07206718337604
-
(2008)
The New England journal of medicine
, vol.358
, Issue.11
, pp. 1148-1159
-
-
Esteller, M.1
-
5
-
-
84865005165
-
Targeting epigenetic readers in cancer
-
22894577,.; (): –.
-
Dawson MA, Kouzarides T, Huntly BJ, Targeting epigenetic readers in cancer. The New England journal of medicine. 2012;367(7):647–57. doi: 10.1056/NEJMra111263522894577
-
(2012)
The New England journal of medicine
, vol.367
, Issue.7
, pp. 647-657
-
-
Dawson, M.A.1
Kouzarides, T.2
Huntly, B.J.3
-
6
-
-
33847076849
-
Chromatin modifications and their function
-
17320507,.; (): –.
-
Kouzarides T, Chromatin modifications and their function. Cell. 2007;128(4):693–705. doi: 10.1016/j.cell.2007.02.00517320507
-
(2007)
Cell
, vol.128
, Issue.4
, pp. 693-705
-
-
Kouzarides, T.1
-
7
-
-
80052942443
-
Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification
-
21925322,..; (): –.; PubMed Central PMCID: PMC3176443.
-
Tan M, Luo H, Lee S, Jin F, Yang JS, Montellier E, et al. Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification. Cell. 2011;146(6):1016–28.; PubMed Central PMCID: PMC3176443. doi: 10.1016/j.cell.2011.08.00821925322
-
(2011)
Cell
, vol.146
, Issue.6
, pp. 1016-1028
-
-
Tan, M.1
Luo, H.2
Lee, S.3
Jin, F.4
Yang, J.S.5
Montellier, E.6
-
8
-
-
84937402257
-
Epigenetic Therapy in Acute Myeloid Leukemia: Current and Future Directions
-
26111464,.; (): –.
-
Kim TK, Gore SD, Zeidan AM, Epigenetic Therapy in Acute Myeloid Leukemia: Current and Future Directions. Seminars in hematology. 2015;52(3):172–83. doi: 10.1053/j.seminhematol.2015.04.00326111464
-
(2015)
Seminars in hematology
, vol.52
, Issue.3
, pp. 172-183
-
-
Kim, T.K.1
Gore, S.D.2
Zeidan, A.M.3
-
9
-
-
0037372003
-
Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
-
12610534,.;: –.
-
Jaenisch R, Bird A, Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nature genetics. 2003;33Suppl:245–54. doi: 10.1038/ng108912610534
-
(2003)
Nature genetics
, vol.33
, Issue.Suppl
, pp. 245-254
-
-
Jaenisch, R.1
Bird, A.2
-
10
-
-
84930343240
-
The role of mutations in epigenetic regulators in myeloid malignancies
-
25510269,.; (): –.
-
Woods BA, Levine RL, The role of mutations in epigenetic regulators in myeloid malignancies. Immunol Rev. 2015;263(1):22–35. doi: 10.1111/imr.1224625510269
-
(2015)
Immunol Rev
, vol.263
, Issue.1
, pp. 22-35
-
-
Woods, B.A.1
Levine, R.L.2
-
11
-
-
84866378702
-
The role of mutations in epigenetic regulators in myeloid malignancies
-
22898539,.; (): –.
-
Shih AH, Abdel-Wahab O, Patel JP, Levine RL, The role of mutations in epigenetic regulators in myeloid malignancies. Nature reviews Cancer. 2012;12(9):599–612. doi: 10.1038/nrc334322898539
-
(2012)
Nature reviews Cancer
, vol.12
, Issue.9
, pp. 599-612
-
-
Shih, A.H.1
Abdel-Wahab, O.2
Patel, J.P.3
Levine, R.L.4
-
12
-
-
84892942381
-
New and emerging HDAC inhibitors for cancer treatment
-
24382387,.; (): –.; PubMed Central PMCID: PMCPMC3871231.
-
West AC, Johnstone RW, New and emerging HDAC inhibitors for cancer treatment. The Journal of clinical investigation. 2014;124(1):30–9.; PubMed Central PMCID: PMCPMC3871231. doi: 10.1172/JCI6973824382387
-
(2014)
The Journal of clinical investigation
, vol.124
, Issue.1
, pp. 30-39
-
-
West, A.C.1
Johnstone, R.W.2
-
13
-
-
84925394779
-
Diverse involvement of EZH2 in cancer epigenetics
-
25901190,.; (): –.; PubMed Central PMCID: PMCPMC4399085.
-
Volkel P, Dupret B, Le Bourhis X, Angrand PO, Diverse involvement of EZH2 in cancer epigenetics. Am J Transl Res. 2015;7(2):175–93.; PubMed Central PMCID: PMCPMC4399085. 25901190
-
(2015)
Am J Transl Res
, vol.7
, Issue.2
, pp. 175-193
-
-
Volkel, P.1
Dupret, B.2
Le Bourhis, X.3
Angrand, P.O.4
-
14
-
-
77649305610
-
The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate
-
20171147,..; (): –.; PubMed Central PMCID: PMC2849316.
-
Ward PS, Patel J, Wise DR, Abdel-Wahab O, Bennett BD, Coller HA, et al. The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate. Cancer cell. 2010;17(3):225–34.; PubMed Central PMCID: PMC2849316. doi: 10.1016/j.ccr.2010.01.02020171147
-
(2010)
Cancer cell
, vol.17
, Issue.3
, pp. 225-234
-
-
Ward, P.S.1
Patel, J.2
Wise, D.R.3
Abdel-Wahab, O.4
Bennett, B.D.5
Coller, H.A.6
-
15
-
-
78650019179
-
Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
-
21130701,..; (): –.; PubMed Central PMCID: PMC4105845.
-
Figueroa ME, Abdel-Wahab O, Lu C, Ward PS, Patel J, Shih A, et al. Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation. Cancer cell. 2010;18(6):553–67.; PubMed Central PMCID: PMC4105845. doi: 10.1016/j.ccr.2010.11.01521130701
-
(2010)
Cancer cell
, vol.18
, Issue.6
, pp. 553-567
-
-
Figueroa, M.E.1
Abdel-Wahab, O.2
Lu, C.3
Ward, P.S.4
Patel, J.5
Shih, A.6
-
16
-
-
84555189994
-
Epigenetic analysis: ChIP-chip and ChIP-seq
-
22130894,.;: –.
-
Pellegrini M, Ferrari R, Epigenetic analysis: ChIP-chip and ChIP-seq. Methods in molecular biology. 2012;802:377–87. doi: 10.1007/978-1-61779-400-1_2522130894
-
(2012)
Methods in molecular biology
, vol.802
, pp. 377-387
-
-
Pellegrini, M.1
Ferrari, R.2
-
18
-
-
79952091071
-
The application of next generation sequencing in DNA methylation analysis
-
24710012,.; (): –.; PubMed Central PMCID: PMCPMC3960863.
-
Zhang Y, Jeltsch A, The application of next generation sequencing in DNA methylation analysis. Genes (Basel). 2010;1(1):85–101.; PubMed Central PMCID: PMCPMC3960863. doi: 10.3390/genes101008524710012
-
(2010)
Genes (Basel)
, vol.1
, Issue.1
, pp. 85-101
-
-
Zhang, Y.1
Jeltsch, A.2
-
19
-
-
84930945903
-
Epigenome editing made easy
-
26057978,.; (): –.
-
Zentner GE, Henikoff S, Epigenome editing made easy. Nature biotechnology. 2015;33(6):606–7. doi: 10.1038/nbt.324826057978
-
(2015)
Nature biotechnology
, vol.33
, Issue.6
, pp. 606-607
-
-
Zentner, G.E.1
Henikoff, S.2
-
20
-
-
84897134020
-
CRISPRs and epigenome editing
-
24524135,.; ():.
-
Rusk N, CRISPRs and epigenome editing. Nature methods. 2014;11(1):28. doi: 10.1038/nmeth.277524524135
-
(2014)
Nature methods
, vol.11
, Issue.1
, pp. 28
-
-
Rusk, N.1
-
21
-
-
67650711140
-
Genome-wide views of chromatin structure
-
19317649,.;: –.; PubMed Central PMCID: PMC2811691.
-
Rando OJ, Chang HY, Genome-wide views of chromatin structure. Annual review of biochemistry. 2009;78:245–71.; PubMed Central PMCID: PMC2811691. doi: 10.1146/annurev.biochem.78.071107.13463919317649
-
(2009)
Annual review of biochemistry
, vol.78
, pp. 245-271
-
-
Rando, O.J.1
Chang, H.Y.2
-
22
-
-
34249026300
-
High-resolution profiling of histone methylations in the human genome
-
17512414,..; (): –.
-
Barski A, Cuddapah S, Cui K, Roh TY, Schones DE, Wang Z, et al. High-resolution profiling of histone methylations in the human genome. Cell. 2007;129(4):823–37. doi: 10.1016/j.cell.2007.05.00917512414
-
(2007)
Cell
, vol.129
, Issue.4
, pp. 823-837
-
-
Barski, A.1
Cuddapah, S.2
Cui, K.3
Roh, T.Y.4
Schones, D.E.5
Wang, Z.6
-
23
-
-
79952534189
-
Regulation of chromatin by histone modifications
-
21321607,.; (): –.; PubMed Central PMCID: PMC3193420.
-
Bannister AJ, Kouzarides T, Regulation of chromatin by histone modifications. Cell research. 2011;21(3):381–95.; PubMed Central PMCID: PMC3193420. doi: 10.1038/cr.2011.2221321607
-
(2011)
Cell research
, vol.21
, Issue.3
, pp. 381-395
-
-
Bannister, A.J.1
Kouzarides, T.2
-
24
-
-
35848961668
-
How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers
-
17984965,.; (): –.
-
Taverna SD, Li H, Ruthenburg AJ, Allis CD, Patel DJ, How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers. Nature structural & molecular biology. 2007;14(11):1025–40. doi: 10.1038/nsmb133817984965
-
(2007)
Nature structural & molecular biology
, vol.14
, Issue.11
, pp. 1025-1040
-
-
Taverna, S.D.1
Li, H.2
Ruthenburg, A.J.3
Allis, C.D.4
Patel, D.J.5
-
25
-
-
36448949026
-
Multivalent engagement of chromatin modifications by linked binding modules
-
18037899,.; (): –.
-
Ruthenburg AJ, Li H, Patel DJ, Allis CD, Multivalent engagement of chromatin modifications by linked binding modules. Nature reviews Molecular cell biology. 2007;8(12):983–94. doi: 10.1038/nrm229818037899
-
(2007)
Nature reviews Molecular cell biology
, vol.8
, Issue.12
, pp. 983-994
-
-
Ruthenburg, A.J.1
Li, H.2
Patel, D.J.3
Allis, C.D.4
-
26
-
-
84927698129
-
Epigenetics reloaded: the single-cell revolution
-
25283892,.; (): –.
-
Bheda P, Schneider R, Epigenetics reloaded: the single-cell revolution. Trends in cell biology. 2014;24(11):712–23. doi: 10.1016/j.tcb.2014.08.01025283892
-
(2014)
Trends in cell biology
, vol.24
, Issue.11
, pp. 712-723
-
-
Bheda, P.1
Schneider, R.2
-
27
-
-
0020699979
-
Hypomethylation distinguishes genes of some human cancers from their normal counterparts
-
6185846,.; (): –.
-
Feinberg AP, Vogelstein B, Hypomethylation distinguishes genes of some human cancers from their normal counterparts. Nature. 1983;301(5895):89–92. doi: 10.1038/301089a06185846
-
(1983)
Nature
, vol.301
, Issue.5895
, pp. 89-92
-
-
Feinberg, A.P.1
Vogelstein, B.2
-
28
-
-
0029011539
-
5' CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers
-
7585152,..; (): –.
-
Merlo A, Herman JG, Mao L, Lee DJ, Gabrielson E, Burger PC, et al. 5' CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers. Nature medicine. 1995;1(7):686–92. doi: 10.1038/nm0795-6867585152
-
(1995)
Nature medicine
, vol.1
, Issue.7
, pp. 686-692
-
-
Merlo, A.1
Herman, J.G.2
Mao, L.3
Lee, D.J.4
Gabrielson, E.5
Burger, P.C.6
-
29
-
-
0025891856
-
Allele-specific hypermethylation of the retinoblastoma tumor-suppressor gene
-
1673287,.; (): –.; PubMed Central PMCID: PMC1683063.
-
Sakai T, Toguchida J, Ohtani N, Yandell DW, Rapaport JM, Dryja TP, Allele-specific hypermethylation of the retinoblastoma tumor-suppressor gene. American journal of human genetics. 1991;48(5):880–8.; PubMed Central PMCID: PMC1683063. 1673287
-
(1991)
American journal of human genetics
, vol.48
, Issue.5
, pp. 880-888
-
-
Sakai, T.1
Toguchida, J.2
Ohtani, N.3
Yandell, D.W.4
Rapaport, J.M.5
Dryja, T.P.6
-
30
-
-
33744805399
-
Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells
-
16766263,..; (): –.
-
Saito Y, Liang G, Egger G, Friedman JM, Chuang JC, Coetzee GA, et al. Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells. Cancer cell. 2006;9(6):435–43. doi: 10.1016/j.ccr.2006.04.02016766263
-
(2006)
Cancer cell
, vol.9
, Issue.6
, pp. 435-443
-
-
Saito, Y.1
Liang, G.2
Egger, G.3
Friedman, J.M.4
Chuang, J.C.5
Coetzee, G.A.6
-
31
-
-
33847763576
-
Genetic unmasking of an epigenetically silenced microRNA in human cancer cells
-
17308079,..; (): –.
-
Lujambio A, Ropero S, Ballestar E, Fraga MF, Cerrato C, Setien F, et al. Genetic unmasking of an epigenetically silenced microRNA in human cancer cells. Cancer research. 2007;67(4):1424–9. doi: 10.1158/0008-5472.CAN-06-421817308079
-
(2007)
Cancer research
, vol.67
, Issue.4
, pp. 1424-1429
-
-
Lujambio, A.1
Ropero, S.2
Ballestar, E.3
Fraga, M.F.4
Cerrato, C.5
Setien, F.6
-
32
-
-
23044514626
-
Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells
-
16007088,..; (): –.
-
Weber M, Davies JJ, Wittig D, Oakeley EJ, Haase M, Lam WL, et al. Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells. Nature genetics. 2005;37(8):853–62. doi: 10.1038/ng159816007088
-
(2005)
Nature genetics
, vol.37
, Issue.8
, pp. 853-862
-
-
Weber, M.1
Davies, J.J.2
Wittig, D.3
Oakeley, E.J.4
Haase, M.5
Lam, W.L.6
-
33
-
-
4143140030
-
A mouse skin multistage carcinogenesis model reflects the aberrant DNA methylation patterns of human tumors
-
15313885,..; (): –.
-
Fraga MF, Herranz M, Espada J, Ballestar E, Paz MF, Ropero S, et al. A mouse skin multistage carcinogenesis model reflects the aberrant DNA methylation patterns of human tumors. Cancer research. 2004;64(16):5527–34. doi: 10.1158/0008-5472.CAN-03-406115313885
-
(2004)
Cancer research
, vol.64
, Issue.16
, pp. 5527-5534
-
-
Fraga, M.F.1
Herranz, M.2
Espada, J.3
Ballestar, E.4
Paz, M.F.5
Ropero, S.6
-
34
-
-
0242584454
-
Chromosomal instability and tumors promoted by DNA hypomethylation
-
12702868,.; ():.
-
Eden A, Gaudet F, Waghmare A, Jaenisch R, Chromosomal instability and tumors promoted by DNA hypomethylation. Science. 2003;300(5618):455. doi: 10.1126/science.108355712702868
-
(2003)
Science
, vol.300
, Issue.5618
, pp. 455
-
-
Eden, A.1
Gaudet, F.2
Waghmare, A.3
Jaenisch, R.4
-
35
-
-
25444475765
-
Genetic disruption of cytosine DNA methyltransferase enzymes induces chromosomal instability in human cancer cells
-
16204030,.; (): –.
-
Karpf AR, Matsui S, Genetic disruption of cytosine DNA methyltransferase enzymes induces chromosomal instability in human cancer cells. Cancer research. 2005;65(19):8635–9. doi: 10.1158/0008-5472.CAN-05-196116204030
-
(2005)
Cancer research
, vol.65
, Issue.19
, pp. 8635-8639
-
-
Karpf, A.R.1
Matsui, S.2
-
36
-
-
23744461983
-
Transposons reanimated in mice
-
16096053,.; (): –.
-
Bestor TH, Transposons reanimated in mice. Cell. 2005;122(3):322–5. doi: 10.1016/j.cell.2005.07.02416096053
-
(2005)
Cell
, vol.122
, Issue.3
, pp. 322-325
-
-
Bestor, T.H.1
-
37
-
-
0033118754
-
Imprinting of a genomic domain of 11p15 and loss of imprinting in cancer: an introduction
-
10197590,.; (): –.
-
Feinberg AP, Imprinting of a genomic domain of 11p15 and loss of imprinting in cancer: an introduction. Cancer research. 1999;59(7 Suppl):1743s–6s. 10197590
-
(1999)
Cancer research
, vol.59
, Issue.7 Suppl
, pp. 1743s-1746s
-
-
Feinberg, A.P.1
-
38
-
-
29244447111
-
Loss of imprinting of IGF2: a common epigenetic modifier of intestinal tumor risk
-
16357124,.; (): –.
-
Kaneda A, Feinberg AP, Loss of imprinting of IGF2: a common epigenetic modifier of intestinal tumor risk. Cancer research. 2005;65(24):11236–40. doi: 10.1158/0008-5472.CAN-05-295916357124
-
(2005)
Cancer research
, vol.65
, Issue.24
, pp. 11236-11240
-
-
Kaneda, A.1
Feinberg, A.P.2
-
39
-
-
26644444345
-
Global loss of imprinting leads to widespread tumorigenesis in adult mice
-
16226703,.; (): –.
-
Holm TM, Jackson-Grusby L, Brambrink T, Yamada Y, Rideout WM, 3rdJaenisch R, Global loss of imprinting leads to widespread tumorigenesis in adult mice. Cancer cell. 2005;8(4):275–85. doi: 10.1016/j.ccr.2005.09.00716226703
-
(2005)
Cancer cell
, vol.8
, Issue.4
, pp. 275-285
-
-
Holm, T.M.1
Jackson-Grusby, L.2
Brambrink, T.3
Yamada, Y.4
Rideout, W.M.5
Jaenisch, R.6
-
40
-
-
0024365892
-
Epigenetic changes may contribute to the formation and spontaneous regression of retinoblastoma
-
2550354,.; (): –.
-
Greger V, Passarge E, Hopping W, Messmer E, Horsthemke B, Epigenetic changes may contribute to the formation and spontaneous regression of retinoblastoma. Hum Genet. 1989;83(2):155–8. doi: 10.1007/BF002867092550354
-
(1989)
Hum Genet
, vol.83
, Issue.2
, pp. 155-158
-
-
Greger, V.1
Passarge, E.2
Hopping, W.3
Messmer, E.4
Horsthemke, B.5
-
41
-
-
0028072991
-
Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma
-
7937876,..; (): –.; PubMed Central PMCID: PMCPMC44884.
-
Herman JG, Latif F, Weng Y, Lerman MI, Zbar B, Liu S, et al. Silencing of the VHL tumor-suppressor gene by DNA methylation in renal carcinoma. Proceedings of the National Academy of Sciences of the United States of America. 1994;91(21):9700–4.; PubMed Central PMCID: PMCPMC44884. doi: 10.1073/pnas.91.21.97007937876
-
(1994)
Proceedings of the National Academy of Sciences of the United States of America
, vol.91
, Issue.21
, pp. 9700-9704
-
-
Herman, J.G.1
Latif, F.2
Weng, Y.3
Lerman, M.I.4
Zbar, B.5
Liu, S.6
-
42
-
-
0034607234
-
Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors
-
10749912,..; (): –.
-
Esteller M, Silva JM, Dominguez G, Bonilla F, Matias-Guiu X, Lerma E, et al. Promoter hypermethylation and BRCA1 inactivation in sporadic breast and ovarian tumors. J Natl Cancer Inst. 2000;92(7):564–9. doi: 10.1093/jnci/92.7.56410749912
-
(2000)
J Natl Cancer Inst
, vol.92
, Issue.7
, pp. 564-569
-
-
Esteller, M.1
Silva, J.M.2
Dominguez, G.3
Bonilla, F.4
Matias-Guiu, X.5
Lerma, E.6
-
43
-
-
0345357773
-
Gene silencing in cancer in association with promoter hypermethylation
-
14627790,.; (): –.
-
Herman JG, Baylin SB, Gene silencing in cancer in association with promoter hypermethylation. The New England journal of medicine. 2003;349(21):2042–54. doi: 10.1056/NEJMra02307514627790
-
(2003)
The New England journal of medicine
, vol.349
, Issue.21
, pp. 2042-2054
-
-
Herman, J.G.1
Baylin, S.B.2
-
44
-
-
0343621494
-
Aberrant CpG-island methylation has non-random and tumour-type-specific patterns
-
10655057,..; (): –.
-
Costello JF, Fruhwald MC, Smiraglia DJ, Rush LJ, Robertson GP, Gao X, et al. Aberrant CpG-island methylation has non-random and tumour-type-specific patterns. Nature genetics. 2000;24(2):132–8. doi: 10.1038/7278510655057
-
(2000)
Nature genetics
, vol.24
, Issue.2
, pp. 132-138
-
-
Costello, J.F.1
Fruhwald, M.C.2
Smiraglia, D.J.3
Rush, L.J.4
Robertson, G.P.5
Gao, X.6
-
45
-
-
0035870248
-
A gene hypermethylation profile of human cancer
-
11309270,.; (): –.
-
Esteller M, Corn PG, Baylin SB, Herman JG, A gene hypermethylation profile of human cancer. Cancer research. 2001;61(8):3225–9. 11309270
-
(2001)
Cancer research
, vol.61
, Issue.8
, pp. 3225-3229
-
-
Esteller, M.1
Corn, P.G.2
Baylin, S.B.3
Herman, J.G.4
-
46
-
-
33947315736
-
Cancer epigenomics: DNA methylomes and histone-modification maps
-
17339880,.; (): –.
-
Esteller M, Cancer epigenomics: DNA methylomes and histone-modification maps. Nature reviews Genetics. 2007;8(4):286–98. doi: 10.1038/nrg200517339880
-
(2007)
Nature reviews Genetics
, vol.8
, Issue.4
, pp. 286-298
-
-
Esteller, M.1
-
47
-
-
73649110641
-
DNA methylation signatures identify biologically distinct subtypes in acute myeloid leukemia
-
20060365,..; (): –.; PubMed Central PMCID: PMCPMC3008568.
-
Figueroa ME, Lugthart S, Li Y, Erpelinck-Verschueren C, Deng X, Christos PJ, et al. DNA methylation signatures identify biologically distinct subtypes in acute myeloid leukemia. Cancer cell. 2010;17(1):13–27.; PubMed Central PMCID: PMCPMC3008568. doi: 10.1016/j.ccr.2009.11.02020060365
-
(2010)
Cancer cell
, vol.17
, Issue.1
, pp. 13-27
-
-
Figueroa, M.E.1
Lugthart, S.2
Li, Y.3
Erpelinck-Verschueren, C.4
Deng, X.5
Christos, P.J.6
-
48
-
-
1442356729
-
CEBPA mutations in younger adults with acute myeloid leukemia and normal cytogenetics: prognostic relevance and analysis of cooperating mutations
-
14726504,..; (): –.
-
Frohling S, Schlenk RF, Stolze I, Bihlmayr J, Benner A, Kreitmeier S, et al. CEBPA mutations in younger adults with acute myeloid leukemia and normal cytogenetics: prognostic relevance and analysis of cooperating mutations. Journal of clinical oncology: official journal of the American Society of Clinical Oncology. 2004;22(4):624–33. doi: 10.1200/JCO.2004.06.06014726504
-
(2004)
Journal of clinical oncology: official journal of the American Society of Clinical Oncology
, vol.22
, Issue.4
, pp. 624-633
-
-
Frohling, S.1
Schlenk, R.F.2
Stolze, I.3
Bihlmayr, J.4
Benner, A.5
Kreitmeier, S.6
-
49
-
-
0035093813
-
Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia
-
11242107,..; (): –.
-
Pabst T, Mueller BU, Zhang P, Radomska HS, Narravula S, Schnittger S, et al. Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia. Nature genetics. 2001;27(3):263–70. doi: 10.1038/8582011242107
-
(2001)
Nature genetics
, vol.27
, Issue.3
, pp. 263-270
-
-
Pabst, T.1
Mueller, B.U.2
Zhang, P.3
Radomska, H.S.4
Narravula, S.5
Schnittger, S.6
-
50
-
-
35348896184
-
Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1
-
17671232,..; (): –.; PubMed Central PMCID: PMCPMC2077318.
-
Wouters BJ, Jorda MA, Keeshan K, Louwers I, Erpelinck-Verschueren CA, Tielemans D, et al. Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1. Blood. 2007;110(10):3706–14.; PubMed Central PMCID: PMCPMC2077318. doi: 10.1182/blood-2007-02-07348617671232
-
(2007)
Blood
, vol.110
, Issue.10
, pp. 3706-3714
-
-
Wouters, B.J.1
Jorda, M.A.2
Keeshan, K.3
Louwers, I.4
Erpelinck-Verschueren, C.A.5
Tielemans, D.6
-
51
-
-
79952323651
-
Characterization of CEBPA mutations and promoter hypermethylation in pediatric acute myeloid leukemia
-
21134981,..; (): –.; PubMed Central PMCID: PMCPMC3046269.
-
Hollink IH, van den Heuvel-Eibrink MM, Arentsen-Peters ST, Zimmermann M, Peeters JK, Valk PJ, et al. Characterization of CEBPA mutations and promoter hypermethylation in pediatric acute myeloid leukemia. Haematologica. 2011;96(3):384–92.; PubMed Central PMCID: PMCPMC3046269. doi: 10.3324/haematol.2010.03133621134981
-
(2011)
Haematologica
, vol.96
, Issue.3
, pp. 384-392
-
-
Hollink, I.H.1
van den Heuvel-Eibrink, M.M.2
Arentsen-Peters, S.T.3
Zimmermann, M.4
Peeters, J.K.5
Valk, P.J.6
-
52
-
-
63849197532
-
Genome-wide epigenetic analysis delineates a biologically distinct immature acute leukemia with myeloid/T-lymphoid features
-
19168792,..; (): –.; PubMed Central PMCID: PMCPMC2945920.
-
Figueroa ME, Wouters BJ, Skrabanek L, Glass J, Li Y, Erpelinck-Verschueren CA, et al. Genome-wide epigenetic analysis delineates a biologically distinct immature acute leukemia with myeloid/T-lymphoid features. Blood. 2009;113(12):2795–804.; PubMed Central PMCID: PMCPMC2945920. doi: 10.1182/blood-2008-08-17238719168792
-
(2009)
Blood
, vol.113
, Issue.12
, pp. 2795-2804
-
-
Figueroa, M.E.1
Wouters, B.J.2
Skrabanek, L.3
Glass, J.4
Li, Y.5
Erpelinck-Verschueren, C.A.6
-
53
-
-
84953924597
-
Insulator dysfunction and oncogene activation in IDH mutant gliomas
-
26700815,..; (): –.; PubMed Central PMCID: PMCPMC4831574.
-
Flavahan WA, Drier Y, Liau BB, Gillespie SM, Venteicher AS, Stemmer-Rachamimov AO, et al. Insulator dysfunction and oncogene activation in IDH mutant gliomas. Nature. 2016;529(7584):110–4.; PubMed Central PMCID: PMCPMC4831574. doi: 10.1038/nature1649026700815
-
(2016)
Nature
, vol.529
, Issue.7584
, pp. 110-114
-
-
Flavahan, W.A.1
Drier, Y.2
Liau, B.B.3
Gillespie, S.M.4
Venteicher, A.S.5
Stemmer-Rachamimov, A.O.6
-
54
-
-
84947031445
-
Disruption of CTCF/cohesin-mediated high-order chromatin structures by DNA methylation downregulates PTGS2 expression
-
25703332,..; (): –.
-
Kang JY, Song SH, Yun J, Jeon MS, Kim HP, Han SW, et al. Disruption of CTCF/cohesin-mediated high-order chromatin structures by DNA methylation downregulates PTGS2 expression. Oncogene. 2015;34(45):5677–84. doi: 10.1038/onc.2015.1725703332
-
(2015)
Oncogene
, vol.34
, Issue.45
, pp. 5677-5684
-
-
Kang, J.Y.1
Song, S.H.2
Yun, J.3
Jeon, M.S.4
Kim, H.P.5
Han, S.W.6
-
55
-
-
84960171833
-
Activation of proto-oncogenes by disruption of chromosome neighborhoods
-
26940867,..; (): –.
-
Hnisz D, Weintraub AS, Day DS, Valton AL, Bak RO, Li CH, et al. Activation of proto-oncogenes by disruption of chromosome neighborhoods. Science. 2016;351(6280):1454–8. doi: 10.1126/science.aad902426940867
-
(2016)
Science
, vol.351
, Issue.6280
, pp. 1454-1458
-
-
Hnisz, D.1
Weintraub, A.S.2
Day, D.S.3
Valton, A.L.4
Bak, R.O.5
Li, C.H.6
-
56
-
-
84881086323
-
Cancer as a dysregulated epigenome allowing cellular growth advantage at the expense of the host
-
23760024,.; (): –.; PubMed Central PMCID: PMC4636434.
-
Timp W, Feinberg AP, Cancer as a dysregulated epigenome allowing cellular growth advantage at the expense of the host. Nature reviews Cancer. 2013;13(7):497–510.; PubMed Central PMCID: PMC4636434. doi: 10.1038/nrc348623760024
-
(2013)
Nature reviews Cancer
, vol.13
, Issue.7
, pp. 497-510
-
-
Timp, W.1
Feinberg, A.P.2
-
57
-
-
68349116524
-
IDH1 mutations are present in the majority of common adult gliomas but rare in primary glioblastomas
-
19435942,..; (): –.; PubMed Central PMCID: PMCPMC2743214.
-
Ichimura K, Pearson DM, Kocialkowski S, Backlund LM, Chan R, Jones DT, et al. IDH1 mutations are present in the majority of common adult gliomas but rare in primary glioblastomas. Neuro Oncol. 2009;11(4):341–7.; PubMed Central PMCID: PMCPMC2743214. doi: 10.1215/15228517-2009-02519435942
-
(2009)
Neuro Oncol
, vol.11
, Issue.4
, pp. 341-347
-
-
Ichimura, K.1
Pearson, D.M.2
Kocialkowski, S.3
Backlund, L.M.4
Chan, R.5
Jones, D.T.6
-
58
-
-
84879698783
-
Mutations in epigenetic modifiers in the pathogenesis and therapy of acute myeloid leukemia
-
23640996,.; (): –.; PubMed Central PMCID: PMC3643757.
-
Abdel-Wahab O, Levine RL, Mutations in epigenetic modifiers in the pathogenesis and therapy of acute myeloid leukemia. Blood. 2013;121(18):3563–72.; PubMed Central PMCID: PMC3643757. doi: 10.1182/blood-2013-01-45178123640996
-
(2013)
Blood
, vol.121
, Issue.18
, pp. 3563-3572
-
-
Abdel-Wahab, O.1
Levine, R.L.2
-
59
-
-
84899495467
-
The epigenetic landscape of acute myeloid leukemia
-
24778653,.;:.; PubMed Central PMCID: PMCPMC3980839.
-
Conway O'Brien E, Prideaux S, Chevassut T, The epigenetic landscape of acute myeloid leukemia. Adv Hematol. 2014;2014:103175.; PubMed Central PMCID: PMCPMC3980839. doi: 10.1155/2014/10317524778653
-
(2014)
Adv Hematol
, vol.2014
, pp. 103175
-
-
Conway O'Brien, E.1
Prideaux, S.2
Chevassut, T.3
-
60
-
-
84875745673
-
Interplay between the cancer genome and epigenome
-
23540689,.; (): –.; PubMed Central PMCID: PMCPMC3648790.
-
Shen H, Laird PW, Interplay between the cancer genome and epigenome. Cell. 2013;153(1):38–55.; PubMed Central PMCID: PMCPMC3648790. doi: 10.1016/j.cell.2013.03.00823540689
-
(2013)
Cell
, vol.153
, Issue.1
, pp. 38-55
-
-
Shen, H.1
Laird, P.W.2
-
61
-
-
78649906060
-
DNMT3A mutations in acute myeloid leukemia
-
21067377,..; (): –.; PubMed Central PMCID: PMCPMC3201818.
-
Ley TJ, Ding L, Walter MJ, McLellan MD, Lamprecht T, Larson DE, et al. DNMT3A mutations in acute myeloid leukemia. The New England journal of medicine. 2010;363(25):2424–33.; PubMed Central PMCID: PMCPMC3201818. doi: 10.1056/NEJMoa100514321067377
-
(2010)
The New England journal of medicine
, vol.363
, Issue.25
, pp. 2424-2433
-
-
Ley, T.J.1
Ding, L.2
Walter, M.J.3
McLellan, M.D.4
Lamprecht, T.5
Larson, D.E.6
-
62
-
-
84862501737
-
Mutant DNMT3A: teaming up to transform
-
22700693,.; (): –.
-
Thiede C, Mutant DNMT3A: teaming up to transform. Blood. 2012;119(24):5615–7. doi: 10.1182/blood-2012-04-42390522700693
-
(2012)
Blood
, vol.119
, Issue.24
, pp. 5615-5617
-
-
Thiede, C.1
-
63
-
-
84863393263
-
Prognostic relevance of integrated genetic profiling in acute myeloid leukemia
-
22417203,..; (): –.; PubMed Central PMCID: PMCPMC3545649.
-
Patel JP, Gonen M, Figueroa ME, Fernandez H, Sun Z, Racevskis J, et al. Prognostic relevance of integrated genetic profiling in acute myeloid leukemia. The New England journal of medicine. 2012;366(12):1079–89.; PubMed Central PMCID: PMCPMC3545649. doi: 10.1056/NEJMoa111230422417203
-
(2012)
The New England journal of medicine
, vol.366
, Issue.12
, pp. 1079-1089
-
-
Patel, J.P.1
Gonen, M.2
Figueroa, M.E.3
Fernandez, H.4
Sun, Z.5
Racevskis, J.6
-
64
-
-
79960255863
-
Recurrent DNMT3A mutations in patients with myelodysplastic syndromes
-
21415852,..; (): –.; PubMed Central PMCID: PMCPMC3202965.
-
Walter MJ, Ding L, Shen D, Shao J, Grillot M, McLellan M, et al. Recurrent DNMT3A mutations in patients with myelodysplastic syndromes. Leukemia. 2011;25(7):1153–8.; PubMed Central PMCID: PMCPMC3202965. doi: 10.1038/leu.2011.4421415852
-
(2011)
Leukemia
, vol.25
, Issue.7
, pp. 1153-1158
-
-
Walter, M.J.1
Ding, L.2
Shen, D.3
Shao, J.4
Grillot, M.5
McLellan, M.6
-
65
-
-
67651065502
-
Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies
-
19420352,..; (): –.; PubMed Central PMCID: PMCPMC2710942.
-
Abdel-Wahab O, Mullally A, Hedvat C, Garcia-Manero G, Patel J, Wadleigh M, et al. Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies. Blood. 2009;114(1):144–7.; PubMed Central PMCID: PMCPMC2710942. doi: 10.1182/blood-2009-03-21003919420352
-
(2009)
Blood
, vol.114
, Issue.1
, pp. 144-147
-
-
Abdel-Wahab, O.1
Mullally, A.2
Hedvat, C.3
Garcia-Manero, G.4
Patel, J.5
Wadleigh, M.6
-
66
-
-
80053620171
-
TET2 mutation is an unfavorable prognostic factor in acute myeloid leukemia patients with intermediate-risk cytogenetics
-
21828143,..; (): –.
-
Chou WC, Chou SC, Liu CY, Chen CY, Hou HA, Kuo YY, et al. TET2 mutation is an unfavorable prognostic factor in acute myeloid leukemia patients with intermediate-risk cytogenetics. Blood. 2011;118(14):3803–10. doi: 10.1182/blood-2011-02-33974721828143
-
(2011)
Blood
, vol.118
, Issue.14
, pp. 3803-3810
-
-
Chou, W.C.1
Chou, S.C.2
Liu, C.Y.3
Chen, C.Y.4
Hou, H.A.5
Kuo, Y.Y.6
-
67
-
-
67349124376
-
TET2 mutations and their clinical correlates in polycythemia vera, essential thrombocythemia and myelofibrosis
-
19262601,..; (): –.; PubMed Central PMCID: PMCPMC4654629.
-
Tefferi A, Pardanani A, Lim KH, Abdel-Wahab O, Lasho TL, Patel J, et al. TET2 mutations and their clinical correlates in polycythemia vera, essential thrombocythemia and myelofibrosis. Leukemia. 2009;23(5):905–11.; PubMed Central PMCID: PMCPMC4654629. doi: 10.1038/leu.2009.4719262601
-
(2009)
Leukemia
, vol.23
, Issue.5
, pp. 905-911
-
-
Tefferi, A.1
Pardanani, A.2
Lim, K.H.3
Abdel-Wahab, O.4
Lasho, T.L.5
Patel, J.6
-
68
-
-
84864100711
-
The role of histone methyltransferase EZH2 in myelodysplastic syndromes
-
22475286,.; (): –.
-
Xu F, Li X, The role of histone methyltransferase EZH2 in myelodysplastic syndromes. Expert review of hematology. 2012;5(2):177–85. doi: 10.1586/ehm.12.522475286
-
(2012)
Expert review of hematology
, vol.5
, Issue.2
, pp. 177-185
-
-
Xu, F.1
Li, X.2
-
69
-
-
84891854229
-
EZH2 in normal and malignant hematopoiesis
-
24097338,.; (): –.
-
Lund K, Adams PD, Copland M, EZH2 in normal and malignant hematopoiesis. Leukemia. 2014;28(1):44–9. doi: 10.1038/leu.2013.28824097338
-
(2014)
Leukemia
, vol.28
, Issue.1
, pp. 44-49
-
-
Lund, K.1
Adams, P.D.2
Copland, M.3
-
70
-
-
84873568880
-
The ASXL-BAP1 axis: new factors in myelopoiesis, cancer and epigenetics
-
23147254,.; (): –.
-
Abdel-Wahab O, Dey A, The ASXL-BAP1 axis: new factors in myelopoiesis, cancer and epigenetics. Leukemia. 2013;27(1):10–5. doi: 10.1038/leu.2012.28823147254
-
(2013)
Leukemia
, vol.27
, Issue.1
, pp. 10-15
-
-
Abdel-Wahab, O.1
Dey, A.2
-
71
-
-
83355173202
-
EZH2 codon 641 mutations are common in BCL2-rearranged germinal center B cell lymphomas
-
22194861,..; ():.; PubMed Central PMCID: PMCPMC3237460.
-
Ryan RJ, Nitta M, Borger D, Zukerberg LR, Ferry JA, Harris NL, et al. EZH2 codon 641 mutations are common in BCL2-rearranged germinal center B cell lymphomas. PLoS ONE. 2011;6(12):e28585.; PubMed Central PMCID: PMCPMC3237460. doi: 10.1371/journal.pone.002858522194861
-
(2011)
PLoS ONE
, vol.6
, Issue.12
, pp. e28585
-
-
Ryan, R.J.1
Nitta, M.2
Borger, D.3
Zukerberg, L.R.4
Ferry, J.A.5
Harris, N.L.6
-
72
-
-
75749124332
-
Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin
-
20081860,..; (): –.; PubMed Central PMCID: PMCPMC2850970.
-
Morin RD, Johnson NA, Severson TM, Mungall AJ, An J, Goya R, et al. Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin. Nature genetics. 2010;42(2):181–5.; PubMed Central PMCID: PMCPMC2850970. doi: 10.1038/ng.51820081860
-
(2010)
Nature genetics
, vol.42
, Issue.2
, pp. 181-185
-
-
Morin, R.D.1
Johnson, N.A.2
Severson, T.M.3
Mungall, A.J.4
An, J.5
Goya, R.6
-
73
-
-
84870573126
-
EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations
-
23051747,..; (): –.
-
McCabe MT, Ott HM, Ganji G, Korenchuk S, Thompson C, Van Aller GS, et al. EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations. Nature. 2012;492(7427):108–12. doi: 10.1038/nature1160623051747
-
(2012)
Nature
, vol.492
, Issue.7427
, pp. 108-112
-
-
McCabe, M.T.1
Ott, H.M.2
Ganji, G.3
Korenchuk, S.4
Thompson, C.5
Van Aller, G.S.6
-
74
-
-
84855695098
-
The HARE-HTH and associated domains: novel modules in the coordination of epigenetic DNA and protein modifications
-
22186017,.; (): –.; PubMed Central PMCID: PMCPMC3272235.
-
Aravind L, Iyer LM, The HARE-HTH and associated domains: novel modules in the coordination of epigenetic DNA and protein modifications. Cell cycle. 2012;11(1):119–31.; PubMed Central PMCID: PMCPMC3272235. doi: 10.4161/cc.11.1.1847522186017
-
(2012)
Cell cycle
, vol.11
, Issue.1
, pp. 119-131
-
-
Aravind, L.1
Iyer, L.M.2
-
75
-
-
84865152223
-
ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression
-
22897849,..; (): –.; PubMed Central PMCID: PMCPMC3422511.
-
Abdel-Wahab O, Adli M, LaFave LM, Gao J, Hricik T, Shih AH, et al. ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression. Cancer cell. 2012;22(2):180–93.; PubMed Central PMCID: PMCPMC3422511. doi: 10.1016/j.ccr.2012.06.03222897849
-
(2012)
Cancer cell
, vol.22
, Issue.2
, pp. 180-193
-
-
Abdel-Wahab, O.1
Adli, M.2
LaFave, L.M.3
Gao, J.4
Hricik, T.5
Shih, A.H.6
-
76
-
-
77149134353
-
Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations
-
20142433,..; (): –.; PubMed Central PMCID: PMCPMC2822606.
-
Gross S, Cairns RA, Minden MD, Driggers EM, Bittinger MA, Jang HG, et al. Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations. The Journal of experimental medicine. 2010;207(2):339–44.; PubMed Central PMCID: PMCPMC2822606. doi: 10.1084/jem.2009250620142433
-
(2010)
The Journal of experimental medicine
, vol.207
, Issue.2
, pp. 339-344
-
-
Gross, S.1
Cairns, R.A.2
Minden, M.D.3
Driggers, E.M.4
Bittinger, M.A.5
Jang, H.G.6
-
77
-
-
84959886681
-
IDH2 inhibition in AML: Finally progress?
-
26590767,.; (): –.
-
Stein EM, IDH2 inhibition in AML: Finally progress?Best practice & research Clinical haematology. 2015;28(2–3):112–5. doi: 10.1016/j.beha.2015.10.01626590767
-
(2015)
Best practice & research Clinical haematology
, vol.28
, Issue.2-3
, pp. 112-115
-
-
Stein, E.M.1
-
78
-
-
60849115270
-
IDH1 and IDH2 mutations in gliomas
-
19228619,..; (): –.; PubMed Central PMCID: PMC2820383.
-
Yan H, Parsons DW, Jin G, McLendon R, Rasheed BA, Yuan W, et al. IDH1 and IDH2 mutations in gliomas. The New England journal of medicine. 2009;360(8):765–73.; PubMed Central PMCID: PMC2820383. doi: 10.1056/NEJMoa080871019228619
-
(2009)
The New England journal of medicine
, vol.360
, Issue.8
, pp. 765-773
-
-
Yan, H.1
Parsons, D.W.2
Jin, G.3
McLendon, R.4
Rasheed, B.A.5
Yuan, W.6
-
79
-
-
79960534917
-
The prognostic significance of IDH2 mutations in AML depends on the location of the mutation
-
21596855,..; (): –.
-
Green CL, Evans CM, Zhao L, Hills RK, Burnett AK, Linch DC, et al. The prognostic significance of IDH2 mutations in AML depends on the location of the mutation. Blood. 2011;118(2):409–12. doi: 10.1182/blood-2010-12-32247921596855
-
(2011)
Blood
, vol.118
, Issue.2
, pp. 409-412
-
-
Green, C.L.1
Evans, C.M.2
Zhao, L.3
Hills, R.K.4
Burnett, A.K.5
Linch, D.C.6
-
80
-
-
84877620952
-
Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation
-
23558173,..; (): –.
-
Wang F, Travins J, DeLaBarre B, Penard-Lacronique V, Schalm S, Hansen E, et al. Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation. Science. 2013;340(6132):622–6. doi: 10.1126/science.123476923558173
-
(2013)
Science
, vol.340
, Issue.6132
, pp. 622-626
-
-
Wang, F.1
Travins, J.2
DeLaBarre, B.3
Penard-Lacronique, V.4
Schalm, S.5
Hansen, E.6
-
81
-
-
78651463452
-
Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases
-
21251613,..; (): –.; PubMed Central PMCID: PMC3229304.
-
Xu W, Yang H, Liu Y, Yang Y, Wang P, Kim SH, et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of alpha-ketoglutarate-dependent dioxygenases. Cancer cell. 2011;19(1):17–30.; PubMed Central PMCID: PMC3229304. doi: 10.1016/j.ccr.2010.12.01421251613
-
(2011)
Cancer cell
, vol.19
, Issue.1
, pp. 17-30
-
-
Xu, W.1
Yang, H.2
Liu, Y.3
Yang, Y.4
Wang, P.5
Kim, S.H.6
-
82
-
-
84862266735
-
TET2 mutations in acute myeloid leukemia (AML): results from a comprehensive genetic and clinical analysis of the AML study group
-
22430270,..; (): –.
-
Gaidzik VI, Paschka P, Spath D, Habdank M, Kohne CH, Germing U, et al. TET2 mutations in acute myeloid leukemia (AML): results from a comprehensive genetic and clinical analysis of the AML study group. Journal of clinical oncology: official journal of the American Society of Clinical Oncology. 2012;30(12):1350–7. doi: 10.1200/JCO.2011.39.288622430270
-
(2012)
Journal of clinical oncology: official journal of the American Society of Clinical Oncology
, vol.30
, Issue.12
, pp. 1350-1357
-
-
Gaidzik, V.I.1
Paschka, P.2
Spath, D.3
Habdank, M.4
Kohne, C.H.5
Germing, U.6
-
83
-
-
84908265816
-
Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders
-
25131830,.; (): –.
-
Falkenberg KJ, Johnstone RW, Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders. Nature reviews Drug discovery. 2014;13(9):673–91. doi: 10.1038/nrd436025131830
-
(2014)
Nature reviews Drug discovery
, vol.13
, Issue.9
, pp. 673-691
-
-
Falkenberg, K.J.1
Johnstone, R.W.2
-
84
-
-
2942612214
-
ETO interacting proteins
-
15156183,.; (): –.
-
Hug BA, Lazar MA, ETO interacting proteins. Oncogene. 2004;23(24):4270–4. doi: 10.1038/sj.onc.120767415156183
-
(2004)
Oncogene
, vol.23
, Issue.24
, pp. 4270-4274
-
-
Hug, B.A.1
Lazar, M.A.2
-
85
-
-
84906083688
-
The acute promyelocytic leukaemia success story: curing leukaemia through targeted therapies
-
24635409,.; (): –.
-
Rice KL, de The H, The acute promyelocytic leukaemia success story: curing leukaemia through targeted therapies. Journal of internal medicine. 2014;276(1):61–70. doi: 10.1111/joim.1220824635409
-
(2014)
Journal of internal medicine
, vol.276
, Issue.1
, pp. 61-70
-
-
Rice, K.L.1
de The, H.2
-
86
-
-
78650983952
-
Aberrant DNA hypermethylation signature in acute myeloid leukemia directed by EVI1
-
20855866,..; (): –.; PubMed Central PMCID: PMCPMC3037746.
-
Lugthart S, Figueroa ME, Bindels E, Skrabanek L, Valk PJ, Li Y, et al. Aberrant DNA hypermethylation signature in acute myeloid leukemia directed by EVI1. Blood. 2011;117(1):234–41.; PubMed Central PMCID: PMCPMC3037746. doi: 10.1182/blood-2010-04-28133720855866
-
(2011)
Blood
, vol.117
, Issue.1
, pp. 234-241
-
-
Lugthart, S.1
Figueroa, M.E.2
Bindels, E.3
Skrabanek, L.4
Valk, P.J.5
Li, Y.6
-
87
-
-
79959794787
-
Clinical effect of point mutations in myelodysplastic syndromes
-
21714648,..; (): –. Epub 2011/07/01.; PubMed Central PMCID: PMC3159042.
-
Bejar R, Stevenson K, Abdel-Wahab O, Galili N, Nilsson B, Garcia-Manero G, et al. Clinical effect of point mutations in myelodysplastic syndromes. N Engl J Med. 2011;364(26):2496–506. Epub 2011/07/01.; PubMed Central PMCID: PMC3159042. doi: 10.1056/NEJMoa101334321714648
-
(2011)
N Engl J Med
, vol.364
, Issue.26
, pp. 2496-2506
-
-
Bejar, R.1
Stevenson, K.2
Abdel-Wahab, O.3
Galili, N.4
Nilsson, B.5
Garcia-Manero, G.6
-
88
-
-
84255176496
-
ASXL1 mutations identify a high-risk subgroup of older patients with primary cytogenetically normal AML within the ELN Favorable genetic category
-
22031865,..; (): –.; PubMed Central PMCID: PMCPMC3245212.
-
Metzeler KH, Becker H, Maharry K, Radmacher MD, Kohlschmidt J, Mrozek K, et al. ASXL1 mutations identify a high-risk subgroup of older patients with primary cytogenetically normal AML within the ELN Favorable genetic category. Blood. 2011;118(26):6920–9.; PubMed Central PMCID: PMCPMC3245212. doi: 10.1182/blood-2011-08-36822522031865
-
(2011)
Blood
, vol.118
, Issue.26
, pp. 6920-6929
-
-
Metzeler, K.H.1
Becker, H.2
Maharry, K.3
Radmacher, M.D.4
Kohlschmidt, J.5
Mrozek, K.6
-
89
-
-
84888218028
-
Targeting IDH: the next big thing in AML
-
24136078,.; (): –.
-
Levis M, Targeting IDH: the next big thing in AML. Blood. 2013;122(16):2770–1. doi: 10.1182/blood-2013-09-52244124136078
-
(2013)
Blood
, vol.122
, Issue.16
, pp. 2770-2771
-
-
Levis, M.1
-
90
-
-
35548934558
-
MLL translocations, histone modifications and leukaemia stem-cell development
-
17957188,.; (): –.
-
Krivtsov AV, Armstrong SA, MLL translocations, histone modifications and leukaemia stem-cell development. Nature reviews Cancer. 2007;7(11):823–33. doi: 10.1038/nrc225317957188
-
(2007)
Nature reviews Cancer
, vol.7
, Issue.11
, pp. 823-833
-
-
Krivtsov, A.V.1
Armstrong, S.A.2
-
91
-
-
33646161959
-
The MLL recombinome of acute leukemias
-
16511515,..; (): –.
-
Meyer C, Schneider B, Jakob S, Strehl S, Attarbaschi A, Schnittger S, et al. The MLL recombinome of acute leukemias. Leukemia. 2006;20(5):777–84. doi: 10.1038/sj.leu.240415016511515
-
(2006)
Leukemia
, vol.20
, Issue.5
, pp. 777-784
-
-
Meyer, C.1
Schneider, B.2
Jakob, S.3
Strehl, S.4
Attarbaschi, A.5
Schnittger, S.6
-
92
-
-
77957128551
-
Licensed to elongate: a molecular mechanism for MLL-based leukaemogenesis
-
20844554,.; (): –.
-
Mohan M, Lin C, Guest E, Shilatifard A, Licensed to elongate: a molecular mechanism for MLL-based leukaemogenesis. Nature reviews Cancer. 2010;10(10):721–8. doi: 10.1038/nrc291520844554
-
(2010)
Nature reviews Cancer
, vol.10
, Issue.10
, pp. 721-728
-
-
Mohan, M.1
Lin, C.2
Guest, E.3
Shilatifard, A.4
-
93
-
-
72949099700
-
Misguided transcriptional elongation causes mixed lineage leukemia
-
19956800,.; ():.; PubMed Central PMCID: PMC2774266.
-
Mueller D, Garcia-Cuellar MP, Bach C, Buhl S, Maethner E, Slany RK, Misguided transcriptional elongation causes mixed lineage leukemia. PLoS Biol. 2009;7(11):e1000249.; PubMed Central PMCID: PMC2774266. doi: 10.1371/journal.pbio.100024919956800
-
(2009)
PLoS Biol
, vol.7
, Issue.11
, pp. e1000249
-
-
Mueller, D.1
Garcia-Cuellar, M.P.2
Bach, C.3
Buhl, S.4
Maethner, E.5
Slany, R.K.6
-
94
-
-
75949126139
-
AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia
-
20159561,..; (): –.; PubMed Central PMCID: PMC2872029.
-
Lin C, Smith ER, Takahashi H, Lai KC, Martin-Brown S, Florens L, et al. AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia. Molecular cell. 2010;37(3):429–37.; PubMed Central PMCID: PMC2872029. doi: 10.1016/j.molcel.2010.01.02620159561
-
(2010)
Molecular cell
, vol.37
, Issue.3
, pp. 429-437
-
-
Lin, C.1
Smith, E.R.2
Takahashi, H.3
Lai, K.C.4
Martin-Brown, S.5
Florens, L.6
-
95
-
-
76349118080
-
A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription
-
20153263,.; (): –.; PubMed Central PMCID: PMC2824033.
-
Yokoyama A, Lin M, Naresh A, Kitabayashi I, Cleary ML, A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription. Cancer cell. 2010;17(2):198–212.; PubMed Central PMCID: PMC2824033. doi: 10.1016/j.ccr.2009.12.04020153263
-
(2010)
Cancer cell
, vol.17
, Issue.2
, pp. 198-212
-
-
Yokoyama, A.1
Lin, M.2
Naresh, A.3
Kitabayashi, I.4
Cleary, M.L.5
-
96
-
-
80054984945
-
Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia
-
21964340,..; (): –.; PubMed Central PMCID: PMC3679520.
-
Dawson MA, Prinjha RK, Dittmann A, Giotopoulos G, Bantscheff M, Chan WI, et al. Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia. Nature. 2011;478(7370):529–33.; PubMed Central PMCID: PMC3679520. doi: 10.1038/nature1050921964340
-
(2011)
Nature
, vol.478
, Issue.7370
, pp. 529-533
-
-
Dawson, M.A.1
Prinjha, R.K.2
Dittmann, A.3
Giotopoulos, G.4
Bantscheff, M.5
Chan, W.I.6
-
97
-
-
78650847770
-
Selective inhibition of BET bromodomains
-
20871596,..; (): –.; PubMed Central PMCID: PMC3010259.
-
Filippakopoulos P, Qi J, Picaud S, Shen Y, Smith WB, Fedorov O, et al. Selective inhibition of BET bromodomains. Nature. 2010;468(7327):1067–73.; PubMed Central PMCID: PMC3010259. doi: 10.1038/nature0950420871596
-
(2010)
Nature
, vol.468
, Issue.7327
, pp. 1067-1073
-
-
Filippakopoulos, P.1
Qi, J.2
Picaud, S.3
Shen, Y.4
Smith, W.B.5
Fedorov, O.6
-
98
-
-
80055000824
-
RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
-
21814200,..; (): –.; PubMed Central PMCID: PMC3328300.
-
Zuber J, Shi J, Wang E, Rappaport AR, Herrmann H, Sison EA, et al. RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia. Nature. 2011;478(7370):524–8.; PubMed Central PMCID: PMC3328300. doi: 10.1038/nature1033421814200
-
(2011)
Nature
, vol.478
, Issue.7370
, pp. 524-528
-
-
Zuber, J.1
Shi, J.2
Wang, E.3
Rappaport, A.R.4
Herrmann, H.5
Sison, E.A.6
-
99
-
-
54549083228
-
H3K79 methylation profiles define murine and human MLL-AF4 leukemias
-
18977325,..; (): –.; PubMed Central PMCID: PMC2591932.
-
Krivtsov AV, Feng Z, Lemieux ME, Faber J, Vempati S, Sinha AU, et al. H3K79 methylation profiles define murine and human MLL-AF4 leukemias. Cancer cell. 2008;14(5):355–68.; PubMed Central PMCID: PMC2591932. doi: 10.1016/j.ccr.2008.10.00118977325
-
(2008)
Cancer cell
, vol.14
, Issue.5
, pp. 355-368
-
-
Krivtsov, A.V.1
Feng, Z.2
Lemieux, M.E.3
Faber, J.4
Vempati, S.5
Sinha, A.U.6
-
100
-
-
84939165694
-
Targeting DOT1L and HOX gene expression in MLL-rearranged leukemia and beyond
-
26118503,.; (): –.; PubMed Central PMCID: PMC4540610.
-
Chen CW, Armstrong SA, Targeting DOT1L and HOX gene expression in MLL-rearranged leukemia and beyond. Experimental hematology. 2015;43(8):673–84.; PubMed Central PMCID: PMC4540610. doi: 10.1016/j.exphem.2015.05.01226118503
-
(2015)
Experimental hematology
, vol.43
, Issue.8
, pp. 673-684
-
-
Chen, C.W.1
Armstrong, S.A.2
-
101
-
-
79960044951
-
MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L
-
21741597,..; (): –.; PubMed Central PMCID: PMC3329803.
-
Bernt KM, Zhu N, Sinha AU, Vempati S, Faber J, Krivtsov AV, et al. MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L. Cancer cell. 2011;20(1):66–78.; PubMed Central PMCID: PMC3329803. doi: 10.1016/j.ccr.2011.06.01021741597
-
(2011)
Cancer cell
, vol.20
, Issue.1
, pp. 66-78
-
-
Bernt, K.M.1
Zhu, N.2
Sinha, A.U.3
Vempati, S.4
Faber, J.5
Krivtsov, A.V.6
-
102
-
-
29244433742
-
Leukemogenic MLL fusion proteins bind across a broad region of the Hox a9 locus, promoting transcription and multiple histone modifications
-
16357144,.; (): –.
-
Milne TA, Martin ME, Brock HW, Slany RK, Hess JL, Leukemogenic MLL fusion proteins bind across a broad region of the Hox a9 locus, promoting transcription and multiple histone modifications. Cancer research. 2005;65(24):11367–74. doi: 10.1158/0008-5472.CAN-05-104116357144
-
(2005)
Cancer research
, vol.65
, Issue.24
, pp. 11367-11374
-
-
Milne, T.A.1
Martin, M.E.2
Brock, H.W.3
Slany, R.K.4
Hess, J.L.5
-
103
-
-
0038240453
-
Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation
-
12637319,..; (): –.
-
Ferrando AA, Armstrong SA, Neuberg DS, Sallan SE, Silverman LB, Korsmeyer SJ, et al. Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation. Blood. 2003;102(1):262–8. doi: 10.1182/blood-2002-10-322112637319
-
(2003)
Blood
, vol.102
, Issue.1
, pp. 262-268
-
-
Ferrando, A.A.1
Armstrong, S.A.2
Neuberg, D.S.3
Sallan, S.E.4
Silverman, L.B.5
Korsmeyer, S.J.6
-
104
-
-
79960058024
-
Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor
-
21741596,..; (): –.; PubMed Central PMCID: PMC4046888.
-
Daigle SR, Olhava EJ, Therkelsen CA, Majer CR, Sneeringer CJ, Song J, et al. Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor. Cancer cell. 2011;20(1):53–65.; PubMed Central PMCID: PMC4046888. doi: 10.1016/j.ccr.2011.06.00921741596
-
(2011)
Cancer cell
, vol.20
, Issue.1
, pp. 53-65
-
-
Daigle, S.R.1
Olhava, E.J.2
Therkelsen, C.A.3
Majer, C.R.4
Sneeringer, C.J.5
Song, J.6
-
105
-
-
84886864184
-
Potent inhibition of DOT1L as treatment of MLL-fusion leukemia
-
23801631,..; (): –.; PubMed Central PMCID: PMC3739029.
-
Daigle SR, Olhava EJ, Therkelsen CA, Basavapathruni A, Jin L, Boriack-Sjodin PA, et al. Potent inhibition of DOT1L as treatment of MLL-fusion leukemia. Blood. 2013;122(6):1017–25.; PubMed Central PMCID: PMC3739029. doi: 10.1182/blood-2013-04-49764423801631
-
(2013)
Blood
, vol.122
, Issue.6
, pp. 1017-1025
-
-
Daigle, S.R.1
Olhava, E.J.2
Therkelsen, C.A.3
Basavapathruni, A.4
Jin, L.5
Boriack-Sjodin, P.A.6
-
106
-
-
84878734445
-
A panoramic view of acute myeloid leukemia
-
23715324,.; (): –.
-
Chen SJ, Shen Y, Chen Z, A panoramic view of acute myeloid leukemia. Nature genetics. 2013;45(6):586–7. doi: 10.1038/ng.265123715324
-
(2013)
Nature genetics
, vol.45
, Issue.6
, pp. 586-587
-
-
Chen, S.J.1
Shen, Y.2
Chen, Z.3
-
107
-
-
70649095120
-
Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts
-
19881528,..; (): –.; PubMed Central PMCID: PMC2958040.
-
Doi A, Park IH, Wen B, Murakami P, Aryee MJ, Irizarry R, et al. Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts. Nature genetics. 2009;41(12):1350–3.; PubMed Central PMCID: PMC2958040. doi: 10.1038/ng.47119881528
-
(2009)
Nature genetics
, vol.41
, Issue.12
, pp. 1350-1353
-
-
Doi, A.1
Park, I.H.2
Wen, B.3
Murakami, P.4
Aryee, M.J.5
Irizarry, R.6
-
108
-
-
59449098943
-
A new link between epigenetic progenitor lesions in cancer and the dynamics of signal transduction
-
19177016,.; (): –.
-
Timp W, Levchenko A, Feinberg AP, A new link between epigenetic progenitor lesions in cancer and the dynamics of signal transduction. Cell cycle. 2009;8(3):383–90. doi: 10.4161/cc.8.3.754219177016
-
(2009)
Cell cycle
, vol.8
, Issue.3
, pp. 383-390
-
-
Timp, W.1
Levchenko, A.2
Feinberg, A.P.3
-
109
-
-
0032512067
-
BRCA2 associates with acetyltransferase activity when bound to P/CAF
-
9824164,.; (): –.
-
Fuks F, Milner J, Kouzarides T, BRCA2 associates with acetyltransferase activity when bound to P/CAF. Oncogene. 1998;17(19):2531–4. doi: 10.1038/sj.onc.12024759824164
-
(1998)
Oncogene
, vol.17
, Issue.19
, pp. 2531-2534
-
-
Fuks, F.1
Milner, J.2
Kouzarides, T.3
-
110
-
-
12844286057
-
Human maintenance DNA (cytosine-5)-methyltransferase and p53 modulate expression of p53-repressed promoters
-
15657147,.; (): –.; PubMed Central PMCID: PMC544618.
-
Esteve PO, Chin HG, Pradhan S, Human maintenance DNA (cytosine-5)-methyltransferase and p53 modulate expression of p53-repressed promoters. Proceedings of the National Academy of Sciences of the United States of America. 2005;102(4):1000–5.; PubMed Central PMCID: PMC544618. doi: 10.1073/pnas.040772910215657147
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.4
, pp. 1000-1005
-
-
Esteve, P.O.1
Chin, H.G.2
Pradhan, S.3
-
111
-
-
0037272898
-
Human DNA methyltransferase gene DNMT1 is regulated by the APC pathway
-
12538344,.; (): –.
-
Campbell PM, Szyf M, Human DNA methyltransferase gene DNMT1 is regulated by the APC pathway. Carcinogenesis. 2003;24(1):17–24. doi: 10.1093/carcin/24.1.1712538344
-
(2003)
Carcinogenesis
, vol.24
, Issue.1
, pp. 17-24
-
-
Campbell, P.M.1
Szyf, M.2
-
112
-
-
0242500847
-
Angiogenesis and the role of epigenetics in metastasis
-
12741680,.; (): –.
-
Coomber BL, Yu JL, Fathers KE, Plumb C, Rak JW, Angiogenesis and the role of epigenetics in metastasis. Clinical & experimental metastasis. 2003;20(3):215–27. 12741680
-
(2003)
Clinical & experimental metastasis
, vol.20
, Issue.3
, pp. 215-227
-
-
Coomber, B.L.1
Yu, J.L.2
Fathers, K.E.3
Plumb, C.4
Rak, J.W.5
-
113
-
-
59449097723
-
How epigenetics can explain human metastasis: a new role for microRNAs
-
19177007,.; (): –.
-
Lujambio A, Esteller M, How epigenetics can explain human metastasis: a new role for microRNAs. Cell cycle. 2009;8(3):377–82. doi: 10.4161/cc.8.3.752619177007
-
(2009)
Cell cycle
, vol.8
, Issue.3
, pp. 377-382
-
-
Lujambio, A.1
Esteller, M.2
-
114
-
-
33847065486
-
The epigenomics of cancer
-
17320506,.; (): –.; PubMed Central PMCID: PMC3894624.
-
Jones PA, Baylin SB, The epigenomics of cancer. Cell. 2007;128(4):683–92.; PubMed Central PMCID: PMC3894624. doi: 10.1016/j.cell.2007.01.02917320506
-
(2007)
Cell
, vol.128
, Issue.4
, pp. 683-692
-
-
Jones, P.A.1
Baylin, S.B.2
-
115
-
-
84942853841
-
Molecular Pathways: At the Crossroads of Cancer Epigenetics and Immunotherapy
-
26374074,..; (): –.
-
Maio M, Covre A, Fratta E, Di Giacomo AM, Taverna P, Natali PG, et al. Molecular Pathways: At the Crossroads of Cancer Epigenetics and Immunotherapy. Clinical cancer research: an official journal of the American Association for Cancer Research. 2015;21(18):4040–7. doi: 10.1158/1078-0432.CCR-14-291426374074
-
(2015)
Clinical cancer research: an official journal of the American Association for Cancer Research
, vol.21
, Issue.18
, pp. 4040-4047
-
-
Maio, M.1
Covre, A.2
Fratta, E.3
Di Giacomo, A.M.4
Taverna, P.5
Natali, P.G.6
-
116
-
-
84912002823
-
Metabolism and epigenetics: a link cancer cells exploit
-
25461508,.;: –.
-
Carrer A, Wellen KE, Metabolism and epigenetics: a link cancer cells exploit. Current opinion in biotechnology. 2015;34:23–9. doi: 10.1016/j.copbio.2014.11.01225461508
-
(2015)
Current opinion in biotechnology
, vol.34
, pp. 23-29
-
-
Carrer, A.1
Wellen, K.E.2
-
117
-
-
84875755814
-
Influence of metabolism on epigenetics and disease
-
23540690,.; (): –.; PubMed Central PMCID: PMC3775362.
-
Kaelin WG, Jr.McKnight SL, Influence of metabolism on epigenetics and disease. Cell. 2013;153(1):56–69.; PubMed Central PMCID: PMC3775362. doi: 10.1016/j.cell.2013.03.00423540690
-
(2013)
Cell
, vol.153
, Issue.1
, pp. 56-69
-
-
Kaelin, W.G.1
McKnight, S.L.2
-
118
-
-
84898893534
-
Epigenetic drugs as immunomodulators for combination therapies in solid tumors
-
24384533,.; (): –.
-
Sigalotti L, Fratta E, Coral S, Maio M, Epigenetic drugs as immunomodulators for combination therapies in solid tumors. Pharmacology & therapeutics. 2014;142(3):339–50. doi: 10.1016/j.pharmthera.2013.12.01524384533
-
(2014)
Pharmacology & therapeutics
, vol.142
, Issue.3
, pp. 339-350
-
-
Sigalotti, L.1
Fratta, E.2
Coral, S.3
Maio, M.4
-
119
-
-
84877151648
-
Immunomodulatory activity of SGI-110, a 5-aza-2'-deoxycytidine-containing demethylating dinucleotide
-
23138873,..; (): –.
-
Coral S, Parisi G, Nicolay HJ, Colizzi F, Danielli R, Fratta E, et al. Immunomodulatory activity of SGI-110, a 5-aza-2'-deoxycytidine-containing demethylating dinucleotide. Cancer immunology, immunotherapy: CII. 2013;62(3):605–14. doi: 10.1007/s00262-012-1365-723138873
-
(2013)
Cancer immunology, immunotherapy: CII
, vol.62
, Issue.3
, pp. 605-614
-
-
Coral, S.1
Parisi, G.2
Nicolay, H.J.3
Colizzi, F.4
Danielli, R.5
Fratta, E.6
-
120
-
-
84910087763
-
Immunomodulatory action of SGI-110, a hypomethylating agent, in acute myeloid leukemia cells and xenografts
-
25260825,..; (): –.
-
Srivastava P, Paluch BE, Matsuzaki J, James SR, Collamat-Lai G, Karbach J, et al. Immunomodulatory action of SGI-110, a hypomethylating agent, in acute myeloid leukemia cells and xenografts. Leukemia research. 2014;38(11):1332–41. doi: 10.1016/j.leukres.2014.09.00125260825
-
(2014)
Leukemia research
, vol.38
, Issue.11
, pp. 1332-1341
-
-
Srivastava, P.1
Paluch, B.E.2
Matsuzaki, J.3
James, S.R.4
Collamat-Lai, G.5
Karbach, J.6
-
121
-
-
77950813628
-
Epigenetically regulated clonal heritability of CTA expression profiles in human melanoma
-
20127705,..; (): –.
-
Fratta E, Sigalotti L, Colizzi F, Covre A, Nicolay HJ, Danielli R, et al. Epigenetically regulated clonal heritability of CTA expression profiles in human melanoma. Journal of cellular physiology. 2010;223(2):352–8. doi: 10.1002/jcp.2204020127705
-
(2010)
Journal of cellular physiology
, vol.223
, Issue.2
, pp. 352-358
-
-
Fratta, E.1
Sigalotti, L.2
Colizzi, F.3
Covre, A.4
Nicolay, H.J.5
Danielli, R.6
-
122
-
-
34250621776
-
Functional up-regulation of human leukocyte antigen class I antigens expression by 5-aza-2'-deoxycytidine in cutaneous melanoma: immunotherapeutic implications
-
17545540,..; (): –.
-
Fonsatti E, Nicolay HJ, Sigalotti L, Calabro L, Pezzani L, Colizzi F, et al. Functional up-regulation of human leukocyte antigen class I antigens expression by 5-aza-2'-deoxycytidine in cutaneous melanoma: immunotherapeutic implications. Clinical cancer research: an official journal of the American Association for Cancer Research. 2007;13(11):3333–8. doi: 10.1158/1078-0432.CCR-06-309117545540
-
(2007)
Clinical cancer research: an official journal of the American Association for Cancer Research
, vol.13
, Issue.11
, pp. 3333-3338
-
-
Fonsatti, E.1
Nicolay, H.J.2
Sigalotti, L.3
Calabro, L.4
Pezzani, L.5
Colizzi, F.6
-
123
-
-
84880300456
-
Oncogenic isocitrate dehydrogenase mutations: mechanisms, models, and clinical opportunities
-
23796461,.; (): –.
-
Cairns RA, Mak TW, Oncogenic isocitrate dehydrogenase mutations: mechanisms, models, and clinical opportunities. Cancer discovery. 2013;3(7):730–41. doi: 10.1158/2159-8290.CD-13-008323796461
-
(2013)
Cancer discovery
, vol.3
, Issue.7
, pp. 730-741
-
-
Cairns, R.A.1
Mak, T.W.2
-
124
-
-
79955960768
-
Acetyl-CoA induces cell growth and proliferation by promoting the acetylation of histones at growth genes
-
21596309,.; (): –.; PubMed Central PMCID: PMC3109073.
-
Cai L, Sutter BM, Li B, Tu BP, Acetyl-CoA induces cell growth and proliferation by promoting the acetylation of histones at growth genes. Molecular cell. 2011;42(4):426–37.; PubMed Central PMCID: PMC3109073. doi: 10.1016/j.molcel.2011.05.00421596309
-
(2011)
Molecular cell
, vol.42
, Issue.4
, pp. 426-437
-
-
Cai, L.1
Sutter, B.M.2
Li, B.3
Tu, B.P.4
-
125
-
-
84867906972
-
Gatekeepers of chromatin: Small metabolites elicit big changes in gene expression
-
22944281,.; (): –.; PubMed Central PMCID: PMC3482309.
-
Kaochar S, Tu BP, Gatekeepers of chromatin: Small metabolites elicit big changes in gene expression. Trends in biochemical sciences. 2012;37(11):477–83.; PubMed Central PMCID: PMC3482309. doi: 10.1016/j.tibs.2012.07.00822944281
-
(2012)
Trends in biochemical sciences
, vol.37
, Issue.11
, pp. 477-483
-
-
Kaochar, S.1
Tu, B.P.2
-
126
-
-
80053900941
-
Frequent pathway mutations of splicing machinery in myelodysplasia
-
21909114,..; (): –.
-
Yoshida K, Sanada M, Shiraishi Y, Nowak D, Nagata Y, Yamamoto R, et al. Frequent pathway mutations of splicing machinery in myelodysplasia. Nature. 2011;478(7367):64–9. doi: 10.1038/nature1049621909114
-
(2011)
Nature
, vol.478
, Issue.7367
, pp. 64-69
-
-
Yoshida, K.1
Sanada, M.2
Shiraishi, Y.3
Nowak, D.4
Nagata, Y.5
Yamamoto, R.6
-
127
-
-
78650961149
-
Epigenetics in alternative pre-mRNA splicing
-
21215366,.; (): –.; PubMed Central PMCID: PMCPMC3038581.
-
Luco RF, Allo M, Schor IE, Kornblihtt AR, Misteli T, Epigenetics in alternative pre-mRNA splicing. Cell. 2011;144(1):16–26.; PubMed Central PMCID: PMCPMC3038581. doi: 10.1016/j.cell.2010.11.05621215366
-
(2011)
Cell
, vol.144
, Issue.1
, pp. 16-26
-
-
Luco, R.F.1
Allo, M.2
Schor, I.E.3
Kornblihtt, A.R.4
Misteli, T.5
-
128
-
-
61349098460
-
Differential chromatin marking of introns and expressed exons by H3K36me3
-
19182803,.; (): –.; PubMed Central PMCID: PMCPMC2648722.
-
Kolasinska-Zwierz P, Down T, Latorre I, Liu T, Liu XS, Ahringer J, Differential chromatin marking of introns and expressed exons by H3K36me3. Nature genetics. 2009;41(3):376–81.; PubMed Central PMCID: PMCPMC2648722. doi: 10.1038/ng.32219182803
-
(2009)
Nature genetics
, vol.41
, Issue.3
, pp. 376-381
-
-
Kolasinska-Zwierz, P.1
Down, T.2
Latorre, I.3
Liu, T.4
Liu, X.S.5
Ahringer, J.6
-
129
-
-
77149175671
-
Regulation of alternative splicing by histone modifications
-
20133523,.; (): –.; PubMed Central PMCID: PMCPMC2913848.
-
Luco RF, Pan Q, Tominaga K, Blencowe BJ, Pereira-Smith OM, Misteli T, Regulation of alternative splicing by histone modifications. Science. 2010;327(5968):996–1000.; PubMed Central PMCID: PMCPMC2913848. doi: 10.1126/science.118420820133523
-
(2010)
Science
, vol.327
, Issue.5968
, pp. 996-1000
-
-
Luco, R.F.1
Pan, Q.2
Tominaga, K.3
Blencowe, B.J.4
Pereira-Smith, O.M.5
Misteli, T.6
-
130
-
-
84859595800
-
Mutations affecting mRNA splicing define distinct clinical phenotypes and correlate with patient outcome in myelodysplastic syndromes
-
22343920,..; (): –.
-
Damm F, Kosmider O, Gelsi-Boyer V, Renneville A, Carbuccia N, Hidalgo-Curtis C, et al. Mutations affecting mRNA splicing define distinct clinical phenotypes and correlate with patient outcome in myelodysplastic syndromes. Blood. 2012;119(14):3211–8. doi: 10.1182/blood-2011-12-40099422343920
-
(2012)
Blood
, vol.119
, Issue.14
, pp. 3211-3218
-
-
Damm, F.1
Kosmider, O.2
Gelsi-Boyer, V.3
Renneville, A.4
Carbuccia, N.5
Hidalgo-Curtis, C.6
-
131
-
-
84978025179
-
Cohesin mutations in myeloid malignancies: underlying mechanisms
-
24904756,.;:.; PubMed Central PMCID: PMCPMC4046106.
-
Leeke B, Marsman J, O'Sullivan JM, Horsfield JA, Cohesin mutations in myeloid malignancies: underlying mechanisms. Exp Hematol Oncol. 2014;3:13.; PubMed Central PMCID: PMCPMC4046106. doi: 10.1186/2162-3619-3-1324904756
-
(2014)
Exp Hematol Oncol
, vol.3
, pp. 13
-
-
Leeke, B.1
Marsman, J.2
O'Sullivan, J.M.3
Horsfield, J.A.4
-
132
-
-
84885021313
-
Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms
-
23955599,..; (): –.
-
Kon A, Shih LY, Minamino M, Sanada M, Shiraishi Y, Nagata Y, et al. Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms. Nature genetics. 2013;45(10):1232–7. doi: 10.1038/ng.273123955599
-
(2013)
Nature genetics
, vol.45
, Issue.10
, pp. 1232-1237
-
-
Kon, A.1
Shih, L.Y.2
Minamino, M.3
Sanada, M.4
Shiraishi, Y.5
Nagata, Y.6
-
133
-
-
84951983365
-
Leukemia-Associated Cohesin Mutants Dominantly Enforce Stem Cell Programs and Impair Human Hematopoietic Progenitor Differentiation
-
26607380,..; (): –.; PubMed Central PMCID: PMCPMC4671831.
-
Mazumdar C, Shen Y, Xavy S, Zhao F, Reinisch A, Li R, et al. Leukemia-Associated Cohesin Mutants Dominantly Enforce Stem Cell Programs and Impair Human Hematopoietic Progenitor Differentiation. Cell stem cell. 2015;17(6):675–88.; PubMed Central PMCID: PMCPMC4671831. doi: 10.1016/j.stem.2015.09.01726607380
-
(2015)
Cell stem cell
, vol.17
, Issue.6
, pp. 675-688
-
-
Mazumdar, C.1
Shen, Y.2
Xavy, S.3
Zhao, F.4
Reinisch, A.5
Li, R.6
-
134
-
-
84952061852
-
Cohesin loss alters adult hematopoietic stem cell homeostasis, leading to myeloproliferative neoplasms
-
26438359,..; (): –.; PubMed Central PMCID: PMCPMC4612095.
-
Mullenders J, Aranda-Orgilles B, Lhoumaud P, Keller M, Pae J, Wang K, et al. Cohesin loss alters adult hematopoietic stem cell homeostasis, leading to myeloproliferative neoplasms. The Journal of experimental medicine. 2015;212(11):1833–50.; PubMed Central PMCID: PMCPMC4612095. doi: 10.1084/jem.2015132326438359
-
(2015)
The Journal of experimental medicine
, vol.212
, Issue.11
, pp. 1833-1850
-
-
Mullenders, J.1
Aranda-Orgilles, B.2
Lhoumaud, P.3
Keller, M.4
Pae, J.5
Wang, K.6
-
136
-
-
33845996135
-
Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL)
-
16960145,..; (): –.
-
Duvic M, Talpur R, Ni X, Zhang C, Hazarika P, Kelly C, et al. Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL). Blood. 2007;109(1):31–9. doi: 10.1182/blood-2006-06-02599916960145
-
(2007)
Blood
, vol.109
, Issue.1
, pp. 31-39
-
-
Duvic, M.1
Talpur, R.2
Ni, X.3
Zhang, C.4
Hazarika, P.5
Kelly, C.6
-
137
-
-
77954879663
-
Final results from a multicenter, international, pivotal study of romidepsin in refractory cutaneous T-cell lymphoma
-
20697094,..; (): –.
-
Whittaker SJ, Demierre MF, Kim EJ, Rook AH, Lerner A, Duvic M, et al. Final results from a multicenter, international, pivotal study of romidepsin in refractory cutaneous T-cell lymphoma. Journal of clinical oncology: official journal of the American Society of Clinical Oncology. 2010;28(29):4485–91. doi: 10.1200/JCO.2010.28.906620697094
-
(2010)
Journal of clinical oncology: official journal of the American Society of Clinical Oncology
, vol.28
, Issue.29
, pp. 4485-4491
-
-
Whittaker, S.J.1
Demierre, M.F.2
Kim, E.J.3
Rook, A.H.4
Lerner, A.5
Duvic, M.6
-
138
-
-
79959503595
-
Peripheral T-cell lymphoma
-
21493798,.; (): –.
-
Foss FM, Zinzani PL, Vose JM, Gascoyne RD, Rosen ST, Tobinai K, Peripheral T-cell lymphoma. Blood. 2011;117(25):6756–67. doi: 10.1182/blood-2010-05-23154821493798
-
(2011)
Blood
, vol.117
, Issue.25
, pp. 6756-6767
-
-
Foss, F.M.1
Zinzani, P.L.2
Vose, J.M.3
Gascoyne, R.D.4
Rosen, S.T.5
Tobinai, K.6
-
139
-
-
84947205028
-
Panobinostat for the Treatment of Multiple Myeloma
-
26362997,.; (): –.
-
Laubach JP, Moreau P, San-Miguel JF, Richardson PG, Panobinostat for the Treatment of Multiple Myeloma. Clinical cancer research: an official journal of the American Association for Cancer Research. 2015;21(21):4767–73. doi: 10.1158/1078-0432.CCR-15-053026362997
-
(2015)
Clinical cancer research: an official journal of the American Association for Cancer Research
, vol.21
, Issue.21
, pp. 4767-4773
-
-
Laubach, J.P.1
Moreau, P.2
San-Miguel, J.F.3
Richardson, P.G.4
-
140
-
-
84940562761
-
Belinostat in Patients With Relapsed or Refractory Peripheral T-Cell Lymphoma: Results of the Pivotal Phase II BELIEF (CLN-19) Study
-
26101246,..; (): –.
-
O'Connor OA, Horwitz S, Masszi T, Van Hoof A, Brown P, Doorduijn J, et al. Belinostat in Patients With Relapsed or Refractory Peripheral T-Cell Lymphoma: Results of the Pivotal Phase II BELIEF (CLN-19) Study. Journal of clinical oncology: official journal of the American Society of Clinical Oncology. 2015;33(23):2492–9. doi: 10.1200/JCO.2014.59.278226101246
-
(2015)
Journal of clinical oncology: official journal of the American Society of Clinical Oncology
, vol.33
, Issue.23
, pp. 2492-2499
-
-
O'Connor, O.A.1
Horwitz, S.2
Masszi, T.3
Van Hoof, A.4
Brown, P.5
Doorduijn, J.6
-
141
-
-
67349227787
-
Isoform-specific histone deacetylase inhibitors: the next step?
-
19289255,.; (): –.
-
Balasubramanian S, Verner E, Buggy JJ, Isoform-specific histone deacetylase inhibitors: the next step?Cancer letters. 2009;280(2):211–21. doi: 10.1016/j.canlet.2009.02.01319289255
-
(2009)
Cancer letters
, vol.280
, Issue.2
, pp. 211-221
-
-
Balasubramanian, S.1
Verner, E.2
Buggy, J.J.3
-
142
-
-
84857779092
-
Results of ENCORE 301, a randomized, phase II, double-blind, placebo-controlled study of exemestane with or without entinostat in postmenopausal women with locally recurrent or metastatic estrogen receptor-positive (ER+) breast cancer progressing on a nonsteroidal aromatase inhibitor (AI)
-
.; (; abstr 268).
-
Yardley D. A., I-K R, Klein P., Results of ENCORE 301, a randomized, phase II, double-blind, placebo-controlled study of exemestane with or without entinostat in postmenopausal women with locally recurrent or metastatic estrogen receptor-positive (ER+) breast cancer progressing on a nonsteroidal aromatase inhibitor (AI). J Clin Oncol. 2011;29(suppl 27; abstr 268).
-
(2011)
J Clin Oncol
, vol.29
-
-
Yardley, D.A.1
Klein, P.2
-
143
-
-
84867632489
-
A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells
-
23023262,..; (): –.
-
Knutson SK, Wigle TJ, Warholic NM, Sneeringer CJ, Allain CJ, Klaus CR, et al. A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells. Nature chemical biology. 2012;8(11):890–6. doi: 10.1038/nchembio.108423023262
-
(2012)
Nature chemical biology
, vol.8
, Issue.11
, pp. 890-896
-
-
Knutson, S.K.1
Wigle, T.J.2
Warholic, N.M.3
Sneeringer, C.J.4
Allain, C.J.5
Klaus, C.R.6
-
144
-
-
84923899867
-
Selective inhibitors of protein methyltransferases
-
25406853,.; (): –.; PubMed Central PMCID: PMC4345896.
-
Kaniskan HU, Konze KD, Jin J, Selective inhibitors of protein methyltransferases. Journal of medicinal chemistry. 2015;58(4):1596–629.; PubMed Central PMCID: PMC4345896. doi: 10.1021/jm501234a25406853
-
(2015)
Journal of medicinal chemistry
, vol.58
, Issue.4
, pp. 1596-1629
-
-
Kaniskan, H.U.1
Konze, K.D.2
Jin, J.3
-
145
-
-
80054787805
-
Targeting Histone Demethylases: A New Avenue for the Fight against Cancer
-
21941621,.; (): –.; PubMed Central PMCID: PMC3174264.
-
Rotili D, Mai A, Targeting Histone Demethylases: A New Avenue for the Fight against Cancer. Genes & cancer. 2011;2(6):663–79.; PubMed Central PMCID: PMC3174264. doi: 10.1177/194760191141797621941621
-
(2011)
Genes & cancer
, vol.2
, Issue.6
, pp. 663-679
-
-
Rotili, D.1
Mai, A.2
-
146
-
-
84930932850
-
-
Stein Eytan M, Altman Jessica K, Collins Robert, DeAngelo Daniel J, AG-221, an Oral, Selective, First-in-Class, Potent Inhibitor of the IDH2 Mutant Metabolic Enzyme, Induces Durable Remissions in a Phase I Study in Patients with IDH2 Mutation Positive Advanced Hematologic Malignancies2014.
-
(2014)
AG-221, an Oral, Selective, First-in-Class, Potent Inhibitor of the IDH2 Mutant Metabolic Enzyme, Induces Durable Remissions in a Phase I Study in Patients with IDH2 Mutation Positive Advanced Hematologic Malignancies
-
-
Stein, E.M.1
Altman, J.K.2
Collins, R.3
DeAngelo, D.J.4
-
147
-
-
84959894443
-
AG-221, an oral, selective, first-in-class, potent inhibitor of the IDH2 mutant enzyme, induced durable responses in a phase 1 study of IDH2 mutation-positive advanced hematologic malignancies
-
., () (), p. [abstr)].
-
DiNardo C., S EM, Altman J.K., Collins R., DeAngelo D.J., Fathi A.T., et al. AG-221, an oral, selective, first-in-class, potent inhibitor of the IDH2 mutant enzyme, induced durable responses in a phase 1 study of IDH2 mutation-positive advanced hematologic malignancies. Haematol Eur Hematol Assoc Annu Meet, 100 (s1) (2015), p. 569 [abstr].
-
(2015)
Haematol Eur Hematol Assoc Annu Meet
, vol.100
, Issue.s1
, pp. 569
-
-
DiNardo, C.1
Altman, J.K.2
Collins, R.3
DeAngelo, D.J.4
Fathi, A.T.5
-
148
-
-
84919489217
-
AF10 regulates progressive H3K79 methylation and HOX gene expression in diverse AML subtypes
-
25464900,..; (): –.; PubMed Central PMCID: PMC4291116.
-
Deshpande AJ, Deshpande A, Sinha AU, Chen L, Chang J, Cihan A, et al. AF10 regulates progressive H3K79 methylation and HOX gene expression in diverse AML subtypes. Cancer cell. 2014;26(6):896–908.; PubMed Central PMCID: PMC4291116. doi: 10.1016/j.ccell.2014.10.00925464900
-
(2014)
Cancer cell
, vol.26
, Issue.6
, pp. 896-908
-
-
Deshpande, A.J.1
Deshpande, A.2
Sinha, A.U.3
Chen, L.4
Chang, J.5
Cihan, A.6
-
149
-
-
80052955256
-
BET bromodomain inhibition as a therapeutic strategy to target c-Myc
-
21889194,..; (): –.; PubMed Central PMCID: PMC3187920.
-
Delmore JE, Issa GC, Lemieux ME, Rahl PB, Shi J, Jacobs HM, et al. BET bromodomain inhibition as a therapeutic strategy to target c-Myc. Cell. 2011;146(6):904–17.; PubMed Central PMCID: PMC3187920. doi: 10.1016/j.cell.2011.08.01721889194
-
(2011)
Cell
, vol.146
, Issue.6
, pp. 904-917
-
-
Delmore, J.E.1
Issa, G.C.2
Lemieux, M.E.3
Rahl, P.B.4
Shi, J.5
Jacobs, H.M.6
-
150
-
-
80053651202
-
Targeting MYC dependence in cancer by inhibiting BET bromodomains
-
21949397,..; (): –.; PubMed Central PMCID: PMC3189078.
-
Mertz JA, Conery AR, Bryant BM, Sandy P, Balasubramanian S, Mele DA, et al. Targeting MYC dependence in cancer by inhibiting BET bromodomains. Proceedings of the National Academy of Sciences of the United States of America. 2011;108(40):16669–74.; PubMed Central PMCID: PMC3189078. doi: 10.1073/pnas.110819010821949397
-
(2011)
Proceedings of the National Academy of Sciences of the United States of America
, vol.108
, Issue.40
, pp. 16669-16674
-
-
Mertz, J.A.1
Conery, A.R.2
Bryant, B.M.3
Sandy, P.4
Balasubramanian, S.5
Mele, D.A.6
-
151
-
-
33644856123
-
Epigenetic therapy of cancer: past, present and future
-
16485345,.; (): –.
-
Yoo CB, Jones PA, Epigenetic therapy of cancer: past, present and future. Nature reviews Drug discovery. 2006;5(1):37–50. doi: 10.1038/nrd193016485345
-
(2006)
Nature reviews Drug discovery
, vol.5
, Issue.1
, pp. 37-50
-
-
Yoo, C.B.1
Jones, P.A.2
-
152
-
-
0034106513
-
A phase I trial of cisplatin plus decitabine, a new DNA-hypomethylating agent, in patients with advanced solid tumors and a follow-up early phase II evaluation in patients with inoperable non-small cell lung cancer
-
10830142,..; (): –.
-
Schwartsmann G, Schunemann H, Gorini CN, Filho AF, Garbino C, Sabini G, et al. A phase I trial of cisplatin plus decitabine, a new DNA-hypomethylating agent, in patients with advanced solid tumors and a follow-up early phase II evaluation in patients with inoperable non-small cell lung cancer. Investigational new drugs. 2000;18(1):83–91. 10830142
-
(2000)
Investigational new drugs
, vol.18
, Issue.1
, pp. 83-91
-
-
Schwartsmann, G.1
Schunemann, H.2
Gorini, C.N.3
Filho, A.F.4
Garbino, C.5
Sabini, G.6
-
153
-
-
84927547043
-
EZH2 inhibition sensitizes BRG1 and EGFR mutant lung tumours to TopoII inhibitors
-
25629630,..; (): –.; PubMed Central PMCID: PMC4393352.
-
Fillmore CM, Xu C, Desai PT, Berry JM, Rowbotham SP, Lin YJ, et al. EZH2 inhibition sensitizes BRG1 and EGFR mutant lung tumours to TopoII inhibitors. Nature. 2015;520(7546):239–42.; PubMed Central PMCID: PMC4393352. doi: 10.1038/nature1412225629630
-
(2015)
Nature
, vol.520
, Issue.7546
, pp. 239-242
-
-
Fillmore, C.M.1
Xu, C.2
Desai, P.T.3
Berry, J.M.4
Rowbotham, S.P.5
Lin, Y.J.6
-
154
-
-
84869064386
-
Epigenetic targeting therapies to overcome chemotherapy resistance
-
22956507,.;: –.
-
Balch C, Nephew KP, Epigenetic targeting therapies to overcome chemotherapy resistance. Advances in experimental medicine and biology. 2013;754:285–311. doi: 10.1007/978-1-4419-9967-2_1422956507
-
(2013)
Advances in experimental medicine and biology
, vol.754
, pp. 285-311
-
-
Balch, C.1
Nephew, K.P.2
-
155
-
-
34548395116
-
A phase II study of epigenetic therapy with hydralazine and magnesium valproate to overcome chemotherapy resistance in refractory solid tumors
-
17761710,..; (): –.
-
Candelaria M, Gallardo-Rincon D, Arce C, Cetina L, Aguilar-Ponce JL, Arrieta O, et al. A phase II study of epigenetic therapy with hydralazine and magnesium valproate to overcome chemotherapy resistance in refractory solid tumors. Annals of oncology: official journal of the European Society for Medical Oncology / ESMO. 2007;18(9):1529–38. doi: 10.1093/annonc/mdm20417761710
-
(2007)
Annals of oncology: official journal of the European Society for Medical Oncology / ESMO
, vol.18
, Issue.9
, pp. 1529-1538
-
-
Candelaria, M.1
Gallardo-Rincon, D.2
Arce, C.3
Cetina, L.4
Aguilar-Ponce, J.L.5
Arrieta, O.6
-
156
-
-
34548414620
-
Phase I and pharmacodynamic trial of the DNA methyltransferase inhibitor decitabine and carboplatin in solid tumors
-
17925555,..; (): –.
-
Appleton K, Mackay HJ, Judson I, Plumb JA, McCormick C, Strathdee G, et al. Phase I and pharmacodynamic trial of the DNA methyltransferase inhibitor decitabine and carboplatin in solid tumors. Journal of clinical oncology: official journal of the American Society of Clinical Oncology. 2007;25(29):4603–9. doi: 10.1200/JCO.2007.10.868817925555
-
(2007)
Journal of clinical oncology: official journal of the American Society of Clinical Oncology
, vol.25
, Issue.29
, pp. 4603-4609
-
-
Appleton, K.1
Mackay, H.J.2
Judson, I.3
Plumb, J.A.4
McCormick, C.5
Strathdee, G.6
-
157
-
-
12444252093
-
Interleukin 12-based immunotherapy improves the antitumor effectiveness of a low-dose 5-Aza-2'-deoxycitidine treatment in L1210 leukemia and B16F10 melanoma models in mice
-
12912964,..; (): –.
-
Kozar K, Kaminski R, Switaj T, Oldak T, Machaj E, Wysocki PJ, et al. Interleukin 12-based immunotherapy improves the antitumor effectiveness of a low-dose 5-Aza-2'-deoxycitidine treatment in L1210 leukemia and B16F10 melanoma models in mice. Clinical cancer research: an official journal of the American Association for Cancer Research. 2003;9(8):3124–33. 12912964
-
(2003)
Clinical cancer research: an official journal of the American Association for Cancer Research
, vol.9
, Issue.8
, pp. 3124-3133
-
-
Kozar, K.1
Kaminski, R.2
Switaj, T.3
Oldak, T.4
Machaj, E.5
Wysocki, P.J.6
-
158
-
-
80755163537
-
Immunotherapy augments the effect of 5-azacytidine on HPV16-associated tumours with different MHC class I-expression status
-
22015556,..; (): –.; PubMed Central PMCID: PMC3242529.
-
Simova J, Pollakova V, Indrova M, Mikyskova R, Bieblova J, Stepanek I, et al. Immunotherapy augments the effect of 5-azacytidine on HPV16-associated tumours with different MHC class I-expression status. British journal of cancer. 2011;105(10):1533–41.; PubMed Central PMCID: PMC3242529.doi: 10.1038/bjc.2011.42822015556
-
(2011)
British journal of cancer
, vol.105
, Issue.10
, pp. 1533-1541
-
-
Simova, J.1
Pollakova, V.2
Indrova, M.3
Mikyskova, R.4
Bieblova, J.5
Stepanek, I.6
-
159
-
-
84856403025
-
Class I histone deacetylase inhibitor entinostat suppresses regulatory T cells and enhances immunotherapies in renal and prostate cancer models
-
22303460,..; ():.; PubMed Central PMCID: PMC3267747.
-
Shen L, Ciesielski M, Ramakrishnan S, Miles KM, Ellis L, Sotomayor P, et al. Class I histone deacetylase inhibitor entinostat suppresses regulatory T cells and enhances immunotherapies in renal and prostate cancer models. PLoS ONE. 2012;7(1):e30815.; PubMed Central PMCID: PMC3267747. doi: 10.1371/journal.pone.003081522303460
-
(2012)
PLoS ONE
, vol.7
, Issue.1
, pp. e30815
-
-
Shen, L.1
Ciesielski, M.2
Ramakrishnan, S.3
Miles, K.M.4
Ellis, L.5
Sotomayor, P.6
-
160
-
-
84940473692
-
Antitumor activity of epigenetic immunomodulation combined with CTLA-4 blockade in syngeneic mouse models
-
26405573,..; ():.; PubMed Central PMCID: PMC4570131.
-
Covre A, Coral S, Nicolay H, Parisi G, Fazio C, Colizzi F, et al. Antitumor activity of epigenetic immunomodulation combined with CTLA-4 blockade in syngeneic mouse models. Oncoimmunology. 2015;4(8):e1019978.; PubMed Central PMCID: PMC4570131. doi: 10.1080/2162402X.2015.101997826405573
-
(2015)
Oncoimmunology
, vol.4
, Issue.8
, pp. e1019978
-
-
Covre, A.1
Coral, S.2
Nicolay, H.3
Parisi, G.4
Fazio, C.5
Colizzi, F.6
-
161
-
-
84929159881
-
Epigenetics meets immune checkpoints
-
25965370,.; (): –.
-
Covre A, Coral S, Di Giacomo AM, Taverna P, Azab M, Maio M, Epigenetics meets immune checkpoints. Seminars in oncology. 2015;42(3):506–13. doi: 10.1053/j.seminoncol.2015.02.00325965370
-
(2015)
Seminars in oncology
, vol.42
, Issue.3
, pp. 506-513
-
-
Covre, A.1
Coral, S.2
Di Giacomo, A.M.3
Taverna, P.4
Azab, M.5
Maio, M.6
-
162
-
-
79952760874
-
Eradication of solid tumors using histone deacetylase inhibitors combined with immune-stimulating antibodies
-
21368108,..; (): –.; PubMed Central PMCID: PMC3054015.
-
Christiansen AJ, West A, Banks KM, Haynes NM, Teng MW, Smyth MJ, et al. Eradication of solid tumors using histone deacetylase inhibitors combined with immune-stimulating antibodies. Proceedings of the National Academy of Sciences of the United States of America. 2011;108(10):4141–6.; PubMed Central PMCID: PMC3054015. doi: 10.1073/pnas.101103710821368108
-
(2011)
Proceedings of the National Academy of Sciences of the United States of America
, vol.108
, Issue.10
, pp. 4141-4146
-
-
Christiansen, A.J.1
West, A.2
Banks, K.M.3
Haynes, N.M.4
Teng, M.W.5
Smyth, M.J.6
-
163
-
-
84555207349
-
Dnmt3a is essential for hematopoietic stem cell differentiation
-
22138693,..; (): –.; PubMed Central PMCID: PMC3637952.
-
Challen GA, Sun D, Jeong M, Luo M, Jelinek J, Berg JS, et al. Dnmt3a is essential for hematopoietic stem cell differentiation. Nature genetics. 2012;44(1):23–31.; PubMed Central PMCID: PMC3637952. doi: 10.1038/ng.100922138693
-
(2012)
Nature genetics
, vol.44
, Issue.1
, pp. 23-31
-
-
Challen, G.A.1
Sun, D.2
Jeong, M.3
Luo, M.4
Jelinek, J.5
Berg, J.S.6
-
164
-
-
84865520089
-
IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics
-
22763442,..; (): –.; PubMed Central PMCID: PMC4005896.
-
Sasaki M, Knobbe CB, Munger JC, Lind EF, Brenner D, Brustle A, et al. IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics. Nature. 2012;488(7413):656–9.; PubMed Central PMCID: PMC4005896. doi: 10.1038/nature1132322763442
-
(2012)
Nature
, vol.488
, Issue.7413
, pp. 656-659
-
-
Sasaki, M.1
Knobbe, C.B.2
Munger, J.C.3
Lind, E.F.4
Brenner, D.5
Brustle, A.6
-
165
-
-
84859789534
-
O(6)-methylguanine-DNA methyltransferase in glioma therapy: promise and problems
-
22244911,.; (): –.; PubMed Central PMCID: PMC3340514.
-
Silber JR, Bobola MS, Blank A, Chamberlain MC, O(6)-methylguanine-DNA methyltransferase in glioma therapy: promise and problems. Biochimica et biophysica acta. 2012;1826(1):71–82.; PubMed Central PMCID: PMC3340514. doi: 10.1016/j.bbcan.2011.12.00422244911
-
(2012)
Biochimica et biophysica acta
, vol.1826
, Issue.1
, pp. 71-82
-
-
Silber, J.R.1
Bobola, M.S.2
Blank, A.3
Chamberlain, M.C.4
-
166
-
-
79952384705
-
Cancer epigenetics reaches mainstream oncology
-
21386836,.; (): –.
-
Rodriguez-Paredes M, Esteller M, Cancer epigenetics reaches mainstream oncology. Nature medicine. 2011;17(3):330–9. doi: 10.1038/nm.230521386836
-
(2011)
Nature medicine
, vol.17
, Issue.3
, pp. 330-339
-
-
Rodriguez-Paredes, M.1
Esteller, M.2
-
167
-
-
84859187259
-
Systematic identification of genomic markers of drug sensitivity in cancer cells
-
22460902,..; (): –.; PubMed Central PMCID: PMC3349233.
-
Garnett MJ, Edelman EJ, Heidorn SJ, Greenman CD, Dastur A, Lau KW, et al. Systematic identification of genomic markers of drug sensitivity in cancer cells. Nature. 2012;483(7391):570–5.; PubMed Central PMCID: PMC3349233. doi: 10.1038/nature1100522460902
-
(2012)
Nature
, vol.483
, Issue.7391
, pp. 570-575
-
-
Garnett, M.J.1
Edelman, E.J.2
Heidorn, S.J.3
Greenman, C.D.4
Dastur, A.5
Lau, K.W.6
-
168
-
-
84859169877
-
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
-
22460905,..; (): –.; PubMed Central PMCID: PMC3320027.
-
Barretina J, Caponigro G, Stransky N, Venkatesan K, Margolin AA, Kim S, et al. The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature. 2012;483(7391):603–7.; PubMed Central PMCID: PMC3320027. doi: 10.1038/nature1100322460905
-
(2012)
Nature
, vol.483
, Issue.7391
, pp. 603-607
-
-
Barretina, J.1
Caponigro, G.2
Stransky, N.3
Venkatesan, K.4
Margolin, A.A.5
Kim, S.6
-
169
-
-
0037436509
-
Loss of IGF2 imprinting: a potential marker of colorectal cancer risk
-
12637750,..; (): –.
-
Cui H, Cruz-Correa M, Giardiello FM, Hutcheon DF, Kafonek DR, Brandenburg S, et al. Loss of IGF2 imprinting: a potential marker of colorectal cancer risk. Science. 2003;299(5613):1753–5. doi: 10.1126/science.108090212637750
-
(2003)
Science
, vol.299
, Issue.5613
, pp. 1753-1755
-
-
Cui, H.1
Cruz-Correa, M.2
Giardiello, F.M.3
Hutcheon, D.F.4
Kafonek, D.R.5
Brandenburg, S.6
-
170
-
-
84861752999
-
Differential variability improves the identification of cancer risk markers in DNA methylation studies profiling precursor cancer lesions
-
22492641,.; (): –.
-
Teschendorff AE, Widschwendter M, Differential variability improves the identification of cancer risk markers in DNA methylation studies profiling precursor cancer lesions. Bioinformatics. 2012;28(11):1487–94. doi: 10.1093/bioinformatics/bts17022492641
-
(2012)
Bioinformatics
, vol.28
, Issue.11
, pp. 1487-1494
-
-
Teschendorff, A.E.1
Widschwendter, M.2
-
171
-
-
84927130807
-
Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential
-
25860605,.; (): –.
-
Sharma P, Allison JP, Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential. Cell. 2015;161(2):205–14. doi: 10.1016/j.cell.2015.03.03025860605
-
(2015)
Cell
, vol.161
, Issue.2
, pp. 205-214
-
-
Sharma, P.1
Allison, J.P.2
-
172
-
-
84880310548
-
Four-year survival rates for patients with metastatic melanoma who received ipilimumab in phase II clinical trials
-
23666915,..; (): –.; PubMed Central PMCID: PMC4081656.
-
Wolchok JD, Weber JS, Maio M, Neyns B, Harmankaya K, Chin K, et al. Four-year survival rates for patients with metastatic melanoma who received ipilimumab in phase II clinical trials. Annals of oncology: official journal of the European Society for Medical Oncology / ESMO. 2013;24(8):2174–80.; PubMed Central PMCID: PMC4081656. doi: 10.1093/annonc/mdt16123666915
-
(2013)
Annals of oncology: official journal of the European Society for Medical Oncology / ESMO
, vol.24
, Issue.8
, pp. 2174-2180
-
-
Wolchok, J.D.1
Weber, J.S.2
Maio, M.3
Neyns, B.4
Harmankaya, K.5
Chin, K.6
|