Cohesin loss alters adult hematopoietic stem cell homeostasis, leading to myeloproliferative neoplasms

Journal of Experimental Medicine

Volumn 212, Issue 11, 2015, Pages 1833-1850

  Mullenders, Jasper ^a   Aranda Orgilles, Beatriz ^a   Lhoumaud, Priscillia ^a   Keller, Matthew ^a   Pae, Juhee ^a   Wang, Kun ^a   Kayembe, Clarisse ^a   Rocha, Pedro P ^a   Raviram, Ramya ^a   Gong, Yixiao ^a   Premsrirut, Prem K ^c   Tsirigos, Aristotelis ^a,b   Bonneau, Richard ^a   Skok, Jane A ^a   Cimmino, Luisa ^a   Hoehn, Daniela ^d   Aifantis, Iannis ^a  

^a NEW YORK UNIVERSITY   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MIRIMUS INC   (United States)

^d NewYork Presbyterian Hospital   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COHESIN; MESSENGER RNA; PROTEIN; RAD21 PROTEIN; SHORT HAIRPIN RNA; SMC1A PROTEIN; SMC3 PROTEIN; STAG2 PROTEIN; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG; CELL CYCLE PROTEIN; CHROMATIN; NONHISTONE PROTEIN;

ACUTE MYELOBLASTIC LEUKEMIA; ADULT; ADULT STEM CELL; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL MATURATION; CELL VIABILITY; CHROMATIN; CONTROLLED STUDY; EXTRAMEDULLARY HEMATOPOIESIS; GAIN OF FUNCTION MUTATION; GENE EXPRESSION; GENE SILENCING; HEMATOPOIETIC STEM CELL; HOMEOSTASIS; IN VITRO STUDY; LEUKEMOGENESIS; LOSS OF FUNCTION MUTATION; MOUSE; MYELOID METAPLASIA; MYELOPOIESIS; MYELOPROLIFERATIVE NEOPLASM; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SPLENOMEGALY; ANIMAL; GENETICS; HUMAN; MYELOPROLIFERATIVE DISORDERS; PHYSIOLOGY;

ADULT; ANIMALS; CELL CYCLE PROTEINS; CELL DIFFERENTIATION; CHROMATIN; CHROMOSOMAL PROTEINS, NON-HISTONE; HEMATOPOIETIC STEM CELLS; HOMEOSTASIS; HUMANS; MICE; MYELOPROLIFERATIVE DISORDERS; TUMOR SUPPRESSOR PROTEINS;

EID: 84952061852     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20151323     Document Type: Article

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