-
2
-
-
84898893534
-
Epigenetic drugs as immunomodulators for combination therapies in solid tumors
-
L. Sigalotti, E. Fratta, S. Coral, and M. Maio Epigenetic drugs as immunomodulators for combination therapies in solid tumors Pharmacol Ther 142 3 2014 339 350
-
(2014)
Pharmacol Ther
, vol.142
, Issue.3
, pp. 339-350
-
-
Sigalotti, L.1
Fratta, E.2
Coral, S.3
Maio, M.4
-
3
-
-
77950813628
-
Epigenetically regulated clonal heritability of CTA expression profiles in human melanoma
-
E. Fratta, L. Sigalotti, and F. Colizzi Epigenetically regulated clonal heritability of CTA expression profiles in human melanoma J Cell Physiol 223 2 2010 352 358
-
(2010)
J Cell Physiol
, vol.223
, Issue.2
, pp. 352-358
-
-
Fratta, E.1
Sigalotti, L.2
Colizzi, F.3
-
4
-
-
79955475321
-
The biology of cancer testis antigens: Putative function, regulation and therapeutic potential
-
E. Fratta, S. Coral, and A. Covre The biology of cancer testis antigens: putative function, regulation and therapeutic potential Mol Oncol 5 2 2011 164 182
-
(2011)
Mol Oncol
, vol.5
, Issue.2
, pp. 164-182
-
-
Fratta, E.1
Coral, S.2
Covre, A.3
-
5
-
-
0036023437
-
5-Aza-2'-deoxycytidine-induced expression of functional cancer testis antigens in human renal cell carcinoma: Immunotherapeutic implications
-
S. Coral, L. Sigalotti, and M. Altomonte 5-Aza-2'-deoxycytidine-induced expression of functional cancer testis antigens in human renal cell carcinoma: immunotherapeutic implications Clin Cancer Res 8 8 2002 2690 2695
-
(2002)
Clin Cancer Res
, vol.8
, Issue.8
, pp. 2690-2695
-
-
Coral, S.1
Sigalotti, L.2
Altomonte, M.3
-
6
-
-
0029029450
-
Human high molecular weight-melanoma associated antigen mimicry by mouse anti-idiotypic monoclonal antibody MK2-23: Modulation of the immunogenicity in patients with malignant melanoma
-
A. Mittelman, G.Z. Chen, G.Y. Wong, C. Liu, S. Hirai, and S. Ferrone Human high molecular weight-melanoma associated antigen mimicry by mouse anti-idiotypic monoclonal antibody MK2-23: modulation of the immunogenicity in patients with malignant melanoma Clin Cancer Res 1 7 1995 705 713
-
(1995)
Clin Cancer Res
, vol.1
, Issue.7
, pp. 705-713
-
-
Mittelman, A.1
Chen, G.Z.2
Wong, G.Y.3
Liu, C.4
Hirai, S.5
Ferrone, S.6
-
7
-
-
53549116447
-
HLA antigen changes in malignant cells: Epigenetic mechanisms and biologic significance
-
M. Campoli, and S. Ferrone HLA antigen changes in malignant cells: epigenetic mechanisms and biologic significance Oncogene 27 45 2008 5869 5885
-
(2008)
Oncogene
, vol.27
, Issue.45
, pp. 5869-5885
-
-
Campoli, M.1
Ferrone, S.2
-
8
-
-
34250621776
-
Functional up-regulation of human leukocyte antigen class I antigens expression by 5-aza-2'-deoxycytidine in cutaneous melanoma: Immunotherapeutic implications
-
E. Fonsatti, H.J. Nicolay, and L. Sigalotti Functional up-regulation of human leukocyte antigen class I antigens expression by 5-aza-2'-deoxycytidine in cutaneous melanoma: immunotherapeutic implications Clin Cancer Res 13 11 2007 3333 3338
-
(2007)
Clin Cancer Res
, vol.13
, Issue.11
, pp. 3333-3338
-
-
Fonsatti, E.1
Nicolay, H.J.2
Sigalotti, L.3
-
9
-
-
33644879237
-
Phenotypic and functional changes of human melanoma xenografts induced by DNA hypomethylation: Immunotherapeutic implications
-
S. Coral, L. Sigalotti, and F. Colizzi Phenotypic and functional changes of human melanoma xenografts induced by DNA hypomethylation: immunotherapeutic implications J Cell Physiol 207 1 2006 58 66
-
(2006)
J Cell Physiol
, vol.207
, Issue.1
, pp. 58-66
-
-
Coral, S.1
Sigalotti, L.2
Colizzi, F.3
-
10
-
-
34047244043
-
5-AZA-2'-deoxycytidine in cancer immunotherapy: A mouse to man story
-
S. Coral, L. Sigalotti, A. Covre, H.J.M. Nicolay, P.G. Natali, and M. Maio 5-AZA-2'-deoxycytidine in cancer immunotherapy: a mouse to man story Cancer Res 67 6 2007 2900
-
(2007)
Cancer Res
, vol.67
, Issue.6
, pp. 2900
-
-
Coral, S.1
Sigalotti, L.2
Covre, A.3
Nicolay, H.J.M.4
Natali, P.G.5
Maio, M.6
-
11
-
-
84866927969
-
Epigenetic remodelling of gene expression profiles of neoplastic and normal tissues: Immunotherapeutic implications
-
S. Coral, A. Covre, and H.J. Nicolay Epigenetic remodelling of gene expression profiles of neoplastic and normal tissues: immunotherapeutic implications Br J Cancer 107 7 2012 1116 1124
-
(2012)
Br J Cancer
, vol.107
, Issue.7
, pp. 1116-1124
-
-
Coral, S.1
Covre, A.2
Nicolay, H.J.3
-
12
-
-
84879783987
-
Pharmacokinetic and pharmacodynamic analysis of 5-aza-2'-deoxycytidine (decitabine) in the design of its dose-schedule for cancer therapy
-
M. Karahoca, and R.L. Momparler Pharmacokinetic and pharmacodynamic analysis of 5-aza-2'-deoxycytidine (decitabine) in the design of its dose-schedule for cancer therapy Clin Epigenetics 5 1 2013 3
-
(2013)
Clin Epigenetics
, vol.5
, Issue.1
, pp. 3
-
-
Karahoca, M.1
Momparler, R.L.2
-
13
-
-
34447123203
-
Delivery of 5-aza-2'-deoxycytidine to cells using oligodeoxynucleotides
-
C.B. Yoo, S. Jeong, and G. Egger Delivery of 5-aza-2'-deoxycytidine to cells using oligodeoxynucleotides Cancer Res 67 13 2007 6400 6408
-
(2007)
Cancer Res
, vol.67
, Issue.13
, pp. 6400-6408
-
-
Yoo, C.B.1
Jeong, S.2
Egger, G.3
-
14
-
-
84877151648
-
Immunomodulatory activity of SGI-110, a 5-aza-2'-deoxycytidine-containing demethylating dinucleotide
-
S. Coral, G. Parisi, and H.J. Nicolay Immunomodulatory activity of SGI-110, a 5-aza-2'-deoxycytidine-containing demethylating dinucleotide Cancer Immunol Immunother 62 3 2013 605 614
-
(2013)
Cancer Immunol Immunother
, vol.62
, Issue.3
, pp. 605-614
-
-
Coral, S.1
Parisi, G.2
Nicolay, H.J.3
-
15
-
-
84929184599
-
Identification of novel biomarker candidates for the treatment outcome prediction of SGI-110, a novel DNA hypomethylating agent, in AML patients using differential methylation hybridization (DMH) Technology
-
March 6-7, Duesseldorf, Germany
-
Jueliger S, Lyons J, Lewin J, Azab M, Taverna P. Identification of novel biomarker candidates for the treatment outcome prediction of SGI-110, a novel DNA hypomethylating agent, in AML patients using differential methylation hybridization (DMH) Technology. Clinical Epigenetics International Meeting, March 6-7, 2014, Duesseldorf, Germany.
-
(2014)
Clinical Epigenetics International Meeting
-
-
Jueliger, S.1
Lyons, J.2
Lewin, J.3
Azab, M.4
Taverna, P.5
-
16
-
-
77952203695
-
S110, a 5-Aza-2'-deoxycytidine-containing dinucleotide, is an effective DNA methylation inhibitor in vivo and can reduce tumor growth
-
J.C. Chuang, S.L. Warner, and D. Vollmer S110, a 5-Aza-2'-deoxycytidine-containing dinucleotide, is an effective DNA methylation inhibitor in vivo and can reduce tumor growth Mol Cancer Ther 9 5 2010 1443 1450
-
(2010)
Mol Cancer Ther
, vol.9
, Issue.5
, pp. 1443-1450
-
-
Chuang, J.C.1
Warner, S.L.2
Vollmer, D.3
-
17
-
-
84929184600
-
Abstract 4076:SGI-110, a novel subcutaneous (SC) second generation DNA hypomethylating agent achieves improved pharmacodynamics (PD), safety and pharmacokinetics (PK) in comparison to IV decitabine in a non-human primate in vivo study
-
Mar 31-Apr 4, Chicago, IL. Cancer Res. 2012
-
Taverna P, Scholl J, Shi C, Oganesian A, Redkar S, Azab M. Abstract 4076:SGI-110, a novel subcutaneous (SC) second generation DNA hypomethylating agent achieves improved pharmacodynamics (PD), safety and pharmacokinetics (PK) in comparison to IV decitabine in a non-human primate in vivo study. Proceedings: AACR 103rd Annual Meeting. Mar 31-Apr 4, 2012; Chicago, IL. Cancer Res. 2012;72:4076
-
(2012)
Proceedings: AACR 103rd Annual Meeting
, vol.72
, pp. 4076
-
-
Taverna, P.1
Scholl, J.2
Shi, C.3
Oganesian, A.4
Redkar, S.5
Azab, M.6
-
18
-
-
84919769943
-
The novel, small-molecule DNA methylation inhibitor SGI-110 as an ovarian cancer chemosensitizer
-
F. Fang, J. Munck, and J. Tang The novel, small-molecule DNA methylation inhibitor SGI-110 as an ovarian cancer chemosensitizer Clin Cancer Res 20 24 2014 6504 6516
-
(2014)
Clin Cancer Res
, vol.20
, Issue.24
, pp. 6504-6516
-
-
Fang, F.1
Munck, J.2
Tang, J.3
-
19
-
-
84907043116
-
Epigenetic targeting of ovarian cancer stem cells
-
Y. Wang, H. Cardenas, and F. Fang Epigenetic targeting of ovarian cancer stem cells Cancer Res 74 17 2014 4922 4936
-
(2014)
Cancer Res
, vol.74
, Issue.17
, pp. 4922-4936
-
-
Wang, Y.1
Cardenas, H.2
Fang, F.3
-
20
-
-
34347375106
-
Epigenetic drugs as pleiotropic agents in cancer treatment: Biomolecular aspects and clinical applications
-
L. Sigalotti, E. Fratta, and S. Coral Epigenetic drugs as pleiotropic agents in cancer treatment: biomolecular aspects and clinical applications J Cell Physiol 212 2 2007 330 344
-
(2007)
J Cell Physiol
, vol.212
, Issue.2
, pp. 330-344
-
-
Sigalotti, L.1
Fratta, E.2
Coral, S.3
-
21
-
-
1642454589
-
Limited gene activation in tumor and normal epithelial cells treated with the DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine
-
A.R. Karpf, A.W. Lasek, T.O. Ririe, A.N. Hanks, D. Grossman, and D.A. Jones Limited gene activation in tumor and normal epithelial cells treated with the DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine Mol Pharmacol 65 1 2004 18 27
-
(2004)
Mol Pharmacol
, vol.65
, Issue.1
, pp. 18-27
-
-
Karpf, A.R.1
Lasek, A.W.2
Ririe, T.O.3
Hanks, A.N.4
Grossman, D.5
Jones, D.A.6
-
22
-
-
84910087763
-
Immunomodulatory action of SGI-110, a hypomethylating agent, in acute myeloid leukemia cells and xenografts
-
P. Srivastava, B.E. Paluch, and J. Matsuzaki Immunomodulatory action of SGI-110, a hypomethylating agent, in acute myeloid leukemia cells and xenografts Leuk Res. 38 11 2014 1332 1341
-
(2014)
Leuk Res.
, vol.38
, Issue.11
, pp. 1332-1341
-
-
Srivastava, P.1
Paluch, B.E.2
Matsuzaki, J.3
-
23
-
-
2342557977
-
A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements
-
A.S. Yang, M.R. Estecio, K. Doshi, Y. Kondo, E.H. Tajara, and J.P. Issa A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements Nucleic Acids Res 32 3 2004 e38
-
(2004)
Nucleic Acids Res
, vol.32
, Issue.3
, pp. e38
-
-
Yang, A.S.1
Estecio, M.R.2
Doshi, K.3
Kondo, Y.4
Tajara, E.H.5
Issa, J.P.6
-
24
-
-
84875626317
-
Results from the dose escalation phase of a randomized phase 1-2 first-in-human (FIH) study of SGI-110, a novel low volume stable subcutaneous (SC) second generation hypomethylating agent (HMA) in patients with relapsed/refractory MDS and AML
-
H.M. Kantarjian, G.J. Roboz, and D.A. Rizzieri Results from the dose escalation phase of a randomized phase 1-2 first-in-human (FIH) study of SGI-110, a novel low volume stable subcutaneous (SC) second generation hypomethylating agent (HMA) in patients with relapsed/refractory MDS and AML Blood (ASH Annual Meeting Abstracts) 120 2012 414
-
(2012)
Blood (ASH Annual Meeting Abstracts)
, vol.120
, pp. 414
-
-
Kantarjian, H.M.1
Roboz, G.J.2
Rizzieri, D.A.3
-
25
-
-
33846011361
-
Results of a randomized study of 3 schedules of low-dose decitabine in higher-risk myelodysplastic syndrome and chronic myelomonocytic leukemia
-
H.M. Kantarjian, Y. Oki, and G. Garcia-Manero Results of a randomized study of 3 schedules of low-dose decitabine in higher-risk myelodysplastic syndrome and chronic myelomonocytic leukemia Blood 109 1 2007 52 57
-
(2007)
Blood
, vol.109
, Issue.1
, pp. 52-57
-
-
Kantarjian, H.M.1
Oki, Y.2
Garcia-Manero, G.3
-
26
-
-
84929184601
-
DNA demethylation activity over time and safety of 3 different dose-escalation regimens of SGI-110, a novel subcutaneous (SC) hypomethylating agent (HMA), in the treatment of relapsed/refractory patients with MDS and AML. (ASH Annual Meeting Abstracts)
-
Roboz GJ, Issa JP, Rizzieri D, et al. DNA demethylation activity over time and safety of 3 different dose-escalation regimens of SGI-110, a novel subcutaneous (SC) hypomethylating agent (HMA), in the treatment of relapsed/refractory patients with MDS and AML. (ASH Annual Meeting Abstracts). Blood. 122(21):1548.
-
Blood
, vol.122
, Issue.21
, pp. 1548
-
-
Roboz, G.J.1
Issa, J.P.2
Rizzieri, D.3
-
27
-
-
84906053256
-
First clinical results of a randomized phase 2 study of SGI-110, a novel subcutaneous (SC) hypomethylating agent (HMA), in adult patients with acute myeloid leukemia (AML)
-
H.M. Kantarjian, E. Jabbour, and K. Yee First clinical results of a randomized phase 2 study of SGI-110, a novel subcutaneous (SC) hypomethylating agent (HMA), in adult patients with acute myeloid leukemia (AML) Blood (ASH Annual Meeting Abstracts) 122 2013 497
-
(2013)
Blood (ASH Annual Meeting Abstracts)
, vol.122
, pp. 497
-
-
Kantarjian, H.M.1
Jabbour, E.2
Yee, K.3
-
28
-
-
84929184602
-
Results of a randomized multicenter phase 2 study of a 5-day regimen of SGI-110, a novel hypomethylating agent, in treatment-naïve elderly acute myeloid leukemia not eligible for intensive therapy
-
Jun 12-15; Milan, Italy
-
Yee K, Daver N, Kropf P, et al. Results of a randomized multicenter phase 2 study of a 5-day regimen of SGI-110, a novel hypomethylating agent, in treatment-naïve elderly acute myeloid leukemia not eligible for intensive therapy. Oral presentation at 19th Congress of the European Hematology Association (EHA); Jun 12-15; Milan, Italy; abstract 5647.
-
19th Congress of the European Hematology Association (EHA)
-
-
Yee, K.1
Daver, N.2
Kropf, P.3
-
29
-
-
84929184603
-
First results of a Phase 2 study using a 10-day subcutaneous (SC) regimen of the novel hypomethylating agent (HMA) SGI-110 for the treatment of relapsed/refractory acute myeloid leukemia (r/r AML)
-
May 30-June 3; Chicago, IL
-
Griffiths E, Kantarjian H, Roboz G, et al. First results of a Phase 2 study using a 10-day subcutaneous (SC) regimen of the novel hypomethylating agent (HMA) SGI-110 for the treatment of relapsed/refractory acute myeloid leukemia (r/r AML). Proceedings of the 50th Annual Meeting of the American Society of Clinical Oncology (ASCO); May 30-June 3; Chicago, IL; abstract 3074.
-
Proceedings of the 50th Annual Meeting of the American Society of Clinical Oncology (ASCO)
-
-
Griffiths, E.1
Kantarjian, H.2
Roboz, G.3
-
30
-
-
85059207698
-
Immunomodulatory activity of SGI-110, a second generation hypomethylating agent. Proceedings of the 11th International Congress on Targeted Anticancer Therapies (TAT. 2013), 4-6 March 2013, Paris, France
-
M. Maio, G. Choy, and A. Covre Immunomodulatory activity of SGI-110, a second generation hypomethylating agent. Proceedings of the 11th International Congress on Targeted Anticancer Therapies (TAT. 2013), 4-6 March 2013, Paris, France Ann Oncol 24 suppl 1 2013 i8 i9
-
(2013)
Ann Oncol
, vol.24
, pp. i8-i9
-
-
Maio, M.1
Choy, G.2
Covre, A.3
-
31
-
-
84929184605
-
In vivo immunomodulatory activity of SGI-110, a second generation hypomethylating agent, in hematologic malignancies
-
AACR Washington, DC. Philadelphia, PA
-
A. Covre, G. Parisi, and H.J. Nicolay In vivo immunomodulatory activity of SGI-110, a second generation hypomethylating agent, in hematologic malignancies Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10 2013 AACR Washington, DC. Philadelphia, PA
-
(2013)
Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10
-
-
Covre, A.1
Parisi, G.2
Nicolay, H.J.3
-
32
-
-
77954801079
-
Improved survival with ipilimumab in patients with metastatic melanoma
-
F.S. Hodi, S.J. O'Day, and D.F. McDermott Improved survival with ipilimumab in patients with metastatic melanoma N Engl J Med 363 8 2010 711 723
-
(2010)
N Engl J Med
, vol.363
, Issue.8
, pp. 711-723
-
-
Hodi, F.S.1
O'Day, S.J.2
McDermott, D.F.3
-
33
-
-
84873714872
-
Update on the role of ipilimumab in melanoma and first data on new combination therapies
-
M. Maio, A.M. Di Giacomo, C. Robert, and A.M. Eggermont Update on the role of ipilimumab in melanoma and first data on new combination therapies Curr Opin Oncol 25 2 2013 166 172
-
(2013)
Curr Opin Oncol
, vol.25
, Issue.2
, pp. 166-172
-
-
Maio, M.1
Di Giacomo, A.M.2
Robert, C.3
Eggermont, A.M.4
|