메뉴 건너뛰기




Volumn 21, Issue 18, 2015, Pages 4040-4047

Molecular pathways: At the crossroads of cancer epigenetics and immunotherapy

Author keywords

[No Author keywords available]

Indexed keywords

AZACITIDINE; CYCLOPHOSPHAMIDE; DECITABINE; DNA METHYLTRANSFERASE INHIBITOR; ENTINOSTAT; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR VACCINE; GUADECITABINE; MONOCLONAL ANTIBODY; ANTINEOPLASTIC AGENT; CHROMATIN;

EID: 84942853841     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-14-2914     Document Type: Article
Times cited : (91)

References (48)
  • 1
    • 53549114206 scopus 로고    scopus 로고
    • NK cells and cancer immunosurveillance
    • Waldhauer I, Steinle A. NK cells and cancer immunosurveillance. Oncogene 2008; 27: 5932-43.
    • (2008) Oncogene , vol.27 , pp. 5932-5943
    • Waldhauer, I.1    Steinle, A.2
  • 2
    • 84862122547 scopus 로고    scopus 로고
    • The role of classical and non-classical HLA class I antigens in human tumors
    • Bukur J, Jasinski S, Seliger B. The role of classical and non-classical HLA class I antigens in human tumors. Semin Cancer Biol 2012; 22: 350-8.
    • (2012) Semin Cancer Biol , vol.22 , pp. 350-358
    • Bukur, J.1    Jasinski, S.2    Seliger, B.3
  • 3
    • 84926648478 scopus 로고    scopus 로고
    • Durable benefit and the potential for long-term survival with immunotherapy in advanced melanoma
    • McDermott D, Lebbe C, Hodi F.S., Maio M., Weber JS, Wolchok JD, et al. Durable benefit and the potential for long-term survival with immunotherapy in advanced melanoma. Cancer Treat Rev 2014; 40:1056-64.
    • (2014) Cancer Treat Rev , vol.40 , pp. 1056-1064
    • McDermott, D.1    Lebbe, C.2    Hodi, F.S.3    Maio, M.4    Weber, J.S.5    Wolchok, J.D.6
  • 4
    • 84927651609 scopus 로고    scopus 로고
    • Five-year survival rates for treatment-naive patients with advanced melanoma who received ipilimumab plus dacarbazine in a phase III trial
    • Maio M, Grob JJ, Aamdal S, Bondarenko I., Robert C, Thomas L, et al Five-year survival rates for treatment-naive patients with advanced melanoma who received ipilimumab plus dacarbazine in a phase III trial. J Clin Oncol 2015; 33: 1191-6.
    • (2015) J Clin Oncol , vol.33 , pp. 1191-1196
    • Maio, M.1    Grob, J.J.2    Aamdal, S.3    Bondarenko, I.4    Robert, C.5    Thomas, L.6
  • 5
    • 77957366305 scopus 로고    scopus 로고
    • DNA methylation and cancer
    • Kulis M, Esteller M. DNA methylation and cancer. Adv Genet 2010; 70: 27-56.
    • (2010) Adv Genet , vol.70 , pp. 27-56
    • Kulis, M.1    Esteller, M.2
  • 6
    • 0033848849 scopus 로고    scopus 로고
    • Histone acetylation and an epigenetic code
    • Turner BM. Histone acetylation and an epigenetic code. Bioessays 2000; 22:836-45.
    • (2000) Bioessays , vol.22 , pp. 836-845
    • Turner, B.M.1
  • 7
    • 14844307097 scopus 로고    scopus 로고
    • Epigenetic regulation by histone methylation and histone variants
    • Cheung P, Lau P. Epigenetic regulation by histone methylation and histone variants. Mol Endocrinol 2005; 19: 563-73.
    • (2005) Mol Endocrinol , vol.19 , pp. 563-573
    • Cheung, P.1    Lau, P.2
  • 8
    • 23044431656 scopus 로고    scopus 로고
    • Histone H3 lysine 9 methylation and HP1gamma are associated with transcription elongation through mammalian chromatin
    • Vakoc CR, Mandat SA, Olenchock B.A., Blobel GA. Histone H3 lysine 9 methylation and HP1gamma are associated with transcription elongation through mammalian chromatin. Mol Cell 2005; 19: 381-91.
    • (2005) Mol Cell , vol.19 , pp. 381-391
    • Vakoc, C.R.1    Mandat, S.A.2    Olenchock, B.A.3    Blobel, G.A.4
  • 9
    • 62049086288 scopus 로고    scopus 로고
    • PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling his-tone and DNA methylation in gene silencing
    • Zhao Q, Rank G, Tan Y.T., Li H., Moritz RL, Simpson RJ, et al. PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling his-tone and DNA methylation in gene silencing. Nat Struct Mol Biol 2009; 16: 304-11.
    • (2009) Nat Struct Mol Biol , vol.16 , pp. 304-311
    • Zhao, Q.1    Rank, G.2    Tan, Y.T.3    Li, H.4    Moritz, R.L.5    Simpson, R.J.6
  • 10
    • 54349095323 scopus 로고    scopus 로고
    • G9a/GLP complexes independently mediate H3K9 and DNA methylation to silence transcription
    • Tachibana M, Matsumura Y, Fukuda M., Kimura H, Shinkai Y. G9a/GLP complexes independently mediate H3K9 and DNA methylation to silence transcription. EMBO J 2008; 27: 2681-90.
    • (2008) EMBO J , vol.27 , pp. 2681-2690
    • Tachibana, M.1    Matsumura, Y.2    Fukuda, M.3    Kimura, H.4    Shinkai, Y.5
  • 11
    • 84898893534 scopus 로고    scopus 로고
    • Epigenetic drugs as immunomodulators for combination therapies in solid tumors
    • Sigalotti L, Fratta E, Coral S., Maio M. Epigenetic drugs as immunomodulators for combination therapies in solid tumors. Pharmacol Ther 2014; 142: 339-50.
    • (2014) Pharmacol Ther , vol.142 , pp. 339-350
    • Sigalotti, L.1    Fratta, E.2    Coral, S.3    Maio, M.4
  • 12
    • 84892942381 scopus 로고    scopus 로고
    • New and emerging HDAC inhibitors for cancer treatment
    • West AC, Johnstone RW New and emerging HDAC inhibitors for cancer treatment. J Clin Invest 2014; 124: 30-9.
    • (2014) J Clin Invest , vol.124 , pp. 30-39
    • West, A.C.1    Johnstone, R.W.2
  • 13
    • 84892919442 scopus 로고    scopus 로고
    • Cancer epigenetics drug discovery and development: The challenge of hitting the mark
    • Campbell RM, Tummino PJ Cancer epigenetics drug discovery and development: the challenge of hitting the mark. J Clin Invest 2014; 124: 64-9.
    • (2014) J Clin Invest , vol.124 , pp. 64-69
    • Campbell, R.M.1    Tummino, P.J.2
  • 15
    • 84912072883 scopus 로고    scopus 로고
    • Development and classes of epigenetic drugs for cancer
    • Dhanak D, Jackson P. Development and classes of epigenetic drugs for cancer. Biochem Biophys Res Commun 2014; 455: 58-69.
    • (2014) Biochem Biophys Res Commun , vol.455 , pp. 58-69
    • Dhanak, D.1    Jackson, P.2
  • 16
    • 77954100842 scopus 로고    scopus 로고
    • Targeting histone deacetylases: Development of vorinostat for the treatment of cancer
    • Richon VM. Targeting histone deacetylases: development of vorinostat for the treatment of cancer. Epigenomics 2010; 2: 457-65.
    • (2010) Epigenomics , vol.2 , pp. 457-465
    • Richon, V.M.1
  • 17
    • 84866927969 scopus 로고    scopus 로고
    • Epigenetic remodelling of gene expression profiles of neoplastic and normal tissues: Immunotherapeutic implications
    • Coral S, Covre A, Nicolay H.J., Parisi G., Rizzo A, Colizzi F, et al Epigenetic remodelling of gene expression profiles of neoplastic and normal tissues: immunotherapeutic implications. Br J Cancer 2012; 107: 1116-24.
    • (2012) Br J Cancer , vol.107 , pp. 1116-1124
    • Coral, S.1    Covre, A.2    Nicolay, H.J.3    Parisi, G.4    Rizzo, A.5    Colizzi, F.6
  • 18
    • 0032948005 scopus 로고    scopus 로고
    • Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer
    • Cameron EE, Bachman KE, Myohanen S, Herman J.G., Baylin SB. Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer. Nat Genet 1999; 21: 103-7.
    • (1999) Nat Genet , vol.21 , pp. 103-107
    • Cameron, E.E.1    Bachman, K.E.2    Myohanen, S.3    Herman, J.G.4    Baylin, S.B.5
  • 19
    • 43749087126 scopus 로고    scopus 로고
    • Transcriptional modulation using HDACi depsipeptide promotes immune cell-mediated tumor destruction of murine B16 melanoma
    • Murakami T, Sato A, Chun N.A., Hara M., Naito Y, Kobayashi Y, et al Transcriptional modulation using HDACi depsipeptide promotes immune cell-mediated tumor destruction of murine B16 melanoma. J Invest Dermatol 2008; 128: 1506-16.
    • (2008) J Invest Dermatol , vol.128 , pp. 1506-1516
    • Murakami, T.1    Sato, A.2    Chun, N.A.3    Hara, M.4    Naito, Y.5    Kobayashi, Y.6
  • 20
    • 84910087763 scopus 로고    scopus 로고
    • Immunomodulatory action of SGI-110, a hypomethylating agent, in acute myeloid leukemia cells and xenografts
    • Srivastava P, Paluch BE, Matsuzaki J, James S.R., Collamat-Lai G, Karbach J, et al Immunomodulatory action of SGI-110, a hypomethylating agent, in acute myeloid leukemia cells and xenografts. Leuk Res 2014; 38: 1332-41.
    • (2014) Leuk Res , vol.38 , pp. 1332-1341
    • Srivastava, P.1    Paluch, B.E.2    Matsuzaki, J.3    James, S.R.4    Collamat-Lai, G.5    Karbach, J.6
  • 21
    • 84920690806 scopus 로고    scopus 로고
    • Histone deacetylase inhibitor SAHA epigenetically regulates miR-17-92 cluster and MCM7 to upregulate MICA expression in hepatoma
    • Yang H, Lan P, Hou Z., Guan Y, Zhang J, Xu W., et al. Histone deacetylase inhibitor SAHA epigenetically regulates miR-17-92 cluster and MCM7 to upregulate MICA expression in hepatoma. Br J Cancer 2015; 112: 112-21.
    • (2015) Br J Cancer , vol.112 , pp. 112-121
    • Yang, H.1    Lan, P.2    Hou, Z.3    Guan, Y.4    Zhang, J.5    Xu, W.6
  • 22
    • 84877151648 scopus 로고    scopus 로고
    • Immunomodulatory activity of SGI-110, a 5-aza-2' -deoxycytidine-containing demethylating dinucleotide
    • Coral S, Parisi G, Nicolay H.J., Colizzi F., Danielli R, Fratta E, et al Immunomodulatory activity of SGI-110, a 5-aza-2' -deoxycytidine-containing demethylating dinucleotide. Cancer Immunol Immunother 2013; 62: 605-14.
    • (2013) Cancer Immunol Immunother , vol.62 , pp. 605-614
    • Coral, S.1    Parisi, G.2    Nicolay, H.J.3    Colizzi, F.4    Danielli, R.5    Fratta, E.6
  • 23
    • 77950813628 scopus 로고    scopus 로고
    • Epigenetically regulated clonal heritability of CTA expression profiles in human melanoma
    • Fratta E, Sigalotti L, Colizzi F., Covre A, Nicolay HJ, Danielli R, et al Epigenetically regulated clonal heritability of CTA expression profiles in human melanoma. J Cell Physiol 2010; 223: 352-8.
    • (2010) J Cell Physiol , vol.223 , pp. 352-358
    • Fratta, E.1    Sigalotti, L.2    Colizzi, F.3    Covre, A.4    Nicolay, H.J.5    Danielli, R.6
  • 24
    • 22244485707 scopus 로고    scopus 로고
    • Natural killer cell-mediated lysis of hepatoma cells via specific induction of NKG2D ligands by the histone deacetylase inhibitor sodium valproate
    • Armeanu S, Bitzer M, Lauer U.M., Venturelli S., Pathil A, Krusch M, et al Natural killer cell-mediated lysis of hepatoma cells via specific induction of NKG2D ligands by the histone deacetylase inhibitor sodium valproate. Cancer Res 2005; 65: 6321-9.
    • (2005) Cancer Res , vol.65 , pp. 6321-6329
    • Armeanu, S.1    Bitzer, M.2    Lauer, U.M.3    Venturelli, S.4    Pathil, A.5    Krusch, M.6
  • 25
    • 84896820241 scopus 로고    scopus 로고
    • Immune regulation by low doses of the DNA methyltransferase inhibitor 5-azacitidine in common human epithelial cancers
    • Li H, Chiappinelli KB, Guzzetta A.A., Easwaran H., Yen RW, Vatapalli R, et al. Immune regulation by low doses of the DNA methyltransferase inhibitor 5-azacitidine in common human epithelial cancers. Oncotarget 2014; 5: 587-98.
    • (2014) Oncotarget , vol.5 , pp. 587-598
    • Li, H.1    Chiappinelli, K.B.2    Guzzetta, A.A.3    Easwaran, H.4    Yen, R.W.5    Vatapalli, R.6
  • 26
    • 33750326078 scopus 로고    scopus 로고
    • Phase I study of decitabine-mediated gene expression in patients with cancers involving the lungs, esophagus, or pleura
    • Schrump DS, Fischette MR, Nguyen D.M., Zhao M., Li X, Kunst TF, et al Phase I study of decitabine-mediated gene expression in patients with cancers involving the lungs, esophagus, or pleura. Clin Cancer Res 2006; 12: 5777-85.
    • (2006) Clin Cancer Res , vol.12 , pp. 5777-5785
    • Schrump, D.S.1    Fischette, M.R.2    Nguyen, D.M.3    Zhao, M.4    Li, X.5    Kunst, T.F.6
  • 27
    • 0038142344 scopus 로고    scopus 로고
    • 5-aza-2'-deoxycytidine (decitabine) treatment of hematopoietic malignancies: A multimechanism therapeutic approach?
    • discussion 4645-6
    • Sigalotti L, Altomonte M, Colizzi F., Degan M, Rupolo M, Zagonel V., et al. 5-Aza-2'-deoxycytidine (decitabine) treatment of hematopoietic malignancies: a multimechanism therapeutic approach? Blood 2003; 101: 4644-6; discussion 4645-6
    • (2003) Blood , vol.101 , pp. 4644-4646
    • Sigalotti, L.1    Altomonte, M.2    Colizzi, F.3    Degan, M.4    Rupolo, M.5    Zagonel, V.6
  • 28
    • 77956924038 scopus 로고    scopus 로고
    • Induction of a CD8+ T-cell response to the MAGE cancer testis antigen by combined treatment with azacitidine and sodium valproate in patients with acute myeloid leukemia and myelodysplasia
    • Goodyear O, Agathanggelou A, Novitzky-Basso I, Siddique S., McSkeane T, Ryan G, et al Induction of a CD8+ T-cell response to the MAGE cancer testis antigen by combined treatment with azacitidine and sodium valproate in patients with acute myeloid leukemia and myelodysplasia. Blood 2010; 116: 1908-18.
    • (2010) Blood , vol.116 , pp. 1908-1918
    • Goodyear, O.1    Agathanggelou, A.2    Novitzky-Basso, I.3    Siddique, S.4    McSkeane, T.5    Ryan, G.6
  • 30
    • 77954677416 scopus 로고    scopus 로고
    • The histone deacetylase inhibitor vorinostat induces calreticulin exposure in childhood brain tumour cells in vitro
    • Sonnemann J, Gressmann S, Becker S., Wittig S, Schmudde M, Beck JF The histone deacetylase inhibitor vorinostat induces calreticulin exposure in childhood brain tumour cells in vitro. Cancer Chemother Pharmacol 2010; 66:611-6.
    • (2010) Cancer Chemother Pharmacol , vol.66 , pp. 611-616
    • Sonnemann, J.1    Gressmann, S.2    Becker, S.3    Wittig, S.4    Schmudde, M.5    Beck, J.F.6
  • 31
    • 84891276397 scopus 로고    scopus 로고
    • An intact immune system is required for the anticancer activities of histone deacetylase inhibitors
    • West AC, Mattarollo SR, Shortt J, Cluse L.A., Christiansen AJ, Smyth MJ, et al. An intact immune system is required for the anticancer activities of histone deacetylase inhibitors. Cancer Res 2013; 73: 7265-76.
    • (2013) Cancer Res , vol.73 , pp. 7265-7276
    • West, A.C.1    Mattarollo, S.R.2    Shortt, J.3    Cluse, L.A.4    Christiansen, A.J.5    Smyth, M.J.6
  • 32
    • 79960364764 scopus 로고    scopus 로고
    • Vaccination with epigenetically treated mesothelioma cells induces immunisation and blocks tumour growth
    • Guillot F, Boutin B, Blanquart C., Fonteneau JF, Robard M, Gregoire M, et al Vaccination with epigenetically treated mesothelioma cells induces immunisation and blocks tumour growth. Vaccine 2011; 29: 5534-43.
    • (2011) Vaccine , vol.29 , pp. 5534-5543
    • Guillot, F.1    Boutin, B.2    Blanquart, C.3    Fonteneau, J.F.4    Robard, M.5    Gregoire, M.6
  • 33
  • 34
    • 77953393113 scopus 로고    scopus 로고
    • An update on the safety and efficacy of decitabine in the treatment of myelodysplastic syndromes
    • Garcia JS, Jain N, Godley LA An update on the safety and efficacy of decitabine in the treatment of myelodysplastic syndromes. Onco Targets Ther 2010; 3: 1-13.
    • (2010) Onco Targets Ther , vol.3 , pp. 1-13
    • Garcia, J.S.1    Jain, N.2    Godley, L.A.3
  • 35
    • 12444252093 scopus 로고    scopus 로고
    • Interleukin 12-based immunotherapy improves the antitumor effectiveness of a low-dose 5-aza-2'-deoxycitidine treatment in L1210 leukemia and B16F10 melanoma models in mice
    • Kozar K, Kaminski R, Switaj T., Oldak T, Machaj E, Wysocki P.J., et al. Interleukin 12-based immunotherapy improves the antitumor effectiveness of a low-dose 5-Aza-2'-deoxycitidine treatment in L1210 leukemia and B16F10 melanoma models in mice. Clin Cancer Res 2003; 9: 3124-33.
    • (2003) Clin Cancer Res , vol.9 , pp. 3124-3133
    • Kozar, K.1    Kaminski, R.2    Switaj, T.3    Oldak, T.4    Machaj, E.5    Wysocki, P.J.6
  • 36
    • 80755163537 scopus 로고    scopus 로고
    • Immunotherapy augments the effect of 5-azacytidine on HPV16-associated tumours with different MHC class I-expression status
    • Simova J, Pollakova V, Indrova M, Mikyskova R, Bieblova J, Stepanek I, et al. Immunotherapy augments the effect of 5-azacytidine on HPV16-associated tumours with different MHC class I-expression status. Br J Cancer 2011; 105: 1533-41.
    • (2011) Br J Cancer , vol.105 , pp. 1533-1541
    • Simova, J.1    Pollakova, V.2    Indrova, M.3    Mikyskova, R.4    Bieblova, J.5    Stepanek, I.6
  • 37
    • 84856403025 scopus 로고    scopus 로고
    • Class I histone deacetylase inhibitor entinostat suppresses regulatory T cells and enhances immunotherapies in renal and prostate cancer models
    • Shen L, Ciesielski M, Ramakrishnan S., Miles KM, Ellis L, Sotomayor P, et al Class I histone deacetylase inhibitor entinostat suppresses regulatory T cells and enhances immunotherapies in renal and prostate cancer models. PLoS One 2012; 7: e30815.
    • (2012) PLoS One , vol.7
    • Shen, L.1    Ciesielski, M.2    Ramakrishnan, S.3    Miles, K.M.4    Ellis, L.5    Sotomayor, P.6
  • 38
    • 84888878651 scopus 로고    scopus 로고
    • Demethylation of cancer/testis antigens and CpG ODN stimulation enhance dendritic cell and cytotoxic tlymphocyte function in a mousemammary model
    • Sun JZ, Gao L, Wang W., Du N, Yang J, Wan L., et al. Demethylation of cancer/testis antigens and CpG ODN stimulation enhance dendritic cell and cytotoxic Tlymphocyte function in a mousemammary model. Biomed Res Int 2013; 2013: 196894.
    • (2013) Biomed Res Int , vol.2013
    • Sun, J.Z.1    Gao, L.2    Wang, W.3    Du, N.4    Yang, J.5    Wan, L.6
  • 39
    • 84977134550 scopus 로고    scopus 로고
    • The histone deacetylase inhibitor, LBH589, promotes the systemic cytokine and effector responses of adoptively transferred CD8+ T cells
    • Lisiero DN, Soto H, Everson R.G., Liau LM, Prins RM. The histone deacetylase inhibitor, LBH589, promotes the systemic cytokine and effector responses of adoptively transferred CD8+ T cells. J Immunother Cancer 2014; 2: 8.
    • (2014) J Immunother Cancer , vol.2 , pp. 8
    • Lisiero, D.N.1    Soto, H.2    Everson, R.G.3    Liau, L.M.4    Prins, R.M.5
  • 40
    • 72249084921 scopus 로고    scopus 로고
    • Enhanced antitumor activity induced by adoptive T-cell transfer and adjunctive use of the histone deacetylase inhibitor LAQ824
    • Vo DD, Prins RM, Begley J.L., Donahue TR, Morris LF, Bruhn KW, et al Enhanced antitumor activity induced by adoptive T-cell transfer and adjunctive use of the histone deacetylase inhibitor LAQ824. Cancer Res 2009; 69: 8693-9.
    • (2009) Cancer Res , vol.69 , pp. 8693-8699
    • Vo, D.D.1    Prins, R.M.2    Begley, J.L.3    Donahue, T.R.4    Morris, L.F.5    Bruhn, K.W.6
  • 41
    • 31544432509 scopus 로고    scopus 로고
    • De novo induction of a cancer/testis antigen by 5-aza-2'-deoxycytidine augments adoptive immunotherapy in a murine tumor model
    • Guo ZS, Hong JA, Irvine K.R., Chen GA, Spiess PJ, Liu Y, et al De novo induction of a cancer/testis antigen by 5-aza-2'-deoxycytidine augments adoptive immunotherapy in a murine tumor model. Cancer Res 2006; 66:1105-13.
    • (2006) Cancer Res , vol.66 , pp. 1105-1113
    • Guo, Z.S.1    Hong, J.A.2    Irvine, K.R.3    Chen, G.A.4    Spiess, P.J.5    Liu, Y.6
  • 42
    • 84926418972 scopus 로고    scopus 로고
    • Efficacy and safety of an intensified schedule of tremelimumab for chemotherapy-resistant malignant mesothelioma: An open-label, single-arm, phase 2 study
    • Calabro L, Morra A, Fonsatti E., Cutaia O, Fazio C, Annesi D., et al. Efficacy and safety of an intensified schedule of tremelimumab for chemotherapy-resistant malignant mesothelioma: an open-label, single-arm, phase 2 study. Lancet Respir Med 2015; 3: 301-9.
    • (2015) Lancet Respir Med , vol.3 , pp. 301-309
    • Calabro, L.1    Morra, A.2    Fonsatti, E.3    Cutaia, O.4    Fazio, C.5    Annesi, D.6
  • 43
    • 84940473692 scopus 로고    scopus 로고
    • Anti-tumor activity of epigenetic immunomodulation combined with CTLA-4 blockade in syngeneic mouse models
    • Apr 2. [Epub ahead of print]
    • Covre A, Coral S, Nicolay H., Parisi G, Fazio C, Colizzi F., et al. Anti-tumor activity of epigenetic immunomodulation combined with CTLA-4 blockade in syngeneic mouse models. Oncoimmunology 2015 Apr 2. [Epub ahead of print].
    • (2015) Oncoimmunology
    • Covre, A.1    Coral, S.2    Nicolay, H.3    Parisi, G.4    Fazio, C.5    Colizzi, F.6
  • 45
    • 84905994658 scopus 로고    scopus 로고
    • Eradication of metastatic mouse cancers resistant to immune checkpoint blockade by suppression of myeloid-derived cells
    • Kim K, Skora AD, Li Z, Liu Q., Tam AJ, Blosser RL, et al. Eradication of metastatic mouse cancers resistant to immune checkpoint blockade by suppression of myeloid-derived cells. Proc Natl Acad Sci U S A 2014; 111: 11774-9.
    • (2014) Proc Natl Acad Sci U S A , vol.111 , pp. 11774-11779
    • Kim, K.1    Skora, A.D.2    Li, Z.3    Liu, Q.4    Tam, A.J.5    Blosser, R.L.6
  • 46
    • 79952760874 scopus 로고    scopus 로고
    • Eradication of solid tumors using histone deacetylase inhibitors combined with immune-stimulating antibodies
    • Christiansen AJ, West A, Banks K.M., Haynes NM, Teng MW, Smyth MJ, et al Eradication of solid tumors using histone deacetylase inhibitors combined with immune-stimulating antibodies. Proc Natl Acad Sci U S A 2011; 108:4141-6.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 4141-4146
    • Christiansen, A.J.1    West, A.2    Banks, K.M.3    Haynes, N.M.4    Teng, M.W.5    Smyth, M.J.6
  • 47
    • 84939875915 scopus 로고    scopus 로고
    • A phase I study of decitabine with pegylated interferon alpha-2b in advanced melanoma: Impact on DNA methylation and lymphocyte populations
    • Plimack ER, Desai JR, Issa J.P., Jelinek J., Sharma P, Vence LM, et al A phase I study of decitabine with pegylated interferon alpha-2b in advanced melanoma: impact on DNA methylation and lymphocyte populations. Invest New Drugs 2014; 32: 969-75.
    • (2014) Invest New Drugs , vol.32 , pp. 969-975
    • Plimack, E.R.1    Desai, J.R.2    Issa, J.P.3    Jelinek, J.4    Sharma, P.5    Vence, L.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.