Deep targeted sequencing in pediatric acute lymphoblastic leukemia unveils distinct mutational patterns between genetic subtypes and novel relapse-associated genes

Oncotarget

Volumn 7, Issue 39, 2016, Pages 64071-64088

  Lindqvist, C Mårten ^a   Lundmark, Anders ^a   Nordlund, Jessica ^a   Freyhult, Eva ^a   Ekman, Diana ^b   Almlöf, Jonas Carlsson ^a   Raine, Amanda ^a   övernäs, Elin ^a   Abrahamsson, Jonas ^c,h   Frost, Britt Marie ^d,h   Grandér, Dan ^e   Heyman, Mats ^f,h   Palle, Josefine ^a,d,h   Forestier, Erik ^g,h   Lönnerholm, Gudmar ^d,h   Berglund, Eva C ^a   Syvänen, Ann Christine ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b STOCKHOLM UNIVERSITY   (Sweden)

^c QUEEN SILVIA CHILDREN'S HOSPITAL   (Sweden)

^d UNIVERSITY CHILDREN S HOSPITAL   (Sweden)

^e KAROLINSKA INSTITUTE   (Sweden)

^f KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^g UMEÅ UNIVERSITY   (Sweden)

^h Nordic Society of Pediatric Hematology and Oncology   (Sweden)

Author keywords

Acute lymphoblastic leukemia; Clonal evolution; Relapse; Somatic mutation; Targeted next generation sequencing

Indexed keywords

BCR ABL PROTEIN; E1A ASSOCIATED P300 PROTEIN; NOTCH RECEPTOR; TRANSCRIPTION FACTOR 7 LIKE 1; TRANSCRIPTION FACTOR ETV6; TRANSCRIPTION FACTOR PBX1; TRANSCRIPTION FACTOR RUNX1; ARID1A PROTEIN, HUMAN; EP300 PROTEIN, HUMAN; LNK PROTEIN, HUMAN; NUCLEAR PROTEIN; ONCOPROTEIN; PROTEIN; TRANSCRIPTION FACTOR;

ACUTE LYMPHOBLASTIC LEUKEMIA; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARID1A GENE; ARTICLE; ATRX GENE; BCR ABL GENE; CANCER RECURRENCE; CONTROLLED STUDY; EP300 GENE; ETV6 GENE; GENE; GENE FUSION; GENE IDENTIFICATION; GENE LOCATION; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC HETEROGENEITY; GENETIC VARIABILITY; HUMAN; LEUKEMOGENESIS; MAJOR CLINICAL STUDY; MALE; MUTATIONAL ANALYSIS; NEXT GENERATION SEQUENCING; OVERALL SURVIVAL; PBX1 GENE; RUNX1 GENE; SEQUENCE ANALYSIS; SH2B3 GENE; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE VARIANT; SOMATIC MUTATION; TCF3 GENE; CHILD; COHORT ANALYSIS; DNA MUTATIONAL ANALYSIS; DNA SEQUENCE; GENE TRANSLOCATION; GENETIC EPIGENESIS; GENETICS; HIGH THROUGHPUT SEQUENCING; IMMUNOPHENOTYPING; INFANT; MUTATION; PRESCHOOL CHILD; RECURRENT DISEASE; REMISSION; TUMOR RECURRENCE;

CHILD; CHILD, PRESCHOOL; COHORT STUDIES; DNA MUTATIONAL ANALYSIS; E1A-ASSOCIATED P300 PROTEIN; EPIGENESIS, GENETIC; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; IMMUNOPHENOTYPING; INFANT; MUTATION; NEOPLASM RECURRENCE, LOCAL; NUCLEAR PROTEINS; ONCOGENE PROTEINS, FUSION; PRECURSOR B-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PRECURSOR T-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; PROTEINS; RECURRENCE; REMISSION INDUCTION; SEQUENCE ANALYSIS, DNA; TRANSCRIPTION FACTORS; TRANSLOCATION, GENETIC;

EID: 84993967702     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.11773     Document Type: Article

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