Notch activation inhibits AML growth and survival: A potential therapeutic approach

Journal of Experimental Medicine

Volumn 210, Issue 2, 2013, Pages 321-337

  Kannan, Sankaranarayanan ^a   Sutphin, Robert M ^b   Hall, Mandy G ^a   Golfman, Leonard S ^a   Fang, Wendy ^a   Nolo, Riitta M ^a   Akers, Lauren J ^c   Hammitt, Richard A ^d   McMurray, John S ^a   Kornblau, Steven M ^a   Melnick, Ari M ^e   Figueroa, Maria E ^f   Zweidler McKay, Patrick A ^a,g  

^a UNIVERSITY OF TEXAS   (United States)

^b M D ANDERSON CANCER CENTER ORLANDO   (United States)

^c Cook Children's Hospital ^*  (United States)

^d Sigma Genosys   (United States)

^e WEILL CORNELL MEDICAL COLLEGE   (United States)

^f UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^g UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NOTCH RECEPTOR; NOTCH1 RECEPTOR; NOTCH2 RECEPTOR; PROTEIN BCL 2; PROTEIN P21; PROTEIN P53; TRANSCRIPTION FACTOR HES 1;

ACUTE GRANULOCYTIC LEUKEMIA; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CANCER GROWTH; CANCER SURVIVAL; CANCER THERAPY; CELL CYCLE ARREST; CELL GROWTH; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VIVO STUDY; INHIBITION KINETICS; MAJOR CLINICAL STUDY; MOUSE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; SIGNAL TRANSDUCTION;

ADOLESCENT; ANIMALS; APOPTOSIS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CHILD; DNA-BINDING PROTEINS; GENE EXPRESSION; HOMEODOMAIN PROTEINS; HUMANS; INFANT; LEUKEMIA, MYELOID, ACUTE; MICE; MICE, INBRED NOD; MICE, KNOCKOUT; MICE, SCID; MUTATION; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTORS, NOTCH; RNA, MESSENGER; RNA, NEOPLASM; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84874556358     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20121527     Document Type: Article

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