메뉴 건너뛰기




Volumn 274, Issue 1, 2016, Pages 16-32

The “ins and outs” of complement-driven immune responses

Author keywords

adaptive immunity; cell metabolism; complement; complosome; inflammasomes; T cells

Indexed keywords

ALTERNATIVE COMPLEMENT PATHWAY C3 C5 CONVERTASE; CLASSICAL COMPLEMENT PATHWAY C3 C5 CONVERTASE; COLLECTIN; COMPLEMENT; COMPLEMENT COMPONENT C1Q; COMPLEMENT COMPONENT C1R; COMPLEMENT COMPONENT C1S; COMPLEMENT COMPONENT C3A; COMPLEMENT COMPONENT C3B; COMPLEMENT COMPONENT C4A; COMPLEMENT COMPONENT C4B; COMPLEMENT COMPONENT C5A RECEPTOR; COMPLEMENT COMPONENT C5B; COMPLEMENT COMPONENT C6; COMPLEMENT COMPONENT C7; COMPLEMENT COMPONENT C8; COMPLEMENT FACTOR H; COMPLEMENT MEMBRANE ATTACK COMPLEX; COMPLEMENT RECEPTOR; CYTOKINE; DECAY ACCELERATING FACTOR; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; FIBRINOGEN; FICOLIN; INFLAMMASOME; INTERCELLULAR ADHESION MOLECULE 1; MANNOSE BINDING LECTIN; MEMBRANE COFACTOR PROTEIN; PROPERDIN; VASCULAR CELL ADHESION MOLECULE 1; PLASMA PROTEIN;

EID: 84992450133     PISSN: 01052896     EISSN: 1600065X     Source Type: Journal    
DOI: 10.1111/imr.12472     Document Type: Review
Times cited : (105)

References (170)
  • 2
    • 0141799911 scopus 로고    scopus 로고
    • Defensins: antimicrobial peptides of innate immunity
    • Ganz T. Defensins: antimicrobial peptides of innate immunity. Nat Rev Immunol. 2003;3:710–720.
    • (2003) Nat Rev Immunol , vol.3 , pp. 710-720
    • Ganz, T.1
  • 3
    • 77249150015 scopus 로고    scopus 로고
    • The role of TLRs, NLRs, and RLRs in mucosal innate immunity and homeostasis
    • Lavelle EC, Murphy C, O'Neill LA, Creagh EM. The role of TLRs, NLRs, and RLRs in mucosal innate immunity and homeostasis. Mucosal Immunol. 2010;3:17–28.
    • (2010) Mucosal Immunol , vol.3 , pp. 17-28
    • Lavelle, E.C.1    Murphy, C.2    O'Neill, L.A.3    Creagh, E.M.4
  • 4
    • 84934436897 scopus 로고    scopus 로고
    • Self, non-self, and danger: a complementary view
    • Kohl J. Self, non-self, and danger: a complementary view. Adv Exp Med Biol. 2006;586:71–94.
    • (2006) Adv Exp Med Biol , vol.586 , pp. 71-94
    • Kohl, J.1
  • 5
    • 84878237993 scopus 로고    scopus 로고
    • Activation and regulation of the inflammasomes
    • Latz E, Xiao TS, Stutz A. Activation and regulation of the inflammasomes. Nat Rev Immunol. 2013;13:397–411.
    • (2013) Nat Rev Immunol , vol.13 , pp. 397-411
    • Latz, E.1    Xiao, T.S.2    Stutz, A.3
  • 6
    • 84884332722 scopus 로고    scopus 로고
    • Mechanisms of NOD-like receptor-associated inflammasome activation
    • Wen H, Miao EA, Ting JP. Mechanisms of NOD-like receptor-associated inflammasome activation. Immunity. 2013;39:432–441.
    • (2013) Immunity , vol.39 , pp. 432-441
    • Wen, H.1    Miao, E.A.2    Ting, J.P.3
  • 7
    • 84890226478 scopus 로고    scopus 로고
    • Intracellular complement activation sustains T cell homeostasis and mediates effector differentiation
    • Liszewski MK, Kolev M, Le Friec G, et al. Intracellular complement activation sustains T cell homeostasis and mediates effector differentiation. Immunity. 2013;39:1143–1157.
    • (2013) Immunity , vol.39 , pp. 1143-1157
    • Liszewski, M.K.1    Kolev, M.2    Le Friec, G.3
  • 8
    • 84937604783 scopus 로고    scopus 로고
    • Complement regulates nutrient influx and metabolic reprogramming during Th1 cell responses
    • Kolev M, Dimeloe S, Le Friec G, et al. Complement regulates nutrient influx and metabolic reprogramming during Th1 cell responses. Immunity. 2015;42:1033–1047.
    • (2015) Immunity , vol.42 , pp. 1033-1047
    • Kolev, M.1    Dimeloe, S.2    Le Friec, G.3
  • 9
    • 77955883153 scopus 로고    scopus 로고
    • Complement: a key system for immune surveillance and homeostasis
    • Ricklin D, Hajishengallis G, Yang K, Lambris JD. Complement: a key system for immune surveillance and homeostasis. Nat Immunol. 2010;11:785–797.
    • (2010) Nat Immunol , vol.11 , pp. 785-797
    • Ricklin, D.1    Hajishengallis, G.2    Yang, K.3    Lambris, J.D.4
  • 10
    • 0021611738 scopus 로고
    • Complement deficiency states and infection: epidemiology, pathogenesis and consequences of neisserial and other infections in an immune deficiency
    • Ross SC, Densen P. Complement deficiency states and infection: epidemiology, pathogenesis and consequences of neisserial and other infections in an immune deficiency. Medicine. 1984;63:243–273.
    • (1984) Medicine , vol.63 , pp. 243-273
    • Ross, S.C.1    Densen, P.2
  • 11
    • 0031778836 scopus 로고    scopus 로고
    • Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies
    • Botto M, Dell'Agnola C, Bygrave AE, et al. Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies. Nat Genet. 1998;19:56–59.
    • (1998) Nat Genet , vol.19 , pp. 56-59
    • Botto, M.1    Dell'Agnola, C.2    Bygrave, A.E.3
  • 12
    • 2442670537 scopus 로고    scopus 로고
    • The complement system in B cell regulation
    • Carroll MC. The complement system in B cell regulation. Mol Immunol. 2004;41:141–146.
    • (2004) Mol Immunol , vol.41 , pp. 141-146
    • Carroll, M.C.1
  • 13
    • 77955876612 scopus 로고    scopus 로고
    • Complement regulator CD46 temporally regulates cytokine production by conventional and unconventional T cells
    • Cardone J, Le Friec G, Vantourout P, et al. Complement regulator CD46 temporally regulates cytokine production by conventional and unconventional T cells. Nat Immunol. 2010;11:862–871.
    • (2010) Nat Immunol , vol.11 , pp. 862-871
    • Cardone, J.1    Le Friec, G.2    Vantourout, P.3
  • 14
    • 84927571620 scopus 로고    scopus 로고
    • Complement–tapping into new sites and effector systems
    • Kolev M, Le Friec G, Kemper C. Complement–tapping into new sites and effector systems. Nat Rev Immunol. 2014;14:811–820.
    • (2014) Nat Rev Immunol , vol.14 , pp. 811-820
    • Kolev, M.1    Le Friec, G.2    Kemper, C.3
  • 15
    • 84890070748 scopus 로고    scopus 로고
    • Human complement C3 deficiency: Th1 induction requires T cell-derived complement C3a and CD46 activation
    • Ghannam A, Fauquert JL, Thomas C, Kemper C, Drouet C. Human complement C3 deficiency: Th1 induction requires T cell-derived complement C3a and CD46 activation. Mol Immunol. 2014;58:98–107.
    • (2014) Mol Immunol , vol.58 , pp. 98-107
    • Ghannam, A.1    Fauquert, J.L.2    Thomas, C.3    Kemper, C.4    Drouet, C.5
  • 16
    • 0031043135 scopus 로고    scopus 로고
    • The internal thioester and the covalent binding properties of the complement proteins C3 and C4
    • Law SK, Dodds AW. The internal thioester and the covalent binding properties of the complement proteins C3 and C4. Protein Sci. 1997;6:263–274.
    • (1997) Protein Sci , vol.6 , pp. 263-274
    • Law, S.K.1    Dodds, A.W.2
  • 17
    • 84956936627 scopus 로고    scopus 로고
    • Structure of the poly-C9 component of the complement membrane attack complex
    • Dudkina NV, Spicer BA, Reboul CF, et al. Structure of the poly-C9 component of the complement membrane attack complex. Nat Commun. 2016;7:10588.
    • (2016) Nat Commun , vol.7 , pp. 10588
    • Dudkina, N.V.1    Spicer, B.A.2    Reboul, C.F.3
  • 18
    • 70349437186 scopus 로고    scopus 로고
    • Complement regulators and inhibitory proteins
    • Zipfel PF, Skerka C. Complement regulators and inhibitory proteins. Nat Rev Immunol. 2009;9:729–740.
    • (2009) Nat Rev Immunol , vol.9 , pp. 729-740
    • Zipfel, P.F.1    Skerka, C.2
  • 19
    • 33744987414 scopus 로고    scopus 로고
    • Generation of C5a in the absence of C3: a new complement activation pathway
    • Huber-Lang M, Sarma JV, Zetoune FS, et al. Generation of C5a in the absence of C3: a new complement activation pathway. Nat Med. 2006;12:682–687.
    • (2006) Nat Med , vol.12 , pp. 682-687
    • Huber-Lang, M.1    Sarma, J.V.2    Zetoune, F.S.3
  • 20
    • 84857041124 scopus 로고    scopus 로고
    • Cathepsin D is released after severe tissue trauma in vivo and is capable of generating C5a in vitro
    • Huber-Lang M, Denk S, Fulda S, et al. Cathepsin D is released after severe tissue trauma in vivo and is capable of generating C5a in vitro. Mol Immunol. 2012;50:60–65.
    • (2012) Mol Immunol , vol.50 , pp. 60-65
    • Huber-Lang, M.1    Denk, S.2    Fulda, S.3
  • 21
    • 80555126033 scopus 로고    scopus 로고
    • Granzyme B: a new crossroad of complement and apoptosis
    • Perl M, Denk S, Kalbitz M, Huber-Lang M. Granzyme B: a new crossroad of complement and apoptosis. Adv Exp Med Biol. 2012;946:135–146.
    • (2012) Adv Exp Med Biol , vol.946 , pp. 135-146
    • Perl, M.1    Denk, S.2    Kalbitz, M.3    Huber-Lang, M.4
  • 22
    • 0343953444 scopus 로고    scopus 로고
    • Cutting edge: CD46, a new costimulatory molecule for T cells, that induces p120CBL and LAT phosphorylation
    • Astier A, Trescol-Biemont MC, Azocar O, Lamouille B, Rabourdin-Combe C. Cutting edge: CD46, a new costimulatory molecule for T cells, that induces p120CBL and LAT phosphorylation. J Immunol. 2000;164:6091–6095.
    • (2000) J Immunol , vol.164 , pp. 6091-6095
    • Astier, A.1    Trescol-Biemont, M.C.2    Azocar, O.3    Lamouille, B.4    Rabourdin-Combe, C.5
  • 23
    • 0026457327 scopus 로고
    • Signal transduction through decay-accelerating factor. Interaction of glycosyl-phosphatidylinositol anchor and protein tyrosine kinases p56lck and p59fyn 1
    • Shenoy-Scaria AM, Kwong J, Fujita T, Olszowy MW, Shaw AS, Lublin DM. Signal transduction through decay-accelerating factor. Interaction of glycosyl-phosphatidylinositol anchor and protein tyrosine kinases p56lck and p59fyn 1. J Immunol. 1992;149:3535–3541.
    • (1992) J Immunol , vol.149 , pp. 3535-3541
    • Shenoy-Scaria, A.M.1    Kwong, J.2    Fujita, T.3    Olszowy, M.W.4    Shaw, A.S.5    Lublin, D.M.6
  • 24
    • 0014248144 scopus 로고
    • The derivation of two distinct anaphylatoxin activities from the third and fifth components of human complement
    • Cochrane CG, Muller-Eberhard HJ. The derivation of two distinct anaphylatoxin activities from the third and fifth components of human complement. J Exp Med. 1968;127:371–386.
    • (1968) J Exp Med , vol.127 , pp. 371-386
    • Cochrane, C.G.1    Muller-Eberhard, H.J.2
  • 25
    • 0016611304 scopus 로고
    • Purification and partial characterization of human and porcine C3a anaphylatoxin
    • Hugli TE, Vallota EH, Muller-Eberhard HJ. Purification and partial characterization of human and porcine C3a anaphylatoxin. J Biol Chem. 1975;250:1472–1478.
    • (1975) J Biol Chem , vol.250 , pp. 1472-1478
    • Hugli, T.E.1    Vallota, E.H.2    Muller-Eberhard, H.J.3
  • 26
    • 0001754187 scopus 로고    scopus 로고
    • Characterisation of complement anaphylatoxins and their biological responses
    • In, Volanakis, JE, Frank MM, eds., New York Marcel Dekker
    • Ember JA, Jagels MA, Hugli TE. Characterisation of complement anaphylatoxins and their biological responses. In: Volanakis, JE, Frank MM, eds. The Human Complement System in Health and Disease. New York: Marcel Dekker; 1998:241–284.
    • (1998) The Human Complement System in Health and Disease , pp. 241-284
    • Ember, J.A.1    Jagels, M.A.2    Hugli, T.E.3
  • 28
    • 0036510770 scopus 로고    scopus 로고
    • The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des-Arg(74)
    • Cain SA, Monk PN. The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des-Arg(74). J Biol Chem. 2002;277:7165–7169.
    • (2002) J Biol Chem , vol.277 , pp. 7165-7169
    • Cain, S.A.1    Monk, P.N.2
  • 29
    • 4644302118 scopus 로고    scopus 로고
    • Renal expression of the C3a receptor and functional responses of primary human proximal tubular epithelial cells
    • Braun MC, Reins RY, Li TB, et al. Renal expression of the C3a receptor and functional responses of primary human proximal tubular epithelial cells. J Immunol. 2004;173:4190–4196.
    • (2004) J Immunol , vol.173 , pp. 4190-4196
    • Braun, M.C.1    Reins, R.Y.2    Li, T.B.3
  • 30
    • 0037103283 scopus 로고    scopus 로고
    • Complement c3a and c5a induce different signal transduction cascades in endothelial cells
    • Schraufstatter IU, Trieu K, Sikora L, Sriramarao P, DiScipio R. Complement c3a and c5a induce different signal transduction cascades in endothelial cells. J Immunol. 2002;169:2102–2110.
    • (2002) J Immunol , vol.169 , pp. 2102-2110
    • Schraufstatter, I.U.1    Trieu, K.2    Sikora, L.3    Sriramarao, P.4    DiScipio, R.5
  • 31
    • 0035253577 scopus 로고    scopus 로고
    • Expression of the complement anaphylatoxin C3a and C5a receptors on bronchial epithelial and smooth muscle cells in models of sepsis and asthma
    • Drouin SM, Kildsgaard J, Haviland J, et al. Expression of the complement anaphylatoxin C3a and C5a receptors on bronchial epithelial and smooth muscle cells in models of sepsis and asthma. J Immunol. 2001;166:2025–2032.
    • (2001) J Immunol , vol.166 , pp. 2025-2032
    • Drouin, S.M.1    Kildsgaard, J.2    Haviland, J.3
  • 32
    • 0028263451 scopus 로고
    • Activation of human neutrophils by C3a and C5A. Comparison of the effects on shape changes, chemotaxis, secretion, and respiratory burst
    • Ehrengruber MU, Geiser T, Deranleau DA. Activation of human neutrophils by C3a and C5A. Comparison of the effects on shape changes, chemotaxis, secretion, and respiratory burst. FEBS Lett. 1994;346:181–184.
    • (1994) FEBS Lett , vol.346 , pp. 181-184
    • Ehrengruber, M.U.1    Geiser, T.2    Deranleau, D.A.3
  • 33
    • 0019487913 scopus 로고
    • Chemotaxis by mouse macrophage cell lines
    • Aksamit RR, Falk W, Leonard EJ. Chemotaxis by mouse macrophage cell lines. J Immunol. 1981;126:2194–2199.
    • (1981) J Immunol , vol.126 , pp. 2194-2199
    • Aksamit, R.R.1    Falk, W.2    Leonard, E.J.3
  • 34
    • 0029122487 scopus 로고
    • Migration of dendritic cells in response to formyl peptides, C5a, and a distinct set of chemokines
    • Sozzani S, Sallusto F, Luini W, et al. Migration of dendritic cells in response to formyl peptides, C5a, and a distinct set of chemokines. J Immunol. 1995;155:3292–3295.
    • (1995) J Immunol , vol.155 , pp. 3292-3295
    • Sozzani, S.1    Sallusto, F.2    Luini, W.3
  • 35
    • 0017345915 scopus 로고
    • Histamine-induced inhibition of normal human basophil chemotaxis to C5a
    • Lett-Brown MA, Leonard EJ. Histamine-induced inhibition of normal human basophil chemotaxis to C5a. J Immunol. 1977;118:815–818.
    • (1977) J Immunol , vol.118 , pp. 815-818
    • Lett-Brown, M.A.1    Leonard, E.J.2
  • 36
    • 0030893717 scopus 로고    scopus 로고
    • C3a and C5a stimulate chemotaxis of human mast cells
    • Hartmann K, Henz BM, Kruger-Krasagakes S, et al. C3a and C5a stimulate chemotaxis of human mast cells. Blood. 1997;89:2863–2870.
    • (1997) Blood , vol.89 , pp. 2863-2870
    • Hartmann, K.1    Henz, B.M.2    Kruger-Krasagakes, S.3
  • 37
    • 0028330051 scopus 로고
    • C3a activates reactive oxygen radical species production and intracellular calcium transients in human eosinophils
    • Elsner J, Oppermann M, Czech W, et al. C3a activates reactive oxygen radical species production and intracellular calcium transients in human eosinophils. Eur J Immunol. 1994;24:518–522.
    • (1994) Eur J Immunol , vol.24 , pp. 518-522
    • Elsner, J.1    Oppermann, M.2    Czech, W.3
  • 38
    • 0028339175 scopus 로고
    • C3a activates the respiratory burst in human polymorphonuclear neutrophilic leukocytes via pertussis toxin-sensitive G-proteins
    • Elsner J, Oppermann M, Czech W, Kapp A. C3a activates the respiratory burst in human polymorphonuclear neutrophilic leukocytes via pertussis toxin-sensitive G-proteins. Blood. 1994;83:3324–3331.
    • (1994) Blood , vol.83 , pp. 3324-3331
    • Elsner, J.1    Oppermann, M.2    Czech, W.3    Kapp, A.4
  • 39
    • 0016756511 scopus 로고
    • Release of histamine from rat mast cells by the complement peptides C3a and C5a
    • Johnson AR, Hugli TE, Muller-Eberhard HJ. Release of histamine from rat mast cells by the complement peptides C3a and C5a. Immunology. 1975;28:1067–1080.
    • (1975) Immunology , vol.28 , pp. 1067-1080
    • Johnson, A.R.1    Hugli, T.E.2    Muller-Eberhard, H.J.3
  • 40
    • 0345008376 scopus 로고
    • Arachidonate metabolism by human polymorphonuclear leukocytes stimulated by N-formyl-Met-Leu-Phe or complement component C5a is independent of phospholipase activation
    • Clancy RM, Dahinden CA, Hugli TE. Arachidonate metabolism by human polymorphonuclear leukocytes stimulated by N-formyl-Met-Leu-Phe or complement component C5a is independent of phospholipase activation. Proc Natl Acad Sci USA. 1983;80:7200–7204.
    • (1983) Proc Natl Acad Sci USA , vol.80 , pp. 7200-7204
    • Clancy, R.M.1    Dahinden, C.A.2    Hugli, T.E.3
  • 41
    • 84888240043 scopus 로고    scopus 로고
    • C3a modulates IL-1beta secretion in human monocytes by regulating ATP efflux and subsequent NLRP3 inflammasome activation
    • Asgari E, Le Friec G, Yamamoto H, et al. C3a modulates IL-1beta secretion in human monocytes by regulating ATP efflux and subsequent NLRP3 inflammasome activation. Blood. 2013;122:3473–3481.
    • (2013) Blood , vol.122 , pp. 3473-3481
    • Asgari, E.1    Le Friec, G.2    Yamamoto, H.3
  • 42
    • 77957280402 scopus 로고    scopus 로고
    • Proinflammatory activation pattern of human umbilical vein endothelial cells induced by IL-1beta, TNF-alpha, and LPS
    • Mako V, Czucz J, Weiszhar Z, et al. Proinflammatory activation pattern of human umbilical vein endothelial cells induced by IL-1beta, TNF-alpha, and LPS. Cytometry A. 2010;77:962–970.
    • (2010) Cytometry A , vol.77 , pp. 962-970
    • Mako, V.1    Czucz, J.2    Weiszhar, Z.3
  • 43
    • 1242293775 scopus 로고    scopus 로고
    • C5a-induced gene expression in human umbilical vein endothelial cells
    • Albrecht EA, Chinnaiyan AM, Varambally S, et al. C5a-induced gene expression in human umbilical vein endothelial cells. Am J Pathol. 2004;164:849–859.
    • (2004) Am J Pathol , vol.164 , pp. 849-859
    • Albrecht, E.A.1    Chinnaiyan, A.M.2    Varambally, S.3
  • 44
    • 84896970663 scopus 로고    scopus 로고
    • Complement and its receptors: new insights into human disease
    • Holers VM. Complement and its receptors: new insights into human disease. Annu Rev Immunol. 2014;32:433–459.
    • (2014) Annu Rev Immunol , vol.32 , pp. 433-459
    • Holers, V.M.1
  • 45
    • 0026538929 scopus 로고
    • The evolution of mouse and human complement C3-binding proteins: divergence of form but conservation of function
    • Holers VM, Kinoshita T, Molina H. The evolution of mouse and human complement C3-binding proteins: divergence of form but conservation of function. Immunol Today. 1992;13:231–236.
    • (1992) Immunol Today , vol.13 , pp. 231-236
    • Holers, V.M.1    Kinoshita, T.2    Molina, H.3
  • 46
    • 0020660996 scopus 로고
    • Increased expression of C3b receptors on polymorphonuclear leukocytes induced by chemotactic factors and by purification procedures
    • Fearon DT, Collins LA. Increased expression of C3b receptors on polymorphonuclear leukocytes induced by chemotactic factors and by purification procedures. J Immunol. 1983;130:370–375.
    • (1983) J Immunol , vol.130 , pp. 370-375
    • Fearon, D.T.1    Collins, L.A.2
  • 47
    • 0025255615 scopus 로고
    • Structure and function of the leukocyte adhesion molecules CD11/CD18
    • Arnaout MA. Structure and function of the leukocyte adhesion molecules CD11/CD18. Blood. 1990;75:1037–1050.
    • (1990) Blood , vol.75 , pp. 1037-1050
    • Arnaout, M.A.1
  • 48
    • 0028265846 scopus 로고
    • The leukocyte integrin p150,95 (CD11c/CD18) as a receptor for iC3b. Activation by a heterologous beta subunit and localization of a ligand recognition site to the I domain
    • Bilsland CA, Diamond MS, Springer TA. The leukocyte integrin p150,95 (CD11c/CD18) as a receptor for iC3b. Activation by a heterologous beta subunit and localization of a ligand recognition site to the I domain. J Immunol. 1994;152:4582–4589.
    • (1994) J Immunol , vol.152 , pp. 4582-4589
    • Bilsland, C.A.1    Diamond, M.S.2    Springer, T.A.3
  • 49
    • 0028130314 scopus 로고
    • Identification of the complement iC3b binding site in the beta 2 integrin CR3 (CD11b/CD18)
    • Ueda T, Rieu P, Brayer J, Arnaout MA. Identification of the complement iC3b binding site in the beta 2 integrin CR3 (CD11b/CD18). Proc Natl Acad Sci USA. 1994;91:10680–10684.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 10680-10684
    • Ueda, T.1    Rieu, P.2    Brayer, J.3    Arnaout, M.A.4
  • 50
    • 0034122721 scopus 로고    scopus 로고
    • CR3: a general purpose adhesion-recognition receptor essential for innate immunity
    • Ehlers MR. CR3: a general purpose adhesion-recognition receptor essential for innate immunity. Microbes Infect. 2000;2:289–294.
    • (2000) Microbes Infect , vol.2 , pp. 289-294
    • Ehlers, M.R.1
  • 51
    • 0031092954 scopus 로고    scopus 로고
    • Characterization of accessory molecules in murine lung dendritic cell function: roles for CD80, CD86, CD54, and CD40L
    • Masten BJ, Yates JL, Pollard Koga AM, Lipscomb MF. Characterization of accessory molecules in murine lung dendritic cell function: roles for CD80, CD86, CD54, and CD40L. Am J Respir Cell Mol Biol. 1997;16:335–342.
    • (1997) Am J Respir Cell Mol Biol , vol.16 , pp. 335-342
    • Masten, B.J.1    Yates, J.L.2    Pollard Koga, A.M.3    Lipscomb, M.F.4
  • 53
    • 41349100253 scopus 로고    scopus 로고
    • Local production and activation of complement up-regulates the allostimulatory function of dendritic cells through C3a-C3aR interaction
    • Peng Q, Li K, Anderson K, et al. Local production and activation of complement up-regulates the allostimulatory function of dendritic cells through C3a-C3aR interaction. Blood. 2008;111:2452–2461.
    • (2008) Blood , vol.111 , pp. 2452-2461
    • Peng, Q.1    Li, K.2    Anderson, K.3
  • 54
    • 0036104834 scopus 로고    scopus 로고
    • Complement component C3 promotes T-cell priming and lung migration to control acute influenza virus infection
    • Kopf M, Abel B, Gallimore A, Carroll M, Bachmann MF. Complement component C3 promotes T-cell priming and lung migration to control acute influenza virus infection. Nat Med. 2002;8:373–378.
    • (2002) Nat Med , vol.8 , pp. 373-378
    • Kopf, M.1    Abel, B.2    Gallimore, A.3    Carroll, M.4    Bachmann, M.F.5
  • 55
    • 34247609345 scopus 로고    scopus 로고
    • Complement protein C1q induces maturation of human dendritic cells
    • Csomor E, Bajtay Z, Sandor N, et al. Complement protein C1q induces maturation of human dendritic cells. Mol Immunol. 2007;44:3389–3397.
    • (2007) Mol Immunol , vol.44 , pp. 3389-3397
    • Csomor, E.1    Bajtay, Z.2    Sandor, N.3
  • 56
    • 84875080678 scopus 로고    scopus 로고
    • Complement mediated signaling on pulmonary CD103(+) dendritic cells is critical for their migratory function in response to influenza infection
    • Kandasamy M, Ying PC, Ho AW, et al. Complement mediated signaling on pulmonary CD103(+) dendritic cells is critical for their migratory function in response to influenza infection. PLoS Pathog. 2013;9:e1003115.
    • (2013) PLoS Pathog , vol.9
    • Kandasamy, M.1    Ying, P.C.2    Ho, A.W.3
  • 57
    • 0014349898 scopus 로고
    • Receptors for complement of leukocytes
    • Lay WH, Nussenzweig V. Receptors for complement of leukocytes. J Exp Med. 1968;128:991–1009.
    • (1968) J Exp Med , vol.128 , pp. 991-1009
    • Lay, W.H.1    Nussenzweig, V.2
  • 58
    • 5444259851 scopus 로고    scopus 로고
    • The complement system in regulation of adaptive immunity
    • Carroll MC. The complement system in regulation of adaptive immunity. Nat Immunol. 2004;5:981–986.
    • (2004) Nat Immunol , vol.5 , pp. 981-986
    • Carroll, M.C.1
  • 59
    • 33845905781 scopus 로고    scopus 로고
    • T-cell regulation: with complements from innate immunity
    • Kemper C, Atkinson JP. T-cell regulation: with complements from innate immunity. Nat Rev Immunol. 2007;7:9–18.
    • (2007) Nat Rev Immunol , vol.7 , pp. 9-18
    • Kemper, C.1    Atkinson, J.P.2
  • 60
    • 0015530804 scopus 로고
    • Role of complement in induction of the allergic response
    • Pepys MB. Role of complement in induction of the allergic response. Nat New Biol. 1972;237:157–159.
    • (1972) Nat New Biol , vol.237 , pp. 157-159
    • Pepys, M.B.1
  • 61
    • 0016165221 scopus 로고
    • Role of complement in induction of antibody production in vivo. Effect of cobra factor and other C3-reactive agents on thymus-dependent and thymus-independent antibody responses
    • Pepys MB. Role of complement in induction of antibody production in vivo. Effect of cobra factor and other C3-reactive agents on thymus-dependent and thymus-independent antibody responses. J Exp Med. 1974;140:126–145.
    • (1974) J Exp Med , vol.140 , pp. 126-145
    • Pepys, M.B.1
  • 62
    • 0025991505 scopus 로고
    • Suppression of the immune response by a soluble complement receptor of B lymphocytes
    • Hebell T, Ahearn JM, Fearon DT. Suppression of the immune response by a soluble complement receptor of B lymphocytes. Science. 1991;254:102–105.
    • (1991) Science , vol.254 , pp. 102-105
    • Hebell, T.1    Ahearn, J.M.2    Fearon, D.T.3
  • 63
    • 0029926153 scopus 로고    scopus 로고
    • Markedly impaired humoral immune response in mice deficient in complement receptors 1 and 2
    • Molina H, Holers VM, Li B, et al. Markedly impaired humoral immune response in mice deficient in complement receptors 1 and 2. Proc Natl Acad Sci USA. 1996;93:3357–3361.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 3357-3361
    • Molina, H.1    Holers, V.M.2    Li, B.3
  • 64
    • 0026587743 scopus 로고
    • CD19: lowering the threshold for antigen receptor stimulation of B lymphocytes
    • Carter RH, Fearon DT. CD19: lowering the threshold for antigen receptor stimulation of B lymphocytes. Science. 1992;256:105–107.
    • (1992) Science , vol.256 , pp. 105-107
    • Carter, R.H.1    Fearon, D.T.2
  • 66
    • 0037103222 scopus 로고    scopus 로고
    • Mice deficient in complement receptors 1 and 2 lack a tissue injury-inducing subset of the natural antibody repertoire
    • Fleming SD, Shea-Donohue T, Guthridge JM, et al. Mice deficient in complement receptors 1 and 2 lack a tissue injury-inducing subset of the natural antibody repertoire. J Immunol. 2002;169:2126–2133.
    • (2002) J Immunol , vol.169 , pp. 2126-2133
    • Fleming, S.D.1    Shea-Donohue, T.2    Guthridge, J.M.3
  • 67
    • 84865389455 scopus 로고    scopus 로고
    • Regulation of humoral immunity by complement
    • Carroll MC, Isenman DE. Regulation of humoral immunity by complement. Immunity. 2012;37:199–207.
    • (2012) Immunity , vol.37 , pp. 199-207
    • Carroll, M.C.1    Isenman, D.E.2
  • 68
    • 0032211714 scopus 로고    scopus 로고
    • A critical role for complement in maintenance of self-tolerance
    • Prodeus AP, Goerg S, Shen LM, et al. A critical role for complement in maintenance of self-tolerance. Immunity. 1998;9:721–731.
    • (1998) Immunity , vol.9 , pp. 721-731
    • Prodeus, A.P.1    Goerg, S.2    Shen, L.M.3
  • 69
    • 61449144409 scopus 로고    scopus 로고
    • Increased B cell deletion and significantly reduced auto-antibody titre due to premature expression of human complement receptor 2 (CR2, CD21)
    • Pappworth IY, Kulik L, Haluszczak C, Reuter JW, Holers VM, Marchbank KJ. Increased B cell deletion and significantly reduced auto-antibody titre due to premature expression of human complement receptor 2 (CR2, CD21). Mol Immunol. 2009;46:1042–1049.
    • (2009) Mol Immunol , vol.46 , pp. 1042-1049
    • Pappworth, I.Y.1    Kulik, L.2    Haluszczak, C.3    Reuter, J.W.4    Holers, V.M.5    Marchbank, K.J.6
  • 70
    • 19344364971 scopus 로고    scopus 로고
    • Decay-accelerating factor modulates induction of T cell immunity
    • Heeger PS, Lalli PN, Lin F, et al. Decay-accelerating factor modulates induction of T cell immunity. J Exp Med. 2005;201:1523–1530.
    • (2005) J Exp Med , vol.201 , pp. 1523-1530
    • Heeger, P.S.1    Lalli, P.N.2    Lin, F.3
  • 71
    • 0036284207 scopus 로고    scopus 로고
    • Local synthesis of complement component C3 regulates acute renal transplant rejection
    • Pratt JR, Basheer SA, Sacks SH. Local synthesis of complement component C3 regulates acute renal transplant rejection. Nat Med. 2002;8:582–587.
    • (2002) Nat Med , vol.8 , pp. 582-587
    • Pratt, J.R.1    Basheer, S.A.2    Sacks, S.H.3
  • 72
    • 57149103158 scopus 로고    scopus 로고
    • Donor deficiency of decay-accelerating factor accelerates murine T cell-mediated cardiac allograft rejection
    • Pavlov V, Raedler H, Yuan S, et al. Donor deficiency of decay-accelerating factor accelerates murine T cell-mediated cardiac allograft rejection. J Immunol. 2008;181:4580–4589.
    • (2008) J Immunol , vol.181 , pp. 4580-4589
    • Pavlov, V.1    Raedler, H.2    Yuan, S.3
  • 73
    • 0026794743 scopus 로고
    • Human adipsin is identical to complement factor D and is expressed at high levels in adipose tissue
    • White RT, Damm D, Hancock N, et al. Human adipsin is identical to complement factor D and is expressed at high levels in adipose tissue. J Biol Chem. 1992;267:9210–9213.
    • (1992) J Biol Chem , vol.267 , pp. 9210-9213
    • White, R.T.1    Damm, D.2    Hancock, N.3
  • 74
    • 0031015026 scopus 로고    scopus 로고
    • Extrahepatic complement biosynthesis: where, when and why?
    • Morgan BP, Gasque P. Extrahepatic complement biosynthesis: where, when and why? Clin Exp Immunol. 1997;107:1–7.
    • (1997) Clin Exp Immunol , vol.107 , pp. 1-7
    • Morgan, B.P.1    Gasque, P.2
  • 76
    • 0029823526 scopus 로고    scopus 로고
    • Organ-specific contribution to circulating C7 levels by the bone marrow and liver in humans
    • Naughton MA, Walport MJ, Wurzner R, et al. Organ-specific contribution to circulating C7 levels by the bone marrow and liver in humans. Eur J Immunol. 1996;26:2108–2112.
    • (1996) Eur J Immunol , vol.26 , pp. 2108-2112
    • Naughton, M.A.1    Walport, M.J.2    Wurzner, R.3
  • 77
    • 57649170093 scopus 로고    scopus 로고
    • Human C3 deficiency associated with impairments in dendritic cell differentiation, memory B cells, and regulatory T cells
    • Ghannam A, Pernollet M, Fauquert JL, et al. Human C3 deficiency associated with impairments in dendritic cell differentiation, memory B cells, and regulatory T cells. J Immunol. 2008;181:5158–5166.
    • (2008) J Immunol , vol.181 , pp. 5158-5166
    • Ghannam, A.1    Pernollet, M.2    Fauquert, J.L.3
  • 78
    • 77749327561 scopus 로고    scopus 로고
    • Dendritic cell function in allostimulation is modulated by C5aR signaling
    • Peng Q, Li K, Wang N, et al. Dendritic cell function in allostimulation is modulated by C5aR signaling. J Immunol. 2009;183:6058–6068.
    • (2009) J Immunol , vol.183 , pp. 6058-6068
    • Peng, Q.1    Li, K.2    Wang, N.3
  • 79
    • 14244257449 scopus 로고    scopus 로고
    • The complement inhibitory protein DAF (CD55) suppresses T cell immunity in vivo
    • Liu J, Miwa T, Hilliard B, et al. The complement inhibitory protein DAF (CD55) suppresses T cell immunity in vivo. J Exp Med. 2005;201:567–577.
    • (2005) J Exp Med , vol.201 , pp. 567-577
    • Liu, J.1    Miwa, T.2    Hilliard, B.3
  • 80
    • 79955922349 scopus 로고    scopus 로고
    • The role of complement in the diagnosis and management of allergic rhinitis and allergic asthma
    • Laumonnier Y, Schmudde I, Kohl J. The role of complement in the diagnosis and management of allergic rhinitis and allergic asthma. Curr Allergy Asthma Rep. 2011;11:122–130.
    • (2011) Curr Allergy Asthma Rep , vol.11 , pp. 122-130
    • Laumonnier, Y.1    Schmudde, I.2    Kohl, J.3
  • 81
    • 38449105692 scopus 로고    scopus 로고
    • Decay accelerating factor can control T cell differentiation into IFN-gamma-producing effector cells via regulating local C5a-induced IL-12 production
    • Lalli PN, Strainic MG, Lin F, Medof ME, Heeger PS. Decay accelerating factor can control T cell differentiation into IFN-gamma-producing effector cells via regulating local C5a-induced IL-12 production. J Immunol. 2007;179:5793–5802.
    • (2007) J Immunol , vol.179 , pp. 5793-5802
    • Lalli, P.N.1    Strainic, M.G.2    Lin, F.3    Medof, M.E.4    Heeger, P.S.5
  • 82
    • 84872681454 scopus 로고    scopus 로고
    • Absence of signaling into CD4(+) cells via C3aR and C5aR enables autoinductive TGF-beta1 signaling and induction of Foxp3(+) regulatory T cells
    • Strainic MG, Shevach EM, An F, Lin F, Medof ME. Absence of signaling into CD4(+) cells via C3aR and C5aR enables autoinductive TGF-beta1 signaling and induction of Foxp3(+) regulatory T cells. Nat Immunol. 2013;14:162–171.
    • (2013) Nat Immunol , vol.14 , pp. 162-171
    • Strainic, M.G.1    Shevach, E.M.2    An, F.3    Lin, F.4    Medof, M.E.5
  • 83
    • 84874562997 scopus 로고    scopus 로고
    • Signaling through C5a receptor and C3a receptor diminishes function of murine natural regulatory T cells
    • Kwan WH, van der Touw W, Paz-Artal E, Li MO, Heeger PS. Signaling through C5a receptor and C3a receptor diminishes function of murine natural regulatory T cells. J Exp Med. 2013;210:257–268.
    • (2013) J Exp Med , vol.210 , pp. 257-268
    • Kwan, W.H.1    van der Touw, W.2    Paz-Artal, E.3    Li, M.O.4    Heeger, P.S.5
  • 84
    • 77953497686 scopus 로고    scopus 로고
    • Complement drives Th17 cell differentiation and triggers autoimmune arthritis
    • Hashimoto M, Hirota K, Yoshitomi H, et al. Complement drives Th17 cell differentiation and triggers autoimmune arthritis. J Exp Med. 2010;207:1135–1143.
    • (2010) J Exp Med , vol.207 , pp. 1135-1143
    • Hashimoto, M.1    Hirota, K.2    Yoshitomi, H.3
  • 85
    • 77749285675 scopus 로고    scopus 로고
    • C5a receptor-deficient dendritic cells promote induction of Treg and Th17 cells
    • Weaver DJ Jr, Reis ES, Pandey MK, et al. C5a receptor-deficient dendritic cells promote induction of Treg and Th17 cells. Eur J Immunol. 2010;40:710–721.
    • (2010) Eur J Immunol , vol.40 , pp. 710-721
    • Weaver, D.J.1    Reis, E.S.2    Pandey, M.K.3
  • 86
    • 77956955243 scopus 로고    scopus 로고
    • Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma
    • Lajoie S, Lewkowich IP, Suzuki Y, et al. Complement-mediated regulation of the IL-17A axis is a central genetic determinant of the severity of experimental allergic asthma. Nat Immunol. 2010;11:928–935.
    • (2010) Nat Immunol , vol.11 , pp. 928-935
    • Lajoie, S.1    Lewkowich, I.P.2    Suzuki, Y.3
  • 87
    • 84860260355 scopus 로고    scopus 로고
    • Complement plays a central role in Candida albicans-induced cytokine production by human PBMCs
    • Cheng SC, Sprong T, Joosten LA, et al. Complement plays a central role in Candida albicans-induced cytokine production by human PBMCs. Eur J Immunol. 2012;42:993–1004.
    • (2012) Eur J Immunol , vol.42 , pp. 993-1004
    • Cheng, S.C.1    Sprong, T.2    Joosten, L.A.3
  • 90
    • 0013622288 scopus 로고
    • Identification of an additional class of C3-binding membrane proteins of human peripheral blood leukocytes and cell lines
    • Cole JL, Housley GA Jr, Dykman TR, MacDermott RP, Atkinson JP. Identification of an additional class of C3-binding membrane proteins of human peripheral blood leukocytes and cell lines. Proc Natl Acad Sci USA. 1985;82:859–863.
    • (1985) Proc Natl Acad Sci USA , vol.82 , pp. 859-863
    • Cole, J.L.1    Housley, G.A.2    Dykman, T.R.3    MacDermott, R.P.4    Atkinson, J.P.5
  • 91
    • 0034327849 scopus 로고    scopus 로고
    • Functional modulation of human macrophages through CD46 (measles virus receptor): production of IL-12 p40 and nitric oxide in association with recruitment of protein-tyrosine phosphatase SHP-1 to CD46
    • Kurita-Taniguchi M, Fukui A, Hazeki K, et al. Functional modulation of human macrophages through CD46 (measles virus receptor): production of IL-12 p40 and nitric oxide in association with recruitment of protein-tyrosine phosphatase SHP-1 to CD46. J Immunol. 2000;165:5143–5152.
    • (2000) J Immunol , vol.165 , pp. 5143-5152
    • Kurita-Taniguchi, M.1    Fukui, A.2    Hazeki, K.3
  • 93
    • 84906243951 scopus 로고    scopus 로고
    • Complement regulatory protein CD46 protects against choroidal neovascularization in mice
    • Lyzogubov V, Wu X, Jha P, et al. Complement regulatory protein CD46 protects against choroidal neovascularization in mice. Am J Pathol. 2014;184:2537–2548.
    • (2014) Am J Pathol , vol.184 , pp. 2537-2548
    • Lyzogubov, V.1    Wu, X.2    Jha, P.3
  • 95
    • 0034651964 scopus 로고    scopus 로고
    • Membrane cofactor protein (MCP; CD46): isoform-specific tyrosine phosphorylation
    • Wang G, Liszewski MK, Chan AC, Atkinson JP. Membrane cofactor protein (MCP; CD46): isoform-specific tyrosine phosphorylation. J Immunol. 2000;164:1839–1846.
    • (2000) J Immunol , vol.164 , pp. 1839-1846
    • Wang, G.1    Liszewski, M.K.2    Chan, A.C.3    Atkinson, J.P.4
  • 96
    • 0343134052 scopus 로고    scopus 로고
    • Crry/p65, a membrane complement regulatory protein, has costimulatory properties on mouse T cells
    • Fernandez-Centeno E, de Ojeda G, Rojo JM, Portoles P. Crry/p65, a membrane complement regulatory protein, has costimulatory properties on mouse T cells. J Immunol. 2000;164:4533–4542.
    • (2000) J Immunol , vol.164 , pp. 4533-4542
    • Fernandez-Centeno, E.1    de Ojeda, G.2    Rojo, J.M.3    Portoles, P.4
  • 97
    • 84861468854 scopus 로고    scopus 로고
    • Complement regulatory protein Crry deficiency contributes to the antigen specific recall response in experimental autoimmune myasthenia gravis
    • Soltys J, Wu X. Complement regulatory protein Crry deficiency contributes to the antigen specific recall response in experimental autoimmune myasthenia gravis. J Inflamm. 2012;9:20.
    • (2012) J Inflamm , vol.9 , pp. 20
    • Soltys, J.1    Wu, X.2
  • 98
    • 77957855881 scopus 로고    scopus 로고
    • Specialized roles for cysteine cathepsins in health and disease
    • Reiser J, Adair B, Reinheckel T. Specialized roles for cysteine cathepsins in health and disease. J Clin Invest. 2010;120:3421–3431.
    • (2010) J Clin Invest , vol.120 , pp. 3421-3431
    • Reiser, J.1    Adair, B.2    Reinheckel, T.3
  • 99
    • 58149349888 scopus 로고    scopus 로고
    • Interaction between the coagulation and complement system
    • Amara U, Rittirsch D, Flierl M, et al. Interaction between the coagulation and complement system. Adv Exp Med Biol. 2008;632:71–79.
    • (2008) Adv Exp Med Biol , vol.632 , pp. 71-79
    • Amara, U.1    Rittirsch, D.2    Flierl, M.3
  • 100
    • 0033564687 scopus 로고    scopus 로고
    • Alterations in C3 activation and binding caused by phosphorylation by a casein kinase released from activated human platelets
    • Ekdahl KN, Nilsson B. Alterations in C3 activation and binding caused by phosphorylation by a casein kinase released from activated human platelets. J Immunol. 1999;162:7426–7433.
    • (1999) J Immunol , vol.162 , pp. 7426-7433
    • Ekdahl, K.N.1    Nilsson, B.2
  • 101
    • 84857843035 scopus 로고    scopus 로고
    • Factor VII-activating protease is activated in multiple trauma patients and generates anaphylatoxin C5a
    • Kanse SM, Gallenmueller A, Zeerleder S, et al. Factor VII-activating protease is activated in multiple trauma patients and generates anaphylatoxin C5a. J Immunol. 2012;188:2858–2865.
    • (2012) J Immunol , vol.188 , pp. 2858-2865
    • Kanse, S.M.1    Gallenmueller, A.2    Zeerleder, S.3
  • 103
    • 33847357422 scopus 로고    scopus 로고
    • Thrombin-activatable procarboxypeptidase B regulates activated complement C5a in vivo
    • Nishimura T, Myles T, Piliponsky AM, Kao PN, Berry GJ, Leung LL. Thrombin-activatable procarboxypeptidase B regulates activated complement C5a in vivo. Blood. 2007;109:1992–1997.
    • (2007) Blood , vol.109 , pp. 1992-1997
    • Nishimura, T.1    Myles, T.2    Piliponsky, A.M.3    Kao, P.N.4    Berry, G.J.5    Leung, L.L.6
  • 104
    • 79958205445 scopus 로고    scopus 로고
    • Sensing disease and danger: a survey of vertebrate PRRs and their origins
    • Hansen JD, Vojtech LN, Laing KJ. Sensing disease and danger: a survey of vertebrate PRRs and their origins. Dev Comp Immunol. 2011;35:886–897.
    • (2011) Dev Comp Immunol , vol.35 , pp. 886-897
    • Hansen, J.D.1    Vojtech, L.N.2    Laing, K.J.3
  • 106
    • 84873087532 scopus 로고    scopus 로고
    • NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice
    • Heneka MT, Kummer MP, Stutz A, et al. NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice. Nature. 2013;493:674–678.
    • (2013) Nature , vol.493 , pp. 674-678
    • Heneka, M.T.1    Kummer, M.P.2    Stutz, A.3
  • 107
    • 84920134906 scopus 로고    scopus 로고
    • Nlrp3-inflammasome activation in non-myeloid-derived cells aggravates diabetic nephropathy
    • Shahzad K, Bock F, Dong W, et al. Nlrp3-inflammasome activation in non-myeloid-derived cells aggravates diabetic nephropathy. Kidney Int. 2015;87:74–84.
    • (2015) Kidney Int , vol.87 , pp. 74-84
    • Shahzad, K.1    Bock, F.2    Dong, W.3
  • 108
    • 84956602696 scopus 로고    scopus 로고
    • CFH Y402H polymorphism and the complement activation product C5a: effects on NF-kappaB activation and inflammasome gene regulation
    • Cao S, Wang JC, Gao J, et al. CFH Y402H polymorphism and the complement activation product C5a: effects on NF-kappaB activation and inflammasome gene regulation. Br J Ophthalmol. 2016;100:713–718.
    • (2016) Br J Ophthalmol , vol.100 , pp. 713-718
    • Cao, S.1    Wang, J.C.2    Gao, J.3
  • 109
    • 84868007565 scopus 로고    scopus 로고
    • Physiological roles of mitochondrial reactive oxygen species
    • Sena LA, Chandel NS. Physiological roles of mitochondrial reactive oxygen species. Mol Cell. 2012;48:158–167.
    • (2012) Mol Cell , vol.48 , pp. 158-167
    • Sena, L.A.1    Chandel, N.S.2
  • 110
    • 84924415042 scopus 로고    scopus 로고
    • A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
    • Coll RC, Robertson AA, Chae JJ, et al. A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nat Med. 2015;21:248–255.
    • (2015) Nat Med , vol.21 , pp. 248-255
    • Coll, R.C.1    Robertson, A.A.2    Chae, J.J.3
  • 111
    • 84978288635 scopus 로고    scopus 로고
    • A novel ‘Complement – Metabolism – Inflammasome Axis’ as a key regulator of immune cell effector function
    • Arbore G, Kemper C. A novel ‘Complement – Metabolism – Inflammasome Axis’ as a key regulator of immune cell effector function. Eur J Immunol. 2016;46:1563–1573.
    • (2016) Eur J Immunol , vol.46 , pp. 1563-1573
    • Arbore, G.1    Kemper, C.2
  • 112
    • 84899639879 scopus 로고    scopus 로고
    • Cytokines in inflammatory bowel disease
    • Neurath MF. Cytokines in inflammatory bowel disease. Nat Rev Immunol. 2014;14:329–342.
    • (2014) Nat Rev Immunol , vol.14 , pp. 329-342
    • Neurath, M.F.1
  • 113
    • 84937779676 scopus 로고    scopus 로고
    • The receptor NLRP3 is a transcriptional regulator of TH2 differentiation
    • Bruchard M, Rebe C, Derangere V, et al. The receptor NLRP3 is a transcriptional regulator of TH2 differentiation. Nat Immunol. 2015;16:859–870.
    • (2015) Nat Immunol , vol.16 , pp. 859-870
    • Bruchard, M.1    Rebe, C.2    Derangere, V.3
  • 114
    • 84904646033 scopus 로고    scopus 로고
    • The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response
    • Baroja-Mazo A, Martin-Sanchez F, Gomez AI, et al. The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response. Nat Immunol. 2014;15:738–748.
    • (2014) Nat Immunol , vol.15 , pp. 738-748
    • Baroja-Mazo, A.1    Martin-Sanchez, F.2    Gomez, A.I.3
  • 115
    • 84879885078 scopus 로고    scopus 로고
    • The role of complement in CD4(+) T cell homeostasis and effector functions
    • Kolev M, Le Friec G, Kemper C. The role of complement in CD4(+) T cell homeostasis and effector functions. Semin Immunol. 2013;25:12–19.
    • (2013) Semin Immunol , vol.25 , pp. 12-19
    • Kolev, M.1    Le Friec, G.2    Kemper, C.3
  • 116
    • 82155197132 scopus 로고    scopus 로고
    • Functional modulation of human monocytes derived DCs by anaphylatoxins C3a and C5a
    • Li K, Fazekasova H, Wang N, et al. Functional modulation of human monocytes derived DCs by anaphylatoxins C3a and C5a. Immunobiology. 2012;217:65–73.
    • (2012) Immunobiology , vol.217 , pp. 65-73
    • Li, K.1    Fazekasova, H.2    Wang, N.3
  • 117
    • 0036260697 scopus 로고    scopus 로고
    • Cellular response to oxidative stress: signaling for suicide and survival
    • Martindale JL, Holbrook NJ. Cellular response to oxidative stress: signaling for suicide and survival. J Cell Physiol. 2002;192:1–15.
    • (2002) J Cell Physiol , vol.192 , pp. 1-15
    • Martindale, J.L.1    Holbrook, N.J.2
  • 118
    • 0029101644 scopus 로고
    • Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death
    • Zamzami N, Marchetti P, Castedo M, et al. Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death. J Exp Med. 1995;182:367–377.
    • (1995) J Exp Med , vol.182 , pp. 367-377
    • Zamzami, N.1    Marchetti, P.2    Castedo, M.3
  • 120
    • 84881030739 scopus 로고    scopus 로고
    • Primary complement C5 deficiencies – molecular characterization and clinical review of two families
    • Schejbel L, Fadnes D, Permin H, Lappegard KT, Garred P, Mollnes TE. Primary complement C5 deficiencies – molecular characterization and clinical review of two families. Immunobiology. 2013;218:1304–1310.
    • (2013) Immunobiology , vol.218 , pp. 1304-1310
    • Schejbel, L.1    Fadnes, D.2    Permin, H.3    Lappegard, K.T.4    Garred, P.5    Mollnes, T.E.6
  • 121
    • 84869508434 scopus 로고    scopus 로고
    • The CD46-Jagged1 interaction is critical for human TH1 immunity
    • Le Friec G, Sheppard D, Whiteman P, et al. The CD46-Jagged1 interaction is critical for human TH1 immunity. Nat Immunol. 2012;13:1213–1221.
    • (2012) Nat Immunol , vol.13 , pp. 1213-1221
    • Le Friec, G.1    Sheppard, D.2    Whiteman, P.3
  • 122
    • 84872790689 scopus 로고    scopus 로고
    • Interleukin-2 at the crossroads of effector responses, tolerance, and immunotherapy
    • Liao W, Lin JX, Leonard WJ. Interleukin-2 at the crossroads of effector responses, tolerance, and immunotherapy. Immunity. 2013;38:13–25.
    • (2013) Immunity , vol.38 , pp. 13-25
    • Liao, W.1    Lin, J.X.2    Leonard, W.J.3
  • 123
    • 84861193543 scopus 로고    scopus 로고
    • IL-7 signaling and CD127 receptor regulation in the control of T cell homeostasis
    • Carrette F, Surh CD. IL-7 signaling and CD127 receptor regulation in the control of T cell homeostasis. Semin Immunol. 2012;24:209–217.
    • (2012) Semin Immunol , vol.24 , pp. 209-217
    • Carrette, F.1    Surh, C.D.2
  • 124
    • 77951639702 scopus 로고    scopus 로고
    • IL-7 is essential for homeostatic control of T cell metabolism in vivo
    • Jacobs SR, Michalek RD, Rathmell JC. IL-7 is essential for homeostatic control of T cell metabolism in vivo. J Immunol. 2010;184:3461–3469.
    • (2010) J Immunol , vol.184 , pp. 3461-3469
    • Jacobs, S.R.1    Michalek, R.D.2    Rathmell, J.C.3
  • 125
    • 41349093966 scopus 로고    scopus 로고
    • IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival
    • Wofford JA, Wieman HL, Jacobs SR, Zhao Y, Rathmell JC. IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival. Blood. 2008;111:2101–2111.
    • (2008) Blood , vol.111 , pp. 2101-2111
    • Wofford, J.A.1    Wieman, H.L.2    Jacobs, S.R.3    Zhao, Y.4    Rathmell, J.C.5
  • 128
    • 32644438232 scopus 로고    scopus 로고
    • Complement-induced regulatory T cells suppress T-cell responses but allow for dendritic-cell maturation
    • Barchet W, Price JD, Cella M, et al. Complement-induced regulatory T cells suppress T-cell responses but allow for dendritic-cell maturation. Blood. 2006;107:1497–1504.
    • (2006) Blood , vol.107 , pp. 1497-1504
    • Barchet, W.1    Price, J.D.2    Cella, M.3
  • 129
    • 23844509111 scopus 로고    scopus 로고
    • T-cell stimulation and regulation: with complements from CD46
    • Kemper C, Verbsky JW, Price JD, Atkinson JP. T-cell stimulation and regulation: with complements from CD46. Immunol Res. 2005;32(1–3):31–43.
    • (2005) Immunol Res , vol.32 , Issue.1-3 , pp. 31-43
    • Kemper, C.1    Verbsky, J.W.2    Price, J.D.3    Atkinson, J.P.4
  • 130
    • 33845302957 scopus 로고    scopus 로고
    • Alterations in CD46-mediated Tr1 regulatory T cells in patients with multiple sclerosis
    • Astier AL, Meiffren G, Freeman S, Hafler DA. Alterations in CD46-mediated Tr1 regulatory T cells in patients with multiple sclerosis. J Clin Invest. 2006;116:3252–3257.
    • (2006) J Clin Invest , vol.116 , pp. 3252-3257
    • Astier, A.L.1    Meiffren, G.2    Freeman, S.3    Hafler, D.A.4
  • 131
    • 0242468041 scopus 로고    scopus 로고
    • Regulation of JAK-STAT signalling in the immune system
    • Shuai K, Liu B. Regulation of JAK-STAT signalling in the immune system. Nat Rev Immunol. 2003;3:900–911.
    • (2003) Nat Rev Immunol , vol.3 , pp. 900-911
    • Shuai, K.1    Liu, B.2
  • 132
    • 84860241847 scopus 로고    scopus 로고
    • Pathogen-induced human TH17 cells produce IFN-gamma or IL-10 and are regulated by IL-1beta
    • Zielinski CE, Mele F, Aschenbrenner D, et al. Pathogen-induced human TH17 cells produce IFN-gamma or IL-10 and are regulated by IL-1beta. Nature. 2012;484:514–518.
    • (2012) Nature , vol.484 , pp. 514-518
    • Zielinski, C.E.1    Mele, F.2    Aschenbrenner, D.3
  • 133
    • 84894239912 scopus 로고    scopus 로고
    • Mechanism of neutrophil dysfunction: neutrophil serine proteases cleave and inactivate the C5a receptor
    • van den Berg CW, Tambourgi DV, Clark HW, Hoong SJ, Spiller OB, McGreal EP. Mechanism of neutrophil dysfunction: neutrophil serine proteases cleave and inactivate the C5a receptor. J Immunol. 2014;192:1787–1795.
    • (2014) J Immunol , vol.192 , pp. 1787-1795
    • van den Berg, C.W.1    Tambourgi, D.V.2    Clark, H.W.3    Hoong, S.J.4    Spiller, O.B.5    McGreal, E.P.6
  • 134
    • 84860338659 scopus 로고    scopus 로고
    • C5aR expression in a novel GFP reporter gene knockin mouse: implications for the mechanism of action of C5aR signaling in T cell immunity
    • Dunkelberger J, Zhou L, Miwa T, Song WC. C5aR expression in a novel GFP reporter gene knockin mouse: implications for the mechanism of action of C5aR signaling in T cell immunity. J Immunol. 2012;188:4032–4042.
    • (2012) J Immunol , vol.188 , pp. 4032-4042
    • Dunkelberger, J.1    Zhou, L.2    Miwa, T.3    Song, W.C.4
  • 135
    • 84878831880 scopus 로고    scopus 로고
    • Posttranscriptional control of T cell effector function by aerobic glycolysis
    • Chang CH, Curtis JD, Maggi LB Jr, et al. Posttranscriptional control of T cell effector function by aerobic glycolysis. Cell. 2013;153:1239–1251.
    • (2013) Cell , vol.153 , pp. 1239-1251
    • Chang, C.H.1    Curtis, J.D.2    Maggi, L.B.3
  • 136
    • 80054046029 scopus 로고    scopus 로고
    • Aerobic glycolysis: meeting the metabolic requirements of cell proliferation
    • Lunt SY, Vander Heiden MG. Aerobic glycolysis: meeting the metabolic requirements of cell proliferation. Annu Rev Cell Dev Biol. 2011;27:441–464.
    • (2011) Annu Rev Cell Dev Biol , vol.27 , pp. 441-464
    • Lunt, S.Y.1    Vander Heiden, M.G.2
  • 138
    • 84255199079 scopus 로고    scopus 로고
    • The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation
    • Wang R, Dillon CP, Shi LZ, et al. The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation. Immunity. 2011;35:871–882.
    • (2011) Immunity , vol.35 , pp. 871-882
    • Wang, R.1    Dillon, C.P.2    Shi, L.Z.3
  • 139
    • 36749081539 scopus 로고    scopus 로고
    • mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex
    • Cunningham JT, Rodgers JT, Arlow DH, Vazquez F, Mootha VK, Puigserver P. mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complex. Nature. 2007;450:736–740.
    • (2007) Nature , vol.450 , pp. 736-740
    • Cunningham, J.T.1    Rodgers, J.T.2    Arlow, D.H.3    Vazquez, F.4    Mootha, V.K.5    Puigserver, P.6
  • 140
    • 66949173728 scopus 로고    scopus 로고
    • The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment
    • Delgoffe GM, Kole TP, Zheng Y, et al. The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment. Immunity. 2009;30:832–844.
    • (2009) Immunity , vol.30 , pp. 832-844
    • Delgoffe, G.M.1    Kole, T.P.2    Zheng, Y.3
  • 141
    • 33846909503 scopus 로고    scopus 로고
    • A role for mammalian target of rapamycin in regulating T cell activation versus anergy
    • Zheng Y, Collins SL, Lutz MA, et al. A role for mammalian target of rapamycin in regulating T cell activation versus anergy. J Immunol. 2007;178:2163–2170.
    • (2007) J Immunol , vol.178 , pp. 2163-2170
    • Zheng, Y.1    Collins, S.L.2    Lutz, M.A.3
  • 142
    • 0037040180 scopus 로고    scopus 로고
    • A functional interaction between CD46 and DLG4: a role for DLG4 in epithelial polarization
    • Ludford-Menting MJ, Thomas SJ, Crimeen B, et al. A functional interaction between CD46 and DLG4: a role for DLG4 in epithelial polarization. J Biol Chem. 2002;277:4477–4484.
    • (2002) J Biol Chem , vol.277 , pp. 4477-4484
    • Ludford-Menting, M.J.1    Thomas, S.J.2    Crimeen, B.3
  • 143
  • 145
    • 79960982822 scopus 로고    scopus 로고
    • The dynamic processing of CD46 intracellular domains provides a molecular rheostat for T cell activation
    • Ni Choileain S, Weyand NJ, Neumann C, Thomas J, So M, Astier AL. The dynamic processing of CD46 intracellular domains provides a molecular rheostat for T cell activation. PLoS ONE. 2011;6:e16287.
    • (2011) PLoS ONE , vol.6
    • Ni Choileain, S.1    Weyand, N.J.2    Neumann, C.3    Thomas, J.4    So, M.5    Astier, A.L.6
  • 146
    • 84905510173 scopus 로고    scopus 로고
    • Metabolic reprogramming towards aerobic glycolysis correlates with greater proliferative ability and resistance to metabolic inhibition in CD8 versus CD4 T cells
    • Cao Y, Rathmell JC, Macintyre AN. Metabolic reprogramming towards aerobic glycolysis correlates with greater proliferative ability and resistance to metabolic inhibition in CD8 versus CD4 T cells. PLoS ONE. 2014;9:e104104.
    • (2014) PLoS ONE , vol.9
    • Cao, Y.1    Rathmell, J.C.2    Macintyre, A.N.3
  • 147
    • 4644366103 scopus 로고    scopus 로고
    • Complement inhibitor membrane cofactor protein (MCP; CD46) is constitutively shed from cancer cell membranes in vesicles and converted by a metalloproteinase to a functionally active soluble form
    • Hakulinen J, Junnikkala S, Sorsa T, Meri S. Complement inhibitor membrane cofactor protein (MCP; CD46) is constitutively shed from cancer cell membranes in vesicles and converted by a metalloproteinase to a functionally active soluble form. Eur J Immunol. 2004;34:2620–2629.
    • (2004) Eur J Immunol , vol.34 , pp. 2620-2629
    • Hakulinen, J.1    Junnikkala, S.2    Sorsa, T.3    Meri, S.4
  • 148
    • 76249122646 scopus 로고    scopus 로고
    • Presenilin/gamma-secretase cleaves CD46 in response to Neisseria infection
    • Weyand NJ, Calton CM, Higashi DL, Kanack KJ, So M. Presenilin/gamma-secretase cleaves CD46 in response to Neisseria infection. J Immunol. 2010;184:694–701.
    • (2010) J Immunol , vol.184 , pp. 694-701
    • Weyand, N.J.1    Calton, C.M.2    Higashi, D.L.3    Kanack, K.J.4    So, M.5
  • 150
    • 79960369458 scopus 로고    scopus 로고
    • HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells
    • Shi LZ, Wang R, Huang G, et al. HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells. J Exp Med. 2011;208:1367–1376.
    • (2011) J Exp Med , vol.208 , pp. 1367-1376
    • Shi, L.Z.1    Wang, R.2    Huang, G.3
  • 152
    • 52649176344 scopus 로고    scopus 로고
    • Locally produced C5a binds to T cell-expressed C5aR to enhance effector T-cell expansion by limiting antigen-induced apoptosis
    • Lalli PN, Strainic MG, Yang M, Lin F, Medof ME, Heeger PS. Locally produced C5a binds to T cell-expressed C5aR to enhance effector T-cell expansion by limiting antigen-induced apoptosis. Blood. 2008;112:1759–1766.
    • (2008) Blood , vol.112 , pp. 1759-1766
    • Lalli, P.N.1    Strainic, M.G.2    Yang, M.3    Lin, F.4    Medof, M.E.5    Heeger, P.S.6
  • 153
    • 84874242919 scopus 로고    scopus 로고
    • Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling
    • Sena LA, Li S, Jairaman A, et al. Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling. Immunity. 2013;38:225–236.
    • (2013) Immunity , vol.38 , pp. 225-236
    • Sena, L.A.1    Li, S.2    Jairaman, A.3
  • 154
    • 84927779736 scopus 로고    scopus 로고
    • NLRP3 at the interface of metabolism and inflammation
    • Haneklaus M, O'Neill LA. NLRP3 at the interface of metabolism and inflammation. Immunol Rev. 2015;265:53–62.
    • (2015) Immunol Rev , vol.265 , pp. 53-62
    • Haneklaus, M.1    O'Neill, L.A.2
  • 155
    • 84874930374 scopus 로고    scopus 로고
    • ATP-P2X4 signaling mediates NLRP3 inflammasome activation: a novel pathway of diabetic nephropathy
    • Chen K, Zhang J, Zhang W, et al. ATP-P2X4 signaling mediates NLRP3 inflammasome activation: a novel pathway of diabetic nephropathy. Int J Biochem Cell Biol. 2013;45:932–943.
    • (2013) Int J Biochem Cell Biol , vol.45 , pp. 932-943
    • Chen, K.1    Zhang, J.2    Zhang, W.3
  • 157
    • 79960920271 scopus 로고    scopus 로고
    • NLRP3 inflammasomes link inflammation and metabolic disease
    • De Nardo D, Latz E. NLRP3 inflammasomes link inflammation and metabolic disease. Trends Immunol. 2011;32:373–379.
    • (2011) Trends Immunol , vol.32 , pp. 373-379
    • De Nardo, D.1    Latz, E.2
  • 158
    • 84872576236 scopus 로고    scopus 로고
    • Metabolism of inflammation limited by AMPK and pseudo-starvation
    • O'Neill LA, Hardie DG. Metabolism of inflammation limited by AMPK and pseudo-starvation. Nature. 2013;493:346–355.
    • (2013) Nature , vol.493 , pp. 346-355
    • O'Neill, L.A.1    Hardie, D.G.2
  • 159
    • 0014422327 scopus 로고
    • Chemotactic and anaphylatoxic fragment cleaved from the fifth component of guinea pig complement
    • Shin HS, Snyderman R, Friedman E, Mellors A, Mayer MM. Chemotactic and anaphylatoxic fragment cleaved from the fifth component of guinea pig complement. Science. 1968;162:361–363.
    • (1968) Science , vol.162 , pp. 361-363
    • Shin, H.S.1    Snyderman, R.2    Friedman, E.3    Mellors, A.4    Mayer, M.M.5
  • 160
    • 0014323790 scopus 로고
    • Interactions of the complement system with endotoxic lipopolysaccharide. Generation of a factor chemotactic for polymorphonuclear leukocytes
    • Snyderman R, Gewurz H, Mergenhagen SE. Interactions of the complement system with endotoxic lipopolysaccharide. Generation of a factor chemotactic for polymorphonuclear leukocytes. J Exp Med. 1968;128:259–275.
    • (1968) J Exp Med , vol.128 , pp. 259-275
    • Snyderman, R.1    Gewurz, H.2    Mergenhagen, S.E.3
  • 161
    • 84934438715 scopus 로고    scopus 로고
    • Functional analysis of C5a effector responses in vitro and in vivo
    • Karsten CM, Laumonnier Y, Kohl J. Functional analysis of C5a effector responses in vitro and in vivo. Methods Mol Biol. 2014;1100:291–304.
    • (2014) Methods Mol Biol , vol.1100 , pp. 291-304
    • Karsten, C.M.1    Laumonnier, Y.2    Kohl, J.3
  • 162
    • 64149093561 scopus 로고    scopus 로고
    • Functions of C5a receptors
    • Ward PA. Functions of C5a receptors. J Mol Med. 2009;87:375–378.
    • (2009) J Mol Med , vol.87 , pp. 375-378
    • Ward, P.A.1
  • 163
    • 36248971186 scopus 로고    scopus 로고
    • The role of the complement anaphylatoxins in the recruitment of eosinophils
    • DiScipio RG, Schraufstatter IU. The role of the complement anaphylatoxins in the recruitment of eosinophils. Int Immunopharmacol. 2007;7:1909–1923.
    • (2007) Int Immunopharmacol , vol.7 , pp. 1909-1923
    • DiScipio, R.G.1    Schraufstatter, I.U.2
  • 164
    • 84934438782 scopus 로고    scopus 로고
    • The role of third complement component (C3) in homing of hematopoietic stem/progenitor cells into bone marrow
    • Reca R, Wysoczynski M, Yan J, Lambris JD, Ratajczak MZ. The role of third complement component (C3) in homing of hematopoietic stem/progenitor cells into bone marrow. Adv Exp Med Biol. 2006;586:35–51.
    • (2006) Adv Exp Med Biol , vol.586 , pp. 35-51
    • Reca, R.1    Wysoczynski, M.2    Yan, J.3    Lambris, J.D.4    Ratajczak, M.Z.5
  • 165
    • 78650970845 scopus 로고    scopus 로고
    • Innate or adaptive immunity? The example of natural killer cells
    • Vivier E, Raulet DH, Moretta A, et al. Innate or adaptive immunity? The example of natural killer cells. Science. 2011;331:44–49.
    • (2011) Science , vol.331 , pp. 44-49
    • Vivier, E.1    Raulet, D.H.2    Moretta, A.3
  • 166
    • 84880711233 scopus 로고    scopus 로고
    • Training innate immunity: the changing concept of immunological memory in innate host defence
    • Netea MG. Training innate immunity: the changing concept of immunological memory in innate host defence. Eur J Clin Invest. 2013;43:881–884.
    • (2013) Eur J Clin Invest , vol.43 , pp. 881-884
    • Netea, M.G.1
  • 167
    • 84912062246 scopus 로고    scopus 로고
    • Brief report: complement C5a promotes human embryonic stem cell pluripotency in the absence of FGF2
    • Hawksworth OA, Coulthard LG, Taylor SM, Wolvetang EJ, Woodruff TM. Brief report: complement C5a promotes human embryonic stem cell pluripotency in the absence of FGF2. Stem Cells. 2014;32:3278–3284.
    • (2014) Stem Cells , vol.32 , pp. 3278-3284
    • Hawksworth, O.A.1    Coulthard, L.G.2    Taylor, S.M.3    Wolvetang, E.J.4    Woodruff, T.M.5
  • 168
    • 4644364097 scopus 로고    scopus 로고
    • Four viruses, two bacteria, and one receptor: membrane cofactor protein (CD46) as pathogens' magnet
    • Cattaneo R. Four viruses, two bacteria, and one receptor: membrane cofactor protein (CD46) as pathogens' magnet. J Virol. 2004;78:4385–4388.
    • (2004) J Virol , vol.78 , pp. 4385-4388
    • Cattaneo, R.1
  • 169
    • 84907212581 scopus 로고    scopus 로고
    • Intracellular sensing of complement C3 activates cell autonomous immunity
    • Tam JC, Bidgood SR, McEwan WA, James LC. Intracellular sensing of complement C3 activates cell autonomous immunity. Science. 2014;345:1256070.
    • (2014) Science , vol.345 , pp. 1256070
    • Tam, J.C.1    Bidgood, S.R.2    McEwan, W.A.3    James, L.C.4
  • 170
    • 77951087292 scopus 로고    scopus 로고
    • The gut microbiota modulates host energy and lipid metabolism in mice
    • Velagapudi VR, Hezaveh R, Reigstad CS, et al. The gut microbiota modulates host energy and lipid metabolism in mice. J Lipid Res. 2010;51:1101–1112.
    • (2010) J Lipid Res , vol.51 , pp. 1101-1112
    • Velagapudi, V.R.1    Hezaveh, R.2    Reigstad, C.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.