Alterations in C3 activation and binding caused by phosphorylation by a casein kinase released from activated human platelets

Journal of Immunology

Volumn 162, Issue 12, 1999, Pages 7426-7433

  Ekdahl, Kristina Nilsson ^a,b   Nilsson, Bo ^a  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

^b LINNAEUS UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED PROTEIN C; CASEIN KINASE; CLASSICAL COMPLEMENT PATHWAY C3 C5 CONVERTASE; COMPLEMENT COMPONENT C3; VITRONECTIN;

ARTICLE; BINDING AFFINITY; COMPLEMENT ACTIVATION; COMPLEX FORMATION; COVALENT BOND; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME RELEASE; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SYSTEMIC LUPUS ERYTHEMATOSUS; THROMBOCYTE ACTIVATION;

ANIMALS; BINDING SITES, ANTIBODY; BLOOD; BLOOD COMPONENT REMOVAL; BLOOD PLATELETS; CASEIN KINASES; COMPLEMENT ACTIVATION; COMPLEMENT C3; COMPLEMENT C3-C5 CONVERTASES; COMPLEMENT FACTOR B; COMPLEMENT PATHWAY, ALTERNATIVE; COMPLEMENT PATHWAY, CLASSICAL; GLYCEROL; GLYCINE; HUMANS; HYDROLYSIS; IMMUNOGLOBULIN G; ISOENZYMES; PHOSPHORYLATION; PLATELET ACTIVATION; PROTEIN BINDING; PROTEIN KINASES; RATS; TRYPSIN;

EID: 0033564687     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. Blombäck, B., M. Blombäck, P. Edman, and B. Hessel. 1962. Amino-acid sequence and the occurrence of phosphorus in human fibrinopeptides. Nature 193:883.
2. Rand, M. D., M. Kalafatis, and K. G. Mann. 1994. Platelet coagulation factor Va: the major secretory platelet phosphoprotein. Blood 83:2180.
3. Mehringer, J. H., C. J. Weigel, and D. M. Tollefsen. 1991. Cyclic AMP-dependent protein kinase phosphorylates serine 378 in vitronectin. Biochem. Biophys. Res. Commun. 179:655.
4. Martin, S. C. 1989. Phosphorylation of complement factor C3 in vivo. Biochem. J. 261:1051.
5. Nilsson Ekdahl, K., and B. Nilsson. 1997. Phosphorylation of complement component C3 after synthesis in U937 cells by a putative CK2, which is regulated by CD11b: evidence that membrane-bound proteases preferentially cleave phosphorylated C3. Biochem. J. 328:625.
6. Humble, E., P. Heldin, P. O. Forsberg, and L. Engström. 1985. Phosphorylation in vitro of fibrinogen from three mammalian species with four different protein kinases. Arch. Biochem. Biophys. 241:225.
7. Forsberg, P. O. 1989. Dephosphorylation of human fibrinogen, previously phosphorylated in vitro by protein kinase C, by whole blood or intestinal alkaline phosphatase. Thromb. Res. 53:1.
8. Martin, S. C., P. O. Forsberg, and S. D. Eriksson. 1991. The effects of in vitro Phosphorylation and dephosphorylation on the thrombin-induced gelation and plasmin degradation of fibrinogen. Thromb. Res. 61:243.
9. Kalafatis, M., M. D. Rand, R. J. Jenny, Y. H. Ehrlich, and K. G. Mann. 1993. Phosphorylation of factor Va and factor VIIla by activated platelets. Blood 81:704.
10. 362 by protein kinase C attenuates its cleavage by plasmin. Eur. J. Biochem. 243:493.
11. Forsberg, P. O., S. C. Martin, B. Nilsson, P. Ekman, U. R. Nilsson, and L. Engström. 1990. In vitro phosphorylation of human complement factor C3 by protein kinase A and protein kinase C. J. Biol. Chem. 265:2941.
12. Hermoso, T., Z. Fishelson, S. I. Becker, K. Hirschberg, and C. L. Jaffe. 1991. Leishmanial protein kinases phosphorylate components of the complement system. EMBO J. 10:4061.
13. Nilsson Ekdahl, K., and B. Nilsson. 1995. Phosphorylation of complement component C3 and C3 fragments by a human platelet protein kinase: inhibition of factor I mediated cleavage of C3b. J. Immunol. 154:6502.
14. Nilsson Ekdahl, K., L. Rönnblom, G. Sturfeldt, and B. Nilsson. 1997. Increased phosphate content in complement component C3, fibrinogen, vitronectin, and other plasma proteins in systemic lupus erythematosus: covariations with platelet activation and possible association with thrombosis. Arthritis Rheum. 40:2178.
15. Gong, J., R. Larsson, K. Nilsson Ekdahl, T. E. Mollnes, U. R. Nilsson, and B. Nilsson. 1996. Tubing loops as a model for cardiopulmonary bypass circuits: both the biomaterial and the blood-gas interfaces induce complement activation in an in vitro model. J. Clin. Immunol. 16:223.
16. Hammer, C. H., G. H. Wirtz, L. Renfer, H. D. Gresham, and B. F. Tack. 1981. Large scale isolation of functionally active components of the human complement system. J. Biol. Chem. 256:3995.
17. Lambris, J. D., and H. J. Müller-Eberhard. 1984. Isolation and characterization of a 33,000-Dalton fragment of complement factor B with catalytic and C3b binding activity. J. Biol. Chem. 259:12685.
18. Catana, E., and J. A. Schifferli. 1991. Purification of human complement factor D from the peritoneal fluid of patients on chronic ambulatory peritoneal dialysis. J. Immunol. Methods 138:265.
19. Ross, G. D., J. D. Lambris, J. A. Cain, and S. L. Newman. 1982. Generation of three different fragments of bound C3 with purified factor I or serum. J. Immunol. 129:2051.
20. Paas, Y., and Z. Fishelson. 1995. Shedding of tyrosine and serine/threonine ectoprotein kinases from human leukemic cells. Arch. Biochem. Biophys. 316:780.
21. Storm, K. E., G. Artursson, and U. R. Nilsson. 1992. Purification and characterization of porcine C3: studies of the biologically active protein and its split products. Vet. Immunol. Immunopathol. 34:47.
22. Mustard, J. F., D. W. Perry, N. G. Ardlie, and M. A. Packham. 1972. Preparation of suspensions of washed platelets from humans. Br. J. Haematol. 22:193.
23. Naik, U. P., E. Kornecki, and Y. H. Ehrlich. 1991. Phosphorylation and dephosphorylation of human platelet surface proteins by an ecto-protein kinase/phosphatase system. Biochim. Biophys. Acta 1092:256.
24. Chijiwa, T., M. Hagiwara, and H. Hidaka. 1989. A newly synthesized selective casein kinase I inhibitor, N-(2-aminoethyl)-5-cloroisoquinoline-8-sulfonamide, and affinity purification of casein kinase I from bovine testis. J. Biol. Chem. 264:4924.
25. Zandomeni, R., M. Zandomeni, D. Shugar, and R. Weinmann. 1986. Casein type II is involved in the inhibition by 5,6-dichloro-1-β-D-ribofuranosylbenzimidazole of specific RNA polymerase II transcription. J. Biol. Chem. 261:3414.
26. Inagaki, M., S. Kawamoto, H. Itoh, M. Saitoh, M. Hagiwara, J. Takahashi, and H. Hidaka. 1986. Naphatlenesulfonamides as calmodulin antagonists and protein kinase inhibitors. Mol. Pharmacol. 29:577.
27. Laemmli, U. K. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680.
28. Ekman, P., and O. Jäger. 1993. Quantification of subnanomolar amounts of phosphate bound to seryl and threonyl residues in phosphoproteins using alkaline hydrolysis and malachite green. Anal. Biochem. 214:138.
29. Nilsson Ekdahl, K., B. Nilsson, M. Pekna, and U. R. Nilsson. 1992. Generation of iC3 on the interphase between blood and gas. Scand. J. Immunol. 35:85.
30. Nilsson, U. R., K.-E. Storm, H. Elwing, and B. Nilsson. 1993. Conformational epitopes of C3 reflecting its mode of binding to an artificial polymer surface. Mol. Immunol. 30:211.
31. Dodds, A. W., and S. K. A. Law. 1990. The complement component C4 of mammals. Biochem. J. 265:495.
32. Kitabayashi, A. N., J. Kusudda, M. Hirani, and K. Hashimoto. 1997. Cloning and chromosomal mapping of human casein kinase 1 γ2 (CKSNK1G2). Genomics 46:133.
33. Robinson, L. C., E. J. Hubbard, P. R. Graves, A. A. DePaoli-Roach, P. J. Roach, C. Kung, D. W. Haas, C. H. Hagedorn, M. Goebl, and M. R. Culbertson. 1992. Yeast casein kinase I homologues: an essential gene pair. Proc. Natl. Acad. Sci. USA 89:23.
34. de Bruijn, M. H. L., and G. H. Fey. 1985. Human complement component C3: cDNA coding sequence and derived primary structure. Proc. Natl. Acad. Sci. USA 82:708.
35. Meggio, F., J. W. Perich, O. Marin, and L. A. Pinna. 1992. The comparative efficiencies of the Ser(P)-, Thr(P)- and Tyr(P)-residues as specificity determinants for casein kinase-1. Biochem. Biophys. Res. Commun. 182:1460.
36. Shohet, J. M., P. Pemberton, and M. C. Carroll. 1993. Identification of a major binding site for complement C3 on the IgG1 heavy chain. J. Biol. Chem. 268:5866.
37. Sahu, A., and M. K. Pangburn. 1994. Covalent attachment of human complement C3 to IgG: identification of the amino acid residue involved in ester linkage formation. J. Biol. Chem. 269:28997.
38. Sahu, A., and M. K. Pangburn. 1995. Tyrosine is a potential site for covalent attachment of activated complement component C3. Mol. Immunol. 32:711.
39. Nagar, B., R. G. Jones, R. J. Diefenbach, D. E. Isenman, and J. M. Rini. 1998. X-ray crystal structure of C3d: a C3 fragment and ligand of complement receptor 2. Science 280:1277.
40. Law, S. K. A., and A. W. Dodds. 1997. The internal thioester and the covalent binding properties of the complement proteins C3 and C4. Protein Sci. 6:263.
41. Schifferli, J. A., C. N. Ng, and D. K. Peters. 1986. The role of complement and its receptor in the elimination of immune complexes. N. Engl. J. Med. 315:486.