Human complement C3 deficiency: Th1 induction requires T cell-derived complement C3a and CD46 activation

Molecular Immunology

Volumn 58, Issue 1, 2014, Pages 98-107

  Ghannam, Arije ^a   Fauquert, Jean Luc ^b   Thomas, Caroline ^c   Kemper, Claudia ^d   Drouet, Christian ^a  

^a UNIV GRENOBLE ALPES   (France)

^b UNIVERSITY HOSPITAL OF CLERMONT FERRAND   (France)

^c NANTES UNIVERSITY HOSPITAL   (France)

^d GUY S HOSPITAL   (United Kingdom)

Author keywords

C3 deficiency; C3a; Complement; T cell effector response

Indexed keywords

CD4 ANTIGEN; COMPLEMENT COMPONENT C3A; COMPLEMENT COMPONENT C3A RECEPTOR; COMPLEMENT COMPONENT C3B; COMPLEMENT COMPONENT C3B RECEPTOR; COMPLEMENT RECEPTOR; IMMUNOGLOBULIN; INTERLEUKIN 10; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 2 RECEPTOR BETA; MEMBRANE COFACTOR PROTEIN; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CASE REPORT; CD4+ T LYMPHOCYTE; COMPLEMENT ACTIVATION; COMPLEMENT DEFICIENCY; CONTROLLED STUDY; EFFECTOR CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; MONOCYTE CULTURE; NUCLEOTIDE SEQUENCE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH2 CELL;

C3 DEFICIENCY; C3A; COMPLEMENT; T CELL EFFECTOR RESPONSE;

ANTIGENS, CD46; COMPLEMENT C3; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-10; INTERLEUKIN-2; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; INTERLEUKIN-2 RECEPTOR BETA SUBUNIT; INTERLEUKIN-4; LYMPHOCYTE ACTIVATION; MALE; RECEPTORS, COMPLEMENT; RECEPTORS, INTERLEUKIN-2; RNA INTERFERENCE; RNA, SMALL INTERFERING; TH1 CELLS; TH2 CELLS;

EID: 84890070748     PISSN: 01615890     EISSN: 18729142     Source Type: Journal    
DOI: 10.1016/j.molimm.2013.11.010     Document Type: Article

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