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Volumn 32, Issue , 2014, Pages 433-459

Complement and its receptors: New insights into human disease

Author keywords

Anaphylatoxins; Complement activation pathways; Complement regulatory proteins; Disease models; Inflammation; Therapeutics; Thrombotic microangiopathies

Indexed keywords

ARGININE CARBOXYPEPTIDASE; CD59 ANTIGEN; COMPLEMENT; COMPLEMENT COMPONENT C3A; COMPLEMENT COMPONENT C5A RECEPTOR; COMPLEMENT FACTOR H; COMPLEMENT RECEPTOR; DECAY ACCELERATING FACTOR; ECULIZUMAB; FIBRINOGEN; ISONIAZID; PETROLEUM; TOLL LIKE RECEPTOR; VITRONECTIN;

EID: 84896970663     PISSN: 07320582     EISSN: 15453278     Source Type: Book Series    
DOI: 10.1146/annurev-immunol-032713-120154     Document Type: Review
Times cited : (333)

References (151)
  • 1
    • 0029987839 scopus 로고    scopus 로고
    • The instructive role of innate immunity in the acquired immune response
    • Fearon DT, Locksley RM. 1996. The instructive role of innate immunity in the acquired immune response. Science 272: 50-54
    • (1996) Science , vol.272 , pp. 50-54
    • Fearon, D.T.1    Locksley, R.M.2
  • 2
    • 0026034434 scopus 로고
    • Complement receptors and phagocytosis
    • Brown EJ. 1991. Complement receptors and phagocytosis. Curr. Opin. Immunol. 3:76-82
    • (1991) Curr. Opin. Immunol. , vol.3 , pp. 76-82
    • Brown, E.J.1
  • 3
    • 0031921084 scopus 로고    scopus 로고
    • The role of complement and complement receptors in the induction and regulation of immunity
    • Carroll MC. 1998. The role of complement and complement receptors in the induction and regulation of immunity. Annu. Rev. Immunol. 16:545-68
    • (1998) Annu. Rev. Immunol. , vol.16 , pp. 545-568
    • Carroll, M.C.1
  • 4
    • 0034891226 scopus 로고    scopus 로고
    • Contribution of the innate immune system to autoimmune myocarditis: A role for complement
    • Kaya Z, Afanasyeva M, Wang Y, Dohmen KM, Schlichting J, et al. 2001. Contribution of the innate immune system to autoimmune myocarditis: a role for complement. Nat. Immunol. 2:739-45
    • (2001) Nat. Immunol. , vol.2 , pp. 739-745
    • Kaya, Z.1    Afanasyeva, M.2    Wang, Y.3    Dohmen, K.M.4    Schlichting, J.5
  • 5
    • 0036747260 scopus 로고    scopus 로고
    • C1q, autoimmunity and apoptosis
    • Botto M, Walport MJ. 2002. C1q, autoimmunity and apoptosis. Immunobiology 205:395-406
    • (2002) Immunobiology , vol.205 , pp. 395-406
    • Botto, M.1    Walport, M.J.2
  • 8
    • 66549124166 scopus 로고    scopus 로고
    • Is complement good or bad for cancer patients? A new perspective on an old dilemma
    • Markiewski MM, Lambris JD. 2009. Is complement good or bad for cancer patients? A new perspective on an old dilemma. Trends Immunol. 30:286-92
    • (2009) Trends Immunol. , vol.30 , pp. 286-292
    • Markiewski, M.M.1    Lambris, J.D.2
  • 9
    • 16344371132 scopus 로고    scopus 로고
    • Complement receptors and the shaping of the natural antibody repertoire
    • Holers VM. 2005. Complement receptors and the shaping of the natural antibody repertoire. Springer Sem. Immunopathol. 26:405-23
    • (2005) Springer Sem. Immunopathol. , vol.26 , pp. 405-423
    • Holers, V.M.1
  • 10
    • 0141449968 scopus 로고    scopus 로고
    • The proinflammatory mediators C3a and C5a are essential for liver regeneration
    • Strey CW, Markiewski M, Matellos D, Tudoran R, Spruce LA, et al. 2003. The proinflammatory mediators C3a and C5a are essential for liver regeneration. J. Exp. Med. 198:913-23
    • (2003) J. Exp. Med. , vol.198 , pp. 913-923
    • Strey, C.W.1    Markiewski, M.2    Matellos, D.3    Tudoran, R.4    Spruce, L.A.5
  • 11
    • 80555149772 scopus 로고    scopus 로고
    • Complement involvement in neovascular ocular diseases
    • Yanai R, Thanos A, Connor KM. 2012. Complement involvement in neovascular ocular diseases. Adv. Exp. Med. Biol. 946:161-83
    • (2012) Adv. Exp. Med. Biol. , vol.946 , pp. 161-183
    • Yanai, R.1    Thanos, A.2    Connor, K.M.3
  • 12
    • 77955883153 scopus 로고    scopus 로고
    • Complement: A key system for immune surveillance and homeostasis
    • Ricklin D, Hajishengallis G, Yang K, Lambris JD. 2010. Complement: a key system for immune surveillance and homeostasis. Nat. Immunol. 11:785-97
    • (2010) Nat. Immunol. , vol.11 , pp. 785-797
    • Ricklin, D.1    Hajishengallis, G.2    Yang, K.3    Lambris, J.D.4
  • 13
    • 37849036955 scopus 로고    scopus 로고
    • Translationalmini-review series on complement factor H: Therapies of renal diseases associated with complement factor H abnormalities: Atypical haemolytic uraemic syndrome and membranoproliferative glomerulonephritis
    • NorisM, Remuzzi G. 2008. Translationalmini-review series on complement factor H: therapies of renal diseases associated with complement factor H abnormalities: atypical haemolytic uraemic syndrome and membranoproliferative glomerulonephritis. Clin. Exp. Immunol. 151:199-209
    • (2008) Clin. Exp. Immunol. , vol.151 , pp. 199-209
    • Norism Remuzzi, G.1
  • 14
    • 37849022343 scopus 로고    scopus 로고
    • Translationalmini-review series on complement factor H: Renal diseases associated with complement factor H: Novel insights from humans and animals
    • PickeringMC, Cook HT. 2008. Translationalmini-review series on complement factor H: renal diseases associated with complement factor H: novel insights from humans and animals. Clin. Exp. Immunol. 151:210-30
    • (2008) Clin. Exp. Immunol. , vol.151 , pp. 210-230
    • Pickering, M.C.1    Cook, H.T.2
  • 15
    • 0038312170 scopus 로고    scopus 로고
    • Clinical manifestations of paroxysmal nocturnal hemoglobinuria: Present state and future problems
    • Rosse WF,Nishimura J. 2003. Clinical manifestations of paroxysmal nocturnal hemoglobinuria: present state and future problems. Int. J. Hematol. 77:113-20
    • (2003) Int. J. Hematol. , vol.77 , pp. 113-120
    • Rosse Wfnishimura, J.1
  • 17
    • 0037527720 scopus 로고    scopus 로고
    • The complement system as a therapeutic target in autoimmunity
    • Holers VM. 2003. The complement system as a therapeutic target in autoimmunity. Clin. Immunol. 107:140-51
    • (2003) Clin. Immunol. , vol.107 , pp. 140-151
    • Holers, V.M.1
  • 18
    • 84934440020 scopus 로고    scopus 로고
    • Progress and trends in complement therapeutics
    • Ricklin D, Lambris JD. 2013. Progress and trends in complement therapeutics. Adv. Exp. Med. Biol. 735:1-22
    • (2013) Adv. Exp. Med. Biol. , vol.735 , pp. 1-22
    • Ricklin, D.1    Lambris, J.D.2
  • 20
    • 84880807089 scopus 로고    scopus 로고
    • Human complement control and complement evasion by pathogenic microbes: Tipping the balance
    • Zipfel PF, Hallstrom T, Riesbeck K. 2013. Human complement control and complement evasion by pathogenic microbes: tipping the balance. Mol. Immunol. 56:152-60
    • (2013) Mol. Immunol. , vol.56 , pp. 152-160
    • Zipfel, P.F.1    Hallstrom, T.2    Riesbeck, K.3
  • 22
    • 84866041623 scopus 로고    scopus 로고
    • Interactions of the humoral pattern recognition molecule PTX3 with the complement system
    • Doni A, Garlanda C, Bottazzi B, Meri S, Garred P, Mantovani A. 2012. Interactions of the humoral pattern recognition molecule PTX3 with the complement system. Immunobiology 217:1122-28
    • (2012) Immunobiology , vol.217 , pp. 1122-1128
    • Doni, A.1    Garlanda, C.2    Bottazzi, B.3    Meri, S.4    Garred, P.5    Mantovani, A.6
  • 23
    • 0023890664 scopus 로고
    • Molecular organization and function of the complement system
    • Muller-Eberhard HJ. 1988. Molecular organization and function of the complement system. Annu. Rev. Biochem. 57:321-47
    • (1988) Annu. Rev. Biochem. , vol.57 , pp. 321-347
    • Muller-Eberhard, H.J.1
  • 24
    • 84866014027 scopus 로고    scopus 로고
    • The tick-over theory revisited: Is C3 a contact-Activated protein?
    • Nilsson B, Ekdahl KN. 2012. The tick-over theory revisited: Is C3 a contact-Activated protein? Immunobiology 217:1106-10
    • (2012) Immunobiology , vol.217 , pp. 1106-1110
    • Nilsson, B.1    Ekdahl, K.N.2
  • 25
    • 77953266787 scopus 로고    scopus 로고
    • The amplification loop of the complement pathways
    • Lachmann PJ. 2009. The amplification loop of the complement pathways. Adv. Immunol. 104:115-49
    • (2009) Adv. Immunol. , vol.104 , pp. 115-149
    • Lachmann, P.J.1
  • 26
    • 84866011957 scopus 로고    scopus 로고
    • Manipulating the mediator: Modulation of the alternative complement pathway C3 convertase in health, disease and therapy
    • Ricklin D. 2012. Manipulating the mediator: modulation of the alternative complement pathway C3 convertase in health, disease and therapy. Immunobiology 217:1057-66
    • (2012) Immunobiology , vol.217 , pp. 1057-1066
    • Ricklin, D.1
  • 27
    • 2442667974 scopus 로고    scopus 로고
    • The alternative pathway of complement in disease: Opportunities for therapeutic targeting
    • Holers VM, Thurman JM. 2004. The alternative pathway of complement in disease: opportunities for therapeutic targeting. Mol. Immunol. 41:147-52
    • (2004) Mol. Immunol. , vol.41 , pp. 147-152
    • Holers, V.M.1    Thurman, J.M.2
  • 28
    • 41649110643 scopus 로고    scopus 로고
    • Ficolins: Novel pattern recognitionmolecules of the innate immune response
    • Runza VL, SchwaebleW,MannelDN. 2008. Ficolins: novel pattern recognitionmolecules of the innate immune response. Immunobiology 213:297-306
    • (2008) Immunobiology , vol.213 , pp. 297-306
    • Runza, V.L.1    Schwaeble, W.2    Mannel, D.N.3
  • 29
    • 2542423115 scopus 로고    scopus 로고
    • Mannan-binding lectin: A soluble pattern recognitionmolecule
    • Gadjeva M, Takahashi K, Thiel S. 2004. Mannan-binding lectin: a soluble pattern recognitionmolecule. Mol. Immunol. 41:113-21
    • (2004) Mol. Immunol. , vol.41 , pp. 113-121
    • Gadjeva, M.1    Takahashi, K.2    Thiel, S.3
  • 30
    • 0027953416 scopus 로고
    • Mammalian lectins in activation and clearance mechanisms involving the complement system
    • Reid KBM, Turner MW. 1994. Mammalian lectins in activation and clearance mechanisms involving the complement system. Springer Semin. Immunopathol. 15:307-25
    • (1994) Springer Semin. Immunopathol. , vol.15 , pp. 307-325
    • Reid, K.B.M.1    Turner, M.W.2
  • 31
    • 0034849547 scopus 로고    scopus 로고
    • Endothelial oxidative stress activates the lectin complement pathway: Role of cytokeratin 1
    • Collard CD, Montalto MC, Reenstra WR, Buras JA, Stahl GL. 2001. Endothelial oxidative stress activates the lectin complement pathway: role of cytokeratin 1. Am. J. Pathol. 159:1045-54
    • (2001) Am. J. Pathol. , vol.159 , pp. 1045-1054
    • Collard, C.D.1    Montalto, M.C.2    Reenstra, W.R.3    Buras, J.A.4    Stahl, G.L.5
  • 32
    • 0035908925 scopus 로고    scopus 로고
    • Inhibition of mannose-binding lectin reduces postischemic myocardial reperfusion injury
    • Jordan JE, Montalto MC, Stahl GL. 2001. Inhibition of mannose-binding lectin reduces postischemic myocardial reperfusion injury. Circulation 104:1413-18
    • (2001) Circulation , vol.104 , pp. 1413-1418
    • Jordan, J.E.1    Montalto, M.C.2    Stahl, G.L.3
  • 33
    • 0035006284 scopus 로고    scopus 로고
    • Structure and biology of complement protein C3, a connecting link between innate and acquired immunity
    • Sahu A, Lambris JD. 2001. Structure and biology of complement protein C3, a connecting link between innate and acquired immunity. Immunol. Rev. 180:35-48
    • (2001) Immunol. Rev. , vol.180 , pp. 35-48
    • Sahu, A.1    Lambris, J.D.2
  • 34
    • 84866049104 scopus 로고    scopus 로고
    • Putting the structure into complement
    • Lea SM, Johnson S. 2012. Putting the structure into complement. Immunobiology 217:1117-21
    • (2012) Immunobiology , vol.217 , pp. 1117-1121
    • Lea, S.M.1    Johnson, S.2
  • 36
    • 0028964378 scopus 로고
    • Structure, function and cellular expression of complement anaphylatoxin receptors
    • Wetsel RA. 1995. Structure, function and cellular expression of complement anaphylatoxin receptors. Curr. Opin. Immunol. 7:48-53
    • (1995) Curr. Opin. Immunol. , vol.7 , pp. 48-53
    • Wetsel, R.A.1
  • 37
    • 0031015026 scopus 로고    scopus 로고
    • Extrahepatic complement biosyn thesis: Where, when and why?
    • Morgan BP, Gasque P. 1997. Extrahepatic complement biosynthesis: where, when and why? Clin. Exp. Immunol. 107:1-7
    • (1997) Clin. Exp. Immunol. , vol.107 , pp. 1-7
    • Morgan, B.P.1    Gasque, P.2
  • 38
    • 0037111219 scopus 로고    scopus 로고
    • Macrophage-derived complement component C4 can restore humoral immunity in C4-deficient mice
    • Gadjeva M, Verschoor A, Brockman MA, Jezak H, Shen LM, et al. 2002. Macrophage-derived complement component C4 can restore humoral immunity in C4-deficient mice. J. Immunol. 169:5489-95
    • (2002) J. Immunol. , vol.169 , pp. 5489-5495
    • Gadjeva, M.1    Verschoor, A.2    Brockman, M.A.3    Jezak, H.4    Shen, L.M.5
  • 39
    • 34548282471 scopus 로고    scopus 로고
    • The relative importance of local and systemic complement production in ischaemia, transplanation and other pathologies
    • Li K, Sacks SH, Zhou W. 2007. The relative importance of local and systemic complement production in ischaemia, transplanation and other pathologies. Mol. Immunol. 44:3866-74
    • (2007) Mol. Immunol. , vol.44 , pp. 3866-3874
    • Li, K.1    Sacks, S.H.2    Zhou, W.3
  • 40
    • 0034861817 scopus 로고    scopus 로고
    • Extrahepatic synthesis of complement proteins in inflammation
    • Laufer J, Katz Y, Passwell JH. 2001. Extrahepatic synthesis of complement proteins in inflammation. Mol. Immunol. 38:221-29
    • (2001) Mol. Immunol. , vol.38 , pp. 221-229
    • Laufer, J.1    Katz, Y.2    Passwell, J.H.3
  • 41
    • 0024488198 scopus 로고
    • Complement receptors
    • Holers VM. 1989. Complement receptors. Year Immunol. 4:231-40
    • (1989) Year Immunol. , vol.4 , pp. 231-240
    • Holers, V.M.1
  • 42
    • 0025809863 scopus 로고
    • Molecular interactions of complement receptors on B lymphocytes: A CR1/CR2 complex distinct from the CR2/CD19 complex
    • Tuveson DA, Ahearn JM, Matsumoto AK, Fearon DT. 1991. Molecular interactions of complement receptors on B lymphocytes: a CR1/CR2 complex distinct from the CR2/CD19 complex. J. Exp. Med. 173:1083-89
    • (1991) J. Exp. Med. , vol.173 , pp. 1083-1089
    • Tuveson, D.A.1    Ahearn, J.M.2    Matsumoto, A.K.3    Fearon, D.T.4
  • 43
    • 0037087320 scopus 로고    scopus 로고
    • Complement receptor type 1 (CD35) mediates inhibitory signals in human B lymphocytes
    • Jozsi M, Prechl J, Bajtay Z, Erdei A. 2001. Complement receptor type 1 (CD35) mediates inhibitory signals in human B lymphocytes. J. Immunol. 168:2782-88
    • (2001) J. Immunol. , vol.168 , pp. 2782-2788
    • Jozsi, M.1    Prechl, J.2    Bajtay, Z.3    Erdei, A.4
  • 45
    • 0033990632 scopus 로고    scopus 로고
    • The role of complement in B cell activation and tolerance
    • Carroll MC. 2000. The role of complement in B cell activation and tolerance. Adv. Immunol. 74:61-88
    • (2000) Adv. Immunol. , vol.74 , pp. 61-88
    • Carroll, M.C.1
  • 46
    • 33644775720 scopus 로고    scopus 로고
    • CRIg: A macrophage complement receptor required for phagocytosis and circulating pathogens
    • Helmy KY, Katschke KJ, Gorgani NN, Klvajin NM, Elliott JM, et al. 2006. CRIg: a macrophage complement receptor required for phagocytosis and circulating pathogens. Cell 124:915-27
    • (2006) Cell , vol.124 , pp. 915-927
    • Helmy, K.Y.1    Katschke, K.J.2    Gorgani, N.N.3    Klvajin, N.M.4    Elliott, J.M.5
  • 47
    • 84866017430 scopus 로고    scopus 로고
    • The immunoglobulin IgG Fc receptor and complement triangle in autoimmune diseases
    • Karsten CM, Kohl J. 2012. The immunoglobulin, IgG Fc receptor and complement triangle in autoimmune diseases. Immunobiology 217:1067-79
    • (2012) Immunobiology , vol.217 , pp. 1067-1079
    • Karsten, C.M.1    Kohl, J.2
  • 48
    • 64149093561 scopus 로고    scopus 로고
    • Functions of C5a receptors
    • Ward PA. 2009. Functions of C5a receptors. J. Mol. Med. 87:378
    • (2009) J. Mol. Med. , vol.87 , pp. 378
    • Ward, P.A.1
  • 49
    • 77749245829 scopus 로고    scopus 로고
    • Complement fragments C3a and C5a: The salt and pepper of the immune response
    • Sacks SH. 2010. Complement fragments C3a and C5a: the salt and pepper of the immune response. Eur. J. Immunol. 40:668-70
    • (2010) Eur. J. Immunol. , vol.40 , pp. 668-670
    • Sacks, S.H.1
  • 50
    • 0034739041 scopus 로고    scopus 로고
    • A role for the C3a anaphylatoxin receptor in the effector phase of asthma
    • Humbles AA, Lu B, Nilsson CA, Lilly C, Israel E, et al. 2000. A role for the C3a anaphylatoxin receptor in the effector phase of asthma. Nature 406:998-1001
    • (2000) Nature , vol.406 , pp. 998-1001
    • Humbles, A.A.1    Lu, B.2    Nilsson, C.A.3    Lilly, C.4    Israel, E.5
  • 51
    • 33846495181 scopus 로고    scopus 로고
    • C3a is required for the production of CXC chemokines by tubular epithelial cells after renal ishemia/reperfusion
    • Thurman JM, Lenderink AM, Royer PA, Coleman KE, Zhou J, et al. 2007. C3a is required for the production of CXC chemokines by tubular epithelial cells after renal ishemia/reperfusion. J. Immunol. 178:1819-28
    • (2007) J. Immunol. , vol.178 , pp. 1819-1828
    • Thurman, J.M.1    Lenderink, A.M.2    Royer, P.A.3    Coleman, K.E.4    Zhou, J.5
  • 53
    • 0024146204 scopus 로고
    • C1 inhibitor and hereditary angioedema
    • Davis AE. 1988. C1 inhibitor and hereditary angioedema. Annu. Rev. Immunol. 6:595-628
    • (1988) Annu. Rev. Immunol. , vol.6 , pp. 595-628
    • Davis, A.E.1
  • 54
    • 0024381235 scopus 로고
    • The regulators of complement activation (RCA) gene cluster
    • Hourcade D, Holers VM, Atkinson JP. 1989. The regulators of complement activation (RCA) gene cluster. Adv. Immunol. 45:381-416
    • (1989) Adv. Immunol. , vol.45 , pp. 381-416
    • Hourcade, D.1    Holers, V.M.2    Atkinson, J.P.3
  • 55
    • 0036838535 scopus 로고    scopus 로고
    • Cutting edge: Localization of the host recognition functions of complement factor H at the carboxyl-terminal: Implications for hemolytic uremic syndrome
    • PangburnMK. 2002. Cutting edge: localization of the host recognition functions of complement factor H at the carboxyl-terminal: implications for hemolytic uremic syndrome. J. Immunol. 169:4702-6
    • (2002) J. Immunol. , vol.169 , pp. 4702-4706
    • Pangburn, M.K.1
  • 56
    • 84855282981 scopus 로고    scopus 로고
    • Complement Factor H-ligand interactions: Selfassociation, multivalency and dissociation constants
    • Perkins SJ, Nan R, Li K, Khan S, Miller M. 2012. Complement Factor H-ligand interactions: selfassociation, multivalency and dissociation constants. Immunobiology 217:281-97
    • (2012) Immunobiology , vol.217 , pp. 281-297
    • Perkins, S.J.1    Nan, R.2    Li, K.3    Khan, S.4    Miller, M.5
  • 58
    • 60549088365 scopus 로고    scopus 로고
    • Polyanion-induced self-Association of complement factor H: Possible mechanism of host protection from an innate immune system
    • Pangburn MK, Rawal N, Cortes C, Alam MN, Ferreira VP, Atkinson MAL. 2009. Polyanion-induced self-Association of complement factor H: possible mechanism of host protection from an innate immune system. J. Immunol. 182:1061-68
    • (2009) J. Immunol. , vol.182 , pp. 1061-1068
    • Pangburn, M.K.1    Rawal, N.2    Cortes, C.3    Alam, M.N.4    Ferreira, V.P.5    Atkinson, M.A.L.6
  • 59
    • 55949096010 scopus 로고    scopus 로고
    • Properdin: New roles in pattern recognition and target clearance
    • Kemper C, Hourcade DE. 2008. Properdin: New roles in pattern recognition and target clearance. Mol. Immunol. 45:4048-56
    • (2008) Mol. Immunol. , vol.45 , pp. 4048-4056
    • Kemper, C.1    Hourcade, D.E.2
  • 60
    • 1842557722 scopus 로고    scopus 로고
    • Complement inhibitorC4b-binding protein-friend or foe in the innate immune system?
    • Blom AM. 2004. Complement inhibitorC4b-binding protein-friend or foe in the innate immune system? Mol. Immunol. 40:1333-46
    • (2004) Mol. Immunol. , vol.40 , pp. 1333-1346
    • Blom, A.M.1
  • 62
    • 10844223613 scopus 로고    scopus 로고
    • Complement C2 receptor inhibitor trispanning: A novel human complement inhibitory receptor
    • Inal JM, Hui KM, Miot S, Lange S, Ramirez MI, et al. 2005. Complement C2 receptor inhibitor trispanning: a novel human complement inhibitory receptor. J. Immunol. 174:356-66
    • (2005) J. Immunol. , vol.174 , pp. 356-366
    • Inal, J.M.1    Hui, K.M.2    Miot, S.3    Lange, S.4    Ramirez, M.I.5
  • 63
    • 84878764817 scopus 로고    scopus 로고
    • Sushi domain-containing protein 4 (SUSD4) inhibits complement by disrupting the formation of the classical C3 convertase
    • Holmquist E, Okroj M, Nodin B, Jirstrom K, Blom AM. 2013. Sushi domain-containing protein 4 (SUSD4) inhibits complement by disrupting the formation of the classical C3 convertase. FASEB J. 27(6):2355-66
    • (2013) FASEB J. , vol.27 , Issue.6 , pp. 2355-2366
    • Holmquist, E.1    Okroj, M.2    Nodin, B.3    Jirstrom, K.4    Blom, A.M.5
  • 64
    • 0346849668 scopus 로고    scopus 로고
    • Carboxypeptidase N: A pleiotropic regulator of inflammation
    • Matthews KW, Mueller-Ortiz SL, Wetsel RA. 2004. Carboxypeptidase N: a pleiotropic regulator of inflammation. Mol. Immunol. 40:785-93
    • (2004) Mol. Immunol. , vol.40 , pp. 785-793
    • Matthews, K.W.1    Mueller-Ortiz, S.L.2    Wetsel, R.A.3
  • 65
    • 80052377390 scopus 로고    scopus 로고
    • Plasma carboxypeptidase B downregulates inflammatory responses in autoimmune arthritis
    • Song JJ, Hwang I, Cho KH, Garcia MA, Kim AJ, et al. 2011. Plasma carboxypeptidase B downregulates inflammatory responses in autoimmune arthritis. J. Clin. Investig. 121:3517-27
    • (2011) J. Clin. Investig. , vol.121 , pp. 3517-3527
    • Song, J.J.1    Hwang, I.2    Cho, K.H.3    Garcia, M.A.4    Kim, A.J.5
  • 66
    • 84866039264 scopus 로고    scopus 로고
    • Complement dysregulation and disease: From genes and proteins to diagnostics and drugs
    • de Cordoba SR, Tortajada A, Harris CL, Morgan BP. 2012. Complement dysregulation and disease: from genes and proteins to diagnostics and drugs. Immunobiology 217:1034-46
    • (2012) Immunobiology , vol.217 , pp. 1034-1046
    • De Cordoba, S.R.1    Tortajada, A.2    Harris, C.L.3    Morgan, B.P.4
  • 67
    • 47749126514 scopus 로고    scopus 로고
    • Factor H family proteins and human diseases
    • Jozsi M, Zipfel PF. 2008. Factor H family proteins and human diseases. Trends Immunol. 29:380-87
    • (2008) Trends Immunol. , vol.29 , pp. 380-387
    • Jozsi, M.1    Zipfel, P.F.2
  • 68
    • 33749123246 scopus 로고    scopus 로고
    • A common CFHhaplotype,with deletion ofCFHR1and CFHR3, is associated with lower risk of age-related macular degeneration
    • Hughes AE, Orr N, Esfandiary H, Diaz-Torres M, Goodship T, Chakravarthy U. 2006. A common CFHhaplotype,with deletion ofCFHR1and CFHR3, is associated with lower risk of age-related macular degeneration. Nat. Genet. 38:1173-77
    • (2006) Nat. Genet. , vol.38 , pp. 1173-1177
    • Hughes, A.E.1    Orr, N.2    Esfandiary, H.3    Diaz-Torres, M.4    Goodship, T.5    Chakravarthy, U.6
  • 73
    • 84880616430 scopus 로고    scopus 로고
    • Crossroads of coagulation and innate immunity: The case of deep vein thrombosis
    • Schulz C, Engelmann B, Massberg S. 2013. Crossroads of coagulation and innate immunity: the case of deep vein thrombosis. J. Thromb. Haemost. 11(Suppl. 1):233-41
    • (2013) J. Thromb. Haemost. , vol.11 , Issue.SUPPL. 1 , pp. 233-241
    • Schulz, C.1    Engelmann, B.2    Massberg, S.3
  • 74
    • 33744987414 scopus 로고    scopus 로고
    • Generation of C5a in the absence of C3: A new complement activation pathway
    • Huber-Lang M, Sarma JV, Zetoune FS, Rittirsch D, Neff TA, et al. 2006. Generation of C5a in the absence of C3: a new complement activation pathway. Nat. Med. 12:682-87
    • (2006) Nat. Med. , vol.12 , pp. 682-687
    • Huber-Lang, M.1    Sarma, J.V.2    Zetoune, F.S.3    Rittirsch, D.4    Neff, T.A.5
  • 75
    • 78649500126 scopus 로고    scopus 로고
    • Mannose-binding lectin and its associated proteases (MASPs) mediate coagulation and its deficiency is a risk factor in developing complications from infection, including disseminated intravascular coagulation
    • Takahashi K, Chang W-C, Takahashi M, Pavlov V, Ishida Y, et al. 2011. Mannose-binding lectin and its associated proteases (MASPs) mediate coagulation and its deficiency is a risk factor in developing complications from infection, including disseminated intravascular coagulation. Immunobiology 216:96-102
    • (2011) Immunobiology , vol.216 , pp. 96-102
    • Takahashi, K.1    Chang, W.-C.2    Takahashi, M.3    Pavlov, V.4    Ishida, Y.5
  • 76
    • 79956293593 scopus 로고    scopus 로고
    • Complement activation on platelet-leukocyte complexes and microparticles in enterohemorrhagic Escherichia coli-induced hemolytic uremic syndrome
    • Shahl AL, Sartz L, Karpman D. 2011. Complement activation on platelet-leukocyte complexes and microparticles in enterohemorrhagic Escherichia coli-induced hemolytic uremic syndrome. Blood 117:5503-13
    • (2011) Blood , vol.117 , pp. 5503-5513
    • Shahl, A.L.1    Sartz, L.2    Karpman, D.3
  • 77
    • 78149477844 scopus 로고    scopus 로고
    • Molecular intercommunication between the complement and coagulation systems
    • Amaru U, Flierl MA, Rittirsch D, Klos A, Chen H, et al. 2010. Molecular intercommunication between the complement and coagulation systems. J. Immunol. 185:5628-36
    • (2010) J. Immunol. , vol.185 , pp. 5628-5636
    • Amaru, U.1    Flierl, M.A.2    Rittirsch, D.3    Klos, A.4    Chen, H.5
  • 78
    • 84866009722 scopus 로고    scopus 로고
    • Bride and groom in systemic inflammation:The bells ring for complement and Toll in cooperation
    • Barratt-Due A, Pischke SE, Brekke O-L, Thorgersen EB, Nielsen EW, et al. 2012. Bride and groom in systemic inflammation:The bells ring for complement and Toll in cooperation. Immunobiology 217:1047-56
    • (2012) Immunobiology , vol.217 , pp. 1047-1056
    • Barratt-Due, A.1    Pischke, S.E.2    Brekke, O.-L.3    Thorgersen, E.B.4    Nielsen, E.W.5
  • 79
    • 34347400796 scopus 로고    scopus 로고
    • Regulation of Toll-like receptor-mediated inflammatory response by complement in vivo
    • Zhang X, Kimura Y, Fang C, Zhou L, Sfyroera G, et al. 2007. Regulation of Toll-like receptor-mediated inflammatory response by complement in vivo. Blood 110:228-36
    • (2007) Blood , vol.110 , pp. 228-236
    • Zhang, X.1    Kimura, Y.2    Fang, C.3    Zhou, L.4    Sfyroera, G.5
  • 80
    • 77950187399 scopus 로고    scopus 로고
    • Microbial hijacking of complement- Toll-like receptor crosstalk
    • ra11
    • Wang M, Krauss JL, Domon H, Hosur KB, Liang S, et al. 2010. Microbial hijacking of complement- Toll-like receptor crosstalk. Sci. Signal. 3(109):ra11
    • (2010) Sci. Signal. , vol.3 , Issue.109
    • Wang, M.1    Krauss, J.L.2    Domon, H.3    Hosur, K.B.4    Liang, S.5
  • 81
    • 84858762160 scopus 로고    scopus 로고
    • Crosstalk between complement and Toll-like receptors
    • Song WC. 2012. Crosstalk between complement and Toll-like receptors. Tox. Path. 40:174-82
    • (2012) Tox. Path. , vol.40 , pp. 174-182
    • Song, W.C.1
  • 82
    • 70349260730 scopus 로고    scopus 로고
    • Complement promotes the development of inflammatory T-helper 17 cells through synergistic interaction with Toll-like receptor signaling and IL-6 production
    • Fang C, Zhang X, Miwa T, SongWC. 2009. Complement promotes the development of inflammatory T-helper 17 cells through synergistic interaction with Toll-like receptor signaling and IL-6 production. Blood 114:1005-15
    • (2009) Blood , vol.114 , pp. 1005-1015
    • Fang, C.1    Zhang, X.2    Miwa, T.3    Song, W.C.4
  • 84
    • 25444465640 scopus 로고    scopus 로고
    • GC1q receptor ligation selectively down-regulates human IL-12 production through activation of the phosphoinositide 3-kinase pathway
    • Waggoner SN,CruiseMW, KasselR,Hahn YS. 2005. gC1q receptor ligation selectively down-regulates human IL-12 production through activation of the phosphoinositide 3-kinase pathway. J. Immunol. 175:4706-14
    • (2005) J. Immunol. , vol.175 , pp. 4706-4714
    • Sncruisemw, W.1    Kasselrhahn, Y.S.2
  • 85
    • 0030593030 scopus 로고    scopus 로고
    • C3d of complement as a molecular adjuvant: Bridging innate and acquired immunity
    • Dempsey P, Allison M, Akkaraju S, Goodnow C, Fearon D. 1996. C3d of complement as a molecular adjuvant: bridging innate and acquired immunity. Science 271:348-50
    • (1996) Science , vol.271 , pp. 348-350
    • Dempsey, P.1    Allison, M.2    Akkaraju, S.3    Goodnow, C.4    Fearon, D.5
  • 86
    • 34548044827 scopus 로고    scopus 로고
    • Subcapsular encounter and complement-dependent transport of immune complexes by lymph node B cells
    • Phan TG, Grigorova I, Okada T, Cyster JG. 2007. Subcapsular encounter and complement-dependent transport of immune complexes by lymph node B cells. Nat. Immunol. 8:992-1000
    • (2007) Nat. Immunol. , vol.8 , pp. 992-1000
    • Phan, T.G.1    Grigorova, I.2    Okada, T.3    Cyster, J.G.4
  • 87
    • 19944428796 scopus 로고    scopus 로고
    • Pharmacological targeting of anaphylatoxin receptors during the effector phase of allergic asthma suppresses airway hyperresponsiveness and airway inflammation
    • BaelderR, Fuchs B, BautschW,Zwirner J, Kohl J, et al. 2005. Pharmacological targeting of anaphylatoxin receptors during the effector phase of allergic asthma suppresses airway hyperresponsiveness and airway inflammation. J. Immunol. 174:783-89
    • (2005) J. Immunol. , vol.174 , pp. 783-789
    • Baelderr Fuchs, B.1    Bautschwzwirner, J.2    Kohl, J.3
  • 88
    • 84872681454 scopus 로고    scopus 로고
    • Absence of signaling into CD4+ cells via C3aR and C5aR enables autoinductive TGF-β1 signaling and induction of Foxp3+ regulatory T cells
    • Strainic MG, Shevach EM, An F, Lin F, Medof ME. 2013. Absence of signaling into CD4+ cells via C3aR and C5aR enables autoinductive TGF-β1 signaling and induction of Foxp3+ regulatory T cells. Nat. Immunol. 14:162-71
    • (2013) Nat. Immunol. , vol.14 , pp. 162-171
    • Strainic, M.G.1    Shevach, E.M.2    An, F.3    Lin, F.4    Medof, M.E.5
  • 89
    • 79955477674 scopus 로고    scopus 로고
    • CD36 in innate and adaptive immunity: An update
    • Cardone J, Le Friec G, Kemper C. 2011. CD36 in innate and adaptive immunity: an update. Clin. Exp. Immunol. 164:301-11
    • (2011) Clin. Exp. Immunol. , vol.164 , pp. 301-311
    • Cardone, J.1    Le Friec, G.2    Kemper, C.3
  • 91
    • 0036289142 scopus 로고    scopus 로고
    • Molecular modeling of mutations in the C-terminal domains of factor H of human complement: A new insight into hemolytic uremic syndrome
    • Perkins SJ, Goodship THJ. 2002. Molecular modeling of mutations in the C-terminal domains of factor H of human complement: a new insight into hemolytic uremic syndrome. J. Mol. Biol. 316:217-24
    • (2002) J. Mol. Biol. , vol.316 , pp. 217-224
    • Perkins, S.J.1    Goodship, T.H.J.2
  • 93
    • 38849102544 scopus 로고    scopus 로고
    • Factor i is required for the development of membranoproliferative glomerulonephritis in factor H-deficient mice
    • Rose KL, Paixao-Cavalcante D, Fish J, Manderson AP, Malik TH, et al. 2008. Factor I is required for the development of membranoproliferative glomerulonephritis in factor H-deficient mice. J. Clin. Investig. 118:608-18
    • (2008) J. Clin. Investig. , vol.118 , pp. 608-618
    • Rose, K.L.1    Paixao-Cavalcante, D.2    Fish, J.3    Manderson, A.P.4    Malik, T.H.5
  • 95
    • 77956394517 scopus 로고    scopus 로고
    • Identification of a mutation in complement factor H-related protein 5 in patients of Cypriot origin with glomerulonephritis
    • Gale DP, Goicoechea de Jorge E, Cook HT, Martinez-Barricarte R, Hadjisavvas A, et al. 2010. Identification of a mutation in complement factor H-related protein 5 in patients of Cypriot origin with glomerulonephritis. Lancet 376:794-801
    • (2010) Lancet , vol.376 , pp. 794-801
    • Gale, D.P.1    Goicoechea De Jorge, E.2    Cook, H.T.3    Martinez-Barricarte, R.4    Hadjisavvas, A.5
  • 97
    • 38349172121 scopus 로고    scopus 로고
    • Membrane cofactor protein mutations in atypical hemolytic uremic syndrome (aHUS), fatal Stx-HUS, C3 glomerulonephritis, and the HELLP syndrome
    • Fang CJ, Fremeaux-Bacchi V, Liszewski MK, Pianetti G, NorisM, et al. 2008. Membrane cofactor protein mutations in atypical hemolytic uremic syndrome (aHUS), fatal Stx-HUS, C3 glomerulonephritis, and the HELLP syndrome. Blood 111:624-32
    • (2008) Blood , vol.111 , pp. 624-632
    • Fang, C.J.1    Fremeaux-Bacchi, V.2    Liszewski, M.K.3    Norism, P.G.4
  • 98
    • 79953691827 scopus 로고    scopus 로고
    • Mutations in complement regulatory proteins predispose to preeclampsia: A genetic analysis of the PROMISSE cohort
    • Salmon JE, Heuser C, Triebwasser M, Liszewski MK, Kavanagh D, et al. 2013 Mutations in complement regulatory proteins predispose to preeclampsia: a genetic analysis of the PROMISSE cohort. PLoS Med. 8 3 e1001013
    • (2013) PLoS Med. , vol.8 , Issue.3
    • Salmon, J.E.1    Heuser, C.2    Triebwasser, M.3    Liszewski, M.K.4    Kavanagh, D.5
  • 99
    • 33748450585 scopus 로고    scopus 로고
    • Complement activation induces dysregulation of angiogenic factors and causes fetal rejection and growth restriction
    • Girardi G, Yarilin D, Thurman JM, Holers VM, Salmon JE. 2006. Complement activation induces dysregulation of angiogenic factors and causes fetal rejection and growth restriction. J. Exp.Med. 203:2165-75
    • (2006) J. Exp.Med. , vol.203 , pp. 2165-2175
    • Girardi, G.1    Yarilin, D.2    Thurman, J.M.3    Holers, V.M.4    Salmon, J.E.5
  • 100
    • 78651381284 scopus 로고    scopus 로고
    • Targeted inhibition of complement activation prevents features of preeclampsia in mice
    • Qing X, Redecha PB, Burmeister MA, Tomlinson S, D'Agati VD, et al. 2011. Targeted inhibition of complement activation prevents features of preeclampsia in mice. Kidney Int. 79:331-39
    • (2011) Kidney Int. , vol.79 , pp. 331-339
    • Qing, X.1    Redecha, P.B.2    Burmeister, M.A.3    Tomlinson, S.4    D'Agati, V.D.5
  • 102
    • 84866027849 scopus 로고    scopus 로고
    • Paroxysmal nocturnal hemoglobinuria and other complement-mediated hematological disorders
    • Risitano AM. 2012. Paroxysmal nocturnal hemoglobinuria and other complement-mediated hematological disorders. Immunobiology 217:1080-87
    • (2012) Immunobiology , vol.217 , pp. 1080-1087
    • Risitano, A.M.1
  • 103
    • 35948959015 scopus 로고    scopus 로고
    • Discovery and development of the complement inhibitor eculizumab for the treatment of paroxysmal nocturnal hemoglobinuria
    • Rother RP, Rollins SA, Mojcik CF, Brodsky RA, Bell L. 2007. Discovery and development of the complement inhibitor eculizumab for the treatment of paroxysmal nocturnal hemoglobinuria. Nat. Biotech. 25:1256-64
    • (2007) Nat. Biotech. , vol.25 , pp. 1256-1264
    • Rother, R.P.1    Rollins, S.A.2    Mojcik, C.F.3    Brodsky, R.A.4    Bell, L.5
  • 104
    • 65449188713 scopus 로고    scopus 로고
    • Complement fraction 3 binding on erythrocytes as an additional mechanism of disease in paroxysmal nocturnal hemoglobinuria patients treated by eculizumab
    • Risitano AM, Notaro R, Marando L, Serio B, Ranaldi D, et al. 2009. Complement fraction 3 binding on erythrocytes as an additional mechanism of disease in paroxysmal nocturnal hemoglobinuria patients treated by eculizumab. Blood 113:4094-100
    • (2009) Blood , vol.113 , pp. 4094-4100
    • Risitano, A.M.1    Notaro, R.2    Marando, L.3    Serio, B.4    Ranaldi, D.5
  • 106
    • 84875324495 scopus 로고    scopus 로고
    • Eculizumab in the treatment of aytpical haemolytic uraemic syndrome and other complement-mediated renal diseases
    • Nester CM, Brophy PD. 2012. Eculizumab in the treatment of aytpical haemolytic uraemic syndrome and other complement-mediated renal diseases. Curr. Opin. Pediatr. 25:225-31
    • (2012) Curr. Opin. Pediatr. , vol.25 , pp. 225-231
    • Nester, C.M.1    Brophy, P.D.2
  • 107
    • 84872336333 scopus 로고    scopus 로고
    • Treatment of atypical hemolytic uremic syndrome and thrombotic microangiopathies: A focus on eculizumab
    • Schmidtko J, Peine S, El-Housseini Y, Pascual M, Meier P. 2013. Treatment of atypical hemolytic uremic syndrome and thrombotic microangiopathies: a focus on eculizumab. Am. J. Kidney Dis. 61:289-99
    • (2013) Am. J. Kidney Dis. , vol.61 , pp. 289-299
    • Schmidtko, J.1    Peine, S.2    El-Housseini, Y.3    Pascual, M.4    Meier, P.5
  • 108
    • 84877919003 scopus 로고    scopus 로고
    • Eculizumab in AQP4- IgG-positive relapsing neuromyelitis optica spectrum disorders: An open-label pilot study
    • Pittock SJ, Lennon VA, McKeon A, Mandrekar J,Weinshenker BG, et al. 2013. Eculizumab in AQP4- IgG-positive relapsing neuromyelitis optica spectrum disorders: an open-label pilot study. Lancet Neurol. 12:554-62
    • (2013) Lancet Neurol. , vol.12 , pp. 554-562
    • Pittock, S.J.1    Lennon, V.A.2    McKeon, A.3    Mandrekar, J.4    Weinshenker, B.G.5
  • 109
    • 73249123246 scopus 로고    scopus 로고
    • Update on therapeutic developments for hereditary angioedema
    • Christiansen SC, Zuraw BL. 2009. Update on therapeutic developments for hereditary angioedema. Allergy Asthma Proc. 30:500-5
    • (2009) Allergy Asthma Proc. , vol.30 , pp. 500-505
    • Christiansen, S.C.1    Zuraw, B.L.2
  • 110
    • 33751103471 scopus 로고    scopus 로고
    • Age-related macular degeneration: Emerging pathogenetic and therapeutic concepts
    • Gehrs KM, Anderson DH, Johnson LV,Hageman GS. 2006. Age-related macular degeneration: emerging pathogenetic and therapeutic concepts. Ann. Med. 38:450-71
    • (2006) Ann. Med. , vol.38 , pp. 450-471
    • Gehrs, K.M.1    Anderson, D.H.2    Johnson, L.V.3    Hageman, G.S.4
  • 111
    • 79952112401 scopus 로고    scopus 로고
    • Oxidation and age-related macular degeneration: Insights frommolecular biology
    • Khandhadia S, Lotery A. 2010. Oxidation and age-related macular degeneration: insights frommolecular biology. Expert Rev. Mol. Med. 12:e34
    • (2010) Expert Rev. Mol. Med. , vol.12
    • Khandhadia, S.1    Lotery, A.2
  • 112
    • 34548303819 scopus 로고    scopus 로고
    • The role of the complement system in ocular diseases including uveitis and macular degeneration
    • Jha P, Bora PS, Bora NS. 2007. The role of the complement system in ocular diseases including uveitis and macular degeneration. Mol. Immunol. 44:3901-8
    • (2007) Mol. Immunol. , vol.44 , pp. 3901-3908
    • Jha, P.1    Bora, P.S.2    Bora, N.S.3
  • 113
    • 79951551543 scopus 로고    scopus 로고
    • The alternative pathway is required, but not alone sufficient, for retinal pathology in mouse laser-induced choroidal neovascularization
    • Rohrer B, Coughlin B, Kunchithapautham K, LongQ,Tomlinson S, et al. 2011. The alternative pathway is required, but not alone sufficient, for retinal pathology in mouse laser-induced choroidal neovascularization. Mol. Immunol. 48:e1-e8
    • (2011) Mol. Immunol. , vol.48
    • Rohrer, B.1    Coughlin, B.2    Kunchithapautham, K.3    Longqtomlinson, S.4
  • 114
    • 33746190776 scopus 로고    scopus 로고
    • Complement activation via alternative pathway is critical in the development of laser-induced choroidal neovascularization: Role of factor B and factor H
    • Bora NS, Kaliappan S, Jha P, Xu Q, Sohn JH, et al. 2006. Complement activation via alternative pathway is critical in the development of laser-induced choroidal neovascularization: role of factor B and factor H. J. Immunol. 177:1872-78
    • (2006) J. Immunol. , vol.177 , pp. 1872-1878
    • Bora, N.S.1    Kaliappan, S.2    Jha, P.3    Xu, Q.4    Sohn, J.H.5
  • 116
    • 79955721853 scopus 로고    scopus 로고
    • A non membrane-targeted human soluble CD59 attenuates choroidal neovascularization in a model of age-related macular degeneration
    • Cashman SM, Ramo K, Kumar-Singh R. 2011. A non membrane-targeted human soluble CD59 attenuates choroidal neovascularization in a model of age-related macular degeneration. PLoS ONE 6:e19078
    • (2011) PLoS ONE , vol.6
    • Cashman, S.M.1    Ramo, K.2    Kumar-Singh, R.3
  • 117
    • 84877125681 scopus 로고    scopus 로고
    • Oxidative stress sensitizes retinal pigmented epithelial (RPE) cells to complement-mediated injury in a natural antibody-, lectin pathway-, and phospholipid epitope-dependent manner
    • Joseph K, Kulik L, Couglin B, Coughlin B, Kunchithapautham K, et al. 2013. Oxidative stress sensitizes retinal pigmented epithelial (RPE) cells to complement-mediated injury in a natural antibody-, lectin pathway-, and phospholipid epitope-dependent manner. J. Biol. Chem. 288:12753-65
    • (2013) J. Biol. Chem. , vol.288 , pp. 12753-12765
    • Joseph, K.1    Kulik, L.2    Couglin, B.3    Coughlin, B.4    Kunchithapautham, K.5
  • 118
    • 0037369949 scopus 로고    scopus 로고
    • Administration of a soluble recombinant complement C3 inhibitor protects against renal disease in MRL/lpr mice
    • Bao L,Haas M, Kraus DM, Hack BK, Rakstang JK, et al. 2003. Administration of a soluble recombinant complement C3 inhibitor protects against renal disease in MRL/lpr mice. J. Am. Soc. Nephrol. 14:670-79
    • (2003) J. Am. Soc. Nephrol. , vol.14 , pp. 670-679
    • Bao Lhaas, M.1    Kraus, D.M.2    Hack, B.K.3    Rakstang, J.K.4
  • 119
    • 0347992784 scopus 로고    scopus 로고
    • Effects of complement factor D deficiency on the renal disease of MRL/lpr mice
    • Elliott MK, Jarmi T, Ruiz P, Xu Y, Holers VM, Gilkeson GS. 2004. Effects of complement factor D deficiency on the renal disease of MRL/lpr mice. Kidney Int. 65:129-38
    • (2004) Kidney Int. , vol.65 , pp. 129-138
    • Elliott, M.K.1    Jarmi, T.2    Ruiz, P.3    Xu, Y.4    Holers, V.M.5    Gilkeson, G.S.6
  • 120
    • 79953729061 scopus 로고    scopus 로고
    • The benefit of targeted and selective inhibition of the alternative complement pathway for modulating autoimmunity and renal disease in MRL/lpr mice
    • Sekine H, Kinser TT, Qiao F, Martinez E, Paulling E, et al. 2011. The benefit of targeted and selective inhibition of the alternative complement pathway for modulating autoimmunity and renal disease in MRL/lpr mice. Arthritis Rheum. 63:1076-85
    • (2011) Arthritis Rheum. , vol.63 , pp. 1076-1085
    • Sekine, H.1    Kinser, T.T.2    Qiao, F.3    Martinez, E.4    Paulling, E.5
  • 121
    • 82455209021 scopus 로고    scopus 로고
    • The dual role of complement in the progression of renal disease in NZB/W F(1) mice and alternative pathway inhibition
    • Sekine H, Ruiz P, Gilkeson GS, Tomlinson S. 2011. The dual role of complement in the progression of renal disease in NZB/W F(1) mice and alternative pathway inhibition. Mol. Immunol. 49:317-23
    • (2011) Mol. Immunol. , vol.49 , pp. 317-323
    • Sekine, H.1    Ruiz, P.2    Gilkeson, G.S.3    Tomlinson, S.4
  • 122
    • 79952481036 scopus 로고    scopus 로고
    • Targeting B cells for the treatment of SLE: The beginning of the end or the end of the beginning? Discov
    • Calero I, Sanz I. 2010. Targeting B cells for the treatment of SLE: the beginning of the end or the end of the beginning? Discov. Med. 10:416-24
    • (2010) Med. , vol.10 , pp. 416-424
    • Calero, I.1    Sanz, I.2
  • 123
    • 79960918034 scopus 로고    scopus 로고
    • BAFF and selection of autoreactive B cells
    • Liu Z, Davidson A. 2011. BAFF and selection of autoreactive B cells. Trends Immunol. 32:388-94
    • (2011) Trends Immunol. , vol.32 , pp. 388-394
    • Liu, Z.1    Davidson, A.2
  • 124
    • 79956335222 scopus 로고    scopus 로고
    • Lessons from an anti-DNA autoantibody
    • Cohen-Solal J, Diamond B. 2011. Lessons from an anti-DNA autoantibody. Mol. Immunol. 48:1328-31
    • (2011) Mol. Immunol. , vol.48 , pp. 1328-1331
    • Cohen-Solal, J.1    Diamond, B.2
  • 125
    • 5044225201 scopus 로고    scopus 로고
    • A protective role for innate immunity in systemic lupus erythematosus
    • Carroll MC. 2004. A protective role for innate immunity in systemic lupus erythematosus. Nat. Rev. Immunol. 4:825-31
    • (2004) Nat. Rev. Immunol. , vol.4 , pp. 825-831
    • Carroll, M.C.1
  • 126
    • 0032211714 scopus 로고    scopus 로고
    • A critical role for complement in maintenance of self-tolerance
    • Prodeus A, Goerg S, Shen L-M, Pozdnyakova OO, Chu L, et al. 1998. A critical role for complement in maintenance of self-tolerance. Immunity 9:721-31
    • (1998) Immunity , vol.9 , pp. 721-731
    • Prodeus, A.1    Goerg, S.2    Shen, L.-M.3    Pozdnyakova, O.O.4    Chu, L.5
  • 127
    • 2342652252 scopus 로고    scopus 로고
    • CR1/CR2 deficiency alters IgG3 autoantibody production and IgA glomerular deposition in the MRL/lpr model of SLE
    • Boackle SA, Culhane KK, Brown JM, Haas M, Bao L, et al. 2004. CR1/CR2 deficiency alters IgG3 autoantibody production and IgA glomerular deposition in the MRL/lpr model of SLE. Autoimmunity 37:111-23
    • (2004) Autoimmunity , vol.37 , pp. 111-123
    • Boackle, S.A.1    Culhane, K.K.2    Brown, J.M.3    Haas, M.4    Bao, L.5
  • 128
    • 0028558328 scopus 로고
    • Epidemiology of rheumatoid arthritis
    • Silman AJ. 1994. Epidemiology of rheumatoid arthritis. APMIS 102:721-28
    • (1994) APMIS , vol.102 , pp. 721-728
    • Silman, A.J.1
  • 129
    • 0002625724 scopus 로고
    • Rheumatoid arthritis
    • ed. AJ Silman, MC Hochberg New York: Oxford Univ. Press
    • Silman AJ, Hochberg MC. 1993. Rheumatoid arthritis. In Epidemiology of the Rheumatic Diseases, ed. AJ Silman, MC Hochberg, pp. 7-68. New York: Oxford Univ. Press
    • (1993) Epidemiology of the Rheumatic Diseases , pp. 7-68
    • Silman, A.J.1    Hochberg, M.C.2
  • 130
    • 0034767917 scopus 로고    scopus 로고
    • The innate immune system in rheumatoid arthritis
    • Arend WP. 2001. The innate immune system in rheumatoid arthritis. Arthritis Rheum. 44:2224-34
    • (2001) Arthritis Rheum. , vol.44 , pp. 2224-2234
    • Arend, W.P.1
  • 131
    • 0038011833 scopus 로고    scopus 로고
    • Evolving concepts of rheumatoid arthritis
    • Firestein GS. 2003. Evolving concepts of rheumatoid arthritis. Nature 423:356-61
    • (2003) Nature , vol.423 , pp. 356-361
    • Firestein, G.S.1
  • 132
    • 0016825142 scopus 로고
    • Identification of immunoglobulins and complement in rheumatoid articular collagenous tissues
    • Cooke TD, Hurd ER, Jasin HE, Bienenstock H, Ziff M. 1975. Identification of immunoglobulins and complement in rheumatoid articular collagenous tissues. Arthritis Rheum. 18:541-51
    • (1975) Arthritis Rheum. , vol.18 , pp. 541-551
    • Cooke, T.D.1    Hurd, E.R.2    Jasin, H.E.3    Bienenstock, H.4    Ziff, M.5
  • 133
    • 0033390443 scopus 로고    scopus 로고
    • Complement activation and inhibition in experimental models of arthritis
    • Linton SM,Morgan BP. 1999. Complement activation and inhibition in experimental models of arthritis. Mol. Immunol. 36:905-14
    • (1999) Mol. Immunol. , vol.36 , pp. 905-914
    • Linton Smmorgan, B.P.1
  • 134
    • 0036226744 scopus 로고    scopus 로고
    • Local production of complement proteins in rheumatoid arthritis synovium
    • Neumann E, Barnum SR, Tarner IH, Echols J, Fleck M, et al. 2002. Local production of complement proteins in rheumatoid arthritis synovium. Arthritis Rheum. 46:934-45
    • (2002) Arthritis Rheum. , vol.46 , pp. 934-945
    • Neumann, E.1    Barnum, S.R.2    Tarner, I.H.3    Echols, J.4    Fleck, M.5
  • 135
    • 33746210208 scopus 로고    scopus 로고
    • Alternative complement pathway activation is essential for inflammation and joint destruction in the passive transfer model of collageninduced arthritis
    • Banda NK, Thurman JM, Kraus D,Wood A, Carroll MC, et al. 2006. Alternative complement pathway activation is essential for inflammation and joint destruction in the passive transfer model of collageninduced arthritis. J. Immunol. 177:1904-12
    • (2006) J. Immunol. , vol.177 , pp. 1904-1912
    • Banda, N.K.1    Thurman, J.M.2    Kraus Dwood, A.3    Carroll, M.C.4
  • 136
    • 35748950136 scopus 로고    scopus 로고
    • Pathogenic complement activation in collagen antibody-induced arthritis inmice requires amplification by the alternative pathway
    • BandaNK, TakahashiK,Wood AK,HolersVM, Arend WP. 2007. Pathogenic complement activation in collagen antibody-induced arthritis inmice requires amplification by the alternative pathway. J. Immunol. 179:4101-9
    • (2007) J. Immunol. , vol.179 , pp. 4101-4109
    • Banda, N.K.1    Takahashi, K.2    Wood, A.K.3    Holers, V.M.4    Arend, W.P.5
  • 137
    • 84863027826 scopus 로고    scopus 로고
    • Role of C3a receptors, C5a receptors, and complement protein C6 deficiency in collagen antibody-induced arthritis in mice
    • Banda NK, Hyatt S, Antonioli AH, White JT, Glogowska M, et al. 2012. Role of C3a receptors, C5a receptors, and complement protein C6 deficiency in collagen antibody-induced arthritis in mice. J. Immunol. 188:1469-78
    • (2012) J. Immunol. , vol.188 , pp. 1469-1478
    • Banda, N.K.1    Hyatt, S.2    Antonioli, A.H.3    White, J.T.4    Glogowska, M.5
  • 138
    • 84866033089 scopus 로고    scopus 로고
    • Interactions of the complement system with molecules of extracellular matrix: Relevance for joint diseases
    • Happonen KE, Heinegard D, Saxne T, Blom AM. 2012. Interactions of the complement system with molecules of extracellular matrix: relevance for joint diseases. Immunobiology 217:1088-96
    • (2012) Immunobiology , vol.217 , pp. 1088-1096
    • Happonen, K.E.1    Heinegard, D.2    Saxne, T.3    Blom, A.M.4
  • 139
    • 41849112297 scopus 로고    scopus 로고
    • Complement receptor CR2/CR1 deficiency protects mice from collagen-induced arthritis and associates with reduced autoantibodies to type II collagen and citrullinated antigens
    • Kuhn KA, Cozine CL, Tomooka B, Robinson WH,Holers VM. 2008. Complement receptor CR2/CR1 deficiency protects mice from collagen-induced arthritis and associates with reduced autoantibodies to type II collagen and citrullinated antigens. Mol. Immunol. 45:2808-19
    • (2008) Mol. Immunol. , vol.45 , pp. 2808-2819
    • Kuhn, K.A.1    Cozine, C.L.2    Tomooka, B.3    Robinson, W.H.4    Holers, V.M.5
  • 140
  • 141
    • 69249152289 scopus 로고    scopus 로고
    • Treatment with a C5aR antagonist decreases pathology and enhances behavioral performance in murine models of Alzheimer's disease
    • FonsecaMI, Ager RR, Chu SH, Yazan O, Sanderson SD, et al. 2009. Treatment with a C5aR antagonist decreases pathology and enhances behavioral performance in murine models of Alzheimer's disease. J. Immunol. 183:1375-83
    • (2009) J. Immunol. , vol.183 , pp. 1375-1383
    • Fonsecami Ager, R.R.1    Chu, S.H.2    Yazan, O.3    Sanderson, S.D.4
  • 142
    • 84858638295 scopus 로고    scopus 로고
    • Early window of diabetes determinism in NOD mice, dependent on the complement receptor CRIg, identified by noninvasive imaging
    • Fu W, Wojtkiewicz G, Weissleder R, Benoist C,MathisD. 2012. Early window of diabetes determinism in NOD mice, dependent on the complement receptor CRIg, identified by noninvasive imaging. Nat. Immunol. 13:361-68
    • (2012) Nat. Immunol. , vol.13 , pp. 361-368
    • Fu, W.1    Wojtkiewicz, G.2    Weissleder, R.3    Benoist, C.4    Mathis, D.5
  • 143
    • 77955901581 scopus 로고    scopus 로고
    • Complement inhibition decreases the procoagulant response and confers organ protection in a baboon model of Escherichia coli sepsis
    • Silasi-Mansat R, Zhu H, Popescu NI, Peer G, Sfyroera G, et al. 2010. Complement inhibition decreases the procoagulant response and confers organ protection in a baboon model of Escherichia coli sepsis. Blood 116:1002-10
    • (2010) Blood , vol.116 , pp. 1002-1010
    • Silasi-Mansat, R.1    Zhu, H.2    Popescu, N.I.3    Peer, G.4    Sfyroera, G.5
  • 144
    • 84891629992 scopus 로고    scopus 로고
    • The role of complement in mAb-based therapies of cancer
    • Taylor RP, Lindorfer MA. 2014. The role of complement in mAb-based therapies of cancer. Methods. 65:18-27
    • (2014) Methods. , vol.65 , pp. 18-27
    • Taylor, R.P.1    Lindorfer, M.A.2
  • 145
    • 84862733696 scopus 로고    scopus 로고
    • A targeted complementdependent strategy to improve the outcome of mAb therapy, and characterization in a murine model of metastatic cancer
    • Elvington M, Huang Y, Morgan BP, Qiao F, van Rooijen N, et al. 2012. A targeted complementdependent strategy to improve the outcome of mAb therapy, and characterization in a murine model of metastatic cancer. Blood 119:6043-51
    • (2012) Blood , vol.119 , pp. 6043-6051
    • Elvington, M.1    Huang, Y.2    Morgan, B.P.3    Qiao, F.4    Van Rooijen, N.5
  • 147
    • 68849091034 scopus 로고    scopus 로고
    • A complement-dependent balance between hepatic ischemia/reperfusion injury and liver regeneration in mice
    • He S, Atkinson C, Qiao F, Cianflone K, Chen C, Tomlinson S. 2009. A complement-dependent balance between hepatic ischemia/reperfusion injury and liver regeneration in mice. J. Clin. Investig. 119:2304-16
    • (2009) J. Clin. Investig. , vol.119 , pp. 2304-2316
    • He, S.1    Atkinson, C.2    Qiao, F.3    Cianflone, K.4    Chen, C.5    Tomlinson, S.6
  • 148
    • 84871389256 scopus 로고    scopus 로고
    • Complement diagnostics: Concepts, indications, and practical guidelines
    • doi: 10.1155/2012/962702
    • Nilsson B, Ekdahl KN. 2012. Complement diagnostics: concepts, indications, and practical guidelines. Clin. Dev. Immunol. 2012:962702. doi: 10.1155/2012/962702
    • (2012) Clin. Dev. Immunol. , vol.2012 , pp. 962702
    • Nilsson, B.1    Ekdahl, K.N.2
  • 149
    • 84882449068 scopus 로고    scopus 로고
    • Genetic insights into common pathways and complex relationships among immune-mediated diseases
    • Parkes M, Cortes A, van Heel DA, Brown MA. 2013. Genetic insights into common pathways and complex relationships among immune-mediated diseases. Nat. Rev. Genet. 14:661-73
    • (2013) Nat. Rev. Genet. , vol.14 , pp. 661-673
    • Parkes, M.1    Cortes, A.2    Van Heel, D.A.3    Brown, M.A.4
  • 150
    • 84877145565 scopus 로고    scopus 로고
    • Detection of complement activation using monoclonal antibodies against C3d
    • Thurman JM, Kulik L, Orth H, Wong M, Renner B, et al. 2103. Detection of complement activation using monoclonal antibodies against C3d. J. Clin. Investig. 123:2218-30
    • J. Clin. Investig. , vol.123 , pp. 2218-2230
    • Thurman, J.M.1    Kulik, L.2    Orth, H.3    Wong, M.4    Renner, B.5
  • 151
    • 84934442096 scopus 로고    scopus 로고
    • CR2-mediated targeting of complement inhibitors: Bench-tobedside using a novel strategy for site-specific complement modulation
    • HolersVM,Rohrer B,Tomlinson S. 2103. CR2-mediated targeting of complement inhibitors: bench-tobedside using a novel strategy for site-specific complement modulation. Adv. Exp.Med. Biol. 735:137-54
    • Adv. Exp.Med. Biol. , vol.735 , pp. 137-154
    • Holers, V.M.1    Rohrer, B.2    Tomlinson, S.3


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