Complement regulatory protein CD46 protects against choroidal neovascularization in mice

American Journal of Pathology

Volumn 184, Issue 9, 2014, Pages 2537-2548

  Lyzogubov, Valeriy ^a   Wu, Xiaobo ^b   Jha, Purushottam ^a   Tytarenko, Ruslana ^a   Triebwasser, Michael ^b   Kolar, Grant ^b   Bertram, Paula ^b   Bora, Puran S ^a   Atkinson, John P ^b   Bora, Nalini S ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT MEMBRANE ATTACK COMPLEX; MEMBRANE COFACTOR PROTEIN; MESSENGER RNA; VASCULOTROPIN; VIMENTIN; MCP PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARGON LASER; ARTICLE; COMPLEMENT ACTIVATION; CONTROLLED STUDY; EYE PROTECTION; GENOTYPE; LASER COAGULATION; MOUSE; NONHUMAN; PHOTORECEPTOR; PIGMENT EPITHELIUM; PRIORITY JOURNAL; SUBRETINAL NEOVASCULARIZATION; ANIMAL; C57BL MOUSE; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOHISTOCHEMISTRY; KNOCKOUT MOUSE; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; ANTIGENS, CD46; BLOTTING, WESTERN; CHOROIDAL NEOVASCULARIZATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; IMMUNOHISTOCHEMISTRY; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84906243951     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2014.06.001     Document Type: Article

References (49)

1. D.S. Friedman, B.J. O'Colmain, B. Muñoz, S.C. Tomany, C. McCarty, P.T. de Jong, B. Nemesure, P. Mitchell, J. Kempen Eye Diseases Prevalence Research Group Prevalence of age-related macular degeneration in the United States [Erratum appeared in Arch Ophthalmol 2011, 129:1188] Arch Ophthalmol 122 2004 564 572
2. H.R. Coleman, C.C. Chan, F.L. Ferris 3rd, and E.Y. Chew Age-related macular degeneration Lancet 372 2008 1835 1845
3. K.M. Gehrs, D.H. Anderson, L.V. Johnson, and G.S. Hageman Age-related macular degeneration-emerging pathogenetic and therapeutic concepts Ann Med 38 2006 450 471
4. J.B. Christoforidis, N. Tecce, R. Dell'Omo, R. Mastropasqua, M. Verolino, and C. Costagliola Age related macular degeneration and visual disability Curr Drug Targets 12 2011 221 233
5. D.B. Rein, J.S. Wittenborn, X. Zhang, A.A. Honeycutt, S.B. Lesesne, J. Saaddine Vision Health Cost-Effectiveness Study Group Forecasting age-related macular degeneration through the year 2050: the potential impact of new treatments Arch Ophthalmol 127 2009 533 540
6. D. Husain, B. Ambati, A.P. Adamis, and J.W. Miller Mechanisms of age-related macular degeneration Ophthalmol Clin North Am 15 2002 87 91
7. W. Smith, J. Assink, R. Klein, P. Mitchell, C.C. Klaver, B.E.K. Klein, A. Hofman, S. Jensen, J.J. Wang, and P.T. de Jong Risk factors for age-related macular degeneration: pooled findings from three continents Ophthalmology 108 2001 697 704
8. J.R. Evans Risk factors for age-related macular degeneration Prog Retin Eye Res 20 2001 227 253
9. S. Khandhadia, J. Cherry, and A.J. Lotery Age-related macular degeneration Adv Exp Med Biol 724 2012 15 36
10. J.R. Yates, and A.T. Moore Genetic susceptibility to age related macular degeneration J Med Genet 37 2000 83 87
11. N.S. Bora, P. Jha, V.V. Lyzogubov, and P.S. Bora Emerging role of complement in ocular diseases Curr Immunol Rev 7 2011 360 367
12. N.S. Bora, P. Jha, and P.S. Bora The role of complement in ocular pathology Semin Immunopathol 30 2008 85 95
13. D.H. Anderson, M.J. Radeke, N.B. Gallo, E.A. Chapin, P.T. Johnson, C.R. Curletti, L.S. Hancox, J. Hu, J.N. Ebright, G. Malek, M.A. Hauser, C.B. Rickman, D. Bok, G.S. Hageman, and L.V. Johnson The pivotal role of the complement system in aging and age-related macular degeneration: hypothesis re-visited Prog Retin Eye Res 29 2010 95 112
14. L.V. Johnson, W.P. Leitner, M.K. Staples, and D.H. Anderson Complement activation and inflammatory processes in drusen formation and age related macular degeneration Exp Eye Res 73 2001 887 896
15. J.M. Seddon, Y. Yu, E.C. Miller, R. Reynolds, P.L. Tan, S. Gowrisankar, J.I. Goldstein, M. Triebwasser, H.E. Anderson, J. Zerbib, D. Kavanagh, E. Souied, N. Katsanis, M.J. Daly, J.P. Atkinson, and S. Raychaudhuri Rare variants in CFI, C3 and C9 are associated with high risk of advanced age-related macular degeneration Nat Genet 45 2013 1366 1370
16. P.S. Bora, J.H. Sohn, J.M. Cruz, P. Jha, H. Nishihori, Y. Wang, S. Kaliappan, H.J. Kaplan, and N.S. Bora Role of complement and complement membrane attack complex in laser-induced choroidal neovascularization J Immunol 174 2005 491 497
17. N.S. Bora, S. Kaliappan, P. Jha, Q. Cu, J.H. Sohn, D.B. Dhaulakhandi, H.J. Kaplan, and P.S. Bora Complement activation via alternative pathway is critical in the development of laser-induced choroidal neovascularization: role of factor B and factor H J Immunol 177 2006 1872 1878
18. N.S. Bora, S. Kaliappan, P. Jha, Q. Xu, B. Sivasankar, C.L. Harris, B.P. Morgan, and P.S. Bora CD59, a complement regulatory protein, controls choroidal neovascularization in a mouse model of wet-type age-related macular degeneration J Immunol 178 2007 1783 1790
19. S. Kaliappan, P. Jha, V.V. Lyzogubov, R.G. Tytarenko, N.S. Bora, and P.S. Bora Alcohol and nicotine consumption exacerbates choroidal neovascularization by modulating the regulation of complement system FEBS Lett 582 2008 3451 3458
20. N.S. Bora, P. Jha, V.V. Lyzogubov, S. Kaliappan, J. Liu, R.G. Tytarenko, D.A. Fraser, B.P. Morgan, and P.S. Bora Recombinant membrane-targeted form of CD59 inhibits the growth of choroidal neovascular complex in mice J Biol Chem 285 2010 33826 33833
21. V.V. Lyzogubov, R.G. Tytarenko, P. Jha, J. Liu, N.S. Bora, and P.S. Bora Role of ocular complement factor H in a murine model of choroidal neovascularization Am J Pathol 177 2010 1870 1880
22. V.V. Lyzogubov, R.G. Tytarenko, J. Liu, N.S. Bora, and P.S. Bora Polyethylene glycol (PEG)-induced mouse model of choroidal neovascularization J Biol Chem 286 2011 16229 16237
23. J. Liu, P. Jha, V.V. Lyzogubov, R.G. Tytarenko, N.S. Bora, and P.S. Bora Relationship between complement membrane attack complex, chemokine (C-C motif) ligand 2 (CCL2) and vascular endothelial growth factor in mouse model of laser-induced choroidal neovascularization J Biol Chem 286 2011 20991 21001
24. M.K. Liszewski, and J.P. Atkinson Regulatory proteins of complement J. Volanakis, M. Frank, The Human Complement System in Health and Disease 1998 Marcel Dekker New York 149 166
25. B.P. Morgan, and C.L. Harris Regulation in the complement system. Complement Regulatory Proteins 1999 Academic Press San Diego 32 38
26. M.K. Liszewski, M. Leung, W. Cui, V.B. Subramanian, J. Parkinson, P.N. Barlow, M. Manchester, and J.P. Atkinson Dissecting sites important for complement regulatory activity in membrane cofactor protein (MCP; CD46) J Biol Chem 275 2000 37692 37701
27. M.K. Liszewski, C. Kemper, J.D. Price, and J.P. Atkinson Emerging roles and new functions of CD46 Springer Semin Immunopathol 27 2005 345 358
28. N.S. Bora, C.L. Gobleman, J.P. Atkinson, J.S. Pepose, and H.J. Kaplan Differential expression of the complement regulatory proteins in the human eye Invest Ophthalmol Vis Sci 34 1993 3579 3584
29. J.H. Sohn, H.J. Kaplan, H.J. Suk, P.S. Bora, and N.S. Bora Complement regulatory activity of normal human intraocular fluid is mediated by MCP, DAF, and CD59 Invest Ophthalmol Vis Sci 41 2000 4195 4202
30. B.J. McLaughlin, W. Fan, J.J. Zheng, H. Cai, L.V. Del Priore, N.S. Bora, and H.J. Kaplan Novel role for a complement regulatory protein (CD46) in retinal pigment epithelial adhesion Invest Ophthalmol Vis Sci 44 2003 3669 3674
31. A.L. Fett, M.M. Hermann, P.S. Muether, B. Kirchhof, and S. Fauser Immunohistochemical localization of complement regulatory proteins in the human retina Histol Histopathol 27 2012 357 364
32. R.C. Riley-Vargas, S. Lanzendorf, and J.P. Atkinson Targeted and restricted complement activation on acrosome-reacted spermatozoa J Clin Invest 115 2005 1241 1249
33. R.C. Riley-Vargas, and J.P. Atkinson Expression of membrane cofactor protein (MCP; CD46) on spermatozoa: just a complement inhibitor? Mod Asp Immunobiol 3 2003 75 78
34. R.C. Riley, C. Kemper, M. Leung, and J.P. Atkinson Characterization of human membrane cofactor protein (MCP; CD46) on spermatozoa Mol Reprod Dev 62 2002 534 546
35. S.J. Ryan Subretinal neovascularization. Natural history of an experimental model Arch Ophthalmol 100 1982 1804 1809
36. P.A. Campochiaro Retinal and choroidal neovascularization J Cell Physiol 184 2000 301 310
37. B. Hogan, R. Beddington, F. Costantini, and E. Lacy Manipulating the Mouse Embryo: A Laboratory Manual ed 2. 1994 Cold Spring Harbor Laboratory Press Cold Spring Harbor, NY
38. M.K. Liszewski, P. Bertram, M.K. Leung, R. Hauhart, L. Zhang, and J.P. Atkinson Smallpox inhibitor of complement enzymes (SPICE): regulation of complement activation on cells and mechanism of its cellular attachment J Immunol 181 2008 4199 4207
39. S.D. Vogt, S.R. Barnum, C.A. Curcio, and R.W. Read Distribution of complement anaphylatoxin receptors and membrane-bound regulators in normal human retina Exp Eye Res 83 2006 834 840
40. K.B. Ebrahimi, N. Fijalkowski, M. Cano, and J.T. Handa Decreased membrane complement regulators in the retinal pigmented epithelium contributes to age-related macular degeneration J Pathol 229 2013 729 742
41. A. Tsujimura, K. Shida, M. Kitamura, M. Nomura, J. Takeda, H. Tanaka, M. Matsumoto, K. Matsumiya, A. Okuyama, Y. Nishimune, M. Okabe, and T. Seya Molecular cloning of a murine homologue of membrane cofactor protein (CD46): preferential expression in testicular germ cells Biochem J 330 1998 163 168
42. Y.U. Kim, T. Kinoshita, H. Molina, D. Hourcade, T. Seya, L.M. Wagner, and V.M. Holers Mouse complement regulatory protein Crry/p65 uses the specific mechanisms of both human decay-accelerating factor and membrane cofactor protein J Exp Med 181 1995 151 159
43. J.N. Mallam, M.Y. Hurwitz, T. Mahoney, P. Chévez-Barrios, and R.L. Hurwitz Efficient gene transfer into retinal cells using adenoviral vectors: dependence on receptor expression Invest Ophthalmol Vis Sci 45 2004 1680 1687
44. J. Ambati, A. Anand, S. Fernandez, E. Sakurai, B.C. Lynn, W.A. Kuziel, B.J. Rollins, and B.K. Ambati An animal model of age-related macular degeneration in senescent Ccl-2- or Ccr-2-deficient mice Nat Med 9 2003 1390 1397
45. S.A. Vinores, P.A. Campochiaro, A. Lee, R. McGehee, C. Gadegbeku, and W.R. Green Localization of blood-retinal barrier breakdown in human pathologic specimens by immunohistochemical staining for albumin Lab Invest 62 1990 742 750
46. J. Zhang, C. Gerhardinger, and M. Lorenzi Early complement activation and decreased levels of glycosylphosphatidylinositol-anchored complement inhibitors in human and experimental diabetic retinopathy Diabetes 51 2002 3499 3504
47. C. Campa, and S.P. Harding Anti-VEGF compounds in the treatment of neovascular age related macular degeneration Curr Drug Targets 12 2011 173 181
48. S.J. Kim, H.S. Toma, J.M. Barnett, and J.S. Penn Ketorolac inhibits choroidal neovascularization by suppression of retinal VEGF Exp Eye Res 91 2010 537 543
49. S.M. Couch, and S.J. Bakri Review of combination therapies for neovascular age-related macular degeneration Semin Ophthalmol 26 2011 114 120