A novel role for CD46 in wound repair

Frontiers in Immunology

Volumn 2, Issue JUL, 2011, Pages

  Cardone, John ^a   Al Shouli, Samia ^a   Kemper, Claudia ^a  

^a GUY S HOSPITAL   (United Kingdom)

Author keywords

CD46; Complement; Epithelial cells; Mucosal immunity; Wound healing

Indexed keywords

EID: 84869487567     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2011.00028     Document Type: Article

References (53)

1. Astier, A., Trescol-Biemont, M. C., Azocar, O., Lamouille, B., and Rabourdin-Combe, C. (2000). Cutting edge: CD46, a new cos-timulatory molecule for T cells, that induces p120CBL and LAT phosphorylation. J. Immunol. 164, 6091-6095.
2. Astier, A. L., and Hafler, D. A. (2007). Abnormal Tr1 differentiation in multiple sclerosis. J. Neuroimmunol. 191, 70-78.
3. Ayollo, D. V., Zhitnyak, I. Y., Vasiliev, J. M., and Gloushankova, N. A. (2009). Rearrangements of the actin cytoskeleton, and E-cadherin-based adherens junctions caused by neo-plasic transformation change cell-cell interactions. PLoS ONE 4, e8027. doi:10.1371/journal.pone.0008027.
4. Cardone, J., Le Friec, G., Vantourout, P., Roberts, A., Fuchs, A., Jackson, I., Suddason, T., Lord, G., Atkinson, J. P., Cope, A., Hayday, A., and Kemper, C. (2010). Complement regulator CD46 temporally regulates cytokine production by conventional and unconventional T cells. Nat. Immunol. 11, 862-871.
5. Cardone, L., Le Friec, G., and Kemper, C. (2011). CD46 in innate and adaptive immunity: an update. Clin. Exp. Immunol. 164, 301-311.
6. Cattaneo, R. (2004). Four viruses, two bacteria, and one receptor: membrane cofactor protein (CD46) as pathogens' magnet. J. Virol. 78, 4385-4388.
7. Cope, A., Le Friec, G., Cardone, J., and Kemper, C. (2011). The Th1 life-cycle: molecular control of IFN-γ to IL-10 switching. Trends Immunol. 32, 278-286.
8. Crimeen-Irwin, B., Ellis, S., Christiansen, D., Ludford-Menting, M. J., Milland, J., Lanteri, M., Love-land, B. E., Gerlier, D., and Russell, S. M. (2003). Ligand binding determines whether CD46 is internalized by clathrin-coated pits or macropinocytosis. J. Biol. Chem. 278, 46927-46937.
9. Delpire, E., and Gagnon, K. B. (2008). SPAK and OSR1: STE20 kinases involved in the regulation of ion homoeostasis and volume control in mammalian cells. Biochem. J. 409, 321-331.
10. Furuse, M., Sasaki, H., Fujimoto, K., and Tsukita, S. (1998). A single gene product, claudin-1 or -2, reconstitutes tight junction strands and recruits occludin in fibroblasts. J. Cell Biol. 143, 391-401.
11. Gill, D. B., and Atkinson, J. P. (2004). CD46 in Neisseria pathogenesis. Trends. Mol. Med. 10, 459-465.
12. He, S., Atkinson, C., Qiao, F., Cian-flone, K., Chen, X., and Tom-linson, S. (2009). A complement-dependent balance between hepatic ischemia/reperfusion injury and liver regeneration in mice. J. Clin. Invest. 119, 2304-2316.
13. Hugot, J. P., Chamaillard, M., Zouali, H., Lesage, S., Cezard, J. P., Belaiche, J., Almer, S., Tysk, C., O'Morain, C. A., Gassull, M., Binder, V., Finkel, Y., Cortot, A., Modigliani, R., Laurent-Puig, P., Gower-Rousseau, C., Macry, J., Colombel, J. F., Sahbatou, M., and Thomas, G. (2001). Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 411, 599-603.
14. Inoue, N., Ikawa, M., Nakanishi, T., Mat-sumoto, M., Nomura, M., Seya, T., and Okabe, M. (2003). Disruption of mouse CD46 causes an accelerated spontaneous acrosome reaction in sperm. Mol. Cell. Biol. 23, 2614-2622.
15. Ivanov, A. I., Young, C., Den Beste, K., Capaldo, C. T., Humbert, P. O., Bren-nwald, P., Parkos, C. A., and Nusrat, A. (2010). Tumor suppressor scribble regulates assembly of tight junctions in the intestinal epithelium. Am. J. Pathol. 176, 134-145.
16. Johansson, L., Rytkonen, A., Wan, H., Bergman, P., Plant, L., Ager-berth, B., Hokfelt, T., and Jonsson, A. B. (2005). Human-like immune responses in CD46 transgenic mice. J. Immunol. 175, 433-440.
17. Johnston, A. M., Naselli, G., Gonez, L. J., Martin, R. M., Harrison, L. C., and DeAizpurua, H. J. (2000). SPAK, a STE20/SPS1 -related kinase that activates the p38 pathway. Oncogene 19, 4290-4297.
18. Kallstrom, H., Islam, M. S., Berggren, P. O., and Jonsson, A. B. (1998). Cell signaling by the type IV pili of pathogenic Neisseria. J. Biol. Chem. 273, 21777-21782.
19. Kemper, C., and Atkinson, J. P. (2007). T-cell regulation: with complements from innate immunity. Nat. Rev. Immunol. 7, 9-18.
20. Kemper, C., Chan, A. C., Green, J. M., Brett, K. A., Murphy, K. M., and Atkinson, J. P. (2003). Activation of human CD4+ cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype. Nature 421, 388-392.
21. Kemper, C., Verbsky, J. W., Price, J. D., and Atkinson, J. P. (2005). T-cell stimulation and regulation: with complements from CD46. Immunol. Res. 32, 31-43.
22. Kobielak, A., and Fuchs, E. (2004). Alpha-catenin: at the junction of intercellular adhesion and actin dynamics. Nat. Rev. Mol. Cell Biol. 5, 614-625.
23. Le Friec, G., Bugeon, L., Dallman, M., and Kemper, C. (2010). CD46: just a notch up your complement regulator. Mol. Immunol. 47, 2229.
24. Lee, S. W., Bonnah, R. A., Higashi, D. L., Atkinson, J. P., Milgram, S. L., and So, M. (2002). CD46 is phospho-rylated at tyrosine 354 upon infection of epithelial cells by Neisseria gonorrhoeae. J. Cell Biol. 156, 951-957.
25. Li, K., Feito, M. J., Sacks, S. H., and Sheerin, N. S. (2006). CD46 (membrane cofactor protein) acts as a human epithelial cell receptor for internalization of opsonized uropathogenic Escherichia coli. J. Immunol. 177, 2543-2551.
26. Li, Y., Hu, J., Vita, R., Sun, B., Tabata, H., and Altman, A. (2004). SPAK kinase is a substrate and target of PKCtheta in T-cell receptor-induced AP-1 activation pathway. EMBO J. 23, 1112-1122.
27. Liszewski, M. K., Leung, M., Cui, W., Subramanian, V B., Parkinson, J., Barlow, P. N., Manchester, M., and Atkinson, J. P. (2000). Dissecting sites important for complement regulatory activity in membrane cofactor protein (MCP; CD46). J. Biol. Chem. 275, 37692-37701.
28. Liszewski, M. K., Post, T. W., and Atkinson, J. P. (1991). Membrane cofactor protein (MCP or CD46): newest member of the regulators of complement activation gene cluster. Annu. Rev. Immunol. 9, 431-455.
29. Lotz, M., Menard, S., and Hornef, M. (2007). Innate immune recognition on the intestinal mucosa. Int. J. Med. Microbiol. 297, 379-392.
30. Ludford-Menting, M. J., Thomas, S. J., Crimeen, B., Harris, L. J., Love-land, B. E., Bills, M., Ellis, S., and Russell, S. M. (2002). A functional interaction between CD46 and DLG4: a role for DLG4 in epithelial polarization. J. Biol. Chem. 277, 4477-4484.
31. Menard, S., Cerf-Bensussan, N., and Heyman, M. (2010). Multiple facets of intestinal permeability and epithelial handling of dietary antigens. Mucosal Immunol. 3, 247-259.
32. Moon, R., Parikh, A. A., Szabo, C., Fischer, J. E., Salzman, A. L., and Has-selgren, P. O. (1997). Complement C3 production in human intestinal epithelial cells is regulated by interleukin 1beta and tumor necrosis factor alpha. Arch. Surg. 132, 1289-1293.
33. Layers of mutualism with commensal bacteria protect us from intestinal inflammation
34. Nakamura, R., Watanabe, M., Sugimura, Y., Matsuno, S., Sato, T., Ishida, K., and Saito, K. (1995). Changes in wound healing factors in liver cirrhosis after esophageal transection for esophageal varices. Hepatogas-troenterology 42, 43-46.
35. Ogura, Y., Bonen, D. K., Inohara, N., Nicolae, D. L., Chen, F. F., Ramos, R., Britton, H., Moran, T., Karaliuskas, R., Duerr, R. H., Achkar, J. P., Brant, S. R., Bayless, T. M., Kirschner, B. S., Hanauer, S. B., Nuñez, G., and Cho, J. H. (2001). A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 411, 603-606.
36. Peignon, G., Durand, A., Cacheux, W., Ayrault, O., Terris, B., Laurent-Puig, P., Shroyer, N. F., Van Seuningen, I., Honjo, T., Perret, C., and Romag-nolo, B. (2011). Complex interplay between beta-catenin signalling and Notch effectors in intestinal tumori-genesis. Gut 60, 166-176.
37. Ricklin, D., Hajishengallis, G., Yang, K., and Lambris, J. D. (2010). Complement: a key system for immune surveillance and homeostasis. Nat. Immunol. 11, 785-797.
38. Riley, R. C., Tannenbaum, P. L., Abbott, D. H., and Atkinson, J. P. (2002). Cutting edge: inhibiting measles virus infection but promoting reproduction: an explanation for splicing and tissue-specific expression of CD46.J. Immunol. 169, 5405-5409.
39. Riley-Vargas, R. C., Gill, D. B., Kemper, C., Liszewski, M. K., and Atkinson, J. P. (2004). CD46: expanding beyond complement regulation. Trends Immunol. 25, 496-503.
40. Sanchez, A., Feito, M. J., and Rojo, J. M. (2004). CD46-mediated costimula-tion induces a Th1-biased response and enhances early TCR/CD3 signaling in human CD4+ T lymphocytes. Eur. J. Immunol. 34, 2439-2448.
41. San-Cristobal, P., Pacheco-Alvarez, D., Richardson, C., Ring, A. M., Vazquez, N., Rafiqi, F. H., Chari, D., Kahle, K. T., Leng, Q., Bobadilla, N. A., Hebert, S. C., Alessi, D. R., Lifton, R. P., and Gamba, G. (2009). Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through aWNK4-SPAK-dependent pathway. Proc. Natl. Acad. Sci. U.S.A. 106, 4384-4389.
42. Sansonetti, P. J. (2004). War and peace at mucosal surfaces. Nat. Rev. Immunol. 4, 953-964.
43. Sinn, P. L., Williams, G., Vongpunsawad, S., Cattaneo, R., and McCray, P. B. Jr. (2002). Measles virus preferentially transduces the basolateral surface of well-differentiated human airway epithelia. J. Virol. 76, 2403-2409.
44. Sjoblom, T., Jones, S., Wood, L. D., Parsons, D. W., Lin, J., Barber, T. D., Mandelker, D., Leary, R. J., Ptak, J., Silliman, N., Szabo, S., Buckhaults, P., Farrell, C., Meeh, P., Markowitz, S. D., Willis, J., Dawson, D., Willson, J. K., Gazdar, A. F., Hartigan, J., Wu, L., Liu, C., Parmigiani, G., Park, B. H., Bachman, K. E., Papadopoulos, N., Vogelstein, B., Kinzler, K. W., and Velculescu, V E. (2006). The consensus coding sequences of human breast and colorectal cancers. Science 314, 268-274.
45. Smith, L., Smallwood, N., Altman, A., and Liedtke, C. M. (2008). PKCdelta acts upstream of SPAK in the activation of NKCC1 by hyper-osmotic stress in human airway epithelial cells. J. Biol. Chem. 283, 22147-22156.
46. Strauss, R., Sova, P., Liu, Y., Li, Z. Y., Tuve, S., Pritchard, D., Brinkkoet-ter, P., Moller, T., Wildner, O., Peso-nen, S., Hemminki, A., Urban, N., Drescher, C., and Lieber, A. (2009). Epithelial phenotype confers resistance of ovarian cancer cells to oncolytic adenoviruses. Cancer Res. 69, 5115-5125.
47. Van Aken, E., De Wever, O., Correia da Rocha, A. S., and Mareel, M. (2001). Defective E-cadherin/catenin complexes in human cancer. Virchows Arch. 439, 725-751.
48. Vermeulen, S. J., Nollet, F., Teugels, E., Vennekens, K. M., Malfait, F., Philippe, J., Speleman, F., Bracke, M. E., van Roy, F. M., and Mareel, M. M. (1999). The alphaE-catenin gene (CTNNA1) acts as an invasion-suppressor gene in human colon cancer cells. Oncogene 18, 905-915.
49. Wang, G., Liszewski, M. K., Chan, A. C., and Atkinson, J. P. (2000). Membrane cofactor protein (MCP; CD46): isoform-specific tyrosine phosphorylation. J. Immunol. 164, 1839-1846.
50. Yamada, S., Pokutta, S., Drees, F., Weis, W. I., and Nelson, W J. (2005). Deconstructing the cadherin-catenin-actin complex. Cell 123, 889-901.
51. Yan, Y., Dalmasso, G., Nguyen, H. T., Obertone, T. S., Sitaraman, S. V., and Merlin, D. (2009). Ste20-related proline/alanine-rich kinase (SPAK) regulated transcriptionally by hyperosmolarity is involved in intestinal barrier function. PLoS ONE 4, e5049. doi: 10.1371/jour-nal.pone.0005049.
52. Yan, Y., Nguyen, H., Dalmasso, G., Sitaraman, S. V., and Merlin, D. (2007). Cloning and characterization of a new intestinal inflammation-associated colonic epithelial Ste20-related protein kinase isoform. Biochim. Biophys. Acta 1769, 106-116.
53. Zeng, Q., and Hong, W (2008). The emerging role of the hippo pathway in cell contact inhibition, organ size control, and cancer development in mammals. Cancer Cell 13, 188-192.