Bioactive small molecules reveal antagonism between the integrated stress response and sterol-regulated gene expression

Cell Metabolism

Volumn 2, Issue 6, 2005, Pages 361-371

  Harding, Heather P ^a   Zhang, Yuhong ^a   Khersonsky, Sonya ^a   Marciniak, Stefan ^a   Scheuner, Donalyn ^b   Kaufman, Randal J ^b   Javitt, Norman ^a   Chang, Young Tae ^a   Ron, David ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; COMPACTIN; INITIATION FACTOR 2ALPHA; KETOCONAZOLE; MESSENGER RNA; MEVALONIC ACID; OLEIC ACID; STEROL 14ALPHA DEMETHYLASE; STEROL REGULATORY ELEMENT BINDING PROTEIN; TUNICAMYCIN; INITIATION FACTOR 2; LIPID; STEROL;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL SURVIVAL; CHEMICAL INTERACTION; CHOLESTEROL SYNTHESIS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; GENE CONTROL; GENE EXPRESSION; GENETIC TRANSCRIPTION; LIPID METABOLISM; MOUSE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STEROL METABOLISM; TRANSCRIPTION REGULATION; TRANSLATION INITIATION; ANIMAL; BIOLOGICAL MODEL; CELL LINE; CHEMICAL MODEL; CHEMISTRY; DOSE RESPONSE; GENE EXPRESSION REGULATION; IMMUNOBLOTTING; METABOLISM; PHOSPHORYLATION; PROTEIN SYNTHESIS; THIN LAYER CHROMATOGRAPHY; TIME;

ANIMALIA;

ANIMALS; BLOTTING, NORTHERN; CELL LINE; CELL SURVIVAL; CHOLESTEROL; CHROMATOGRAPHY, THIN LAYER; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPLASMIC RETICULUM; EUKARYOTIC INITIATION FACTOR-2; GENE EXPRESSION REGULATION; IMMUNOBLOTTING; KETOCONAZOLE; LIPIDS; MICE; MODELS, BIOLOGICAL; MODELS, CHEMICAL; PHOSPHORYLATION; PROTEIN BIOSYNTHESIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; STEROL REGULATORY ELEMENT BINDING PROTEINS; STEROLS; TIME FACTORS; TRANSCRIPTION, GENETIC;

EID: 33644876816     PISSN: 15504131     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cmet.2005.11.005     Document Type: Article

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