Single treatment with RNAi against prion protein rescues early neuronal dysfunction and prolongs survival in mice with prion disease

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 29, 2008, Pages 10238-10243

  White, Melanie D ^a,b   Farmer, Michael ^a   Mirabile, Ilaria ^a   Brandner, Sebastian ^a   Collinge, John ^a   Mallucci, Giovanna R ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Behavior; Gene therapy; Neurodegeneration

Indexed keywords

LENTIVIRUS VECTOR; PRION PROTEIN; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR DISORDER; BRAIN SPONGIOSIS; COGNITIVE DEFECT; CONTROLLED STUDY; DRUG EFFICACY; GENE SILENCING; HIPPOCAMPUS; MOUSE; NERVE CELL DEGENERATION; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PRION DISEASE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; PROTEIN TARGETING; RNA INTERFERENCE; SURVIVAL TIME;

ANIMALS; BASE SEQUENCE; BEHAVIOR, ANIMAL; GENE THERAPY; GENES, REPORTER; GREEN FLUORESCENT PROTEINS; HIPPOCAMPUS; LENTIVIRUS; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; PRION DISEASES; PRIONS; PRPC PROTEINS; PRPSC PROTEINS; RNA INTERFERENCE; RNA, MESSENGER; RNA, SMALL INTERFERING;

ANIMALIA; LENTIVIRUS; MUS;

EID: 48249108696     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0802759105     Document Type: Article

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