Targeting the unfolded protein response in neurodegeneration: A new approach to therapy

Neuropharmacology

Volumn 76, Issue PART A, 2014, Pages 169-174

  Halliday, Mark ^a   Mallucci, Giovanna R ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

Alzheimer's disease; Neurodegeneration; Prion; Therapy; Translational control; Unfolded protein response

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; ACTIVATING TRANSCRIPTION FACTOR 6; ALPHA SYNUCLEIN; AMYLOID BETA PROTEIN; GLYCOGEN SYNTHASE KINASE 3BETA; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INITIATION FACTOR 2ALPHA; LEUCINE RICH REPEAT KINASE 2; MUTANT PROTEIN; PARKIN; PERK PROTEIN; PROTEIN IRE1; PROTEIN IRE1 ALPHA; PROTEIN IRE1 BETA; PROTEIN KINASE; PROTEIN KINASE R; SALUBRINAL; TAU PROTEIN; TRANSCRIPTION FACTOR NRF2; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1;

ALZHEIMER DISEASE; CELL PROTECTION; CELLULAR STRESS RESPONSE; DISEASE ASSOCIATION; DOPAMINERGIC NERVE CELL; DRUG EFFECT; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUNTINGTON CHOREA; MISSENSE MUTATION; MOLECULARLY TARGETED THERAPY; NERVE CELL NECROSIS; NERVE DEGENERATION; NEUROTOXICITY; NONHUMAN; PARKINSON DISEASE; PATHOGENESIS; PRION DISEASE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; PROTEIN SYNTHESIS; PROTEIN TARGETING; REVIEW; RNA TRANSLATION; TAUOPATHY; UNFOLDED PROTEIN RESPONSE;

ALZHEIMER'S DISEASE; NEURODEGENERATION; PRION; THERAPY; TRANSLATIONAL CONTROL; UNFOLDED PROTEIN RESPONSE;

ANIMALS; ENDOPLASMIC RETICULUM STRESS; HUMANS; MODELS, BIOLOGICAL; MOLECULAR TARGETED THERAPY; NEURODEGENERATIVE DISEASES; UNFOLDED PROTEIN RESPONSE;

EID: 84886581781     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2013.08.034     Document Type: Review

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