-
1
-
-
0001007610
-
Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells
-
Martin, G. R., Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proc. Natl. Acad. Sci. USA 1981, 78, 7634–7638.
-
(1981)
Proc. Natl. Acad. Sci. USA
, vol.78
, pp. 7634-7638
-
-
Martin, G.R.1
-
2
-
-
0019826665
-
Establishment in culture of pluripotential cells from mouse embryos
-
Evans, M. J., Kaufman, M. H., Establishment in culture of pluripotential cells from mouse embryos. Nature 1981, 292, 154–156.
-
(1981)
Nature
, vol.292
, pp. 154-156
-
-
Evans, M.J.1
Kaufman, M.H.2
-
3
-
-
0032491416
-
Embryonic stem cell lines derived from human blastocysts
-
Thomson, J. A., Itskovitz-Eldor, J., Shapiro, S. S., Waknitz, M. A. et al., Embryonic stem cell lines derived from human blastocysts. Science 1998, 282, 1145–1147.
-
(1998)
Science
, vol.282
, pp. 1145-1147
-
-
Thomson, J.A.1
Itskovitz-Eldor, J.2
Shapiro, S.S.3
Waknitz, M.A.4
-
4
-
-
34447528757
-
New cell lines from mouse epiblast share defining features with human embryonic stem cells
-
Tesar, P. J., Chenoweth, J. G., Brook, F. A., Davies, T. J. et al., New cell lines from mouse epiblast share defining features with human embryonic stem cells. Nature 2007, 448, 196–199.
-
(2007)
Nature
, vol.448
, pp. 196-199
-
-
Tesar, P.J.1
Chenoweth, J.G.2
Brook, F.A.3
Davies, T.J.4
-
5
-
-
34447527158
-
Derivation of pluripotent epiblast stem cells from mammalian embryos
-
Brons, I. G. M., Smithers, L. E., Trotter, M. W. B., Rugg-Gunn, P. et al., Derivation of pluripotent epiblast stem cells from mammalian embryos. Nature 2007, 448, 191–195.
-
(2007)
Nature
, vol.448
, pp. 191-195
-
-
Brons, I.G.M.1
Smithers, L.E.2
Trotter, M.W.B.3
Rugg-Gunn, P.4
-
6
-
-
33747195353
-
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
-
Takahashi, K., Yamanaka, S., Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006, 126, 663–676.
-
(2006)
Cell
, vol.126
, pp. 663-676
-
-
Takahashi, K.1
Yamanaka, S.2
-
7
-
-
36248966518
-
Induction of pluripotent stem cells from adult human fibroblasts by defined factors
-
Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M. et al., Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007, 131, 861–872.
-
(2007)
Cell
, vol.131
, pp. 861-872
-
-
Takahashi, K.1
Tanabe, K.2
Ohnuki, M.3
Narita, M.4
-
8
-
-
36749043230
-
Induced pluripotent stem cell lines derived from human somatic cells
-
Yu, J., Vodyanik, M. A., Smuga-Otto, K., Antosiewicz-Bourget, J. et al., Induced pluripotent stem cell lines derived from human somatic cells. Science 2007, 318, 1917–1920.
-
(2007)
Science
, vol.318
, pp. 1917-1920
-
-
Yu, J.1
Vodyanik, M.A.2
Smuga-Otto, K.3
Antosiewicz-Bourget, J.4
-
9
-
-
84959297971
-
Naive pluripotent stem cells derived directly from isolated cells of the human inner cell mass
-
Guo, G., Meyenn, von, F., Santos, F., Chen, Y. et al., Naive pluripotent stem cells derived directly from isolated cells of the human inner cell mass. Stem Cell Rep. 2016, 6, 437–446.
-
(2016)
Stem Cell Rep.
, vol.6
, pp. 437-446
-
-
Guo, G.1
von Meyenn, F.2
Santos, F.3
Chen, Y.4
-
10
-
-
84901837819
-
Defining an essential transcription factor program for naïve pluripotency
-
Dunn, S.-J., Martello, G., Yordanov, B., Emmott, S., Smith, A. G., Defining an essential transcription factor program for naïve pluripotency. Science 2014, 344, 1156–1160.
-
(2014)
Science
, vol.344
, pp. 1156-1160
-
-
Dunn, S.-J.1
Martello, G.2
Yordanov, B.3
Emmott, S.4
Smith, A.G.5
-
11
-
-
70450162700
-
Non-genetic heterogeneity of cells in development: more than just noise
-
Huang, S., Non-genetic heterogeneity of cells in development: more than just noise. Development 2009, 136, 3853–3862.
-
(2009)
Development
, vol.136
, pp. 3853-3862
-
-
Huang, S.1
-
12
-
-
84881171093
-
Statistical mechanics of pluripotency
-
MacArthur, B. D., Lemischka, I. R., Statistical mechanics of pluripotency. Cell 2013, 154, 484–489.
-
(2013)
Cell
, vol.154
, pp. 484-489
-
-
MacArthur, B.D.1
Lemischka, I.R.2
-
13
-
-
84901473732
-
Transcription factor heterogeneity in pluripotent stem cells: a stochastic advantage
-
Torres-Padilla, M.-E., Chambers, I., Transcription factor heterogeneity in pluripotent stem cells: a stochastic advantage. Development 2014, 141, 2173–2181.
-
(2014)
Development
, vol.141
, pp. 2173-2181
-
-
Torres-Padilla, M.-E.1
Chambers, I.2
-
14
-
-
84904012047
-
Stochastic NANOG fluctuations allow mouse embryonic stem cells to explore pluripotency
-
Abranches, E., Guedes, A. M. V., Moravec, M., Maamar, H. et al., Stochastic NANOG fluctuations allow mouse embryonic stem cells to explore pluripotency. Development 2014, 141, 2770–2779.
-
(2014)
Development
, vol.141
, pp. 2770-2779
-
-
Abranches, E.1
Guedes, A.M.V.2
Moravec, M.3
Maamar, H.4
-
15
-
-
84923188586
-
Deconstructing transcriptional heterogeneity in pluripotent stem cells
-
Kumar, R. M., Cahan, P., Shalek, A. K., Satija, R. et al., Deconstructing transcriptional heterogeneity in pluripotent stem cells. Nature 2014, 516, 56–61.
-
(2014)
Nature
, vol.516
, pp. 56-61
-
-
Kumar, R.M.1
Cahan, P.2
Shalek, A.K.3
Satija, R.4
-
16
-
-
84942981648
-
Network plasticity of pluripotency transcription factors in embryonic stem cells
-
Filipczyk, A., Marr, C., Hastreiter, S., Feigelman, J. et al., Network plasticity of pluripotency transcription factors in embryonic stem cells. Nat. Cell Biol. 2015, 17, 1235–1246.
-
(2015)
Nat. Cell Biol.
, vol.17
, pp. 1235-1246
-
-
Filipczyk, A.1
Marr, C.2
Hastreiter, S.3
Feigelman, J.4
-
17
-
-
39149130361
-
Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming
-
Jaenisch, R., Young, R., Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming. Cell 2008, 132, 567–582.
-
(2008)
Cell
, vol.132
, pp. 567-582
-
-
Jaenisch, R.1
Young, R.2
-
18
-
-
70349445264
-
Systems biology of stem cell fate and cellular reprogramming
-
MacArthur, B. D., Ma'ayan, A., Lemischka, I. R., Systems biology of stem cell fate and cellular reprogramming. Nat. Rev. Mol. Cell Biol. 2009, 10, 672–681.
-
(2009)
Nat. Rev. Mol. Cell Biol.
, vol.10
, pp. 672-681
-
-
MacArthur, B.D.1
Ma'ayan, A.2
Lemischka, I.R.3
-
19
-
-
77953365784
-
Extrinsic regulation of pluripotent stem cells
-
Pera, M. F., Tam, P. P. L., Extrinsic regulation of pluripotent stem cells. Nature 2010, 465, 713–720.
-
(2010)
Nature
, vol.465
, pp. 713-720
-
-
Pera, M.F.1
Tam, P.P.L.2
-
20
-
-
79952660821
-
Control of the embryonic stem cell state
-
Young, R. A., Control of the embryonic stem cell state. Cell 2011, 144, 940–954.
-
(2011)
Cell
, vol.144
, pp. 940-954
-
-
Young, R.A.1
-
21
-
-
79958252915
-
Chromatin connections to pluripotency and cellular reprogramming
-
Orkin, S. H., Hochedlinger, K., Chromatin connections to pluripotency and cellular reprogramming. Cell 2011, 145, 835–850.
-
(2011)
Cell
, vol.145
, pp. 835-850
-
-
Orkin, S.H.1
Hochedlinger, K.2
-
22
-
-
25144525014
-
Core transcriptional regulatory circuitry in human embryonic stem cells
-
Boyer, L. A., Lee, T. I., Cole, M. F., Johnstone, S. E. et al., Core transcriptional regulatory circuitry in human embryonic stem cells. Cell 2005, 122, 947–956.
-
(2005)
Cell
, vol.122
, pp. 947-956
-
-
Boyer, L.A.1
Lee, T.I.2
Cole, M.F.3
Johnstone, S.E.4
-
23
-
-
33646865180
-
Control of developmental regulators by Polycomb in human embryonic stem cells
-
Lee, T. I., Jenner, R. G., Boyer, L. A., Guenther, M. G. et al., Control of developmental regulators by Polycomb in human embryonic stem cells. Cell 2006, 125, 301–313.
-
(2006)
Cell
, vol.125
, pp. 301-313
-
-
Lee, T.I.1
Jenner, R.G.2
Boyer, L.A.3
Guenther, M.G.4
-
24
-
-
44649117905
-
Integration of external signaling pathways with the core transcriptional network in embryonic stem cells
-
Chen, X., Xu, H., Yuan, P., Fang, F. et al., Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell 2008, 133, 1106–1117.
-
(2008)
Cell
, vol.133
, pp. 1106-1117
-
-
Chen, X.1
Xu, H.2
Yuan, P.3
Fang, F.4
-
25
-
-
84924369505
-
Glycolysis-mediated changes in acetyl-CoA and histone acetylation control the early differentiation of embryonic stem cells
-
Moussaieff, A., Rouleau, M., Kitsberg, D., Cohen, M. et al., Glycolysis-mediated changes in acetyl-CoA and histone acetylation control the early differentiation of embryonic stem cells. Cell Metab. 2015, 21, 392–402.
-
(2015)
Cell Metab
, vol.21
, pp. 392-402
-
-
Moussaieff, A.1
Rouleau, M.2
Kitsberg, D.3
Cohen, M.4
-
26
-
-
0742305866
-
Network biology: understanding the cell's functional organization
-
Barabási, A.-L., Oltvai, Z. N., Network biology: understanding the cell's functional organization. Nat. Rev. Genet. 2004, 5, 101–113.
-
(2004)
Nat. Rev. Genet.
, vol.5
, pp. 101-113
-
-
Barabási, A.-L.1
Oltvai, Z.N.2
-
27
-
-
44349170450
-
The ground state of embryonic stem cell self-renewal
-
Ying, Q.-L., Wray, J., Nichols, J., Batlle-Morera, L. et al., The ground state of embryonic stem cell self-renewal. Nature 2008, 453, 519–523.
-
(2008)
Nature
, vol.453
, pp. 519-523
-
-
Ying, Q.-L.1
Wray, J.2
Nichols, J.3
Batlle-Morera, L.4
-
28
-
-
84901758151
-
The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification
-
Boroviak, T., Loos, R., Bertone, P., Smith, A., Nichols, J., The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification. Nat. Cell Biol. 2014, 16, 516–528.
-
(2014)
Nat. Cell Biol.
, vol.16
, pp. 516-528
-
-
Boroviak, T.1
Loos, R.2
Bertone, P.3
Smith, A.4
Nichols, J.5
-
29
-
-
84869095801
-
Nanog-dependent feedback loops regulate murine embryonic stem cell heterogeneity
-
MacArthur, B. D., Sevilla, A., Lenz, M., Müller, F.-J. et al., Nanog-dependent feedback loops regulate murine embryonic stem cell heterogeneity. Nat. Cell Biol. 2012, 14, 1139–1147.
-
(2012)
Nat. Cell Biol.
, vol.14
, pp. 1139-1147
-
-
MacArthur, B.D.1
Sevilla, A.2
Lenz, M.3
Müller, F.-J.4
-
30
-
-
0032582513
-
Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4
-
Nichols, J., Zevnik, B., Anastassiadis, K., Niwa, H. et al., Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell 1998, 95, 379–391.
-
(1998)
Cell
, vol.95
, pp. 379-391
-
-
Nichols, J.1
Zevnik, B.2
Anastassiadis, K.3
Niwa, H.4
-
31
-
-
38049028459
-
Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts
-
Nakagawa, M., Koyanagi, M., Tanabe, K., Takahashi, K. et al., Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts. Nat. Biotechnol. 2008, 26, 101–106.
-
(2008)
Nat. Biotechnol.
, vol.26
, pp. 101-106
-
-
Nakagawa, M.1
Koyanagi, M.2
Tanabe, K.3
Takahashi, K.4
-
32
-
-
70349687407
-
Direct reprogramming of human neural stem cells by OCT4
-
Kim, J. B., Greber, B., Araúzo-Bravo, M. J., Meyer, J. et al., Direct reprogramming of human neural stem cells by OCT4. Nature 2009, 461, 649–653.
-
(2009)
Nature
, vol.461
, pp. 649-653
-
-
Kim, J.B.1
Greber, B.2
Araúzo-Bravo, M.J.3
Meyer, J.4
-
33
-
-
33751092246
-
A protein interaction network for pluripotency of embryonic stem cells
-
Wang, J., Rao, S., Chu, J., Shen, X. et al., A protein interaction network for pluripotency of embryonic stem cells. Nature 2006, 444, 364–368.
-
(2006)
Nature
, vol.444
, pp. 364-368
-
-
Wang, J.1
Rao, S.2
Chu, J.3
Shen, X.4
-
34
-
-
44649086468
-
Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells
-
Liang, J., Wan, M., Zhang, Y., Gu, P. et al., Nanog and Oct4 associate with unique transcriptional repression complexes in embryonic stem cells. Nat. Cell Biol. 2008, 10, 731–739.
-
(2008)
Nat. Cell Biol.
, vol.10
, pp. 731-739
-
-
Liang, J.1
Wan, M.2
Zhang, Y.3
Gu, P.4
-
35
-
-
77957757417
-
A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs
-
Kim, J., Woo, A. J., Chu, J., Snow, J. W. et al., A Myc network accounts for similarities between embryonic stem and cancer cell transcription programs. Cell 2010, 143, 313–324.
-
(2010)
Cell
, vol.143
, pp. 313-324
-
-
Kim, J.1
Woo, A.J.2
Chu, J.3
Snow, J.W.4
-
36
-
-
77949900026
-
An Oct4-centered protein interaction network in embryonic stem cells
-
van den Berg, D. L. C., Snoek, T., Mullin, N. P., Yates, A. et al., An Oct4-centered protein interaction network in embryonic stem cells. Cell Stem Cell 2010, 6, 369–381.
-
(2010)
Cell Stem Cell
, vol.6
, pp. 369-381
-
-
van den Berg, D.L.C.1
Snoek, T.2
Mullin, N.P.3
Yates, A.4
-
37
-
-
77949881949
-
An expanded Oct4 interaction network: implications for stem cell biology, development, and disease
-
Pardo, M., Lang, B., Yu, L., Prosser, H. et al., An expanded Oct4 interaction network: implications for stem cell biology, development, and disease. Cell Stem Cell 2010, 6, 382–395.
-
(2010)
Cell Stem Cell
, vol.6
, pp. 382-395
-
-
Pardo, M.1
Lang, B.2
Yu, L.3
Prosser, H.4
-
38
-
-
84859313829
-
Determination of protein interactome of transcription factor Sox2 in embryonic stem cells engineered for inducible expression of four reprogramming factors
-
Gao, Z., Cox, J. L., Gilmore, J. M., Ormsbee, B. D. et al., Determination of protein interactome of transcription factor Sox2 in embryonic stem cells engineered for inducible expression of four reprogramming factors. J. Biol. Chem. 2012, 287, 11384–11397.
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 11384-11397
-
-
Gao, Z.1
Cox, J.L.2
Gilmore, J.M.3
Ormsbee, B.D.4
-
39
-
-
33645381936
-
The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells
-
Loh, Y.-H., Wu, Q., Chew, J.-L., Vega, V. B. et al., The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat. Genet. 2006, 38, 431–440.
-
(2006)
Nat. Genet.
, vol.38
, pp. 431-440
-
-
Loh, Y.-H.1
Wu, Q.2
Chew, J.-L.3
Vega, V.B.4
-
40
-
-
40749104852
-
An extended transcriptional network for pluripotency of embryonic stem cells
-
Kim, J., Chu, J., Shen, X., Wang, J., Orkin, S. H., An extended transcriptional network for pluripotency of embryonic stem cells. Cell 2008, 132, 1049–1061.
-
(2008)
Cell
, vol.132
, pp. 1049-1061
-
-
Kim, J.1
Chu, J.2
Shen, X.3
Wang, J.4
Orkin, S.H.5
-
41
-
-
84855476375
-
Oct4 links multiple epigenetic pathways to the pluripotency network
-
Ding, J., Xu, H., Faiola, F., Ma'ayan, A., Wang, J., Oct4 links multiple epigenetic pathways to the pluripotency network. Cell Res. 2012, 22, 155–167.
-
(2012)
Cell Res
, vol.22
, pp. 155-167
-
-
Ding, J.1
Xu, H.2
Faiola, F.3
Ma'ayan, A.4
Wang, J.5
-
42
-
-
84867054759
-
Zfp281 mediates Nanog autorepression through recruitment of the NuRD complex and inhibits somatic cell reprogramming
-
Fidalgo, M., Faiola, F., Pereira, C.-F., Ding, J. et al., Zfp281 mediates Nanog autorepression through recruitment of the NuRD complex and inhibits somatic cell reprogramming. Proc. Natl. Acad. Sci. USA 2012, 109, 16202–16207.
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. 16202-16207
-
-
Fidalgo, M.1
Faiola, F.2
Pereira, C.-F.3
Ding, J.4
-
43
-
-
42649094468
-
Global transcription in pluripotent embryonic stem cells
-
Efroni, S., Duttagupta, R., Cheng, J., Dehghani, H. et al., Global transcription in pluripotent embryonic stem cells. Cell Stem Cell 2008, 2, 437–447.
-
(2008)
Cell Stem Cell
, vol.2
, pp. 437-447
-
-
Efroni, S.1
Duttagupta, R.2
Cheng, J.3
Dehghani, H.4
-
44
-
-
33646070846
-
A bivalent chromatin structure marks key developmental genes in embryonic stem cells
-
Bernstein, B. E., Mikkelsen, T. S., Xie, X., Kamal, M. et al., A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell 2006, 125, 315–326.
-
(2006)
Cell
, vol.125
, pp. 315-326
-
-
Bernstein, B.E.1
Mikkelsen, T.S.2
Xie, X.3
Kamal, M.4
-
45
-
-
34547624303
-
Genome-wide maps of chromatin state in pluripotent and lineage-committed cells
-
Mikkelsen, T. S., Ku, M., Jaffe, D. B., Issac, B. et al., Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. Nature 2007, 448, 553–560.
-
(2007)
Nature
, vol.448
, pp. 553-560
-
-
Mikkelsen, T.S.1
Ku, M.2
Jaffe, D.B.3
Issac, B.4
-
46
-
-
49649125042
-
Genome-scale DNA methylation maps of pluripotent and differentiated cells
-
Meissner, A., Mikkelsen, T. S., Gu, H., Wernig, M. et al., Genome-scale DNA methylation maps of pluripotent and differentiated cells. Nature 2008, 454, 766–770.
-
(2008)
Nature
, vol.454
, pp. 766-770
-
-
Meissner, A.1
Mikkelsen, T.S.2
Gu, H.3
Wernig, M.4
-
47
-
-
33847323881
-
DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal
-
Wang, Y., Medvid, R., Melton, C., Jaenisch, R., Blelloch, R., DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal. Nat. Genet. 2007, 39, 380–385.
-
(2007)
Nat. Genet.
, vol.39
, pp. 380-385
-
-
Wang, Y.1
Medvid, R.2
Melton, C.3
Jaenisch, R.4
Blelloch, R.5
-
48
-
-
66149160608
-
Embryonic stem cell-specific microRNAs promote induced pluripotency
-
Judson, R. L., Babiarz, J. E., Venere, M., Blelloch, R., Embryonic stem cell-specific microRNAs promote induced pluripotency. Nat. Biotechnol. 2009, 27, 459–461.
-
(2009)
Nat. Biotechnol.
, vol.27
, pp. 459-461
-
-
Judson, R.L.1
Babiarz, J.E.2
Venere, M.3
Blelloch, R.4
-
49
-
-
67349149082
-
MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells
-
Xu, N., Papagiannakopoulos, T., Pan, G., Thomson, J. A., Kosik, K. S., MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells. Cell 2009, 137, 647–658.
-
(2009)
Cell
, vol.137
, pp. 647-658
-
-
Xu, N.1
Papagiannakopoulos, T.2
Pan, G.3
Thomson, J.A.4
Kosik, K.S.5
-
50
-
-
84869002238
-
The functions of microRNAs in pluripotency and reprogramming
-
Leonardo, T. R., Schultheisz, H. L., Loring, J. F., Laurent, L. C., The functions of microRNAs in pluripotency and reprogramming. Nat. Cell Biol. 2012, 14, 1114–1121.
-
(2012)
Nat. Cell Biol.
, vol.14
, pp. 1114-1121
-
-
Leonardo, T.R.1
Schultheisz, H.L.2
Loring, J.F.3
Laurent, L.C.4
-
51
-
-
81055155799
-
Ribosome profiling of mouse embryonic stem cells reveals the complexity and dynamics of mammalian proteomes
-
Ingolia, N. T., Lareau, L. F., Weissman, J. S., Ribosome profiling of mouse embryonic stem cells reveals the complexity and dynamics of mammalian proteomes. Cell 2011, 147, 789–802.
-
(2011)
Cell
, vol.147
, pp. 789-802
-
-
Ingolia, N.T.1
Lareau, L.F.2
Weissman, J.S.3
-
52
-
-
84911462077
-
A comparative encyclopedia of DNA elements in the mouse genome
-
Yue, F., Cheng, Y., Breschi, A., Vierstra, J. et al., A comparative encyclopedia of DNA elements in the mouse genome. Nature 2014, 515, 355–364.
-
(2014)
Nature
, vol.515
, pp. 355-364
-
-
Yue, F.1
Cheng, Y.2
Breschi, A.3
Vierstra, J.4
-
53
-
-
0024205842
-
Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells
-
Williams, R. L., Hilton, D. J., Pease, S., Willson, T. A. et al., Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells. Nature 1988, 336, 684–687.
-
(1988)
Nature
, vol.336
, pp. 684-687
-
-
Williams, R.L.1
Hilton, D.J.2
Pease, S.3
Willson, T.A.4
-
54
-
-
0024245022
-
Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides
-
Smith, A. G., Heath, J. K., Donaldson, D. D., Wong, G. G. et al., Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides. Nature 1988, 336, 688–690.
-
(1988)
Nature
, vol.336
, pp. 688-690
-
-
Smith, A.G.1
Heath, J.K.2
Donaldson, D.D.3
Wong, G.G.4
-
55
-
-
0344845415
-
BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3
-
Ying, Q. L., Nichols, J., Chambers, I., Smith, A., BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3. Cell 2003, 115, 281–292.
-
(2003)
Cell
, vol.115
, pp. 281-292
-
-
Ying, Q.L.1
Nichols, J.2
Chambers, I.3
Smith, A.4
-
56
-
-
0033152966
-
Suppression of SHP-2 and ERK signalling promotes self-renewal of mouse embryonic stem cells
-
Burdon, T., Stracey, C., Chambers, I., Nichols, J., Smith, A., Suppression of SHP-2 and ERK signalling promotes self-renewal of mouse embryonic stem cells. Dev. Biol. 1999, 210, 30–43.
-
(1999)
Dev. Biol.
, vol.210
, pp. 30-43
-
-
Burdon, T.1
Stracey, C.2
Chambers, I.3
Nichols, J.4
Smith, A.5
-
57
-
-
34548596749
-
A discrete period of FGF-induced Erk1/2 signalling is required for vertebrate neural specification
-
Stavridis, M. P., Lunn, J. S., Collins, B. J., Storey, K. G., A discrete period of FGF-induced Erk1/2 signalling is required for vertebrate neural specification. Development 2007, 134, 2889–2894.
-
(2007)
Development
, vol.134
, pp. 2889-2894
-
-
Stavridis, M.P.1
Lunn, J.S.2
Collins, B.J.3
Storey, K.G.4
-
58
-
-
34548587064
-
FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment
-
Kunath, T., Saba-El-Leil, M. K., Almousailleakh, M., Wray, J. et al., FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment. Development 2007, 134, 2895–2902.
-
(2007)
Development
, vol.134
, pp. 2895-2902
-
-
Kunath, T.1
Saba-El-Leil, M.K.2
Almousailleakh, M.3
Wray, J.4
-
59
-
-
0034669082
-
Clonally derived human embryonic stem cell lines maintain pluripotency and proliferative potential for prolonged periods of culture
-
Amit, M., Carpenter, M. K., Inokuma, M. S., Chiu, C. P. et al., Clonally derived human embryonic stem cell lines maintain pluripotency and proliferative potential for prolonged periods of culture. Dev. Biol. 2000, 227, 271–278.
-
(2000)
Dev. Biol.
, vol.227
, pp. 271-278
-
-
Amit, M.1
Carpenter, M.K.2
Inokuma, M.S.3
Chiu, C.P.4
-
60
-
-
18744375483
-
Basic FGF and suppression of BMP signaling sustain undifferentiated proliferation of human ES cells
-
Xu, R.-H., Peck, R. M., Li, D. S., Feng, X. et al., Basic FGF and suppression of BMP signaling sustain undifferentiated proliferation of human ES cells. Nat. Methods 2005, 2, 185–190.
-
(2005)
Nat. Methods
, vol.2
, pp. 185-190
-
-
Xu, R.-H.1
Peck, R.M.2
Li, D.S.3
Feng, X.4
-
61
-
-
1242267927
-
Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor
-
Sato, N., Meijer, L., Skaltsounis, L., Greengard, P., Brivanlou, A. H., Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor. Nat. Med. 2004, 10, 55–63.
-
(2004)
Nat. Med.
, vol.10
, pp. 55-63
-
-
Sato, N.1
Meijer, L.2
Skaltsounis, L.3
Greengard, P.4
Brivanlou, A.H.5
-
62
-
-
84906266596
-
Embryonic stem cell-specific microRNAs contribute to pluripotency by inhibiting regulators of multiple differentiation pathways
-
Gruber, A. J., Grandy, W. A., Balwierz, P. J., Dimitrova, Y. A. et al., Embryonic stem cell-specific microRNAs contribute to pluripotency by inhibiting regulators of multiple differentiation pathways. Nucleic Acids Res. 2014, 42, 9313–9326.
-
(2014)
Nucleic Acids Res.
, vol.42
, pp. 9313-9326
-
-
Gruber, A.J.1
Grandy, W.A.2
Balwierz, P.J.3
Dimitrova, Y.A.4
-
63
-
-
84860171972
-
Using cell-to-cell variability—a new era in molecular biology
-
Pelkmans, L., Using cell-to-cell variability—a new era in molecular biology. Science 2012, 336, 425–426.
-
(2012)
Science
, vol.336
, pp. 425-426
-
-
Pelkmans, L.1
-
64
-
-
0032562720
-
Visualization of single RNA transcripts in situ
-
Femino, A. M., Fay, F. S., Fogarty, K., Singer, R. H., Visualization of single RNA transcripts in situ. Science 1998, 280, 585–590.
-
(1998)
Science
, vol.280
, pp. 585-590
-
-
Femino, A.M.1
Fay, F.S.2
Fogarty, K.3
Singer, R.H.4
-
65
-
-
53349161901
-
Imaging individual mRNA molecules using multiple singly labeled probes
-
Raj, A., van den Bogaard, P., Rifkin, S. A., van Oudenaarden, A., Tyagi, S., Imaging individual mRNA molecules using multiple singly labeled probes. Nat. Methods 2008, 5, 877–879.
-
(2008)
Nat. Methods
, vol.5
, pp. 877-879
-
-
Raj, A.1
van den Bogaard, P.2
Rifkin, S.A.3
van Oudenaarden, A.4
Tyagi, S.5
-
66
-
-
80052174976
-
High-throughput microfluidic single-cell RT-qPCR
-
White, A. K., Vaninsberghe, M., Petriv, O. I., Hamidi, M. et al., High-throughput microfluidic single-cell RT-qPCR. Proc. Natl. Acad. Sci. USA 2011, 108, 13999–14004.
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 13999-14004
-
-
White, A.K.1
Vaninsberghe, M.2
Petriv, O.I.3
Hamidi, M.4
-
67
-
-
67349146589
-
mRNA-Seq whole-transcriptome analysis of a single cell
-
Tang, F., Barbacioru, C., Wang, Y., Nordman, E. et al., mRNA-Seq whole-transcriptome analysis of a single cell. Nat. Methods 2009, 6, 377–382.
-
(2009)
Nat. Methods
, vol.6
, pp. 377-382
-
-
Tang, F.1
Barbacioru, C.2
Wang, Y.3
Nordman, E.4
-
68
-
-
84922012748
-
Single-cell technologies sharpen up mammalian stem cell research
-
Hoppe, P. S., Coutu, D. L., Schroeder, T., Single-cell technologies sharpen up mammalian stem cell research. Nat. Cell Biol. 2014, 16, 919–927.
-
(2014)
Nat. Cell Biol.
, vol.16
, pp. 919-927
-
-
Hoppe, P.S.1
Coutu, D.L.2
Schroeder, T.3
-
69
-
-
0842288337
-
Inferring cellular networks using probabilistic graphical models
-
Friedman, N., Inferring cellular networks using probabilistic graphical models. Science 2004, 303, 799–805.
-
(2004)
Science
, vol.303
, pp. 799-805
-
-
Friedman, N.1
-
70
-
-
17644427718
-
Causal protein-signaling networks derived from multiparameter single-cell data
-
Sachs, K., Perez, O., Pe'er, D., Lauffenburger, D. A., Nolan, G. P., Causal protein-signaling networks derived from multiparameter single-cell data. Science 2005, 308, 523–529.
-
(2005)
Science
, vol.308
, pp. 523-529
-
-
Sachs, K.1
Perez, O.2
Pe'er, D.3
Lauffenburger, D.A.4
Nolan, G.P.5
-
71
-
-
84884287890
-
Single-cell analysis reveals that expression of nanog is biallelic and equally variable as that of other pluripotency factors in mouse ESCs
-
Faddah, D. A., Wang, H., Cheng, A. W., Katz, Y. et al., Single-cell analysis reveals that expression of nanog is biallelic and equally variable as that of other pluripotency factors in mouse ESCs. Cell Stem Cell 2013, 13, 23–29.
-
(2013)
Cell Stem Cell
, vol.13
, pp. 23-29
-
-
Faddah, D.A.1
Wang, H.2
Cheng, A.W.3
Katz, Y.4
-
72
-
-
84904460344
-
Dynamic heterogeneity and DNA methylation in embryonic stem cells
-
Singer, Z. S., Yong, J., Tischler, J., Hackett, J. A. et al., Dynamic heterogeneity and DNA methylation in embryonic stem cells. Mol. Cell 2014, 55, 319–331.
-
(2014)
Mol. Cell
, vol.55
, pp. 319-331
-
-
Singer, Z.S.1
Yong, J.2
Tischler, J.3
Hackett, J.A.4
-
73
-
-
77956261738
-
Sequence signatures and mRNA concentration can explain two-thirds of protein abundance variation in a human cell line
-
Vogel, C., Abreu, R. de S., Ko, D., Le, S.-Y. et al., Sequence signatures and mRNA concentration can explain two-thirds of protein abundance variation in a human cell line. Mol. Syst. Biol. 2010, 6, 400.
-
(2010)
Mol. Syst. Biol.
, vol.6
, pp. 400
-
-
Vogel, C.1
Abreu, R.2
De, S.3
Ko, D.4
Le, S.-Y.5
-
74
-
-
79956322553
-
Global quantification of mammalian gene expression control
-
Schwanhäusser, B., Busse, D., Li, N., Dittmar, G. et al., Global quantification of mammalian gene expression control. Nature 2011, 473, 337–342.
-
(2011)
Nature
, vol.473
, pp. 337-342
-
-
Schwanhäusser, B.1
Busse, D.2
Li, N.3
Dittmar, G.4
-
75
-
-
84858439862
-
Insights into the regulation of protein abundance from proteomic and transcriptomic analyses
-
Vogel, C., Marcotte, E. M., Insights into the regulation of protein abundance from proteomic and transcriptomic analyses. Nat. Rev. Genet. 2012, 13, 227–232.
-
(2012)
Nat. Rev. Genet.
, vol.13
, pp. 227-232
-
-
Vogel, C.1
Marcotte, E.M.2
-
76
-
-
84903616029
-
Single-cell western blotting
-
Hughes, A. J., Spelke, D. P., Xu, Z., Kang, C.-C. et al., Single-cell western blotting. Nat. Methods 2014, 11, 749–755.
-
(2014)
Nat. Methods
, vol.11
, pp. 749-755
-
-
Hughes, A.J.1
Spelke, D.P.2
Xu, Z.3
Kang, C.-C.4
-
77
-
-
84959248377
-
Highly multiplexed simultaneous detection of RNAs and proteins in single cells
-
Frei, A. P., Bava, F.-A., Zunder, E. R., Hsieh, E. W. Y. et al., Highly multiplexed simultaneous detection of RNAs and proteins in single cells. Nat. Methods 2016, 13, 269–275.
-
(2016)
Nat. Methods
, vol.13
, pp. 269-275
-
-
Frei, A.P.1
Bava, F.-A.2
Zunder, E.R.3
Hsieh, E.W.Y.4
-
78
-
-
84862676726
-
A deep profiler's guide to cytometry
-
Bendall, S. C., Nolan, G. P., Roederer, M., Chattopadhyay, P. K., A deep profiler's guide to cytometry. Trends Immunol. 2012, 33, 323–332.
-
(2012)
Trends Immunol
, vol.33
, pp. 323-332
-
-
Bendall, S.C.1
Nolan, G.P.2
Roederer, M.3
Chattopadhyay, P.K.4
-
79
-
-
68849103521
-
Mass cytometry: technique for real time single cell multitarget immunoassay based on inductively coupled plasma time-of-flight mass spectrometry
-
Bandura, D. R., Baranov, V. I., Ornatsky, O. I., Antonov, A. et al., Mass cytometry: technique for real time single cell multitarget immunoassay based on inductively coupled plasma time-of-flight mass spectrometry. Anal. Chem. 2009, 81, 6813–6822.
-
(2009)
Anal. Chem.
, vol.81
, pp. 6813-6822
-
-
Bandura, D.R.1
Baranov, V.I.2
Ornatsky, O.I.3
Antonov, A.4
-
80
-
-
84921301669
-
Unraveling cell populations in tumors by single-cell mass cytometry
-
Di Palma, S., Bodenmiller, B., Unraveling cell populations in tumors by single-cell mass cytometry. Curr. Opin. Biotechnol. 2015, 31, 122–129.
-
(2015)
Curr. Opin. Biotechnol.
, vol.31
, pp. 122-129
-
-
Di Palma, S.1
Bodenmiller, B.2
-
81
-
-
37549002155
-
Nanog safeguards pluripotency and mediates germline development
-
Chambers, I., Silva, J., Colby, D., Nichols, J. et al., Nanog safeguards pluripotency and mediates germline development. Nature 2007, 450, 1230–1234.
-
(2007)
Nature
, vol.450
, pp. 1230-1234
-
-
Chambers, I.1
Silva, J.2
Colby, D.3
Nichols, J.4
-
82
-
-
42149192008
-
Identification and characterization of subpopulations in undifferentiated ES cell culture
-
Toyooka, Y., Shimosato, D., Murakami, K., Takahashi, K., Niwa, H., Identification and characterization of subpopulations in undifferentiated ES cell culture. Development 2008, 135, 909–918.
-
(2008)
Development
, vol.135
, pp. 909-918
-
-
Toyooka, Y.1
Shimosato, D.2
Murakami, K.3
Takahashi, K.4
Niwa, H.5
-
83
-
-
53049092465
-
Dynamic equilibrium and heterogeneity of mouse pluripotent stem cells with distinct functional and epigenetic states
-
Hayashi, K., Lopes, S. M. C. de S., Tang, F., Surani, M. A., Dynamic equilibrium and heterogeneity of mouse pluripotent stem cells with distinct functional and epigenetic states. Cell Stem Cell 2008, 3, 391–401.
-
(2008)
Cell Stem Cell
, vol.3
, pp. 391-401
-
-
Hayashi, K.1
Lopes, S.M.C.2
De, S.3
Tang, F.4
Surani, M.A.5
-
84
-
-
84947748539
-
Single cell RNA-sequencing of pluripotent states unlocks modular transcriptional variation
-
Kolodziejczyk, A. A., Kim, J. K., Tsang, J. C. H., Ilicic, T. et al., Single cell RNA-sequencing of pluripotent states unlocks modular transcriptional variation. Cell Stem Cell 2015, 17, 471–485.
-
(2015)
Cell Stem Cell
, vol.17
, pp. 471-485
-
-
Kolodziejczyk, A.A.1
Kim, J.K.2
Tsang, J.C.H.3
Ilicic, T.4
-
85
-
-
0035902599
-
Intrinsic noise in gene regulatory networks
-
Thattai, M., van Oudenaarden, A., Intrinsic noise in gene regulatory networks. Proc. Natl. Acad. Sci. USA 2001, 98, 8614–8619.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 8614-8619
-
-
Thattai, M.1
van Oudenaarden, A.2
-
86
-
-
25144450143
-
Contributions of low molecule number and chromosomal positioning to stochastic gene expression
-
Becskei, A., Kaufmann, B. B., van Oudenaarden, A., Contributions of low molecule number and chromosomal positioning to stochastic gene expression. Nat. Genet. 2005, 37, 937–944.
-
(2005)
Nat. Genet.
, vol.37
, pp. 937-944
-
-
Becskei, A.1
Kaufmann, B.B.2
van Oudenaarden, A.3
-
87
-
-
84857199176
-
A., Dissecting ensemble networks in ES cell populations reveals micro-heterogeneity underlying pluripotency
-
Trott, J., Hayashi, K., Surani, A., Babu, M. M., Martinez Arias, A., Dissecting ensemble networks in ES cell populations reveals micro-heterogeneity underlying pluripotency. Mol. Biosyst. 2012, 8, 744–752.
-
(2012)
Mol. Biosyst.
, vol.8
, pp. 744-752
-
-
Trott, J.1
Hayashi, K.2
Surani, A.3
Babu, M.M.4
Arias, M.5
-
88
-
-
84923692243
-
Construction and validation of a regulatory network for pluripotency and self-renewal of mouse embryonic stem cells
-
Xu, H., Ang, Y.-S., Sevilla, A., Lemischka, I. R., Ma'ayan, A., Construction and validation of a regulatory network for pluripotency and self-renewal of mouse embryonic stem cells. PLoS Comput. Biol. 2014, 10, e1003777.
-
(2014)
PLoS Comput. Biol.
, vol.10
-
-
Xu, H.1
Ang, Y.-S.2
Sevilla, A.3
Lemischka, I.R.4
Ma'ayan, A.5
-
89
-
-
84896312424
-
Collective dynamics of stem cell populations
-
MacArthur, B. D., Collective dynamics of stem cell populations. Proc. Natl. Acad. Sci. USA 2014, 111, 3653–3654.
-
(2014)
Proc. Natl. Acad. Sci. USA
, vol.111
, pp. 3653-3654
-
-
MacArthur, B.D.1
-
90
-
-
4644326931
-
Genomic analysis of regulatory network dynamics reveals large topological changes
-
Luscombe, N. M., Babu, M. M., Yu, H., Snyder, M. et al., Genomic analysis of regulatory network dynamics reveals large topological changes. Nature 2004, 431, 308–312.
-
(2004)
Nature
, vol.431
, pp. 308-312
-
-
Luscombe, N.M.1
Babu, M.M.2
Yu, H.3
Snyder, M.4
-
91
-
-
58149481232
-
Properties of developmental gene regulatory networks
-
Davidson, E. H., Levine, M. S., Properties of developmental gene regulatory networks. Proc. Natl. Acad. Sci. USA 2008, 105, 20063–20066.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 20063-20066
-
-
Davidson, E.H.1
Levine, M.S.2
-
92
-
-
52149097555
-
Regulatory networks define phenotypic classes of human stem cell lines
-
Müller, F.-J., Laurent, L. C., Kostka, D., Ulitsky, I. et al., Regulatory networks define phenotypic classes of human stem cell lines. Nature 2008, 455, 401–405.
-
(2008)
Nature
, vol.455
, pp. 401-405
-
-
Müller, F.-J.1
Laurent, L.C.2
Kostka, D.3
Ulitsky, I.4
-
93
-
-
84908446782
-
CellNet: network biology applied to stem cell engineering
-
Cahan, P., Li, H., Morris, S. A., Lummertz da Rocha, E. et al., CellNet: network biology applied to stem cell engineering. Cell 2014, 158, 903–915.
-
(2014)
Cell
, vol.158
, pp. 903-915
-
-
Cahan, P.1
Li, H.2
Morris, S.A.3
Lummertz da Rocha, E.4
-
94
-
-
33646527782
-
Early lineage segregation between epiblast and primitive endoderm in mouse blastocysts through the Grb2-MAPK pathway
-
Chazaud, C., Yamanaka, Y., Pawson, T., Rossant, J., Early lineage segregation between epiblast and primitive endoderm in mouse blastocysts through the Grb2-MAPK pathway. Dev. Cell 2006, 10, 615–624.
-
(2006)
Dev. Cell
, vol.10
, pp. 615-624
-
-
Chazaud, C.1
Yamanaka, Y.2
Pawson, T.3
Rossant, J.4
-
95
-
-
76449083746
-
FGF signal-dependent segregation of primitive endoderm and epiblast in the mouse blastocyst
-
Yamanaka, Y., Lanner, F., Rossant, J., FGF signal-dependent segregation of primitive endoderm and epiblast in the mouse blastocyst. Development 2010, 137, 715–724.
-
(2010)
Development
, vol.137
, pp. 715-724
-
-
Yamanaka, Y.1
Lanner, F.2
Rossant, J.3
-
96
-
-
58149118293
-
Distinct sequential cell behaviours direct primitive endoderm formation in the mouse blastocyst
-
Plusa, B., Piliszek, A., Frankenberg, S., Artus, J., Hadjantonakis, A.-K., Distinct sequential cell behaviours direct primitive endoderm formation in the mouse blastocyst. Development 2008, 135, 3081–3091.
-
(2008)
Development
, vol.135
, pp. 3081-3091
-
-
Plusa, B.1
Piliszek, A.2
Frankenberg, S.3
Artus, J.4
Hadjantonakis, A.-K.5
-
97
-
-
67549089476
-
Active cell movements coupled to positional induction are involved in lineage segregation in the mouse blastocyst
-
Meilhac, S. M., Adams, R. J., Morris, S. A., Danckaert, A. et al., Active cell movements coupled to positional induction are involved in lineage segregation in the mouse blastocyst. Dev. Biol. 2009, 331, 210–221.
-
(2009)
Dev. Biol.
, vol.331
, pp. 210-221
-
-
Meilhac, S.M.1
Adams, R.J.2
Morris, S.A.3
Danckaert, A.4
-
98
-
-
33748302271
-
Cell and molecular regulation of the mouse blastocyst
-
Yamanaka, Y., Ralston, A., Stephenson, R. O., Rossant, J., Cell and molecular regulation of the mouse blastocyst. Dev. Dyn. 2006, 235, 2301–2314.
-
(2006)
Dev. Dyn.
, vol.235
, pp. 2301-2314
-
-
Yamanaka, Y.1
Ralston, A.2
Stephenson, R.O.3
Rossant, J.4
-
99
-
-
77950908516
-
Origin and formation of the first two distinct cell types of the inner cell mass in the mouse embryo
-
Morris, S. A., Teo, R. T. Y., Li, H., Robson, P. et al., Origin and formation of the first two distinct cell types of the inner cell mass in the mouse embryo. Proc. Natl. Acad. Sci. USA 2010, 107, 6364–6369.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 6364-6369
-
-
Morris, S.A.1
Teo, R.T.Y.2
Li, H.3
Robson, P.4
-
100
-
-
84896739105
-
The differential response to Fgf signalling in cells internalized at different times influences lineage segregation in preimplantation mouse embryos
-
Morris, S. A., Graham, S. J. L., Jedrusik, A., Zernicka-Goetz, M., The differential response to Fgf signalling in cells internalized at different times influences lineage segregation in preimplantation mouse embryos. Open Biol. 2013, 3, 130104.
-
(2013)
Open Biol.
, vol.3
, pp. 130104
-
-
Morris, S.A.1
Graham, S.J.L.2
Jedrusik, A.3
Zernicka-Goetz, M.4
-
101
-
-
84962688754
-
Single-cell RNA-Seq reveals lineage and X chromosome dynamics in human preimplantation embryos
-
Petropoulos, S., Edsgärd, D., Reinius, B., Deng, Q. et al., Single-cell RNA-Seq reveals lineage and X chromosome dynamics in human preimplantation embryos. Cell 2016, 165, 1012–1026.
-
(2016)
Cell
, vol.165
, pp. 1012-1026
-
-
Petropoulos, S.1
Edsgärd, D.2
Reinius, B.3
Deng, Q.4
-
102
-
-
66049136895
-
Klf4 reverts developmentally programmed restriction of ground state pluripotency
-
Guo, G., Yang, J., Nichols, J., Hall, J. S. et al., Klf4 reverts developmentally programmed restriction of ground state pluripotency. Development 2009, 136, 1063–1069.
-
(2009)
Development
, vol.136
, pp. 1063-1069
-
-
Guo, G.1
Yang, J.2
Nichols, J.3
Hall, J.S.4
-
103
-
-
68749110887
-
Nanog is the gateway to the pluripotent ground state
-
Silva, J., Nichols, J., Theunissen, T. W., Guo, G. et al., Nanog is the gateway to the pluripotent ground state. Cell 2009, 138, 722–737.
-
(2009)
Cell
, vol.138
, pp. 722-737
-
-
Silva, J.1
Nichols, J.2
Theunissen, T.W.3
Guo, G.4
-
104
-
-
77956199358
-
Stat3 activation is limiting for reprogramming to ground state pluripotency
-
Yang, J., van Oosten, A. L., Theunissen, T. W., Guo, G. et al., Stat3 activation is limiting for reprogramming to ground state pluripotency. Cell Stem Cell 2010, 7, 319–328.
-
(2010)
Cell Stem Cell
, vol.7
, pp. 319-328
-
-
Yang, J.1
van Oosten, A.L.2
Theunissen, T.W.3
Guo, G.4
-
105
-
-
77956566519
-
A genome-wide screen in EpiSCs identifies Nr5a nuclear receptors as potent inducers of ground state pluripotency
-
Guo, G., Smith, A., A genome-wide screen in EpiSCs identifies Nr5a nuclear receptors as potent inducers of ground state pluripotency. Development 2010, 137, 3185–3192.
-
(2010)
Development
, vol.137
, pp. 3185-3192
-
-
Guo, G.1
Smith, A.2
-
106
-
-
77952699848
-
Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs
-
Hanna, J., Cheng, A. W., Saha, K., Kim, J. et al., Human embryonic stem cells with biological and epigenetic characteristics similar to those of mouse ESCs. Proc. Natl. Acad. Sci. USA 2010, 107, 9222–9227.
-
(2010)
Proc. Natl. Acad. Sci. USA
, vol.107
, pp. 9222-9227
-
-
Hanna, J.1
Cheng, A.W.2
Saha, K.3
Kim, J.4
-
107
-
-
84908074395
-
Resetting transcription factor control circuitry toward ground-state pluripotency in human
-
Takashima, Y., Guo, G., Loos, R., Nichols, J. et al., Resetting transcription factor control circuitry toward ground-state pluripotency in human. Cell 2014, 158, 1254–1269.
-
(2014)
Cell
, vol.158
, pp. 1254-1269
-
-
Takashima, Y.1
Guo, G.2
Loos, R.3
Nichols, J.4
-
108
-
-
70350627509
-
Epigenetic reversion of post-implantation epiblast to pluripotent embryonic stem cells
-
Bao, S., Tang, F., Li, X., Hayashi, K. et al., Epigenetic reversion of post-implantation epiblast to pluripotent embryonic stem cells. Nature 2009, 461, 1292–1295.
-
(2009)
Nature
, vol.461
, pp. 1292-1295
-
-
Bao, S.1
Tang, F.2
Li, X.3
Hayashi, K.4
-
109
-
-
77956902055
-
Conversion of mouse epiblast stem cells to an earlier pluripotency state by small molecules
-
Zhou, H., Li, W., Zhu, S., Joo, J. Y. et al., Conversion of mouse epiblast stem cells to an earlier pluripotency state by small molecules. J. Biol. Chem. 2010, 285, 29676–29680.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 29676-29680
-
-
Zhou, H.1
Li, W.2
Zhu, S.3
Joo, J.Y.4
-
110
-
-
84885619736
-
Deterministic direct reprogramming of somatic cells to pluripotency
-
Rais, Y., Zviran, A., Geula, S., Gafni, O. et al., Deterministic direct reprogramming of somatic cells to pluripotency. Nature 2013, 502, 65–70.
-
(2013)
Nature
, vol.502
, pp. 65-70
-
-
Rais, Y.1
Zviran, A.2
Geula, S.3
Gafni, O.4
-
111
-
-
84890079514
-
Induction of a human pluripotent state with distinct regulatory circuitry that resembles preimplantation epiblast
-
Chan, Y.-S., Göke, J., Ng, J. H., Lu, X. et al., Induction of a human pluripotent state with distinct regulatory circuitry that resembles preimplantation epiblast. Cell Stem Cell 2013, 13, 663–675.
-
(2013)
Cell Stem Cell
, vol.13
, pp. 663-675
-
-
Chan, Y.-S.1
Göke, J.2
Ng, J.H.3
Lu, X.4
-
112
-
-
84890439421
-
Derivation of novel human ground state naive pluripotent stem cells
-
Gafni, O., Weinberger, L., Mansour, A. A., Manor, Y. S. et al., Derivation of novel human ground state naive pluripotent stem cells. Nature 2013, 504, 282–286.
-
(2013)
Nature
, vol.504
, pp. 282-286
-
-
Gafni, O.1
Weinberger, L.2
Mansour, A.A.3
Manor, Y.S.4
-
113
-
-
84896093612
-
Platform for induction and maintenance of transgene-free hiPSCs resembling ground state pluripotent stem cells
-
Valamehr, B., Robinson, M., Abujarour, R., Rezner, B. et al., Platform for induction and maintenance of transgene-free hiPSCs resembling ground state pluripotent stem cells. Stem Cell Rep. 2014, 2, 366–381.
-
(2014)
Stem Cell Rep.
, vol.2
, pp. 366-381
-
-
Valamehr, B.1
Robinson, M.2
Abujarour, R.3
Rezner, B.4
-
114
-
-
84865112255
-
The H3K27 demethylase Utx regulates somatic and germ cell epigenetic reprogramming
-
Mansour, A. A., Gafni, O., Weinberger, L., Zviran, A. et al., The H3K27 demethylase Utx regulates somatic and germ cell epigenetic reprogramming. Nature 2012, 488, 409–413.
-
(2012)
Nature
, vol.488
, pp. 409-413
-
-
Mansour, A.A.1
Gafni, O.2
Weinberger, L.3
Zviran, A.4
-
115
-
-
84896912846
-
Derivation of naive human embryonic stem cells
-
Ware, C. B., Nelson, A. M., Mecham, B., Hesson, J. et al., Derivation of naive human embryonic stem cells. Proc. Natl. Acad. Sci. USA 2014, 111, 4484–4489.
-
(2014)
Proc. Natl. Acad. Sci. USA
, vol.111
, pp. 4484-4489
-
-
Ware, C.B.1
Nelson, A.M.2
Mecham, B.3
Hesson, J.4
-
116
-
-
84867172892
-
DNA and chromatin modification networks distinguish stem cell pluripotent ground states
-
Song, J., Saha, S., Gokulrangan, G., Tesar, P. J., Ewing, R. M., DNA and chromatin modification networks distinguish stem cell pluripotent ground states. Mol. Cell. Proteomics 2012, 11, 1036–1047.
-
(2012)
Mol. Cell. Proteomics
, vol.11
, pp. 1036-1047
-
-
Song, J.1
Saha, S.2
Gokulrangan, G.3
Tesar, P.J.4
Ewing, R.M.5
-
117
-
-
65549115574
-
Blastocyst lineage formation, early embryonic asymmetries and axis patterning in the mouse
-
Rossant, J., Tam, P. P. L., Blastocyst lineage formation, early embryonic asymmetries and axis patterning in the mouse. Development 2009, 136, 701–713.
-
(2009)
Development
, vol.136
, pp. 701-713
-
-
Rossant, J.1
Tam, P.P.L.2
-
118
-
-
84875456720
-
A localized Wnt signal orients asymmetric stem cell division in vitro
-
Habib, S. J., Chen, B.-C., Tsai, F.-C., Anastassiadis, K. et al., A localized Wnt signal orients asymmetric stem cell division in vitro. Science 2013, 339, 1445–1448.
-
(2013)
Science
, vol.339
, pp. 1445-1448
-
-
Habib, S.J.1
Chen, B.-C.2
Tsai, F.-C.3
Anastassiadis, K.4
-
119
-
-
84923366467
-
Transcription factor binding dynamics during human ES cell differentiation
-
Tsankov, A. M., Gu, H., Akopian, V., Ziller, M. J. et al., Transcription factor binding dynamics during human ES cell differentiation. Nature 2015, 518, 344–349.
-
(2015)
Nature
, vol.518
, pp. 344-349
-
-
Tsankov, A.M.1
Gu, H.2
Akopian, V.3
Ziller, M.J.4
-
120
-
-
84923366733
-
Chromatin architecture reorganization during stem cell differentiation
-
Dixon, J. R., Jung, I., Selvaraj, S., Shen, Y. et al., Chromatin architecture reorganization during stem cell differentiation. Nature 2015, 518, 331–336.
-
(2015)
Nature
, vol.518
, pp. 331-336
-
-
Dixon, J.R.1
Jung, I.2
Selvaraj, S.3
Shen, Y.4
-
121
-
-
84908556534
-
Lineage-specific interface proteins match up the cell cycle and differentiation in embryo stem cells
-
Re, A., Workman, C. T., Waldron, L., Quattrone, A., Brunak, S., Lineage-specific interface proteins match up the cell cycle and differentiation in embryo stem cells. Stem Cell Res. 2014, 13, 316–328.
-
(2014)
Stem Cell Res.
, vol.13
, pp. 316-328
-
-
Re, A.1
Workman, C.T.2
Waldron, L.3
Quattrone, A.4
Brunak, S.5
-
122
-
-
84884844190
-
The cell-cycle state of stem cells determines cell fate propensity
-
Pauklin, S., Vallier, L., The cell-cycle state of stem cells determines cell fate propensity. Cell 2013, 155, 135–147.
-
(2013)
Cell
, vol.155
, pp. 135-147
-
-
Pauklin, S.1
Vallier, L.2
-
123
-
-
84958972959
-
Initiation of stem cell differentiation involves cell cycle-dependent regulation of developmental genes by Cyclin D
-
Pauklin, S., Madrigal, P., Bertero, A., Vallier, L., Initiation of stem cell differentiation involves cell cycle-dependent regulation of developmental genes by Cyclin D. Genes Dev. 2016, 30, 421–433.
-
(2016)
Genes Dev.
, vol.30
, pp. 421-433
-
-
Pauklin, S.1
Madrigal, P.2
Bertero, A.3
Vallier, L.4
-
124
-
-
84886859638
-
Chromatin dynamics during cellular reprogramming
-
Apostolou, E., Hochedlinger, K., Chromatin dynamics during cellular reprogramming. Nature 2013, 502, 462–471.
-
(2013)
Nature
, vol.502
, pp. 462-471
-
-
Apostolou, E.1
Hochedlinger, K.2
-
125
-
-
75349088911
-
The nuclear receptor Nr5a2 can replace Oct4 in the reprogramming of murine somatic cells to pluripotent cells
-
Heng, J.-C. D., Feng, B., Han, J., Jiang, J. et al., The nuclear receptor Nr5a2 can replace Oct4 in the reprogramming of murine somatic cells to pluripotent cells. Cell Stem Cell 2010, 6, 167–174.
-
(2010)
Cell Stem Cell
, vol.6
, pp. 167-174
-
-
Heng, J.-C.D.1
Feng, B.2
Han, J.3
Jiang, J.4
-
126
-
-
77957551870
-
A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts
-
Li, R., Liang, J., Ni, S., Zhou, T. et al., A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts. Cell Stem Cell 2010, 7, 51–63.
-
(2010)
Cell Stem Cell
, vol.7
, pp. 51-63
-
-
Li, R.1
Liang, J.2
Ni, S.3
Zhou, T.4
-
127
-
-
39149115929
-
Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse
-
Stadtfeld, M., Maherali, N., Breault, D. T., Hochedlinger, K., Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse. Cell Stem Cell 2008, 2, 230–240.
-
(2008)
Cell Stem Cell
, vol.2
, pp. 230-240
-
-
Stadtfeld, M.1
Maherali, N.2
Breault, D.T.3
Hochedlinger, K.4
-
128
-
-
46449094276
-
Dissecting direct reprogramming through integrative genomic analysis
-
Mikkelsen, T. S., Hanna, J., Zhang, X., Ku, M. et al., Dissecting direct reprogramming through integrative genomic analysis. Nature 2008, 454, 49–55.
-
(2008)
Nature
, vol.454
, pp. 49-55
-
-
Mikkelsen, T.S.1
Hanna, J.2
Zhang, X.3
Ku, M.4
-
129
-
-
49449096588
-
A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types
-
Wernig, M., Lengner, C. J., Hanna, J., Lodato, M. A. et al., A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types. Nat. Biotechnol. 2008, 26, 916–924.
-
(2008)
Nat. Biotechnol.
, vol.26
, pp. 916-924
-
-
Wernig, M.1
Lengner, C.J.2
Hanna, J.3
Lodato, M.A.4
-
130
-
-
71449109765
-
Direct cell reprogramming is a stochastic process amenable to acceleration
-
Hanna, J., Saha, K., Pando, B., van Zon, J. et al., Direct cell reprogramming is a stochastic process amenable to acceleration. Nature 2009, 462, 595–601.
-
(2009)
Nature
, vol.462
, pp. 595-601
-
-
Hanna, J.1
Saha, K.2
Pando, B.3
van Zon, J.4
-
131
-
-
52649162487
-
Stochasticity and the molecular mechanisms of induced pluripotency
-
MacArthur, B. D., Please, C. P., Oreffo, R. O. C., Stochasticity and the molecular mechanisms of induced pluripotency. PLoS One 2008, 3, e3086.
-
(2008)
PLoS One
, vol.3
-
-
MacArthur, B.D.1
Please, C.P.2
Oreffo, R.O.C.3
-
132
-
-
67650095196
-
Elite and stochastic models for induced pluripotent stem cell generation
-
Yamanaka, S., Elite and stochastic models for induced pluripotent stem cell generation. Nature 2009, 460, 49–52.
-
(2009)
Nature
, vol.460
, pp. 49-52
-
-
Yamanaka, S.1
-
133
-
-
84904050254
-
MBD3/NuRD facilitates induction of pluripotency in a context-dependent manner
-
dos Santos, R. L., Tosti, L., Radzisheuskaya, A., Caballero, I. M. et al., MBD3/NuRD facilitates induction of pluripotency in a context-dependent manner. Cell Stem Cell 2014, 15, 102–110.
-
(2014)
Cell Stem Cell
, vol.15
, pp. 102-110
-
-
dos Santos, R.L.1
Tosti, L.2
Radzisheuskaya, A.3
Caballero, I.M.4
-
134
-
-
84866369892
-
Single-cell expression analyses during cellular reprogramming reveal an early stochastic and a late hierarchic phase
-
Buganim, Y., Faddah, D. A., Cheng, A. W., Itskovich, E. et al., Single-cell expression analyses during cellular reprogramming reveal an early stochastic and a late hierarchic phase. Cell 2012, 150, 1209–1222.
-
(2012)
Cell
, vol.150
, pp. 1209-1222
-
-
Buganim, Y.1
Faddah, D.A.2
Cheng, A.W.3
Itskovich, E.4
-
135
-
-
84924258718
-
A continuous molecular roadmap to iPSC reprogramming through progression analysis of single-cell mass cytometry
-
Zunder, E. R., Lujan, E., Goltsev, Y., Wernig, M., Nolan, G. P., A continuous molecular roadmap to iPSC reprogramming through progression analysis of single-cell mass cytometry. Cell Stem Cell 2015, 16, 323–337.
-
(2015)
Cell Stem Cell
, vol.16
, pp. 323-337
-
-
Zunder, E.R.1
Lujan, E.2
Goltsev, Y.3
Wernig, M.4
Nolan, G.P.5
-
136
-
-
84930224978
-
Early reprogramming regulators identified by prospective isolation and mass cytometry
-
Lujan, E., Zunder, E. R., Ng, Y. H., Goronzy, I. N. et al., Early reprogramming regulators identified by prospective isolation and mass cytometry. Nature 2015, 521, 352–356.
-
(2015)
Nature
, vol.521
, pp. 352-356
-
-
Lujan, E.1
Zunder, E.R.2
Ng, Y.H.3
Goronzy, I.N.4
-
137
-
-
33746773659
-
Dissecting self-renewal in stem cells with RNA interference
-
Ivanova, N., Dobrin, R., Lu, R., Kotenko, I. et al., Dissecting self-renewal in stem cells with RNA interference. Nature 2006, 442, 533–538.
-
(2006)
Nature
, vol.442
, pp. 533-538
-
-
Ivanova, N.1
Dobrin, R.2
Lu, R.3
Kotenko, I.4
-
138
-
-
70450160004
-
Systems-level dynamic analyses of fate change in murine embryonic stem cells
-
Lu, R., Markowetz, F., Unwin, R. D., Leek, J. T. et al., Systems-level dynamic analyses of fate change in murine embryonic stem cells. Nature 2009, 462, 358–362.
-
(2009)
Nature
, vol.462
, pp. 358-362
-
-
Lu, R.1
Markowetz, F.2
Unwin, R.D.3
Leek, J.T.4
-
139
-
-
84859539293
-
Distinct lineage specification roles for NANOG, OCT4, and SOX2 in human embryonic stem cells
-
Wang, Z., Oron, E., Nelson, B., Razis, S., Ivanova, N., Distinct lineage specification roles for NANOG, OCT4, and SOX2 in human embryonic stem cells. Stem Cell 2012, 10, 440–454.
-
(2012)
Stem Cell
, vol.10
, pp. 440-454
-
-
Wang, Z.1
Oron, E.2
Nelson, B.3
Razis, S.4
Ivanova, N.5
-
140
-
-
0000383132
-
Mathematical description of linear dynamical systems
-
Kalman, R. E., Mathematical description of linear dynamical systems. SIAM J. Control 1963, 1, 152–192.
-
(1963)
SIAM J. Control
, vol.1
, pp. 152-192
-
-
Kalman, R.E.1
-
141
-
-
79955879494
-
Controllability of complex networks
-
Liu, Y.-Y., Slotine, J.-J., Barabási, A.-Á., Controllability of complex networks. Nature 2011, 473, 167–173.
-
(2011)
Nature
, vol.473
, pp. 167-173
-
-
Liu, Y.-Y.1
Slotine, J.-J.2
Barabási, A.-Á.3
-
142
-
-
84959344588
-
A predictive computational framework for direct reprogramming between human cell types
-
Rackham, O. J. L., Firas, J., Fang, H., Oates, M. E. et al., A predictive computational framework for direct reprogramming between human cell types. Nat. Genet. 2016, 48, 331–335.
-
(2016)
Nat. Genet.
, vol.48
, pp. 331-335
-
-
Rackham, O.J.L.1
Firas, J.2
Fang, H.3
Oates, M.E.4
-
143
-
-
77955124773
-
Learning Bayesian networks with the bnlearn R package
-
Scutari, M., Learning Bayesian networks with the bnlearn R package. J. Stat. Softw. 2010, 35, 1–22.
-
(2010)
J. Stat. Softw.
, vol.35
, pp. 1-22
-
-
Scutari, M.1
-
144
-
-
77957930628
-
Statistical inference of the time-varying structure of gene-regulation networks
-
Lèbre, S., Becq, J., Devaux, F., Stumpf, M. P., Lelandais, G., Statistical inference of the time-varying structure of gene-regulation networks. BMC Syst. Biol. 2010, 4, 130.
-
(2010)
BMC Syst. Biol.
, vol.4
, pp. 130
-
-
Lèbre, S.1
Becq, J.2
Devaux, F.3
Stumpf, M.P.4
Lelandais, G.5
-
145
-
-
84900517167
-
Microfluidic single-cell whole-transcriptome sequencing
-
Streets, A. M., Zhang, X., Cao, C., Pang, Y. et al., Microfluidic single-cell whole-transcriptome sequencing. Proc. Natl. Acad. Sci. USA 2014, 111, 7048–7053.
-
(2014)
Proc. Natl. Acad. Sci. USA
, vol.111
, pp. 7048-7053
-
-
Streets, A.M.1
Zhang, X.2
Cao, C.3
Pang, Y.4
-
146
-
-
84929684998
-
Droplet barcoding for single-cell transcriptomics applied to embryonic stem cells
-
Klein, A. M., Mazutis, L., Akartuna, I., Tallapragada, N. et al., Droplet barcoding for single-cell transcriptomics applied to embryonic stem cells. Cell 2015, 161, 1187–1201.
-
(2015)
Cell
, vol.161
, pp. 1187-1201
-
-
Klein, A.M.1
Mazutis, L.2
Akartuna, I.3
Tallapragada, N.4
|