Epigenetic reversion of post-implantation epiblast to pluripotent embryonic stem cells

Nature

Volumn 461, Issue 7268, 2009, Pages 1292-1295

  Bao, Siqin ^a   Tang, Fuchou ^a   Li, Xihe ^b   Hayashi, Katsuhiko ^a,d   Gillich, Astrid ^a   Lao, Kaiqin ^c   Surani, M Azim ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b Mongolia University   (China)

^c APPLIED BIOSYSTEMS   (United States)

^d KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVIN; BASIC FIBROBLAST GROWTH FACTOR; NERVE CELL ADHESION MOLECULE; STAT3 PROTEIN; TRANSCRIPTOME; UVOMORULIN;

BIOLOGICAL DEVELOPMENT; CHROMOSOME; DNA; EMBRYO; GENE EXPRESSION; GENETIC ANALYSIS; GERM CELL; INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BLASTOCYST; DNA METHYLATION; ECTODERM; EMBRYO; EMBRYONIC STEM CELL; EPIGENETICS; GERM CELL; MOUSE; NIDATION; NONHUMAN; PHENOTYPE; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; X CHROMOSOME INACTIVATION;

ANIMALS; BIOLOGICAL MARKERS; CADHERINS; CELLS, CULTURED; DNA METHYLATION; ECTODERM; EMBRYO, MAMMALIAN; EMBRYONIC DEVELOPMENT; EMBRYONIC STEM CELLS; EPIGENESIS, GENETIC; GENE EXPRESSION PROFILING; GERM LAYERS; LEUKEMIA INHIBITORY FACTOR; MICE; NUCLEAR REPROGRAMMING; PLURIPOTENT STEM CELLS; STAT3 TRANSCRIPTION FACTOR; Y CHROMOSOME;

CHIMAERIFORMES;

EID: 70350627509     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature08534     Document Type: Article

References (31)

1. Gardner, R. L. & Rossant, J. Investigation of the fate of 4-5 day post-coitum mouse inner cell mass cells by blastocyst injection. J. Embryol. Exp. Morphol. 52, 141-152 (1979).
2. Surani, M. A., Hayashi, K. & Hajkova, P. Genetic and epigenetic regulators of pluripotency. Cell 128, 747-762 (2007).
3. Tesar, P. J. et al. New cell lines from mouse epiblast share defining features with human embryonic stem cells. Nature 448, 196-199 (2007).
4. Brons, I. G. et al. Derivation of pluripotent epiblast stem cells from mammalian embryos. Nature 448, 191-195 (2007).
5. Evans, M. J. & Kaufman, M. H. Establishment in culture of pluripotential cells from mouse embryos. Nature 292, 154-156 (1981).
6. Yeom, Y. I. et al. Germline regulatory element of Oct-4 specific for the totipotent cycle of embryonal cells. Development 122, 881-894 (1996).
7. Chen, X. et al. Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell 133, 1106-1117 (2008).
8. Takahashi, K. & Yamanaka, S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126, 663-676 (2006).
9. Niwa, H. How is pluripotency determined and maintained? Development 134, 635-646 (2007).
10. Rathjen, J., Washington, J. M., Bettess, M. D. & Rathjen, P. D. Identification of a biological activity that supports maintenance and proliferation of pluripotent cells from the primitive ectoderm of the mouse. Biol. Reprod. 69, 1863-1871 (2003).
11. Chou, Y. F. et al. The growth factor environment defines distinct pluripotent ground states in novel blastocyst-derived stem cells. Cell 135, 449-461 (2008).
12. Takagi, N., Sugawara, O. & Sasaki, M. Regional and temporal changes in the pattern of X-chromosome replication during the early post-implantation development of the female mouse. Chromosoma 85, 275-286 (1982).
13. Silva, J. et al. Establishment of histone h3 methylation on the inactive X chromosome requires transient recruitment of Eed-Enx1 polycomb group complexes. Dev. Cell 4, 481-495 (2003).
14. Chuva de Sousa Lopes, S. M. et al. X chromosome activity in mouse XX primordial germ cells. PLoS Genet. 4, e30 (2008).
15. Plath, K. et al. Role of histone H3 lysine 27 methylation in X inactivation. Science 300, 131-135 (2003).
16. Mikkelsen, T. S. et al. Dissecting direct reprogramming through integrative genomic analysis. Nature 454, 49-55 (2008).
17. Maherali, N. et al. Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution. Cell Stem Cell 1, 55-70 (2007).
18. Tada, M., Takahama, Y., Abe, K., Nakatsuji, N. & Tada, T. Nuclear reprogramming of somatic cells by in vitro hybridization with ES cells. Curr. Biol. 11, 1553-1558 (2001).
19. Bao, S. et al. Initiation of epigenetic reprogramming of the X chromosome in somatic nuclei transplanted to a mouse oocyte. EMBO Rep. 6, 748-754 (2005).
20. Hayashi, K., Lopes, S. M., Tang, F. & Surani, M. A. Dynamic equilibrium and heterogeneity of mouse pluripotent stem cells with distinct functional and epigenetic states. Cell Stem Cell 3, 391-401 (2008).
21. Ohinata, Y. et al. A signaling principle for the specification of the germ cell lineage in mice. Cell 137, 571-584 (2009).
22. Shovlin, T. C., Durcova-Hills, G., Surani, A. & McLaren, A. Heterogeneity in imprinted methylation patterns of pluripotent embryonic germ cells derived from pre-migratory mouse germ cells. Dev. Biol. 313, 674-681 (2008).
23. Meissner, A. et al. Genome-scale DNA methylation maps of pluripotent and differentiated cells. Nature 454, 766-770 (2008).
24. Guo, G. et al. Klf4 reverts developmentally programmed restriction of ground state pluripotency. Development 136, 1063-1069 (2009).
25. Hanna, J. et al. Metastable pluripotent states in NOD-mouse-derived ESCs. Cell Stem Cell 4, 513-524 (2009).
26. Thomson, J. A. et al. Embryonic stem cell lines derived from human blastocysts. Science 282, 1145-1147 (1998).
27. Silva, J. et al. Promotion of reprogramming to ground state pluripotency by signal inhibition. PLoS Biol. 6, e253 (2008).
28. Wernig, M. et al. A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types. Nature Biotechnol. 26, 916-924 (2008).
29. Hayashi, K. & Surani, M. A. Resetting the epigenome beyond pluripotency in the germline. Cell Stem Cell 4, 493-498 (2009).
30. Surani, M. A., Durcova-Hills, G., Hajkova, P., Hayashi, K. & Tee, W. W. Germ line, stem cells, and epigenetic reprogramming. Cold Spring Harb. Symp. Quant. Biol. 73, 9-15 (2008).
31. Hayashi, K. & Surani, M. A. Self-renewing epiblast stem cells exhibit continual delineation of germ cells with epigenetic reprogramming in vitro. Development 136, 3549-3556 (2009).