Glycolysis-mediated changes in acetyl-CoA and histone acetylation control the early differentiation of embryonic stem cells

Cell Metabolism

Volumn 21, Issue 3, 2015, Pages 392-402

  Moussaieff, Arieh ^a,b,c   Rouleau, Matthieu ^d,e   Kitsberg, Daniel ^a   Cohen, Merav ^a   Levy, Gahl ^a   Barasch, Dinorah ^a   Nemirovski, Alina ^a   Shen Orr, Shai ^f   Laevsky, Ilana ^f   Amit, Michal ^f   Bomze, David ^a   Elena Herrmann, Bénédicte ^g   Scherf, Tali ^h   Nissim Rafinia, Malka ^a   Kempa, Stefan ⁱ   Itskovitz Eldor, Joseph ^f   Meshorer, Eran ^a   Aberdam, Daniel ^b,c   Nahmias, Yaakov ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b INSERM   (France)

^c UNIVERSITÉ PARIS DESCARTES   (France)

^d Nice Sophia Antipolis University   (France)

^e UNIVERSITÉ CÔTE D'AZUR   (France)

^f TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^g UNIVERSITÉ DE LYON   (France)

^h WEIZMANN INSTITUTE OF SCIENCE   (Israel)

ⁱ MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A; ACETYL COENZYME A SYNTHETASE; MONOCARBOXYLATE TRANSPORTER 1; PYRUVATE DEHYDROGENASE; HISTONE;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CHOLESTEROL SYNTHESIS; CHROMATIN STRUCTURE; CONTROLLED STUDY; DEACETYLATION; EMBRYONIC STEM CELL; FATTY ACID OXIDATION; GENE EXPRESSION; GLYCOLYSIS; HISTONE ACETYLATION; HUMAN; HUMAN CELL; MASS SPECTROMETRY; METABOLIC REGULATION; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; OXIDATIVE PHOSPHORYLATION; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; ACETYLATION; ANIMAL; CELL LINE; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; PHYSIOLOGY;

ACETYL COENZYME A; ACETYLATION; ANIMALS; CELL DIFFERENTIATION; CELL LINE; EMBRYONIC STEM CELLS; GLYCOLYSIS; HISTONES; HUMANS; MICE; TRANSCRIPTION, GENETIC;

EID: 84924369505     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2015.02.002     Document Type: Article

References (23)

1. M. Amit, I. Laevsky, Y. Miropolsky, K. Shariki, M. Peri, and J. Itskovitz-Eldor Dynamic suspension culture for scalable expansion of undifferentiated human pluripotent stem cells Nat. Protoc. 6 2011 572 579
2. K. Blair, J. Wray, and A. Smith The liberation of embryonic stem cells PLoS Genet. 7 2011 e1002019
3. G.G. Cezar, J.A. Quam, A.M. Smith, G.J. Rosa, M.S. Piekarczyk, J.F. Brown, F.H. Gage, and A.R. Muotri Identification of small molecules from human embryonic stem cells using metabolomics Stem Cells Dev. 16 2007 869 882
4. M. Dejosez, and T.P. Zwaka Pluripotency and nuclear reprogramming Annu. Rev. Biochem. 81 2012 737 765
5. M. Drukker, C. Tang, R. Ardehali, Y. Rinkevich, J. Seita, A.S. Lee, A.R. Mosley, I.L. Weissman, and Y. Soen Isolation of primitive endoderm, mesoderm, vascular endothelial and trophoblast progenitors from human pluripotent stem cells Nat. Biotechnol. 30 2012 531 542
6. C.D. Folmes, T.J. Nelson, A. Martinez-Fernandez, D.K. Arrell, J.Z. Lindor, P.P. Dzeja, Y. Ikeda, C. Perez-Terzic, and A. Terzic Somatic oxidative bioenergetics transitions into pluripotency-dependent glycolysis to facilitate nuclear reprogramming Cell Metab. 14 2011 264 271
7. H. Hezroni, I. Tzchori, A. Davidi, A. Mattout, A. Biran, M. Nissim-Rafinia, H. Westphal, and E. Meshorer H3K9 histone acetylation predicts pluripotency and reprogramming capacity of ES cells Nucleus 2 2011 300 309
8. L. Liu, J. Ulbrich, J. Müller, T. Wüstefeld, L. Aeberhard, T.R. Kress, N. Muthalagu, L. Rycak, R. Rudalska, and R. Moll Deregulated MYC expression induces dependence upon AMPK-related kinase 5 Nature 483 2012 608 612
9. J.K. Meissen, B.T. Yuen, T. Kind, J.W. Riggs, D.K. Barupal, P.S. Knoepfler, and O. Fiehn Induced pluripotent stem cells show metabolomic differences to embryonic stem cells in polyunsaturated phosphatidylcholines and primary metabolism PLoS ONE 7 2012 e46770
10. S. Melcer, H. Hezroni, E. Rand, M. Nissim-Rafinia, A. Skoultchi, C.L. Stewart, M. Bustin, and E. Meshorer Histone modifications and lamin A regulate chromatin protein dynamics in early embryonic stem cell differentiation Nat. Commun. 3 2012 910
11. C.M. Metallo, and M.G. Vander Heiden Understanding metabolic regulation and its influence on cell physiology Mol. Cell 49 2013 388 398
12. A.D. Panopoulos, O. Yanes, S. Ruiz, Y.S. Kida, D. Diep, R. Tautenhahn, A. Herrerías, E.M. Batchelder, N. Plongthongkum, and M. Lutz The metabolome of induced pluripotent stem cells reveals metabolic changes occurring in somatic cell reprogramming Cell Res. 22 2012 168 177
13. H. Pearson Cancer patients opt for unapproved drug Nature 446 2007 474 475
14. N. Shyh-Chang, J.W. Locasale, C.A. Lyssiotis, Y. Zheng, R.Y. Teo, S. Ratanasirintrawoot, J. Zhang, T. Onder, J.J. Unternaehrer, and H. Zhu Influence of threonine metabolism on S-adenosylmethionine and histone methylation Science 339 2013 222 226
15. M.G. Vander Heiden, L.C. Cantley, and C.B. Thompson Understanding the Warburg effect: the metabolic requirements of cell proliferation Science 324 2009 1029 1033
16. S. Varum, A.S. Rodrigues, M.B. Moura, O. Momcilovic, C.A. Easley 4th, J. Ramalho-Santos, B. Van Houten, and G. Schatten Energy metabolism in human pluripotent stem cells and their differentiated counterparts PLoS ONE 6 2011 e20914
17. C.B. Ware, L. Wang, B.H. Mecham, L. Shen, A.M. Nelson, M. Bar, D.A. Lamba, D.S. Dauphin, B. Buckingham, and B. Askari Histone deacetylase inhibition elicits an evolutionarily conserved self-renewal program in embryonic stem cells Cell Stem Cell 4 2009 359 369
18. K.E. Wellen, G. Hatzivassiliou, U.M. Sachdeva, T.V. Bui, J.R. Cross, and C.B. Thompson ATP-citrate lyase links cellular metabolism to histone acetylation Science 324 2009 1076 1080
19. J. Xia, N. Psychogios, N. Young, and D.S. Wishart MetaboAnalyst: a web server for metabolomic data analysis and interpretation Nucleic Acids Res. 37 2009 W652 W660
20. H.N. Xu, G. Zheng, J. Tchou, S. Nioka, and L.Z. Li Characterizing the metabolic heterogeneity in human breast cancer xenografts by 3D high resolution fluorescence imaging Springerplus 2 2013 73
21. O. Yanes, J. Clark, D.M. Wong, G.J. Patti, A. Sánchez-Ruiz, H.P. Benton, S.A. Trauger, C. Desponts, S. Ding, and G. Siuzdak Metabolic oxidation regulates embryonic stem cell differentiation Nat. Chem. Biol. 6 2010 411 417
22. J. Zhang, I. Khvorostov, J.S. Hong, Y. Oktay, L. Vergnes, E. Nuebel, P.N. Wahjudi, K. Setoguchi, G. Wang, and A. Do UCP2 regulates energy metabolism and differentiation potential of human pluripotent stem cells EMBO J. 30 2011 4860 4873
23. S. Zhu, W. Li, H. Zhou, W. Wei, R. Ambasudhan, T. Lin, J. Kim, K. Zhang, and S. Ding Reprogramming of human primary somatic cells by OCT4 and chemical compounds Cell Stem Cell 7 2010 651 655