A novel allosteric activator of free fatty acid 2 receptor displays unique Gi-functional bias

Journal of Biological Chemistry

Volumn 291, Issue 36, 2016, Pages 18915-18931

  Bolognini, Daniele ^a   Moss, Catherine E ^a,b   Nilsson, Karolina ^c   Petersson, Annika U ^c   Donnelly, Iona ^a   Sergeev, Eugenia ^a   König, Gabriele M ^d   Kostenis, Evi ^d   Kurowska Stolarska, Mariola ^a   Miller, Ashley ^a   Dekker, Niek ^c   Tobin, Andrew B ^a,b   Milligan, Graeme ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b UNIVERSITY OF LEICESTER   (United Kingdom)

^c ASTRAZENECA R AND D   (Sweden)

^d UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CELL SIGNALING; CHAINS; ENZYMES; MAMMALS; MODULATORS; PHYSIOLOGICAL MODELS; PHYSIOLOGY; POINT CONTACTS; SIGNALING;

ALLOSTERIC ACTIVATOR; HUMAN NEUTROPHIL; MAP KINASE SIGNALING; PHYSIOLOGICAL RESPONSE; POSITIVE ALLOSTERIC MODULATOR; RECEPTOR LIGANDS; SHORT-CHAIN FATTY ACIDS; SIGNALING PATHWAYS;

FATTY ACIDS;

AMINO ACID RECEPTOR STIMULATING AGENT; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; FATTY ACID 2 RECEPTOR; FR 900359; GLUCAGON LIKE PEPTIDE 1; GUANINE NUCLEOTIDE BINDING PROTEIN ALPHA SUBUNIT; INHIBITORY GUANINE NUCLEOTIDE BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; N [3 (2 CARBAMIMIDAMIDO 4 METHYL 1,3 THIAZOL 5 YL)PHENYL] 4 FLUOROBENZAMIDE; PHOSPHOPROTEIN; PROPIONIC ACID; PROTEIN INHIBITOR; RECEPTOR; UNCLASSIFIED DRUG; CELL SURFACE RECEPTOR; DEPSIPEPTIDE; FFAR2 PROTEIN, MOUSE; FR900359; G PROTEIN COUPLED RECEPTOR; G-PROTEIN COUPLED RECEPTOR 43, HUMAN; GNAQ PROTEIN, HUMAN; MAPK1 PROTEIN, HUMAN;

ADIPOCYTE; ALLOSTERISM; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CHEMOTAXIS; CONTROLLED STUDY; HUMAN; HUMAN CELL; LIPOLYSIS; MALE; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; AGONISTS; ANIMAL; ANTAGONISTS AND INHIBITORS; COLON; DRUG EFFECTS; GENETICS; KNOCKOUT MOUSE; METABOLISM;

ALLOSTERIC REGULATION; ANIMALS; COLON; DEPSIPEPTIDES; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; GTP-BINDING PROTEIN ALPHA SUBUNITS, GQ-G11; HUMANS; LIPOLYSIS; MAP KINASE SIGNALING SYSTEM; MICE; MICE, KNOCKOUT; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NEUTROPHILS; RECEPTORS, CELL SURFACE; RECEPTORS, G-PROTEIN-COUPLED;

EID: 84984870564     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M116.736157     Document Type: Article

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