Selective novel inverse agonists for human GPR43 augment GLP-1 secretion

European Journal of Pharmacology

Volumn 771, Issue , 2016, Pages 1-9

  Park, Bi Oh ^a,e   Kim, Seong Heon ^a,b   Kong, Gye Yeong ^a,e   Kim, Da Hui ^a,e   Kwon, Mi So ^c   Lee, Su Ui ^a   Kim, Mun Ock ^a   Cho, Sungchan ^a,b   Lee, Sangku ^a   Lee, Hyun Jun ^a   Han, Sang Bae ^e   Kwak, Young Shin ^d   Lee, Sung Bae ^f   Kim, Sunhong ^a,b  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^b University of Science and Technology (UST)   (South Korea)

^c Korea Institute of Toxicology   (South Korea)

^d Korea University   (South Korea)

^e Chungbuk National University   (South Korea)

^f Daegu Gyeongbuk Institute of Science and Technology   (South Korea)

Author keywords

BTI A 202; BTI A 404; GLP 1; GPR43; Inverse agonist; SCFA

Indexed keywords

AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; BTI A 292; BTI A 404; CALCIUM ION; CYCLIC AMP; G PROTEIN COUPLED RECEPTOR; GLUCAGON LIKE PEPTIDE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN GPR43; UNCLASSIFIED DRUG; ANILINE DERIVATIVE; BTI-A-404; CALCIUM; CELL SURFACE RECEPTOR; G-PROTEIN COUPLED RECEPTOR 43, HUMAN; PYRIMIDINONE DERIVATIVE;

ARTICLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; CYTOPLASM; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; HIGH THROUGHPUT SCREENING; PRIORITY JOURNAL; PROTEIN SECRETION; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; AGONISTS; ANIMAL; CELL LINE; DRUG EFFECTS; GENETICS; HUMAN; METABOLISM; MOUSE;

ANILINE COMPOUNDS; ANIMALS; CALCIUM; CELL LINE; CYCLIC AMP; CYTOPLASM; GLUCAGON-LIKE PEPTIDE 1; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MICE; PYRIMIDINONES; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84949758588     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2015.12.010     Document Type: Article

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