A Molecular Mechanism for Sequential Activation of a G Protein-Coupled Receptor

Cell Chemical Biology

Volumn 23, Issue 3, 2016, Pages 392-403

  Grundmann, Manuel ^a   Tikhonova, Irina G ^b   Hudson, Brian D ^c   Smith, Nicola J ^c,d   Mohr, Klaus ^a   Ulven, Trond ^e   Milligan, Graeme ^c   Kenakin, Terry ^f   Kostenis, Evi ^a  

^a UNIVERSITY OF BONN   (Germany)

^b QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

^d UNIVERSITY OF NEW SOUTH WALES   (Australia)

^e UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^f UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (4 CHLOROPHENYL) 3 METHYL N (THIAZOL 2 YL)BUTANAMIDE; CHEMOKINE RECEPTOR AGONIST; FREE FATTY ACID RECEPTOR 2; G PROTEIN COUPLED RECEPTOR; PROPIONIC ACID; UNCLASSIFIED DRUG; LIGAND; MOLECULAR LIBRARY;

ALLOSTERISM; ARTICLE; BINDING SITE; CALCIUM TRANSPORT; CELL ACTIVATION; CONTROLLED STUDY; DRUG MECHANISM; DRUG RECEPTOR BINDING; HUMAN; HUMAN CELL; LIGAND BINDING; MOLECULAR DYNAMICS; MUTATIONAL ANALYSIS; PROTEIN EXPRESSION; SEQUENTIAL RECEPTOR ACTIVATION; SIGNAL TRANSDUCTION; AGONISTS; CELL CULTURE; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; MOLECULAR LIBRARY; MOLECULAR MODEL; PHARMACOLOGY; STRUCTURE ACTIVITY RELATION; TIME FACTOR;

ALLOSTERIC REGULATION; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; RECEPTORS, G-PROTEIN-COUPLED; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP; TIME FACTORS;

EID: 84965025689     PISSN: 24519456     EISSN: 24519448     Source Type: Journal    
DOI: 10.1016/j.chembiol.2016.02.014     Document Type: Article

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