Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: Identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3

Journal of Biological Chemistry

Volumn 286, Issue 12, 2011, Pages 10628-10640

  Schmidt, Johannes ^a   Smith, Nicola J ^b   Christiansen, Elisabeth ^c   Tikhonova, Irina G ^d   Grundmann, Manuel ^a   Hudson, Brian D ^b   Ward, Richard J ^b   Drewke, Christel ^a   Milligan, Graeme ^b   Kostenis, Evi ^a   Ulven, Trond ^c  

^a UNIVERSITY OF BONN   (Germany)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

^c UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^d QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE RESIDUE; BINDING MODES; DYNAMIC MASS REDISTRIBUTION; FREE FATTY ACID; G PROTEIN; GUANOSINES; INOSITOL PHOSPHATE; LABEL FREE; LIGAND BINDING; METABOLIC DISORDERS; MODE OF BINDING; MOLECULAR BASIS; PRIMARY SCREENING; RATIONAL DESIGN; SELECTIVE ACTIVATION; SELECTIVE LIGANDS; SELECTIVE MUTATION; SHORT-CHAIN FATTY ACIDS; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATIONSHIPS; THERAPEUTIC COMPOUNDS; TRANSMEMBRANE RECEPTORS; TRIPHOSPHATE;

AMINO ACIDS; BINDING ENERGY; BINDING SITES; CARBOXYLIC ACIDS; FETAL MONITORING; SUGARS; VOLATILE FATTY ACIDS;

LIGANDS;

AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; ALANINE; ARGININE; CARBOXYLIC ACID DERIVATIVE; CYCLIC AMP; FREE FATTY ACID RECEPTOR 2; FREE FATTY ACID RECEPTOR 2 AGONIST; FREE FATTY ACID RECEPTOR 3; G PROTEIN COUPLED RECEPTOR; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); INOSITOL PHOSPHATE; LIGAND; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CELL STRAIN HEK293; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; LIGAND BINDING; PLASMID; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN STRUCTURE; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION;

BINDING SITES; HEK293 CELLS; HUMANS; LIGANDS; PROPIONATES; RECEPTORS, CELL SURFACE; RECEPTORS, G-PROTEIN-COUPLED; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79953216793     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.210872     Document Type: Article

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