β-Arrestin biosensors reveal a rapid, receptor-dependent activation/deactivation cycle

Nature

Volumn 531, Issue 7596, 2016, Pages 661-664

  Nuber, Susanne ^a,b   Zabel, Ulrike ^a,b   Lorenz, Kristina ^a,c,f   Nuber, Andreas ^a   Milligan, Graeme ^d   Tobin, Andrew B ^e   Lohse, Martin J ^a,b,c,g   Hoffmann, Carsten ^a,b  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

^d UNIVERSITY OF GLASGOW   (United Kingdom)

^e UNIVERSITY OF LEICESTER   (United Kingdom)

^f LEIBNIZ INSTITUT FÜR ANALYTISCHE WISSENSCHAFTEN ISAS E V   (Germany)

^g MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ARRESTIN; G PROTEIN COUPLED RECEPTOR; PROTEIN BINDING; RETINA S ANTIGEN;

CELLS AND CELL COMPONENTS; CYTOLOGY; ENZYME; ENZYME ACTIVITY; PROTEIN;

ARTICLE; BINDING AFFINITY; BIOSENSOR; CELL SURFACE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DISSOCIATION; FLUORESCENCE RESONANCE ENERGY TRANSFER; HEK293 CELL LINE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; ANIMAL; BOVINE; CELL LINE; CELL MEMBRANE; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME SPECIFICITY; GENETIC PROCEDURES; KINETICS; METABOLISM; PROTEIN CONFORMATION; TIME FACTOR; X RAY CRYSTALLOGRAPHY;

ANIMALS; ARRESTINS; BIOSENSING TECHNIQUES; CATTLE; CELL LINE; CELL MEMBRANE; CELL SURVIVAL; CRYSTALLOGRAPHY, X-RAY; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMANS; KINETICS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION; SUBSTRATE SPECIFICITY; TIME FACTORS;

EID: 84962420929     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature17198     Document Type: Article

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