The conformational signature of β-arrestin2 predicts its trafficking and signalling functions

Nature

Volumn 531, Issue 7596, 2016, Pages 665-668

  Lee, Mi Hye ^a   Appleton, Kathryn M ^a   Strungs, Erik G ^a   Kwon, Joshua Y ^a   Morinelli, Thomas A ^a   Peterson, Yuri K ^b   Laporte, Stephane A ^c,d   Luttrell, Louis M ^a,e  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c RESEARCH INSTITUTE OF THE MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^d MCGILL UNIVERSITY   (Canada)

^e RALPH H JOHNSON VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ARRESTIN 2; FLUORESCEIN; FLUORESCEIN ARSENICAL HAIRPIN; G PROTEIN COUPLED RECEPTOR; UNCLASSIFIED DRUG; BETA ARRESTIN; LIGAND; MAPK1 PROTEIN, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; RETINA S ANTIGEN;

BIOLUMINESCENCE; LIGAND; PROTEIN; SIGNALING;

ARTICLE; BIOLUMINESCENCE RESONANCE ENERGY TRANSFER; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING; HEK293 CELL LINE; HUMAN; HUMAN CELL; PREDICTION; PRIORITY JOURNAL; PROTEIN STABILITY; SIGNAL TRANSDUCTION; ANIMAL; CHEMISTRY; ENZYME ACTIVATION; METABOLISM; PROTEIN CONFORMATION; PROTEIN TRANSPORT; RAT;

ANIMALS; ARRESTINS; ENZYME ACTIVATION; HEK293 CELLS; HUMANS; LIGANDS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PROTEIN CONFORMATION; PROTEIN TRANSPORT; RATS; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION;

EID: 84962459565     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature17154     Document Type: Article

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