Identification and functional characterization of allosteric agonists for the G protein-coupled receptor FFA2

Molecular Pharmacology

Volumn 74, Issue 6, 2008, Pages 1599-1609

  Lee, Taeweon ^a   Schwandner, Ralf ^b   Swaminath, Gayathri ^a   Weiszmann, Jennifer ^a   Cardozo, Mario ^a   Greenberg, Joanne ^a   Jaeckel, Peter ^b   Ge, Hongfei ^a   Wang, Yingcai ^a   Jiao, Xianyun ^a   Liu, Jiwen ^a   Kayser, Frank ^a   Tian, Hui ^a   Li, Yang ^a  

^a AMGEN INC   (United States)

^b Amgen Research GmbH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACETANILIDE DERIVATIVE; ACETIC ACID; BETA 2 ADRENERGIC RECEPTOR; CYCLIC AMP; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 40; G PROTEIN COUPLED RECEPTOR 41; G PROTEIN COUPLED RECEPTOR 43; PROPIONIC ACID; SHORT CHAIN FATTY ACID; UNCLASSIFIED DRUG;

ADIPOCYTE; ALLOSTERISM; ANIMAL CELL; ARTICLE; BINDING SITE; CALCIUM MOBILIZATION; CHEMICAL STRUCTURE; CONTROLLED STUDY; HIGH THROUGHPUT SCREENING; HUMAN; LIPOLYSIS; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR BINDING;

3T3-L1 CELLS; ADIPOCYTES; ALLOSTERIC REGULATION; AMINO ACID SEQUENCE; ANIMALS; BENZENEACETAMIDES; CHO CELLS; CRICETINAE; CRICETULUS; HUMANS; LIGANDS; LIPOLYSIS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; RADIOLIGAND ASSAY; RECEPTORS, CELL SURFACE; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 57349142454     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.108.049536     Document Type: Article

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