메뉴 건너뛰기




Volumn 17, Issue 12, 2016, Pages 1341-1349

Tapping into mitochondria to find novel targets for diabetes complications

Author keywords

Diabetic complications; Mitochondria; Nephropathy; Networking; Oxidative phosphorylation; Retinopathy; ROS; Superoxide

Indexed keywords

ACETYLCYSTEINE; ALPHA TOCOPHEROL; CARNITINE; CURCUMIN; CYTOCHROME C; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PROTEIN BAX; REACTIVE OXYGEN METABOLITE; RESVERATROL; RHO KINASE; THIOCTIC ACID; UBIDECARENONE; UNCOUPLING PROTEIN; FATTY ACID; GLUCOSE; KETONE;

EID: 84983781432     PISSN: 13894501     EISSN: 18735592     Source Type: Journal    
DOI: 10.2174/1389450116666150727114410     Document Type: Review
Times cited : (21)

References (117)
  • 1
    • 79959936188 scopus 로고    scopus 로고
    • National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: Systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2.7 million participants
    • Danaei G, Finucane MM, Lu Y, et al. National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2.7 million participants. Lancet 2011; 378(9785): 31-40.
    • (2011) Lancet , vol.378 , Issue.9785 , pp. 31-40
    • Danaei, G.1    Finucane, M.M.2    Lu, Y.3
  • 2
    • 0032511566 scopus 로고    scopus 로고
    • Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)
    • UK Prospective Diabetes Study (UKPDS) Group
    • Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). UK Prospective Diabetes Study (UKPDS) Group. Lancet 1998; 352(9131): 854-65.
    • (1998) Lancet , vol.352 , Issue.9131 , pp. 854-865
  • 3
    • 0034628425 scopus 로고    scopus 로고
    • Retinopathy and nephropathy in patients with type 1 diabetes four years after a trial of intensive therapy. The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group
    • Retinopathy and nephropathy in patients with type 1 diabetes four years after a trial of intensive therapy. The Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group. N Engl J Med 2000; 342(6): 381-9.
    • (2000) N Engl J Med , vol.342 , Issue.6 , pp. 381-389
  • 4
    • 29144453326 scopus 로고    scopus 로고
    • Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes
    • Nathan DM, Cleary PA, Backlund JY, et al. Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes. N Engl J Med 2005; 353(25): 2643-53.
    • (2005) N Engl J Med , vol.353 , Issue.25 , pp. 2643-2653
    • Nathan, D.M.1    Cleary, P.A.2    Backlund, J.Y.3
  • 5
    • 53749096863 scopus 로고    scopus 로고
    • 10-year follow-up of intensive glucose control in type 2 diabetes
    • Holman RR, Paul SK, Bethel MA, Matthews DR, Neil HA. 10-year follow-up of intensive glucose control in type 2 diabetes. N Engl J Med 2008; 359(15): 1577-89.
    • (2008) N Engl J Med , vol.359 , Issue.15 , pp. 1577-1589
    • Holman, R.R.1    Paul, S.K.2    Bethel, M.A.3    Matthews, D.R.4    Neil, H.A.5
  • 6
    • 58149389215 scopus 로고    scopus 로고
    • Glucose control and vascular complications in veterans with type 2 diabetes
    • Duckworth W, Abraira C, Moritz T, et al. Glucose control and vascular complications in veterans with type 2 diabetes. N Engl J Med. 2009; 360(2): 129-39.
    • (2009) N Engl J Med , vol.360 , Issue.2 , pp. 129-139
    • Duckworth, W.1    Abraira, C.2    Moritz, T.3
  • 7
    • 45149133036 scopus 로고    scopus 로고
    • Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes
    • Patel A, MacMahon S, Chalmers J, et al. Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med 2008; 358(24): 2560-72.
    • (2008) N Engl J Med , vol.358 , Issue.24 , pp. 2560-2572
    • Patel, A.1    Macmahon, S.2    Chalmers, J.3
  • 8
    • 45149131667 scopus 로고    scopus 로고
    • Effects of Intensive Glucose Lowering in Type 2 Diabetes
    • Effects of Intensive Glucose Lowering in Type 2 Diabetes. N Engl J Med 2008; 358(24): 2545-59.
    • (2008) N Engl J Med , vol.358 , Issue.24 , pp. 2545-2559
  • 9
    • 46349110918 scopus 로고    scopus 로고
    • Diabetes- induced up-regulation of uncoupling protein-2 results in increased mitochondrial uncoupling in kidney proximal tubular cells
    • Friederich M, Fasching A, Hansell P, Nordquist L, Palm F. Diabetes- induced up-regulation of uncoupling protein-2 results in increased mitochondrial uncoupling in kidney proximal tubular cells. Biochim Biophys Acta 2008; 1777(7-8): 935-40.
    • (2008) Biochim Biophys Acta , vol.1777 , Issue.7-8 , pp. 935-940
    • Friederich, M.1    Fasching, A.2    Hansell, P.3    Nordquist, L.4    Palm, F.5
  • 10
    • 0031917746 scopus 로고    scopus 로고
    • Retinal oxygen consumption during hyperglycemia in patients with diabetes without retinopathy
    • Tiedeman JS, Kirk SE, Srinivas S, Beach JM. Retinal oxygen consumption during hyperglycemia in patients with diabetes without retinopathy. Ophthalmology 1998; 105(1): 31-6.
    • (1998) Ophthalmology , vol.105 , Issue.1 , pp. 31-36
    • Tiedeman, J.S.1    Kirk, S.E.2    Srinivas, S.3    Beach, J.M.4
  • 11
    • 33644784921 scopus 로고    scopus 로고
    • Increased myocardial oxygen consumption reduces cardiac efficiency in diabetic mice
    • How OJ, Aasum E, Severson DL, et al. Increased myocardial oxygen consumption reduces cardiac efficiency in diabetic mice. Diabetes 2006; 55(2): 466-73.
    • (2006) Diabetes , vol.55 , Issue.2 , pp. 466-473
    • How, O.J.1    Aasum, E.2    Severson, D.L.3
  • 12
    • 31644445201 scopus 로고    scopus 로고
    • Increased myocardial fatty acid metabolism in patients with type 1 diabetes mellitus
    • Herrero P, Peterson LR, McGill JB, et al. Increased myocardial fatty acid metabolism in patients with type 1 diabetes mellitus. J Am Coll Cardiol 2006; 47(3): 598-604.
    • (2006) J am Coll Cardiol , vol.47 , Issue.3 , pp. 598-604
    • Herrero, P.1    Peterson, L.R.2    McGill, J.B.3
  • 13
    • 84923880080 scopus 로고    scopus 로고
    • Activation of hypoxia-inducible factors prevents diabetic nephropathy
    • Nordquist L, Friederich-Persson M, Fasching A, et al. Activation of hypoxia-inducible factors prevents diabetic nephropathy. J Am Soc Nephrol 2015; 26(2): 328-58.
    • (2015) J am Soc Nephrol , vol.26 , Issue.2 , pp. 328-358
    • Nordquist, L.1    Friederich-Persson, M.2    Fasching, A.3
  • 14
    • 33644622570 scopus 로고    scopus 로고
    • HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
    • Papandreou I, Cairns RA, Fontana L, Lim AL, Denko NC. HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. Cell Metab 2006; 3(3): 187-97.
    • (2006) Cell Metab , vol.3 , Issue.3 , pp. 187-197
    • Papandreou, I.1    Cairns, R.A.2    Fontana, L.3    Lim, A.L.4    Denko, N.C.5
  • 15
    • 0042266280 scopus 로고    scopus 로고
    • Minimum birth prevalence of mitochondrial respiratory chain disorders in children
    • Skladal D, Halliday J, Thorburn DR. Minimum birth prevalence of mitochondrial respiratory chain disorders in children. Brain 2003; 126(Pt 8): 1905-12.
    • (2003) Brain , vol.126 , pp. 1905-1912
    • Skladal, D.1    Halliday, J.2    Thorburn, D.R.3
  • 16
    • 33845232634 scopus 로고    scopus 로고
    • Leigh syndrome with nephropathy and CoQ10 deficiency due to decaprenyl diphosphate synthase subunit 2 (PDSS2) mutations
    • Lopez LC, Schuelke M, Quinzii CM, et al. Leigh syndrome with nephropathy and CoQ10 deficiency due to decaprenyl diphosphate synthase subunit 2 (PDSS2) mutations. Am J Hum Genet 2006; 79(6): 1125-9.
    • (2006) Am J Hum Genet , vol.79 , Issue.6 , pp. 1125-1129
    • Lopez, L.C.1    Schuelke, M.2    Quinzii, C.M.3
  • 17
    • 0031253821 scopus 로고    scopus 로고
    • Aconitase and mitochondrial iron-sulphur protein deficiency in Friedreich ataxia
    • Rotig A, de Lonlay P, Chretien D, et al. Aconitase and mitochondrial iron-sulphur protein deficiency in Friedreich ataxia. Nat Genet 1997; 17(2): 215-7.
    • (1997) Nat Genet , vol.17 , Issue.2 , pp. 215-217
    • Rotig, A.1    De Lonlay, P.2    Chretien, D.3
  • 18
    • 84879855808 scopus 로고    scopus 로고
    • Deficiency in mitochondrial complex I activity due to Ndufs6 gene trap insertion induces renal disease
    • Forbes JM, Ke BX, Nguyen TV, et al. Deficiency in mitochondrial complex I activity due to Ndufs6 gene trap insertion induces renal disease. Antioxid Redox Signal 2013; 19(4): 331-43.
    • (2013) Antioxid Redox Signal , vol.19 , Issue.4 , pp. 331-343
    • Forbes, J.M.1    Ke, B.X.2    Nguyen, T.V.3
  • 19
    • 65249153029 scopus 로고    scopus 로고
    • RAGE-induced cytosolic ROS promote mitochondrial superoxide generation in diabetes
    • Coughlan MT, Thorburn DR, Penfold SA, et al. RAGE-induced cytosolic ROS promote mitochondrial superoxide generation in diabetes. J Am Soc Nephrol 2009; 20(4): 742-52.
    • (2009) J am Soc Nephrol , vol.20 , Issue.4 , pp. 742-752
    • Coughlan, M.T.1    Thorburn, D.R.2    Penfold, S.A.3
  • 20
    • 78649755150 scopus 로고    scopus 로고
    • Prevention of diabetic nephropathy in Ins2(+/)(-)(AkitaJ) mice by the mitochondriatargeted therapy MitoQ
    • Chacko BK, Reily C, Srivastava A, et al. Prevention of diabetic nephropathy in Ins2(+/)(-)(AkitaJ) mice by the mitochondriatargeted therapy MitoQ. Biochem J 2010; 432(1): 9-19.
    • (2010) Biochem J , vol.432 , Issue.1 , pp. 9-19
    • Chacko, B.K.1    Reily, C.2    Srivastava, A.3
  • 21
    • 0036084953 scopus 로고    scopus 로고
    • Alterations in renal mitochondrial respiration in response to the reactive oxoaldehyde methylglyoxal
    • Rosca MG, Monnier VM, Szweda LI, Weiss MF. Alterations in renal mitochondrial respiration in response to the reactive oxoaldehyde methylglyoxal. Am J Physiol Renal Physiol 2002; 283(1): F52-9.
    • (2002) Am J Physiol Renal Physiol , vol.283 , Issue.1
    • Rosca, M.G.1    Monnier, V.M.2    Szweda, L.I.3    Weiss, M.F.4
  • 22
    • 33845808854 scopus 로고    scopus 로고
    • The not so 'mighty chondrion': Emergence of renal diseases due to mitochondrial dysfunction
    • Hall AM, Unwin RJ. The not so 'mighty chondrion': emergence of renal diseases due to mitochondrial dysfunction. Nephron Physiol 2007; 105(1): p1-10.
    • (2007) Nephron Physiol , vol.105 , Issue.1 , pp. 1-10
    • Hall, A.M.1    Unwin, R.J.2
  • 23
    • 84887108045 scopus 로고    scopus 로고
    • Metabolomics reveals signature of mitochondrial dysfunction in diabetic kidney disease
    • Sharma K, Karl B, Mathew AV, et al. Metabolomics reveals signature of mitochondrial dysfunction in diabetic kidney disease. J Am Soc Nephrol 2013; 24(11): 1901-12.
    • (2013) J am Soc Nephrol , vol.24 , Issue.11 , pp. 1901-1912
    • Sharma, K.1    Karl, B.2    Mathew, A.V.3
  • 24
    • 79954564411 scopus 로고    scopus 로고
    • (1)H-NMR-based metabonomic analysis of metabolic profiling in diabetic nephropathy rats induced by streptozotocin
    • Zhao L, Gao H, Lian F, et al. (1)H-NMR-based metabonomic analysis of metabolic profiling in diabetic nephropathy rats induced by streptozotocin. Am J Physiol Renal Physiol 2011; 300(4): F947-56.
    • (2011) Am J Physiol Renal Physiol , vol.300 , Issue.4
    • Zhao, L.1    Gao, H.2    Lian, F.3
  • 25
    • 84878648388 scopus 로고    scopus 로고
    • GC/TOFMS analysis of metabolites in serum and urine reveals metabolic perturbation of TCA cycle in db/db mice involved in diabetic nephropathy
    • Li M, Wang X, Aa J, et al. GC/TOFMS analysis of metabolites in serum and urine reveals metabolic perturbation of TCA cycle in db/db mice involved in diabetic nephropathy. Am J Physiol Renal Physiol 2013; 304(11): F1317-24.
    • (2013) Am J Physiol Renal Physiol , vol.304 , Issue.11
    • Li, M.1    Wang, X.2    Aa, J.3
  • 26
    • 56649095917 scopus 로고    scopus 로고
    • Respiratory-chain diseases related to complex III deficiency
    • Benit P, Lebon S, Rustin P. Respiratory-chain diseases related to complex III deficiency. Biochim Biophys Acta 2009; 1793(1): 181-5.
    • (2009) Biochim Biophys Acta , vol.1793 , Issue.1 , pp. 181-185
    • Benit, P.1    Lebon, S.2    Rustin, P.3
  • 27
    • 22344442393 scopus 로고    scopus 로고
    • Glycation of mitochondrial proteins from diabetic rat kidney is associated with excess superoxide formation
    • Rosca MG, Mustata TG, Kinter MT, et al. Glycation of mitochondrial proteins from diabetic rat kidney is associated with excess superoxide formation. Am J Physiol Renal Physiol 2005; 289(2): F420-30.
    • (2005) Am J Physiol Renal Physiol , vol.289 , Issue.2
    • Rosca, M.G.1    Mustata, T.G.2    Kinter, M.T.3
  • 28
    • 77956186783 scopus 로고    scopus 로고
    • Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes
    • Hamanaka RB, Chandel NS. Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes. Trends Biochem Sci 2010; 35(9): 505-13.
    • (2010) Trends Biochem Sci , vol.35 , Issue.9 , pp. 505-513
    • Hamanaka, R.B.1    Chandel, N.S.2
  • 29
    • 79952186370 scopus 로고    scopus 로고
    • Oxidative stress in early diabetic nephropathy: Fueling the fire
    • Singh DK, Winocour P, Farrington K. Oxidative stress in early diabetic nephropathy: fueling the fire. Nat Rev Endocrinol 2011; 7(3): 176-84.
    • (2011) Nat Rev Endocrinol , vol.7 , Issue.3 , pp. 176-184
    • Singh, D.K.1    Winocour, P.2    Farrington, K.3
  • 30
    • 78650456535 scopus 로고    scopus 로고
    • Angiotensin II blockade: A strategy to slow ageing by protecting mitochondria?
    • de Cavanagh EM, Inserra F, Ferder L. Angiotensin II blockade: a strategy to slow ageing by protecting mitochondria? Cardiovasc Res 2011; 89(1): 31-40.
    • (2011) Cardiovasc Res , vol.89 , Issue.1 , pp. 31-40
    • De Cavanagh, E.M.1    Inserra, F.2    Ferder, L.3
  • 31
    • 33646716659 scopus 로고    scopus 로고
    • The mechanism of superoxide production by NADH:Ubiquinone oxidoreductase (complex I) from bovine heart mitochondria
    • Kussmaul L, Hirst J. The mechanism of superoxide production by NADH:ubiquinone oxidoreductase (complex I) from bovine heart mitochondria. Proc Natl Acad Sci USA 2006; 103(20): 7607-12.
    • (2006) Proc Natl Acad Sci USA , vol.103 , Issue.20 , pp. 7607-7612
    • Kussmaul, L.1    Hirst, J.2
  • 32
    • 0030056515 scopus 로고    scopus 로고
    • Mitochondrial complex I deficiency leads to increased production of superoxide radicals and induction of superoxide dismutase
    • Pitkanen S, Robinson BH. Mitochondrial complex I deficiency leads to increased production of superoxide radicals and induction of superoxide dismutase. J Clin Invest 1996; 98(2): 345-51.
    • (1996) J Clin Invest , vol.98 , Issue.2 , pp. 345-351
    • Pitkanen, S.1    Robinson, B.H.2
  • 33
    • 58249093939 scopus 로고    scopus 로고
    • How mitochondria produce reactive oxygen species
    • Murphy MP. How mitochondria produce reactive oxygen species. Biochem J 2009; 417(1): 1-13.
    • (2009) Biochem J , vol.417 , Issue.1 , pp. 1-13
    • Murphy, M.P.1
  • 34
    • 38749087624 scopus 로고    scopus 로고
    • High rates of superoxide production in skeletal-muscle mitochondria respiring on both complex I- and complex II-linked substrates
    • Muller FL, Liu Y, Abdul-Ghani MA, et al. High rates of superoxide production in skeletal-muscle mitochondria respiring on both complex I- and complex II-linked substrates. Biochem J 2008; 409(2): 491-9.
    • (2008) Biochem J , vol.409 , Issue.2 , pp. 491-499
    • Muller, F.L.1    Liu, Y.2    Abdul-Ghani, M.A.3
  • 35
    • 46749087465 scopus 로고    scopus 로고
    • Succinate receptor GPR91 provides a direct link between high glucose levels and renin release in murine and rabbit kidney
    • Toma I, Kang JJ, Sipos A, et al. Succinate receptor GPR91 provides a direct link between high glucose levels and renin release in murine and rabbit kidney. J Clin Invest 2008; 118(7): 2526-34.
    • (2008) J Clin Invest , vol.118 , Issue.7 , pp. 2526-2534
    • Toma, I.1    Kang, J.J.2    Sipos, A.3
  • 36
    • 77649119983 scopus 로고    scopus 로고
    • Disparate effects on renal and oxidative parameters following RAGE deletion, AGE accumulation inhibition, or dietary AGE control in experimental diabetic nephropathy
    • Tan AL, Sourris KC, Harcourt BE, et al. Disparate effects on renal and oxidative parameters following RAGE deletion, AGE accumulation inhibition, or dietary AGE control in experimental diabetic nephropathy. Am J Physiol Renal Physiol 2010; 298(3): F763-70.
    • (2010) Am J Physiol Renal Physiol , vol.298 , Issue.3
    • Tan, A.L.1    Sourris, K.C.2    Harcourt, B.E.3
  • 37
    • 80053186332 scopus 로고    scopus 로고
    • Impaired mitochondrial complex III and melatonin responsive reactive oxygen species generation in kidney mitochondria of db/db mice
    • Zhang H, Zhang HM, Wu LP, et al. Impaired mitochondrial complex III and melatonin responsive reactive oxygen species generation in kidney mitochondria of db/db mice. J Pineal Res 2011; 51(3): 338-44.
    • (2011) J Pineal Res , vol.51 , Issue.3 , pp. 338-344
    • Zhang, H.1    Zhang, H.M.2    Wu, L.P.3
  • 38
    • 10344221083 scopus 로고    scopus 로고
    • Releases superoxide to both sides of the inner mitochondrial membrane
    • Muller FL, Liu Y, Van Remmen H. Complex III releases superoxide to both sides of the inner mitochondrial membrane. J Biol Chem 2004; 279(47): 49064-73.
    • (2004) J Biol Chem , vol.279 , Issue.47 , pp. 49064-49073
    • Muller, F.L.1    Liu, Y.2    Van Remmen, H.3    Complex, I.4
  • 39
    • 0035863011 scopus 로고    scopus 로고
    • Mitochondrial respiratory chaindependent generation of superoxide anion and its release into the intermembrane space
    • Han D, Williams E, Cadenas E. Mitochondrial respiratory chaindependent generation of superoxide anion and its release into the intermembrane space. Biochem J 2001; 353(Pt 2): 411-6.
    • (2001) Biochem J , vol.353 , pp. 411-416
    • Han, D.1    Williams, E.2    Cadenas, E.3
  • 40
    • 34447283547 scopus 로고    scopus 로고
    • Hyperglycemia induced oxidative stress in type- 1 and type-2 diabetic patients with and without nephropathy
    • Dave GS, Kalia K. Hyperglycemia induced oxidative stress in type- 1 and type-2 diabetic patients with and without nephropathy. Cell Mol Biol (Noisy-le-grand) 2007; 53(5): 68-78.
    • (2007) Cell Mol Biol (Noisy-Le-Grand) , vol.53 , Issue.5 , pp. 68-78
    • Dave, G.S.1    Kalia, K.2
  • 41
    • 78751577772 scopus 로고    scopus 로고
    • The oxidative stress status in diabetes mellitus and diabetic nephropathy
    • Pan HZ, Zhang L, Guo MY, et al. The oxidative stress status in diabetes mellitus and diabetic nephropathy. Acta Diabetol 2010; 47 Suppl 1: 71-6.
    • (2010) Acta Diabetol , vol.47 , pp. 71-76
    • Pan, H.Z.1    Zhang, L.2    Guo, M.Y.3
  • 42
    • 0031708582 scopus 로고    scopus 로고
    • Oxidative stress at onset and in early stages of type 1 diabetes in children and adolescents
    • Dominguez C, Ruiz E, Gussinye M, Carrascosa A. Oxidative stress at onset and in early stages of type 1 diabetes in children and adolescents. Diabetes Care 1998; 21(10): 1736-42.
    • (1998) Diabetes Care , vol.21 , Issue.10 , pp. 1736-1742
    • Dominguez, C.1    Ruiz, E.2    Gussinye, M.3    Carrascosa, A.4
  • 43
    • 84870208571 scopus 로고    scopus 로고
    • Characterization of blood oxidative stress in type 2 diabetes mellitus patients: Increase in lipid peroxidation and SOD activity
    • Bandeira Sde M, Guedes Gda S, da Fonseca LJ, et al. Characterization of blood oxidative stress in type 2 diabetes mellitus patients: increase in lipid peroxidation and SOD activity. Oxid Med Cell Longev 2012; 2012: 819310.
    • (2012) Oxid Med Cell Longev , vol.2012 , pp. 819310
    • Bandeira Sde, M.1    Guedes Gda, S.2    Da Fonseca, L.J.3
  • 44
    • 29344475463 scopus 로고    scopus 로고
    • Protein oxidation parameters in type 2 diabetic patients with good and poor glycaemic control
    • Cakatay U. Protein oxidation parameters in type 2 diabetic patients with good and poor glycaemic control. Diabetes Metab 2005; 31(6): 551-7.
    • (2005) Diabetes Metab , vol.31 , Issue.6 , pp. 551-557
    • Cakatay, U.1
  • 45
    • 84921354808 scopus 로고    scopus 로고
    • The investigation of the oxidative stress-related parameters in type 2 diabetes mellitus
    • Aouacheri O, Saka S, Krim M, Messaadia A, Maidi I. The investigation of the oxidative stress-related parameters in type 2 diabetes mellitus. Can J Diabetes 2015; 39(1): 44-9.
    • (2015) Can J Diabetes , vol.39 , Issue.1 , pp. 44-49
    • Aouacheri, O.1    Saka, S.2    Krim, M.3    Messaadia, A.4    Maidi, I.5
  • 46
    • 80051777094 scopus 로고    scopus 로고
    • Oxidative lipid, protein, and DNA damage as oxidative stress markers in vascular complications of diabetes mellitus
    • Tabak O, Gelisgen R, Erman H, et al. Oxidative lipid, protein, and DNA damage as oxidative stress markers in vascular complications of diabetes mellitus. Clin Invest Med 2011; 34(3): E163-71.
    • (2011) Clin Invest Med , vol.34 , Issue.3
    • Tabak, O.1    Gelisgen, R.2    Erman, H.3
  • 47
    • 51649103541 scopus 로고    scopus 로고
    • Renal and metabolic effects of tempol in obese ZSF1 rats--distinct role for superoxide and hydrogen peroxide in diabetic renal injury
    • Rafikova O, Salah EM, Tofovic SP. Renal and metabolic effects of tempol in obese ZSF1 rats--distinct role for superoxide and hydrogen peroxide in diabetic renal injury. Metabolism 2008; 57(10): 1434-44.
    • (2008) Metabolism , vol.57 , Issue.10 , pp. 1434-1444
    • Rafikova, O.1    Salah, E.M.2    Tofovic, S.P.3
  • 48
    • 70350445742 scopus 로고    scopus 로고
    • Substrate-specific derangements in mitochondrial metabolism and redox balance in the atrium of the type 2 diabetic human heart
    • Anderson EJ, Kypson AP, Rodriguez E, et al. Substrate-specific derangements in mitochondrial metabolism and redox balance in the atrium of the type 2 diabetic human heart. J Am Coll Cardiol 2009; 54(20): 1891-8.
    • (2009) J am Coll Cardiol , vol.54 , Issue.20 , pp. 1891-1898
    • Erson, E.J.1    Kypson, A.P.2    Rodriguez, E.3
  • 49
    • 33646698671 scopus 로고    scopus 로고
    • Hydrogen peroxide: A signaling messenger
    • Stone JR, Yang S. Hydrogen peroxide: a signaling messenger. Antioxid Redox Signal 2006; 8(3-4): 243-70.
    • (2006) Antioxid Redox Signal , vol.8 , Issue.3-4 , pp. 243-270
    • Stone, J.R.1    Yang, S.2
  • 50
    • 84887466140 scopus 로고    scopus 로고
    • AMPK dysregulation promotes diabetes-related reduction of superoxide and mitochondrial function
    • Dugan LL, You YH, Ali SS, et al. AMPK dysregulation promotes diabetes-related reduction of superoxide and mitochondrial function. J Clin Invest 2013; 123(11): 4888-99.
    • (2013) J Clin Invest , vol.123 , Issue.11 , pp. 4888-4899
    • Dugan, L.L.1    You, Y.H.2    Ali, S.S.3
  • 51
    • 33644877703 scopus 로고    scopus 로고
    • Functional polymorphisms of UCP2 and UCP3 are associated with a reduced prevalence of diabetic neuropathy in patients with type 1 diabetes
    • Rudofsky G, Jr., Schroedter A, Schlotterer A, et al. Functional polymorphisms of UCP2 and UCP3 are associated with a reduced prevalence of diabetic neuropathy in patients with type 1 diabetes. Diabetes Care 2006; 29(1): 89-94.
    • (2006) Diabetes Care , vol.29 , Issue.1 , pp. 89-94
    • Rudofsky, G.1    Schroedter, A.2    Schlotterer, A.3
  • 52
    • 84863615264 scopus 로고    scopus 로고
    • Acute knockdown of uncoupling protein-2 increases uncoupling via the adenine nucleotide transporter and decreases oxidative stress in diabetic kidneys
    • Friederich-Persson M, Aslam S, Nordquist L, et al. Acute knockdown of uncoupling protein-2 increases uncoupling via the adenine nucleotide transporter and decreases oxidative stress in diabetic kidneys. PLoS One 2012; 7(7): e39635.
    • (2012) Plos One , vol.7 , Issue.7
    • Friederich-Persson, M.1    Aslam, S.2    Nordquist, L.3
  • 53
    • 84862528769 scopus 로고    scopus 로고
    • Coenzyme Q10 prevents GDP-sensitive mitochondrial uncoupling, glomerular hyperfiltration and proteinuria in kidneys from db/db mice as a model of type 2 diabetes
    • Persson MF, Franzen S, Catrina SB, et al. Coenzyme Q10 prevents GDP-sensitive mitochondrial uncoupling, glomerular hyperfiltration and proteinuria in kidneys from db/db mice as a model of type 2 diabetes. Diabetologia 2012; 55(5): 1535-43.
    • (2012) Diabetologia , vol.55 , Issue.5 , pp. 1535-1543
    • Persson, M.F.1    Franzen, S.2    Catrina, S.B.3
  • 55
    • 33644666564 scopus 로고    scopus 로고
    • Plasma free fatty acids and peroxisome proliferator-activated receptor alpha in the control of myocardial uncoupling protein levels
    • Murray AJ, Panagia M, Hauton D, Gibbons GF, Clarke K. Plasma free fatty acids and peroxisome proliferator-activated receptor alpha in the control of myocardial uncoupling protein levels. Diabetes 2005; 54(12): 3496-502.
    • (2005) Diabetes , vol.54 , Issue.12 , pp. 3496-3502
    • Murray, A.J.1    Panagia, M.2    Hauton, D.3    Gibbons, G.F.4    Clarke, K.5
  • 56
    • 34548848059 scopus 로고    scopus 로고
    • Mitochondrial energetics in the heart in obesity-related diabetes: Direct evidence for increased uncoupled respiration and activation of uncoupling proteins
    • Boudina S, Sena S, Theobald H, et al. Mitochondrial energetics in the heart in obesity-related diabetes: direct evidence for increased uncoupled respiration and activation of uncoupling proteins. Diabetes 2007; 56(10): 2457-66.
    • (2007) Diabetes , vol.56 , Issue.10 , pp. 2457-2466
    • Boudina, S.1    Sena, S.2    Theobald, H.3
  • 57
    • 84875906572 scopus 로고    scopus 로고
    • Mitochondrial dynamics in the regulation of nutrient utilization and energy expenditure
    • Liesa M, Shirihai OS. Mitochondrial dynamics in the regulation of nutrient utilization and energy expenditure. Cell Metab 2013; 17(4): 491-506.
    • (2013) Cell Metab , vol.17 , Issue.4 , pp. 491-506
    • Liesa, M.1    Shirihai, O.S.2
  • 58
    • 84911862896 scopus 로고    scopus 로고
    • IHG-1 Increases mitochondrial fusion and bioenergetic function
    • Hickey FB, Corcoran JB, Griffin B, et al. IHG-1 Increases mitochondrial fusion and bioenergetic function. Diabetes 2014; 63(12): 4314-25.
    • (2014) Diabetes , vol.63 , Issue.12 , pp. 4314-4325
    • Hickey, F.B.1    Corcoran, J.B.2    Griffin, B.3
  • 59
    • 79960951730 scopus 로고    scopus 로고
    • IHG-1 promotes mitochondrial biogenesis by stabilizing PGC-1alpha
    • Hickey FB, Corcoran JB, Docherty NG, et al. IHG-1 promotes mitochondrial biogenesis by stabilizing PGC-1alpha. J Am Soc Nephrol 2011; 22(8): 1475-85.
    • (2011) J am Soc Nephrol , vol.22 , Issue.8 , pp. 1475-1485
    • Hickey, F.B.1    Corcoran, J.B.2    Docherty, N.G.3
  • 60
    • 33749999530 scopus 로고    scopus 로고
    • Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators
    • St-Pierre J, Drori S, Uldry M, et al. Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators. Cell 2006; 127(2): 397-408.
    • (2006) Cell , vol.127 , Issue.2 , pp. 397-408
    • St-Pierre, J.1    Drori, S.2    Uldry, M.3
  • 61
    • 84863023552 scopus 로고    scopus 로고
    • Mitochondrial fission triggered by hyperglycemia is mediated by ROCK1 activation in podocytes and endothelial cells
    • Wang W, Wang Y, Long J, et al. Mitochondrial fission triggered by hyperglycemia is mediated by ROCK1 activation in podocytes and endothelial cells. Cell Metab 2012; 15(2): 186-200.
    • (2012) Cell Metab , vol.15 , Issue.2 , pp. 186-200
    • Wang, W.1    Wang, Y.2    Long, J.3
  • 62
    • 79961021186 scopus 로고    scopus 로고
    • Altered mitochondrial dynamics contributes to endothelial dysfunction in diabetes mellitus
    • Shenouda SM, Widlansky ME, Chen K, et al. Altered mitochondrial dynamics contributes to endothelial dysfunction in diabetes mellitus. Circulation 2011; 124(4): 444-53.
    • (2011) Circulation , vol.124 , Issue.4 , pp. 444-453
    • Shenouda, S.M.1    Widlansky, M.E.2    Chen, K.3
  • 63
    • 84855611491 scopus 로고    scopus 로고
    • Mitochondrial dysregulation in the pathogenesis of diabetes: Potential for mitochondrial biogenesis-mediated interventions
    • Joseph AM, Joanisse DR, Baillot RG, Hood DA. Mitochondrial dysregulation in the pathogenesis of diabetes: potential for mitochondrial biogenesis-mediated interventions. Exp Diabetes Res 2012; 2012: 642038.
    • (2012) Exp Diabetes Res , vol.2012 , pp. 642038
    • Joseph, A.M.1    Joanisse, D.R.2    Baillot, R.G.3    Hood, D.A.4
  • 64
    • 0034214103 scopus 로고    scopus 로고
    • Increase of mitochondria and mitochondrial DNA in response to oxidative stress in human cells
    • Lee HC, Yin PH, Lu CY, Chi CW, Wei YH. Increase of mitochondria and mitochondrial DNA in response to oxidative stress in human cells. Biochem J 2000; 348 Pt 2: 425-32.
    • (2000) Biochem J , vol.348 , pp. 425-432
    • Lee, H.C.1    Yin, P.H.2    Lu, C.Y.3    Chi, C.W.4    Wei, Y.H.5
  • 65
    • 33847110733 scopus 로고    scopus 로고
    • Insulinresistant heart exhibits a mitochondrial biogenic response driven by the peroxisome proliferator-activated receptor-alpha/PGC-1alpha gene regulatory pathway
    • Duncan JG, Fong JL, Medeiros DM, Finck BN, Kelly DP. Insulinresistant heart exhibits a mitochondrial biogenic response driven by the peroxisome proliferator-activated receptor-alpha/PGC-1alpha gene regulatory pathway. Circulation 2007; 115(7): 909-17.
    • (2007) Circulation , vol.115 , Issue.7 , pp. 909-917
    • Duncan, J.G.1    Fong, J.L.2    Medeiros, D.M.3    Finck, B.N.4    Kelly, D.P.5
  • 66
    • 27444441492 scopus 로고    scopus 로고
    • Reduced mitochondrial oxidative capacity and increased mitochondrial uncoupling impair myocardial energetics in obesity
    • Boudina S, Sena S, O'Neill BT, et al. Reduced mitochondrial oxidative capacity and increased mitochondrial uncoupling impair myocardial energetics in obesity. Circulation 2005; 112(17): 2686-95.
    • (2005) Circulation , vol.112 , Issue.17 , pp. 2686-2695
    • Boudina, S.1    Sena, S.2    O'neill, B.T.3
  • 67
    • 6044224889 scopus 로고    scopus 로고
    • Cardiac mitochondrial damage and biogenesis in a chronic model of type 1 diabetes
    • Shen X, Zheng S, Thongboonkerd V, et al. Cardiac mitochondrial damage and biogenesis in a chronic model of type 1 diabetes. Am J Physiol Endocrinol Metab 2004; 287(5): E896-905.
    • (2004) Am J Physiol Endocrinol Metab , vol.287 , Issue.5
    • Shen, X.1    Zheng, S.2    Thongboonkerd, V.3
  • 69
    • 0031032817 scopus 로고    scopus 로고
    • Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress
    • Yakes FM, Van Houten B. Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress. Proc Natl Acad Sci U S A 1997; 94(2): 514-9.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , Issue.2 , pp. 514-519
    • Yakes, F.M.1    Van Houten, B.2
  • 71
    • 79960184112 scopus 로고    scopus 로고
    • Stability of mitochondrial DNA against reactive oxygen species (ROS) generated in diabetes
    • Savu O, Sunkari VG, Botusan IR, et al. Stability of mitochondrial DNA against reactive oxygen species (ROS) generated in diabetes. Diabetes Metab Res Rev 2011; 27(5): 470-9.
    • (2011) Diabetes Metab Res Rev , vol.27 , Issue.5 , pp. 470-479
    • Savu, O.1    Sunkari, V.G.2    Botusan, I.R.3
  • 72
    • 77249096912 scopus 로고    scopus 로고
    • Oxidative damage of mitochondrial DNA in diabetes and its protection by manganese superoxide dismutase
    • Madsen-Bouterse SA, Zhong Q, Mohammad G, Ho YS, Kowluru RA. Oxidative damage of mitochondrial DNA in diabetes and its protection by manganese superoxide dismutase. Free Radic Res 2010; 44(3): 313-21.
    • (2010) Free Radic Res , vol.44 , Issue.3 , pp. 313-321
    • Madsen-Bouterse, S.A.1    Zhong, Q.2    Mohammad, G.3    Ho, Y.S.4    Kowluru, R.A.5
  • 73
    • 75949098487 scopus 로고    scopus 로고
    • PINK1-dependent recruitment of Parkin to mitochondria in mitophagy
    • Vives-Bauza C, Zhou C, Huang Y, et al. PINK1-dependent recruitment of Parkin to mitochondria in mitophagy. Proc Natl Acad Sci U S A 2010; 107(1): 378-83.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.1 , pp. 378-383
    • Vives-Bauza, C.1    Zhou, C.2    Huang, Y.3
  • 74
    • 75949130828 scopus 로고    scopus 로고
    • PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
    • Geisler S, Holmstrom KM, Skujat D, et al. PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1. Nat Cell Biol 2010; 12(2): 119-31.
    • (2010) Nat Cell Biol , vol.12 , Issue.2 , pp. 119-131
    • Geisler, S.1    Holmstrom, K.M.2    Skujat, D.3
  • 75
    • 35948950608 scopus 로고    scopus 로고
    • Altered regulation of the PINK1 locus: A link between type 2 diabetes and neurodegeneration?
    • Scheele C, Nielsen AR, Walden TB, et al. Altered regulation of the PINK1 locus: a link between type 2 diabetes and neurodegeneration? FASEB J 2007; 21(13): 3653-65.
    • (2007) FASEB J , vol.21 , Issue.13 , pp. 3653-3665
    • Scheele, C.1    Nielsen, A.R.2    Walden, T.B.3
  • 76
    • 84930462727 scopus 로고    scopus 로고
    • Disruption of renal tubular mitochondrial quality control by myo-inositol oxygenase in diabetic kidney disease
    • Zhan M, Usman IM, Sun L, Kanwar YS. Disruption of renal tubular mitochondrial quality control by myo-inositol oxygenase in diabetic kidney disease. J Am Soc Nephrol 2015; 26(6): 1304-21.
    • (2015) J am Soc Nephrol , vol.26 , Issue.6 , pp. 1304-1321
    • Zhan, M.1    Usman, I.M.2    Sun, L.3    Kanwar, Y.S.4
  • 77
    • 79958152853 scopus 로고    scopus 로고
    • Superoxide dismutase in redox biology: The roles of superoxide and hydrogen peroxide
    • Buettner GR. Superoxide dismutase in redox biology: the roles of superoxide and hydrogen peroxide. Anticancer Agents Med Chem 2011; 11(4): 341-6.
    • (2011) Anticancer Agents Med Chem , vol.11 , Issue.4 , pp. 341-346
    • Buettner, G.R.1
  • 78
    • 78649287952 scopus 로고    scopus 로고
    • Functional mimics of glutathione peroxidase: Bioinspired synthetic antioxidants
    • Bhabak KP, Mugesh G. Functional mimics of glutathione peroxidase: bioinspired synthetic antioxidants. Acc Chem Res 2010; 43(11): 1408-19.
    • (2010) Acc Chem Res , vol.43 , Issue.11 , pp. 1408-1419
    • Bhabak, K.P.1    Mugesh, G.2
  • 80
    • 0034643340 scopus 로고    scopus 로고
    • Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage
    • Nishikawa T, Edelstein D, Du XL, et al. Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature 2000; 404(6779): 787-90.
    • (2000) Nature , vol.404 , Issue.6779 , pp. 787-790
    • Nishikawa, T.1    Edelstein, D.2    Du, X.L.3
  • 81
    • 33644766038 scopus 로고    scopus 로고
    • Protection of cardiac mitochondria by overexpression of MnSOD reduces diabetic cardiomyopathy
    • Shen X, Zheng S, Metreveli NS, Epstein PN. Protection of cardiac mitochondria by overexpression of MnSOD reduces diabetic cardiomyopathy. Diabetes 2006; 55(3): 798-805.
    • (2006) Diabetes , vol.55 , Issue.3 , pp. 798-805
    • Shen, X.1    Zheng, S.2    Metreveli, N.S.3    Epstein, P.N.4
  • 82
    • 33645474281 scopus 로고    scopus 로고
    • Therapeutic approach for diabetic nephropathy using gene delivery of translocase of inner mitochondrial membrane 44 by reducing mitochondrial superoxide production
    • Zhang Y, Wada J, Hashimoto I, et al. Therapeutic approach for diabetic nephropathy using gene delivery of translocase of inner mitochondrial membrane 44 by reducing mitochondrial superoxide production. J Am Soc Nephrol 2006; 17(4): 1090-101.
    • (2006) J am Soc Nephrol , vol.17 , Issue.4 , pp. 1090-1101
    • Zhang, Y.1    Wada, J.2    Hashimoto, I.3
  • 84
    • 84901250530 scopus 로고    scopus 로고
    • Manganese superoxide dismutase (SOD2) polymorphisms, plasma advanced oxidation protein products (AOPP) concentration and risk of kidney complications in subjects with type 1 diabetes
    • Mohammedi K, Bellili-Munoz N, Driss F, et al. Manganese superoxide dismutase (SOD2) polymorphisms, plasma advanced oxidation protein products (AOPP) concentration and risk of kidney complications in subjects with type 1 diabetes. PLoS One 2014; 9(5): e96916.
    • (2014) Plos One , vol.9 , Issue.5
    • Mohammedi, K.1    Bellili-Munoz, N.2    Driss, F.3
  • 85
    • 70949106507 scopus 로고    scopus 로고
    • The V16A polymorphism in SOD2 is associated with increased risk of diabetic nephropathy and cardiovascular disease in type 1 diabetes
    • Mollsten A, Jorsal A, Lajer M, Vionnet N, Tarnow L. The V16A polymorphism in SOD2 is associated with increased risk of diabetic nephropathy and cardiovascular disease in type 1 diabetes. Diabetologia 2009; 52(12): 2590-3.
    • (2009) Diabetologia , vol.52 , Issue.12 , pp. 2590-2593
    • Mollsten, A.1    Jorsal, A.2    Lajer, M.3    Vionnet, N.4    Tarnow, L.5
  • 86
    • 84872185416 scopus 로고    scopus 로고
    • Coenzyme Q10 prevents peripheral neuropathy and attenuates neuron loss in the db-/dbmouse, a type 2 diabetes model
    • Shi TJ, Zhang MD, Zeberg H, et al. Coenzyme Q10 prevents peripheral neuropathy and attenuates neuron loss in the db-/dbmouse, a type 2 diabetes model. Proc Natl Acad Sci USA 2013;110(2): 690-5.
    • (2013) Proc Natl Acad Sci USA , vol.110 , Issue.2 , pp. 690-695
    • Shi, T.J.1    Zhang, M.D.2    Zeberg, H.3
  • 87
    • 84875898962 scopus 로고    scopus 로고
    • Prophylactic and antinociceptive effects of coenzyme Q10 on diabetic neuropathic pain in a mouse model of type 1 diabetes
    • Zhang YP, Eber A, Yuan Y, et al. Prophylactic and antinociceptive effects of coenzyme Q10 on diabetic neuropathic pain in a mouse model of type 1 diabetes. Anesthesiology 2013; 118(4): 945-54.
    • (2013) Anesthesiology , vol.118 , Issue.4 , pp. 945-954
    • Zhang, Y.P.1    Eber, A.2    Yuan, Y.3
  • 88
    • 84879476551 scopus 로고    scopus 로고
    • Diabetic neuropathic pain development in type 2 diabetic mouse model and the prophylactic and therapeutic effects of coenzyme Q10
    • Zhang YP, Song CY, Yuan Y, et al. Diabetic neuropathic pain development in type 2 diabetic mouse model and the prophylactic and therapeutic effects of coenzyme Q10. Neurobiol Dis 2013; 58: 169-78.
    • (2013) Neurobiol Dis , vol.58 , pp. 169-178
    • Zhang, Y.P.1    Song, C.Y.2    Yuan, Y.3
  • 89
    • 84916208765 scopus 로고    scopus 로고
    • Effect of coenzyme Q10 alone and its combination with metformin on streptozotocin- nicotinamide-induced diabetic nephropathy in rats
    • Maheshwari RA, Balaraman R, Sen AK, Seth AK. Effect of coenzyme Q10 alone and its combination with metformin on streptozotocin- nicotinamide-induced diabetic nephropathy in rats. Indian J Pharmacol 2014; 46(6): 627-32.
    • (2014) Indian J Pharmacol , vol.46 , Issue.6 , pp. 627-632
    • Maheshwari, R.A.1    Balaraman, R.2    Sen, A.K.3    Seth, A.K.4
  • 90
    • 84856239775 scopus 로고    scopus 로고
    • Ubiquinone (Coenzyme Q10) prevents renal mitochondrial dysfunction in an experimental model of type 2 diabetes
    • Sourris KC, Harcourt BE, Tang PH, et al. Ubiquinone (coenzyme Q10) prevents renal mitochondrial dysfunction in an experimental model of type 2 diabetes. Free Radic Biol Med 2012; 52(3): 716-23.
    • (2012) Free Radic Biol Med , vol.52 , Issue.3 , pp. 716-723
    • Sourris, K.C.1    Harcourt, B.E.2    Tang, P.H.3
  • 91
    • 84889878507 scopus 로고    scopus 로고
    • Tempol ameliorates cardiac fibrosis in streptozotocin-induced diabetic rats: Role of oxidative stress in diabetic cardiomyopathy
    • Taye A, Abouzied MM, Mohafez OM. Tempol ameliorates cardiac fibrosis in streptozotocin-induced diabetic rats: role of oxidative stress in diabetic cardiomyopathy. Naunyn Schmiedebergs Arch Pharmacol 2013; 386(12): 1071-80.
    • (2013) Naunyn Schmiedebergs Arch Pharmacol , vol.386 , Issue.12 , pp. 1071-1080
    • Taye, A.1    Abouzied, M.M.2    Mohafez, O.M.3
  • 92
    • 33645220950 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3beta together with 14-3-3 protein regulates diabetic cardiomyopathy: Effect of losartan and tempol
    • Gurusamy N, Watanabe K, Ma M, et al. Glycogen synthase kinase 3beta together with 14-3-3 protein regulates diabetic cardiomyopathy: effect of losartan and tempol. FEBS Lett 2006; 580(8): 1932-40.
    • (2006) FEBS Lett , vol.580 , Issue.8 , pp. 1932-1940
    • Gurusamy, N.1    Watanabe, K.2    Ma, M.3
  • 93
    • 84859642245 scopus 로고    scopus 로고
    • P53 promotes cardiac dysfunction in diabetic mellitus caused by excessive mitochondrial respiration-mediated reactive oxygen species generation and lipid accumulation
    • Nakamura H, Matoba S, Iwai-Kanai E, et al. p53 promotes cardiac dysfunction in diabetic mellitus caused by excessive mitochondrial respiration-mediated reactive oxygen species generation and lipid accumulation. Circ Heart Fail 2012; 5(1): 106-15.
    • (2012) Circ Heart Fail , vol.5 , Issue.1 , pp. 106-115
    • Nakamura, H.1    Matoba, S.2    Iwai-Kanai, E.3
  • 94
    • 84863083735 scopus 로고    scopus 로고
    • Renal protection of in vivo administration of tempol in streptozotocin-induced diabetic rats
    • Luan J, Li W, Han J, et al. Renal protection of in vivo administration of tempol in streptozotocin-induced diabetic rats. J Pharmacol Sci 2012; 119(2): 167-76.
    • (2012) J Pharmacol Sci , vol.119 , Issue.2 , pp. 167-176
    • Luan, J.1    Li, W.2    Han, J.3
  • 95
    • 67449104064 scopus 로고    scopus 로고
    • Reduction of renal superoxide dismutase in progressive diabetic nephropathy
    • Fujita H, Fujishima H, Chida S, et al. Reduction of renal superoxide dismutase in progressive diabetic nephropathy. J Am Soc Nephrol 2009; 20(6): 1303-13.
    • (2009) J am Soc Nephrol , vol.20 , Issue.6 , pp. 1303-1313
    • Fujita, H.1    Fujishima, H.2    Chida, S.3
  • 96
    • 84862020461 scopus 로고    scopus 로고
    • Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy
    • Bierhaus A, Fleming T, Stoyanov S, et al. Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy. Nat Med 2012; 18(6): 926-33.
    • (2012) Nat Med , vol.18 , Issue.6 , pp. 926-933
    • Bierhaus, A.1    Fleming, T.2    Stoyanov, S.3
  • 97
    • 84873177708 scopus 로고    scopus 로고
    • The protective effect of alpha- Lipoic acid on mitochondria in the kidney of diabetic rats
    • Wang L, Wu CG, Fang CQ, et al. The protective effect of alpha- Lipoic acid on mitochondria in the kidney of diabetic rats. Int J Clin Exp Med 2013; 6(2): 90-7.
    • (2013) Int J Clin Exp Med , vol.6 , Issue.2 , pp. 90-97
    • Wang, L.1    Wu, C.G.2    Fang, C.Q.3
  • 98
    • 84881663186 scopus 로고    scopus 로고
    • Oxidative stress in skeletal muscle impairs mitochondrial function in alloxan induced diabetic rats: Role of alpha lipoic acid
    • Saraswathi R, Devaraj SN. Oxidative stress in skeletal muscle impairs mitochondrial function in alloxan induced diabetic rats: Role of alpha lipoic acid. Biomed Prev Nutr 2013; 3(3): 213-9.
    • (2013) Biomed Prev Nutr , vol.3 , Issue.3 , pp. 213-219
    • Saraswathi, R.1    Devaraj, S.N.2
  • 99
    • 84894380843 scopus 로고    scopus 로고
    • Effects of combined lipoic acid and pyridoxine on albuminuria, advanced glycation end-products, and blood pressure in diabetic nephropathy
    • Noori N, Tabibi H, Hosseinpanah F, Hedayati M, Nafar M. Effects of combined lipoic acid and pyridoxine on albuminuria, advanced glycation end-products, and blood pressure in diabetic nephropathy. Int J Vitam Nutr Res 2013; 83(2): 77-85.
    • (2013) Int J Vitam Nutr Res , vol.83 , Issue.2 , pp. 77-85
    • Noori, N.1    Tabibi, H.2    Hosseinpanah, F.3    Hedayati, M.4    Nafar, M.5
  • 100
    • 0042879795 scopus 로고    scopus 로고
    • Reactive oxygen species cause diabetes-induced decrease in renal oxygen tension
    • Palm F, Cederberg J, Hansell P, Liss P, Carlsson PO. Reactive oxygen species cause diabetes-induced decrease in renal oxygen tension. Diabetologia 2003; 46(8): 1153-60.
    • (2003) Diabetologia , vol.46 , Issue.8 , pp. 1153-1160
    • Palm, F.1    Cederberg, J.2    Hansell, P.3    Liss, P.4    Carlsson, P.O.5
  • 101
    • 84871618965 scopus 로고    scopus 로고
    • Resveratrol prevents renal lipotoxicity and inhibits mesangial cell glucotoxicity in a manner dependent on the AMPK-SIRT1-PGC1alpha axis in db/db mice
    • Kim MY, Lim JH, Youn HH, et al. Resveratrol prevents renal lipotoxicity and inhibits mesangial cell glucotoxicity in a manner dependent on the AMPK-SIRT1-PGC1alpha axis in db/db mice. Diabetologia 2013; 56(1): 204-17.
    • (2013) Diabetologia , vol.56 , Issue.1 , pp. 204-217
    • Kim, M.Y.1    Lim, J.H.2    Youn, H.H.3
  • 102
    • 84897811327 scopus 로고    scopus 로고
    • Resveratrol prevention of diabetic nephropathy is associated with the suppression of renal inflammation and mesangial cell proliferation: Possible roles of Akt/NFkappaB pathway
    • Xu F, Wang Y, Cui W, et al. Resveratrol prevention of diabetic nephropathy is associated with the suppression of renal inflammation and mesangial cell proliferation: possible roles of Akt/NFkappaB pathway. Int J Endocrinol 2014; 2014: 289327.
    • (2014) Int J Endocrinol , vol.2014 , pp. 289327
    • Xu, F.1    Wang, Y.2    Cui, W.3
  • 103
    • 84988850973 scopus 로고    scopus 로고
    • Curcumin restores mitochondrial functions and decreases lipid peroxidation in liver and kidneys of diabetic db/db mice
    • Soto-Urquieta MG, Lopez-Briones S, Perez-Vazquez V, et al. Curcumin restores mitochondrial functions and decreases lipid peroxidation in liver and kidneys of diabetic db/db mice. Biol Res 2014; 47(1): 74.
    • (2014) Biol Res , vol.47 , Issue.1 , pp. 74
    • Soto-Urquieta, M.G.1    Lopez-Briones, S.2    Perez-Vazquez, V.3
  • 104
    • 84886483694 scopus 로고    scopus 로고
    • Antioxidant N-acetylcysteine protects pancreatic beta-cells against aldosterone-induced oxidative stress and apoptosis in female db/db mice and insulin-producing MIN6 cells
    • Jin HM, Zhou DC, Gu HF, et al. Antioxidant N-acetylcysteine protects pancreatic beta-cells against aldosterone-induced oxidative stress and apoptosis in female db/db mice and insulin-producing MIN6 cells. Endocrinology 2013; 154(11): 4068-77.
    • (2013) Endocrinology , vol.154 , Issue.11 , pp. 4068-4077
    • Jin, H.M.1    Zhou, D.C.2    Gu, H.F.3
  • 105
    • 84904677293 scopus 로고    scopus 로고
    • Effects of warfarin and L-carnitine on hemostatic function and oxidative stress in streptozotocin-induced diabetic rats
    • ElGendy AA, Abbas AM. Effects of warfarin and L-carnitine on hemostatic function and oxidative stress in streptozotocin-induced diabetic rats. J Physiol Biochem 2014; 70(2): 535-46.
    • (2014) J Physiol Biochem , vol.70 , Issue.2 , pp. 535-546
    • Elgendy, A.A.1    Abbas, A.M.2
  • 106
    • 77955283395 scopus 로고    scopus 로고
    • Animal and human studies with the mitochondria- targeted antioxidant MitoQ
    • Smith RA, Murphy MP. Animal and human studies with the mitochondria- targeted antioxidant MitoQ. Ann N Y Acad Sci 2010; 1201: 96-103.
    • (2010) Ann N Y Acad Sci , vol.1201 , pp. 96-103
    • Smith, R.A.1    Murphy, M.P.2
  • 107
    • 0036311298 scopus 로고    scopus 로고
    • Superoxide dismutase mimetics: Synthesis and structure-activity relationship study of MnTBAP analogues
    • Gauuan PJ, Trova MP, Gregor-Boros L, et al. Superoxide dismutase mimetics: synthesis and structure-activity relationship study of MnTBAP analogues. Bioorg Med Chem 2002; 10(9): 3013-21.
    • (2002) Bioorg Med Chem , vol.10 , Issue.9 , pp. 3013-3021
    • Gauuan, P.J.1    Trova, M.P.2    Gregor-Boros, L.3
  • 108
    • 58049131646 scopus 로고    scopus 로고
    • Pure MnTBAP selectively scavenges peroxynitrite over superoxide: Comparison of pure and commercial MnTBAP samples to MnTE-2-PyP in two models of oxidative stress injury, an SOD-specific Escherichia coli model and carrageenan-induced pleurisy
    • Batinic-Haberle I, Cuzzocrea S, Reboucas JS, et al. Pure MnTBAP selectively scavenges peroxynitrite over superoxide: comparison of pure and commercial MnTBAP samples to MnTE-2-PyP in two models of oxidative stress injury, an SOD-specific Escherichia coli model and carrageenan-induced pleurisy. Free Radic Biol Med 2009; 46(2): 192-201.
    • (2009) Free Radic Biol Med , vol.46 , Issue.2 , pp. 192-201
    • Batinic-Haberle, I.1    Cuzzocrea, S.2    Reboucas, J.S.3
  • 109
    • 77954141949 scopus 로고    scopus 로고
    • Coenzyme Q10 treatment ameliorates acute cisplatin nephrotoxicity in mice
    • Fouad AA, Al-Sultan AI, Refaie SM, Yacoubi MT. Coenzyme Q10 treatment ameliorates acute cisplatin nephrotoxicity in mice. Toxicology 2010; 274(1-3): 49-56.
    • (2010) Toxicology , vol.274 , Issue.1-3 , pp. 49-56
    • Fouad, A.A.1    Al-Sultan, A.I.2    Refaie, S.M.3    Yacoubi, M.T.4
  • 111
    • 48849114553 scopus 로고    scopus 로고
    • Is alpha-lipoic acid a scavenger of reactive oxygen species in vivo? Evidence for its initiation of stress signaling pathways that promote endogenous antioxidant capacity
    • Shay KP, Moreau RF, Smith EJ, Hagen TM. Is alpha-lipoic acid a scavenger of reactive oxygen species in vivo? Evidence for its initiation of stress signaling pathways that promote endogenous antioxidant capacity. IUBMB Life 2008; 60(6): 362-7.
    • (2008) IUBMB Life , vol.60 , Issue.6 , pp. 362-367
    • Shay, K.P.1    Moreau, R.F.2    Smith, E.J.3    Hagen, T.M.4
  • 112
    • 65349101182 scopus 로고    scopus 로고
    • Alpha-tocopherol: Looking beyond an antioxidant
    • Engin KN. Alpha-tocopherol: looking beyond an antioxidant. Mol Vis 2009; 15: 855-60.
    • (2009) Mol Vis , vol.15 , pp. 855-860
    • Engin, K.N.1
  • 114
    • 0035895888 scopus 로고    scopus 로고
    • Selective targeting of a redox-active ubiquinone to mitochondria within cells: Antioxidant and antiapoptotic properties
    • Kelso GF, Porteous CM, Coulter CV, et al. Selective targeting of a redox-active ubiquinone to mitochondria within cells: antioxidant and antiapoptotic properties. J Biol Chem 2001; 276(7): 4588-96.
    • (2001) J Biol Chem , vol.276 , Issue.7 , pp. 4588-4596
    • Kelso, G.F.1    Porteous, C.M.2    Coulter, C.V.3
  • 115
    • 45849115079 scopus 로고    scopus 로고
    • Antioxidant and radical scavenging properties of curcumin
    • Ak T, Gulcin I. Antioxidant and radical scavenging properties of curcumin. Chem Biol Interact 2008; 174(1): 27-37.
    • (2008) Chem Biol Interact , vol.174 , Issue.1 , pp. 27-37
    • Ak, T.1    Gulcin, I.2
  • 116
    • 0024394697 scopus 로고
    • The antioxidant action of N-acetylcysteine: Its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid
    • Aruoma OI, Halliwell B, Hoey BM, Butler J. The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid. Free Radic Biol Med 1989; 6(6): 593-7.
    • (1989) Free Radic Biol Med , vol.6 , Issue.6 , pp. 593-597
    • Aruoma, O.I.1    Halliwell, B.2    Hoey, B.M.3    Butler, J.4
  • 117
    • 30544455318 scopus 로고    scopus 로고
    • Antioxidant and antiradical activities of L-carnitine
    • Gulcin I. Antioxidant and antiradical activities of L-carnitine. Life Sci 2006; 78(8): 803-11.
    • (2006) Life Sci , vol.78 , Issue.8 , pp. 803-811
    • Gulcin, I.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.