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Volumn 57, Issue 10, 2008, Pages 1434-1444

Renal and metabolic effects of tempol in obese ZSF1 rats-distinct role for superoxide and hydrogen peroxide in diabetic renal injury

Author keywords

[No Author keywords available]

Indexed keywords

CATALASE; COLLAGEN TYPE 4; HYDROGEN PEROXIDE; PEROXIDASE; SUPEROXIDE; SUPEROXIDE DISMUTASE; TEMPOL;

EID: 51649103541     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.metabol.2008.05.014     Document Type: Article
Times cited : (38)

References (52)
  • 1
    • 30344486998 scopus 로고    scopus 로고
    • Oxidative stress and diabetic cardiovascular complications
    • Jay D., Hitomi H., and Griendling K.K. Oxidative stress and diabetic cardiovascular complications. Free Radic Biol Med 40 (2006) 183-192
    • (2006) Free Radic Biol Med , vol.40 , pp. 183-192
    • Jay, D.1    Hitomi, H.2    Griendling, K.K.3
  • 2
    • 2442421194 scopus 로고    scopus 로고
    • Is oxidative stress the pathogenic mechanism underlying insulin resistance, diabetes, and cardiovascular disease? The common soil hypothesis revisited
    • Ceriello A., and Motz E. Is oxidative stress the pathogenic mechanism underlying insulin resistance, diabetes, and cardiovascular disease? The common soil hypothesis revisited. Arterioscler Thromb Vasc Biol 24 (2004) 816-823
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 816-823
    • Ceriello, A.1    Motz, E.2
  • 3
    • 33745138155 scopus 로고    scopus 로고
    • Oxidative stress and dysregulation of NAD(P)H oxidase and antioxidant enzymes in diet-induced metabolic syndrome
    • Roberts C.K., Barnard R.J., Sindhu R.K., et al. Oxidative stress and dysregulation of NAD(P)H oxidase and antioxidant enzymes in diet-induced metabolic syndrome. Metabolism 55 (2006) 928-934
    • (2006) Metabolism , vol.55 , pp. 928-934
    • Roberts, C.K.1    Barnard, R.J.2    Sindhu, R.K.3
  • 4
    • 0041865372 scopus 로고    scopus 로고
    • ROS generation by nonphagocytic NADPH oxidase: potential relevance in diabetic nephropathy
    • Li M.-J., and Shah A.M. ROS generation by nonphagocytic NADPH oxidase: potential relevance in diabetic nephropathy. J Am Soc Nephrol 14 (2003) S221-S226
    • (2003) J Am Soc Nephrol , vol.14
    • Li, M.-J.1    Shah, A.M.2
  • 5
    • 1342346794 scopus 로고    scopus 로고
    • Dysregulation of hepatic superoxide dismutase, catalase and glutathione peroxidase in diabetes: response to insulin and antioxidant therapies
    • Sindhu R.K., Koo J.R., Roberts C.K., et al. Dysregulation of hepatic superoxide dismutase, catalase and glutathione peroxidase in diabetes: response to insulin and antioxidant therapies. Clin Exp Hypertens 26 (2004) 43-53
    • (2004) Clin Exp Hypertens , vol.26 , pp. 43-53
    • Sindhu, R.K.1    Koo, J.R.2    Roberts, C.K.3
  • 6
    • 0033868421 scopus 로고    scopus 로고
    • Tempol, a membrane-permeable radical scavenger, reduces oxidant stress-mediated renal dysfunction and injury in the rat
    • Chatterjee P.K., Cuzzocrea S., Brown P.A.J., et al. Tempol, a membrane-permeable radical scavenger, reduces oxidant stress-mediated renal dysfunction and injury in the rat. Kidney Int 5 (2000) 658-673
    • (2000) Kidney Int , vol.5 , pp. 658-673
    • Chatterjee, P.K.1    Cuzzocrea, S.2    Brown, P.A.J.3
  • 7
    • 0031727611 scopus 로고    scopus 로고
    • Decline in the expression of copper/zinc superoxide dismutase in the kidney of rat with endotoxic shock: effects of the superoxide anion radical scavenger, tempol, on organ injury
    • Leach M., Frank S., Olbrich A., et al. Decline in the expression of copper/zinc superoxide dismutase in the kidney of rat with endotoxic shock: effects of the superoxide anion radical scavenger, tempol, on organ injury. Br J Pharmacol 125 (1998) 817-825
    • (1998) Br J Pharmacol , vol.125 , pp. 817-825
    • Leach, M.1    Frank, S.2    Olbrich, A.3
  • 8
    • 0033208768 scopus 로고    scopus 로고
    • A membrane permeable radical scavenger reduces the organ injury in hemorrhagic shock
    • Mota-Filipe H., McDonald M.C., Cuzzocrea S., et al. A membrane permeable radical scavenger reduces the organ injury in hemorrhagic shock. Shock 12 (1999) 255-261
    • (1999) Shock , vol.12 , pp. 255-261
    • Mota-Filipe, H.1    McDonald, M.C.2    Cuzzocrea, S.3
  • 9
    • 0032956654 scopus 로고    scopus 로고
    • Two-week administration of tempol attenuates both hypertension and renal excretion of 8-Iso prostaglandin f2 alpha
    • Schnackenberg C.G., and Wilcox C.S. Two-week administration of tempol attenuates both hypertension and renal excretion of 8-Iso prostaglandin f2 alpha. Hypertension 33 (1999) 424-428
    • (1999) Hypertension , vol.33 , pp. 424-428
    • Schnackenberg, C.G.1    Wilcox, C.S.2
  • 10
    • 0035095743 scopus 로고    scopus 로고
    • Long-term antioxidant administration attenuates mineralocorticoid hypertension and renal inflammatory response
    • Beswick R.A., Zhang H., Marable D., et al. Long-term antioxidant administration attenuates mineralocorticoid hypertension and renal inflammatory response. Hypertension 37 (2001) 781-786
    • (2001) Hypertension , vol.37 , pp. 781-786
    • Beswick, R.A.1    Zhang, H.2    Marable, D.3
  • 11
    • 0942287120 scopus 로고    scopus 로고
    • The SOD mimetic tempol ameliorates glomerular injury and reduces mitogen-activated protein kinase activity in Dahl salt-sensitive rats
    • Nishiyama A., Yoshizumi M., Hitomi H., et al. The SOD mimetic tempol ameliorates glomerular injury and reduces mitogen-activated protein kinase activity in Dahl salt-sensitive rats. J Am Soc Nephrol 15 (2004) 306-315
    • (2004) J Am Soc Nephrol , vol.15 , pp. 306-315
    • Nishiyama, A.1    Yoshizumi, M.2    Hitomi, H.3
  • 12
    • 33644810519 scopus 로고    scopus 로고
    • Enhanced superoxide generation modulates renal function in ANG II-induced hypertensive rats
    • Kopkan L., Castillo A., Navar G.L., et al. Enhanced superoxide generation modulates renal function in ANG II-induced hypertensive rats. Am J Physiol Renal Physiol 290 (2006) F80-F86
    • (2006) Am J Physiol Renal Physiol , vol.290
    • Kopkan, L.1    Castillo, A.2    Navar, G.L.3
  • 13
    • 34548721060 scopus 로고    scopus 로고
    • Simvastatin reverses target organ damage and oxidative stress in angiotensin II hypertension: comparison with apocynin, tempol and hydralazine
    • Rugale C., Delbosc S., Mimran A., and Jover B. Simvastatin reverses target organ damage and oxidative stress in angiotensin II hypertension: comparison with apocynin, tempol and hydralazine. J Cardiovasc Pharmacol 50 (2007) 293-298
    • (2007) J Cardiovasc Pharmacol , vol.50 , pp. 293-298
    • Rugale, C.1    Delbosc, S.2    Mimran, A.3    Jover, B.4
  • 14
    • 33644790140 scopus 로고    scopus 로고
    • Acute effects of the superoxide dismutase mimetic tempol on split kidney function in two-kidney one-clip hypertensive rats
    • Gregor G.S., Grimberg E.S., Basu S., et al. Acute effects of the superoxide dismutase mimetic tempol on split kidney function in two-kidney one-clip hypertensive rats. J Hypertension 24 (2006) 387-394
    • (2006) J Hypertension , vol.24 , pp. 387-394
    • Gregor, G.S.1    Grimberg, E.S.2    Basu, S.3
  • 15
    • 21344447490 scopus 로고    scopus 로고
    • Tempol reduces oxidative stress, improves insulin sensitivity, decreases renal domapine D1 receptor hyperphosphorylation, and restores D1 receptor-G-protein coupling and function in obese Zucker rats
    • Banday A.A., Marwaha A., Tallam L.S., et al. Tempol reduces oxidative stress, improves insulin sensitivity, decreases renal domapine D1 receptor hyperphosphorylation, and restores D1 receptor-G-protein coupling and function in obese Zucker rats. Diabetes 54 (2005) 2219-2226
    • (2005) Diabetes , vol.54 , pp. 2219-2226
    • Banday, A.A.1    Marwaha, A.2    Tallam, L.S.3
  • 16
    • 33846611038 scopus 로고    scopus 로고
    • Double-edged action of SOD mimetic in diabetic nephropathy
    • Asaba K., Tojo A., Onozato M.L., et al. Double-edged action of SOD mimetic in diabetic nephropathy. J Cardiovasc Pharmacol 49 (2007) 13-19
    • (2007) J Cardiovasc Pharmacol , vol.49 , pp. 13-19
    • Asaba, K.1    Tojo, A.2    Onozato, M.L.3
  • 17
    • 0033936107 scopus 로고    scopus 로고
    • Renal function and structure in diabetic, hypertensive, obese ZDF × SHHF-hybrid rats
    • Tofovic S.P., Kusaka H., Kost C.K., et al. Renal function and structure in diabetic, hypertensive, obese ZDF × SHHF-hybrid rats. Ren Fail 22 (2000) 387-406
    • (2000) Ren Fail , vol.22 , pp. 387-406
    • Tofovic, S.P.1    Kusaka, H.2    Kost, C.K.3
  • 19
    • 0042733747 scopus 로고    scopus 로고
    • Animal models of the metabolic syndrome
    • Tofovic S.P., and Jackson E.K. Animal models of the metabolic syndrome. Methods Mol Med 86 (2003) 29-36
    • (2003) Methods Mol Med , vol.86 , pp. 29-36
    • Tofovic, S.P.1    Jackson, E.K.2
  • 20
    • 71849104860 scopus 로고
    • Protein measurement with the Folin phenol reagent
    • Lowry O.H., Rosebrough N.J., Farr A.L., et al. Protein measurement with the Folin phenol reagent. J Biol Chem 193 (1951) 265-275
    • (1951) J Biol Chem , vol.193 , pp. 265-275
    • Lowry, O.H.1    Rosebrough, N.J.2    Farr, A.L.3
  • 21
    • 0014691242 scopus 로고
    • Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein)
    • McCord J.M., and Fridovich I. Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). J Biol Chem 244 (1969) 6049-6055
    • (1969) J Biol Chem , vol.244 , pp. 6049-6055
    • McCord, J.M.1    Fridovich, I.2
  • 22
    • 0000024076 scopus 로고
    • Catalase
    • Bergmeyer H.U. (Ed), VCH Verlagsgesellschaft mbH, Weinheim
    • Aebi H.E. Catalase. In: Bergmeyer H.U. (Ed). Methods of enzymatic analysis vol. 3 (1987), VCH Verlagsgesellschaft mbH, Weinheim 273-286
    • (1987) Methods of enzymatic analysis , vol.3 , pp. 273-286
    • Aebi, H.E.1
  • 23
    • 0346100519 scopus 로고    scopus 로고
    • Dityrosine as a product of oxidative stress and fluorescent probe
    • Malencik D.A., and Anderson S.R. Dityrosine as a product of oxidative stress and fluorescent probe. Amino Acids 25 (2003) 233-247
    • (2003) Amino Acids , vol.25 , pp. 233-247
    • Malencik, D.A.1    Anderson, S.R.2
  • 24
    • 0026764147 scopus 로고
    • Oxoammonium cation intermediate in the nitroxide-catalyzed dismutation of superoxide
    • Krishna M.C., Grahame D.A., Samuni A., et al. Oxoammonium cation intermediate in the nitroxide-catalyzed dismutation of superoxide. Proc Natl Acad Sci U S A 89 (1992) 5537-5541
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 5537-5541
    • Krishna, M.C.1    Grahame, D.A.2    Samuni, A.3
  • 25
    • 15544370549 scopus 로고    scopus 로고
    • Systemic arterial pressure response to two weeks of tempol therapy in SHR: involvement of NO, the RAS, and oxidative stress
    • Yanes L., Romero D., Iliescu R., et al. Systemic arterial pressure response to two weeks of tempol therapy in SHR: involvement of NO, the RAS, and oxidative stress. Am J Physiol Regul Integr Comp Physiol 288 (2005) R903-R908
    • (2005) Am J Physiol Regul Integr Comp Physiol , vol.288
    • Yanes, L.1    Romero, D.2    Iliescu, R.3
  • 28
    • 27144449315 scopus 로고    scopus 로고
    • Cardiac and renal antioxidant enzymes and effects of tempol in hyperthyroid rats
    • Moreno J.M., Gomez I.R., Wangesteen R., et al. Cardiac and renal antioxidant enzymes and effects of tempol in hyperthyroid rats. Am J Physiol Endocrinol Metab 289 (2005) E776-E783
    • (2005) Am J Physiol Endocrinol Metab , vol.289
    • Moreno, J.M.1    Gomez, I.R.2    Wangesteen, R.3
  • 29
    • 33847007713 scopus 로고    scopus 로고
    • Early experimental obesity is associated with coronary endothelial dysfunction and oxidative stress
    • Galili O., Versari D., Satttler K.J., et al. Early experimental obesity is associated with coronary endothelial dysfunction and oxidative stress. Am J Physiol Heart Circ Physiol 292 (2007) H904-H911
    • (2007) Am J Physiol Heart Circ Physiol , vol.292
    • Galili, O.1    Versari, D.2    Satttler, K.J.3
  • 30
    • 33750006856 scopus 로고    scopus 로고
    • Relationship between insulin resistance and inflammatory markers and anti-inflammatory effect of losartan in patients with type-2 diabetes and hypertension
    • Park H., Hasegawa G., Obayash H., et al. Relationship between insulin resistance and inflammatory markers and anti-inflammatory effect of losartan in patients with type-2 diabetes and hypertension. Clin Chim Acta 374 (2006) 129-134
    • (2006) Clin Chim Acta , vol.374 , pp. 129-134
    • Park, H.1    Hasegawa, G.2    Obayash, H.3
  • 31
    • 19944429129 scopus 로고    scopus 로고
    • Abrogation of oxidative stress improves insulin sensitivity in the Ren-2 rat model of tissue angiotensin II overexpression
    • Blendea M.C., Jacobs D., Stump C.S., et al. Abrogation of oxidative stress improves insulin sensitivity in the Ren-2 rat model of tissue angiotensin II overexpression. Am J Physiol Endocrinol Metab 288 (2005) E353-E359
    • (2005) Am J Physiol Endocrinol Metab , vol.288
    • Blendea, M.C.1    Jacobs, D.2    Stump, C.S.3
  • 32
    • 34547693219 scopus 로고    scopus 로고
    • Acceleration of diabetic renal injury in the superoxide dismutase knockout mouse: effects of tempol
    • DeRubetis F.R., Carven P.A., and Melhem M.F. Acceleration of diabetic renal injury in the superoxide dismutase knockout mouse: effects of tempol. Metab Clin Exp 56 (2007) 1256-1264
    • (2007) Metab Clin Exp , vol.56 , pp. 1256-1264
    • DeRubetis, F.R.1    Carven, P.A.2    Melhem, M.F.3
  • 33
    • 0035461381 scopus 로고    scopus 로고
    • Over-expression of Cu2+/Zn2+ superoxide dismutase protects against early diabetic glomerular injury in transgenic mice
    • Craven P.A., Melhem M.F., Phillips S.L., et al. Over-expression of Cu2+/Zn2+ superoxide dismutase protects against early diabetic glomerular injury in transgenic mice. Diabetes 50 (2001) 2114-2125
    • (2001) Diabetes , vol.50 , pp. 2114-2125
    • Craven, P.A.1    Melhem, M.F.2    Phillips, S.L.3
  • 34
    • 1442349987 scopus 로고    scopus 로고
    • Attenuation of renal injury in db/db mice overexpressing superoxide dismutase: evidence for reduced superoxide-nitric oxide interaction
    • Deubertis F.R., Craven P.A., Melhem M.F., et al. Attenuation of renal injury in db/db mice overexpressing superoxide dismutase: evidence for reduced superoxide-nitric oxide interaction. Diabetes 53 (2004) 762-768
    • (2004) Diabetes , vol.53 , pp. 762-768
    • Deubertis, F.R.1    Craven, P.A.2    Melhem, M.F.3
  • 35
    • 1542284719 scopus 로고    scopus 로고
    • Superoxide dismutase-overexpressing mice are resistant to ozone-induced tissue injury and increases in nitric oxide and tumor necrosis factor-alpha
    • Fakhrzadeh L., Laskin J.D., Gardner, et al. Superoxide dismutase-overexpressing mice are resistant to ozone-induced tissue injury and increases in nitric oxide and tumor necrosis factor-alpha. Am J Respir Cell Mol Biol 30 (2004) 280-287
    • (2004) Am J Respir Cell Mol Biol , vol.30 , pp. 280-287
    • Fakhrzadeh, L.1    Laskin, J.D.2    Gardner3
  • 36
    • 0035140553 scopus 로고    scopus 로고
    • Superoxide anions and endothelial cell proliferation in normoglycemia and hyperglycemia
    • Zanetti M., Zwacka R., Engelhardt J., et al. Superoxide anions and endothelial cell proliferation in normoglycemia and hyperglycemia. Arterioscler Thromb Vasc Biol 21 (2001) 195-2001
    • (2001) Arterioscler Thromb Vasc Biol , vol.21 , pp. 195-2001
    • Zanetti, M.1    Zwacka, R.2    Engelhardt, J.3
  • 37
    • 2542533734 scopus 로고    scopus 로고
    • The role of nitric oxide in the development of diabetic angiopathy
    • Santilli F., Cipollone F., Mezzetti A., et al. The role of nitric oxide in the development of diabetic angiopathy. Horm Metab Res 36 (2004) 319-335
    • (2004) Horm Metab Res , vol.36 , pp. 319-335
    • Santilli, F.1    Cipollone, F.2    Mezzetti, A.3
  • 38
    • 33846863589 scopus 로고    scopus 로고
    • Nitric oxide and peroxynitrite in health and disease
    • Pacher P., Beckman J.S., and Liaudet L. Nitric oxide and peroxynitrite in health and disease. Physiol Rev 87 (2007) 315-424
    • (2007) Physiol Rev , vol.87 , pp. 315-424
    • Pacher, P.1    Beckman, J.S.2    Liaudet, L.3
  • 39
    • 0025322028 scopus 로고
    • Biologically active metal-independent superoxide dismutase mimics
    • Mitchell J.B., Samuni A., Krishna M.C., et al. Biologically active metal-independent superoxide dismutase mimics. Biochemistry 29 (1990) 2802-2807
    • (1990) Biochemistry , vol.29 , pp. 2802-2807
    • Mitchell, J.B.1    Samuni, A.2    Krishna, M.C.3
  • 40
    • 33847669673 scopus 로고    scopus 로고
    • Hypertension aggravates glomerular dysfunction with oxidative stress in a rat model of diabetic nephropathy
    • Tomohiro T., Kumai T., Sato T., et al. Hypertension aggravates glomerular dysfunction with oxidative stress in a rat model of diabetic nephropathy. Life Sci 80 (2007) 1364-1372
    • (2007) Life Sci , vol.80 , pp. 1364-1372
    • Tomohiro, T.1    Kumai, T.2    Sato, T.3
  • 41
    • 0036744927 scopus 로고    scopus 로고
    • Plasma lipid peroxidation products and antioxidant enzyme activities in patients with type 2 diabetes mellitus
    • Turk H.M., Sevinc A., Camci C., et al. Plasma lipid peroxidation products and antioxidant enzyme activities in patients with type 2 diabetes mellitus. Acta Diabetol 39 (2002) 117-122
    • (2002) Acta Diabetol , vol.39 , pp. 117-122
    • Turk, H.M.1    Sevinc, A.2    Camci, C.3
  • 42
    • 0141792792 scopus 로고    scopus 로고
    • 2 counteracts the vasodilator and natriuretic effects of superoxide dismutation by tempol in renal medulla
    • 2 counteracts the vasodilator and natriuretic effects of superoxide dismutation by tempol in renal medulla. Am J Physiol Regul Integr Comp Physiol 285 (2003) R827-R833
    • (2003) Am J Physiol Regul Integr Comp Physiol , vol.285
    • Chen, Y.F.1    Cowley, A.W.2    Zou, A.-P.3
  • 43
    • 0344514747 scopus 로고    scopus 로고
    • Myeloperoxidase in kidney disease
    • Malle E., Buch T., and Grone H.J. Myeloperoxidase in kidney disease. Kidney Int 64 (2003) 1956-1967
    • (2003) Kidney Int , vol.64 , pp. 1956-1967
    • Malle, E.1    Buch, T.2    Grone, H.J.3
  • 44
    • 0026233110 scopus 로고
    • Reactive oxygen metabolites cause massive, reversible proteinuria and glomerular sieving defect without apparent ultrastructural abnormality
    • Yoshioka T., Ichikawa I., and Fogo A. Reactive oxygen metabolites cause massive, reversible proteinuria and glomerular sieving defect without apparent ultrastructural abnormality. J Am Soc Nephrol 2 (1991) 902-912
    • (1991) J Am Soc Nephrol , vol.2 , pp. 902-912
    • Yoshioka, T.1    Ichikawa, I.2    Fogo, A.3
  • 45
    • 0023237155 scopus 로고
    • New mechanism for glomerular injury. Myeloperoxidase-hydrogen peroxide-halide system
    • Johnson R.J., Couser W.G., Chi E.Y., et al. New mechanism for glomerular injury. Myeloperoxidase-hydrogen peroxide-halide system. J Clin Invest 79 (1987) 1379-1387
    • (1987) J Clin Invest , vol.79 , pp. 1379-1387
    • Johnson, R.J.1    Couser, W.G.2    Chi, E.Y.3
  • 46
    • 0021858659 scopus 로고
    • Role of oxygen radicals in phorbol myristate acetate-induced glomerular injury
    • Rehan A., Johnson K.J., Kunkel R.G., et al. Role of oxygen radicals in phorbol myristate acetate-induced glomerular injury. Kidney Int 27 (1985) 503-511
    • (1985) Kidney Int , vol.27 , pp. 503-511
    • Rehan, A.1    Johnson, K.J.2    Kunkel, R.G.3
  • 47
    • 0021203006 scopus 로고
    • Evidence for the role of oxygen radicals in acute nephrotoxic nephritis
    • Rehan A., Johnson K.J., Wiggins R.C., et al. Evidence for the role of oxygen radicals in acute nephrotoxic nephritis. Lab Invest 51 (1984) 396-403
    • (1984) Lab Invest , vol.51 , pp. 396-403
    • Rehan, A.1    Johnson, K.J.2    Wiggins, R.C.3
  • 48
    • 33846204372 scopus 로고    scopus 로고
    • H2O2 increases production of constrictor prostaglandins in smooth muscle leading to enhanced arteriolar tone in type 2 diabetic mice
    • Erdei N., Bagi Z., Edes I., et al. H2O2 increases production of constrictor prostaglandins in smooth muscle leading to enhanced arteriolar tone in type 2 diabetic mice. Am J Physiol Heart Circ Physiol 292 (2007) H649-H656
    • (2007) Am J Physiol Heart Circ Physiol , vol.292
    • Erdei, N.1    Bagi, Z.2    Edes, I.3
  • 49
    • 28944438838 scopus 로고    scopus 로고
    • Hydrogen peroxide is an endothelium-dependent contracting factor in rat renal artery
    • Gao Y.J., and Lee R.M. Hydrogen peroxide is an endothelium-dependent contracting factor in rat renal artery. Br J Pharmacol 146 (2005) 1061-1068
    • (2005) Br J Pharmacol , vol.146 , pp. 1061-1068
    • Gao, Y.J.1    Lee, R.M.2
  • 51
    • 0141792792 scopus 로고    scopus 로고
    • 2 counteracts the vasodilatory and natriuretic effects of superoxide dismutation by tempol in renal medulla
    • 2 counteracts the vasodilatory and natriuretic effects of superoxide dismutation by tempol in renal medulla. Am J Physiol Regul Integr Comp Physiol 285 (2003) R827-R833
    • (2003) Am J Physiol Regul Integr Comp Physiol , vol.285
    • Chen, Y.F.1    Cowley, A.W.2    Zou, A.P.3
  • 52
    • 0030465044 scopus 로고    scopus 로고
    • EUK-134, a synthetic superoxide dismutase and catalase mimetic, protects rat kidneys from ischemia-reperfusion-induced damage
    • Gianello P., Saliez A., Bufkens X., et al. EUK-134, a synthetic superoxide dismutase and catalase mimetic, protects rat kidneys from ischemia-reperfusion-induced damage. Transplantation 62 (1996) 1664-1666
    • (1996) Transplantation , vol.62 , pp. 1664-1666
    • Gianello, P.1    Saliez, A.2    Bufkens, X.3


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