Acute knockdown of uncoupling protein-2 increases uncoupling via the adenine nucleotide transporter and decreases oxidative stress in diabetic kidneys

PLoS ONE

Volumn 7, Issue 7, 2012, Pages

  Friederich Persson, Malou ^a,b   Aslam, Shakil ^b   Nordquist, Lina ^a   Welch, William J ^b   Wilcox, Christopher S ^b   Palm, Fredrik ^a,c  

^a UPPSALA UNIVERSITY   (Sweden)

^b GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

^c LINKÖPING UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE NUCLEOTIDE TRANSLOCASE; ADENOSINE TRIPHOSPHATE; GLUCOSE; MALONALDEHYDE; SMALL INTERFERING RNA; THIOBARBITURIC ACID; UNCOUPLING PROTEIN 2; ADENOSINE DIPHOSPHATE; GUANOSINE DIPHOSPHATE; ION CHANNEL; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL UNCOUPLING PROTEIN 2; OXYGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETIC NEPHROPATHY; GENE SILENCING; GLUCOSE BLOOD LEVEL; IN VIVO STUDY; KIDNEY CORTEX; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; MOLECULAR DYNAMICS; MOLECULAR PATHOLOGY; NONHUMAN; OXIDATIVE PHOSPHORYLATION UNCOUPLING; OXIDATIVE STRESS; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; SIGNAL TRANSDUCTION; STREPTOZOCIN DIABETES; UPREGULATION; ANIMAL; EXPERIMENTAL DIABETES MELLITUS; GENETICS; METABOLISM; PATHOLOGY; SPRAGUE DAWLEY RAT;

RATTUS;

ADENOSINE DIPHOSPHATE; ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEPHROPATHIES; GENE KNOCKDOWN TECHNIQUES; GUANOSINE DIPHOSPHATE; ION CHANNELS; KIDNEY CORTEX; MALE; MALONDIALDEHYDE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; MITOCHONDRIAL ADP, ATP TRANSLOCASES; MITOCHONDRIAL PROTEINS; OXIDATIVE STRESS; OXYGEN; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84863615264     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0039635     Document Type: Article

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