메뉴 건너뛰기




Volumn 304, Issue 11, 2013, Pages 1317-1324

GC/TOFMS analysis of metabolites in serum and urine reveals metabolic perturbation of TCA cycle in db/db mice involved in diabetic nephropathy

Author keywords

Diabetic nephropathy; Gas chromatography mass spectrometry; Metabonomics; Tricarboxylic acid cycle

Indexed keywords

12 HYDROXYICOSATETRAENOIC ACID; ACONITIC ACID; ALBUMIN; ARGININE; CITRIC ACID; CORIOLIC ACID; ERYTHRONATE; ETHANOLAMINE; GLUCOSE; GLUCURONIC ACID; LYSINE; MALIC ACID; METHIONINE; PALMITIC ACID; STEARIC ACID; SUCCINIC ACID; TRICARBOXYLIC ACID; UNCLASSIFIED DRUG; VALINE;

EID: 84878648388     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00536.2012     Document Type: Article
Times cited : (94)

References (40)
  • 4
    • 79958080469 scopus 로고    scopus 로고
    • GC-TOFMS analysis of metabolites in adherent MDCK cells and a novel strategy for identifying intracellular metabolic markers for use as cell amount indicators in data normalization
    • Cao B, Aa J, Wang G, Wu X, Liu L, Li M, Shi J, Wang X, Zhao C, Zheng T, Guo S, Duan J. GC-TOFMS analysis of metabolites in adherent MDCK cells and a novel strategy for identifying intracellular metabolic markers for use as cell amount indicators in data normalization. Anal Bioanal Chem 400: 2983-2993, 2011.
    • (2011) Anal Bioanal Chem , vol.400 , pp. 2983-2993
    • Cao, B.1    Aa, J.2    Wang, G.3    Wu, X.4    Liu, L.5    Li, M.6    Shi, J.7    Wang, X.8    Zhao, C.9    Zheng, T.10    Guo, S.11    Duan, J.12
  • 6
    • 0024345894 scopus 로고
    • Clinical utility of kidney biopsies in the diagnosis and management of renal disease
    • Cohen AH, Nast CC, Adler SG, Kopple JD. Clinical utility of kidney biopsies in the diagnosis and management of renal disease. Am J Nephrol 9: 309-315, 1989.
    • (1989) Am J Nephrol , vol.9 , pp. 309-315
    • Cohen, A.H.1    Nast, C.C.2    Adler, S.G.3    Kopple, J.D.4
  • 7
    • 82455162521 scopus 로고    scopus 로고
    • The contribution of chronic kidney disease to the global burden of major noncommunicable diseases
    • Couser WG, Remuzzi G, Mendis S, Tonelli M. The contribution of chronic kidney disease to the global burden of major noncommunicable diseases. Kidney Int 80: 1258-1270, 2011.
    • (2011) Kidney Int , vol.80 , pp. 1258-1270
    • Couser, W.G.1    Remuzzi, G.2    Mendis, S.3    Tonelli, M.4
  • 8
    • 12244254135 scopus 로고    scopus 로고
    • Multi- and megavariate data analysis principles and applications
    • Eriksson L, Johansson E, Kettaneh-Wold N. Multi- and megavariate data analysis principles and applications. J Chemom 16: 262-262, 2002.
    • (2002) J Chemom , vol.16 , pp. 262
    • Eriksson, L.1    Johansson, E.2    Kettaneh-Wold, N.3
  • 9
    • 79951725634 scopus 로고    scopus 로고
    • Plasma esterified and nonesterified fatty acids metabolic profiling using gas chromatography-mass spectrometry and its application in the study of diabetic mellitus and diabetic nephropathy
    • Han LD, Xia JF, Liang QL, Wang Y, Wang YM, Hu P, Li P, Luo GA. Plasma esterified and nonesterified fatty acids metabolic profiling using gas chromatography-mass spectrometry and its application in the study of diabetic mellitus and diabetic nephropathy. Anal Chim Acta 689: 85-91, 2011.
    • (2011) Anal Chim Acta , vol.689 , pp. 85-91
    • Han, L.D.1    Xia, J.F.2    Liang, Q.L.3    Wang, Y.4    Wang, Y.M.5    Hu, P.6    Li, P.7    Luo, G.A.8
  • 10
    • 84874405179 scopus 로고    scopus 로고
    • Decreased glycolytic and tricarboxylic acid cycle intermediates coincide with peripheral nervous system oxidative stress in a murine model of type 2 diabetes
    • Hinder LM, Vivekanandan-Giri A, McLean LL, Pennathur S, Feld-man EL. Decreased glycolytic and tricarboxylic acid cycle intermediates coincide with peripheral nervous system oxidative stress in a murine model of type 2 diabetes. J Endocrinol 216: 1-11, 2013.
    • (2013) J Endocrinol , vol.216 , pp. 1-11
    • Hinder, L.M.1    Vivekanandan-Giri, A.2    McLean, L.L.3    Pennathur, S.4    Feld-Man, E.L.5
  • 12
    • 35948948708 scopus 로고    scopus 로고
    • Combined therapy of rhein and benazepril on the treatment of diabetic nephropathy in db/db mice
    • Jia ZH, Liu ZH, Zheng JM, Zeng CH, Li LS. Combined therapy of rhein and benazepril on the treatment of diabetic nephropathy in db/db mice. Exp Clin Endocrinol Diabetes 115: 571-576, 2007.
    • (2007) Exp Clin Endocrinol Diabetes , vol.115 , pp. 571-576
    • Jia, Z.H.1    Liu, Z.H.2    Zheng, J.M.3    Zeng, C.H.4    Li, L.S.5
  • 15
    • 0033956846 scopus 로고    scopus 로고
    • The db/db mouse, a model for diabetic dyslipidemia: Molecular characterization and effects of Western diet feeding
    • Kobayashi K, Forte TM, Taniguchi S, Ishida BY, Oka K, Chan L. The db/db mouse, a model for diabetic dyslipidemia: molecular characterization and effects of Western diet feeding. Metabolism 49: 22-31, 2000.
    • (2000) Metabolism , vol.49 , pp. 22-31
    • Kobayashi, K.1    Forte, T.M.2    Taniguchi, S.3    Ishida, B.Y.4    Oka, K.5    Chan, L.6
  • 20
    • 75449102360 scopus 로고    scopus 로고
    • A guidance for renal biomarker lead optimization and use in translational pharmacodynamics
    • Ozer JS. A guidance for renal biomarker lead optimization and use in translational pharmacodynamics. Drug Discov Today 15: 142-147, 2010.
    • (2010) Drug Discov Today , vol.15 , pp. 142-147
    • Ozer, J.S.1
  • 21
    • 0019486989 scopus 로고
    • The effect of biopsy on therapy in renal disease
    • Paone DB, Meyer LE. The effect of biopsy on therapy in renal disease. Arch Intern Med 141: 1039-1041, 1981.
    • (1981) Arch Intern Med , vol.141 , pp. 1039-1041
    • Paone, D.B.1    Meyer, L.E.2
  • 22
  • 23
    • 0033533807 scopus 로고    scopus 로고
    • Nephropathy in patients with type 2 diabetes mellitus
    • Ritz E, Orth SR. Nephropathy in patients with type 2 diabetes mellitus. N Engl J Med 341: 1127-1133, 1999.
    • (1999) N Engl J Med , vol.341 , pp. 1127-1133
    • Ritz, E.1    Orth, S.R.2
  • 24
    • 0025249259 scopus 로고
    • The natural history and epidemiology of diabetic nephropathy. Implications for prevention and control
    • Selby JV, FitzSimmons SC, Newman JM, Katz PP, Sepe S, Showstack J. The natural history and epidemiology of diabetic nephropathy. Implications for prevention and control. JAMA 263: 1954-1960, 1990.
    • (1990) JAMA , vol.263 , pp. 1954-1960
    • Selby, J.V.1    Fitzsimmons, S.C.2    Newman, J.M.3    Katz, P.P.4    Sepe, S.5    Showstack, J.6
  • 26
    • 79952821873 scopus 로고    scopus 로고
    • Metabolomic analyses reveal profound differences in glycolytic and tricarboxylic acid cycle metabolism in glucose-responsive and -unresponsive clonal beta-cell lines
    • Spegel P, Malmgren S, Sharoyko VV, Newsholme P, Koeck T, Mulder H. Metabolomic analyses reveal profound differences in glycolytic and tricarboxylic acid cycle metabolism in glucose-responsive and -unresponsive clonal beta-cell lines. Biochem J 435: 277-284, 2011.
    • (2011) Biochem J , vol.435 , pp. 277-284
    • Spegel, P.1    Malmgren, S.2    Sharoyko, V.V.3    Newsholme, P.4    Koeck, T.5    Mulder, H.6
  • 29
    • 0032132761 scopus 로고    scopus 로고
    • The USRDS and its products
    • The United States Renal Data System
    • The United States Renal Data System. The USRDS and its products. Am J Kidney Dis 32: S20-37, 1998.
    • (1998) Am J Kidney Dis , vol.32 , pp. 20-37
  • 30
    • 46749087465 scopus 로고    scopus 로고
    • Succinate receptor GPR91 provides a direct link between high glucose levels and renin release in murine and rabbit kidney
    • Toma I, Kang JJ, Sipos A, Vargas S, Bansal E, Hanner F, Meer E, Peti-Peterdi J. Succinate receptor GPR91 provides a direct link between high glucose levels and renin release in murine and rabbit kidney. J Clin Invest 118: 2526-2534, 2008.
    • (2008) J Clin Invest , vol.118 , pp. 2526-2534
    • Toma, I.1    Kang, J.J.2    Sipos, A.3    Vargas, S.4    Bansal, E.5    Hanner, F.6    Meer, E.7    Peti-Peterdi, J.8
  • 31
    • 74449084536 scopus 로고    scopus 로고
    • Genetic analysis of albuminuria in aging mice and concordance with loci for human diabetic nephropathy found in a genome-wide association scan
    • Tsaih SW, Pezzolesi MG, Yuan R, Warram JH, Krolewski AS, Korstanje R. Genetic analysis of albuminuria in aging mice and concordance with loci for human diabetic nephropathy found in a genome-wide association scan. Kidney Int 77: 201-210, 2010.
    • (2010) Kidney Int , vol.77 , pp. 201-210
    • Tsaih, S.W.1    Pezzolesi, M.G.2    Yuan, R.3    Warram, J.H.4    Krolewski, A.S.5    Korstanje, R.6
  • 33
    • 21644479604 scopus 로고    scopus 로고
    • Plasma phospholipid metabolic profiling and biomarkers of type 2 diabetes mel-litus based on high-performance liquid chromatography/electrospray mass spectrometry and multivariate statistical analysis
    • Wang C, Kong H, Guan Y, Yang J, Gu J, Yang S, Xu G. Plasma phospholipid metabolic profiling and biomarkers of type 2 diabetes mel-litus based on high-performance liquid chromatography/electrospray mass spectrometry and multivariate statistical analysis. Anal Chem 77: 4108-4116, 2005.
    • (2005) Anal Chem , vol.77 , pp. 4108-4116
    • Wang, C.1    Kong, H.2    Guan, Y.3    Yang, J.4    Gu, J.5    Yang, S.6    Xu, G.7
  • 35
    • 84951601886 scopus 로고
    • Cross-validatory estimation of the number of components in factor and principal components models
    • Wold S. Cross-validatory estimation of the number of components in factor and principal components models. Technometris 20: 397-405, 1978.
    • (1978) Technometris , vol.20 , pp. 397-405
    • Wold, S.1
  • 36
    • 0041429499 scopus 로고    scopus 로고
    • Regression of microalbuminuria in type 1 diabetes
    • author reply 906-908
    • Zerbini G. Regression of microalbuminuria in type 1 diabetes. N Engl J Med 349: 906-908; author reply 906-908, 2003.
    • (2003) N Engl J Med , vol.349 , pp. 906-908
    • Zerbini, G.1
  • 37
    • 69249127046 scopus 로고    scopus 로고
    • Metabonomics research of diabetic nephropathy and type 2 diabetes mellitus based on UPLC-oaTOF-MS system
    • Zhang J, Yan L, Chen W, Lin L, Song X, Yan X, Hang W, Huang B. Metabonomics research of diabetic nephropathy and type 2 diabetes mellitus based on UPLC-oaTOF-MS system. Anal ChimActa 650: 16-22, 2009.
    • (2009) Anal ChimActa , vol.650 , pp. 16-22
    • Zhang, J.1    Yan, L.2    Chen, W.3    Lin, L.4    Song, X.5    Yan, X.6    Hang, W.7    Huang, B.8
  • 39
    • 78650111437 scopus 로고    scopus 로고
    • 1H NMR-based metabonomic analysis of metabolic changes in streptozotocin-induced diabetic rats
    • Zhao L, Liu X, Xie L, Gao H, Lin D. 1H NMR-based metabonomic analysis of metabolic changes in streptozotocin-induced diabetic rats. Anal Sci 26: 1277-1282, 2010.
    • (2010) Anal Sci , vol.26 , pp. 1277-1282
    • Zhao, L.1    Liu, X.2    Xie, L.3    Gao, H.4    Lin, D.5
  • 40
    • 83955163615 scopus 로고    scopus 로고
    • Intrarenal metabolomics reveals the association of local organic toxins with the progression of diabetic kidney disease
    • Zhao T, Zhang H, Zhang X, Lu J, Yin T, Liang Q, Wang Y, Luo G, Lan H, Li P. Intrarenal metabolomics reveals the association of local organic toxins with the progression of diabetic kidney disease. J Pharm Biomed Anal 60: 32-43, 2012.
    • (2012) J Pharm Biomed Anal , vol.60 , pp. 32-43
    • Zhao, T.1    Zhang, H.2    Zhang, X.3    Lu, J.4    Yin, T.5    Liang, Q.6    Wang, Y.7    Luo, G.8    Lan, H.9    Li, P.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.