메뉴 건너뛰기




Volumn 63, Issue 12, 2014, Pages 4314-4325

IHG-1 increases mitochondrial fusion and bioenergetic function

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE INHIBITOR; ADENOSINE TRIPHOSPHATE; DYNAMIN RELATED PROTEIN 1; FISSION 1; GLUCOSE OXIDASE; GUANINE NUCLEOTIDE EXCHANGE FACTOR; INDUCED IN HIGH GLUCOSE 1; MITOCHONDRIAL PROTEIN; MITOFUSIN 1; MITOFUSIN 2; REACTIVE OXYGEN METABOLITE; SHORT HAIRPIN RNA; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; CARRIER PROTEIN; GUANOSINE TRIPHOSPHATASE; IHG-1 PROTEIN, HUMAN; MFN1 PROTEIN, HUMAN; MFN2 PROTEIN, HUMAN; PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84911862896     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db13-1256     Document Type: Article
Times cited : (18)

References (52)
  • 1
    • 0033605162 scopus 로고    scopus 로고
    • Suppression subtractive hybridization identifies high glucose levels as a stimulus for expression of connective tissue growth factor and other genes in human mesangial cells
    • Murphy M, Godson C, Cannon S, et al. Suppression subtractive hybridization identifies high glucose levels as a stimulus for expression of connective tissue growth factor and other genes in human mesangial cells. J Biol Chem 1999;274: 5830-5834
    • (1999) J Biol Chem , vol.274 , pp. 5830-5834
    • Murphy, M.1    Godson, C.2    Cannon, S.3
  • 2
    • 84871783659 scopus 로고    scopus 로고
    • IHG-1 amplifies TGF-β1 signalling and mitochondrial biogenesis and is increased in diabetic kidney disease
    • Murphy M, Hickey F, Godson C. IHG-1 amplifies TGF-β1 signalling and mitochondrial biogenesis and is increased in diabetic kidney disease. Curr Opin Nephrol Hypertens 2013;22:77-84
    • (2013) Curr Opin Nephrol Hypertens , vol.22 , pp. 77-84
    • Murphy, M.1    Hickey, F.2    Godson, C.3
  • 3
    • 0037155860 scopus 로고    scopus 로고
    • High glucose-altered gene expression in mesangial cells. Actin-regulatory protein gene expression is triggered by oxidative stress and cytoskeletal disassembly
    • Clarkson MR, Murphy M, Gupta S, et al. High glucose-altered gene expression in mesangial cells. Actin-regulatory protein gene expression is triggered by oxidative stress and cytoskeletal disassembly. J Biol Chem 2002;277:9707-9712
    • (2002) J Biol Chem , vol.277 , pp. 9707-9712
    • Clarkson, M.R.1    Murphy, M.2    Gupta, S.3
  • 4
    • 79960951730 scopus 로고    scopus 로고
    • IHG-1 promotes mitochondrial biogenesis by stabilizing PGC-1α
    • Hickey FB, Corcoran JB, Docherty NG, et al. IHG-1 promotes mitochondrial biogenesis by stabilizing PGC-1α. J Am Soc Nephrol 2011;22:1475-1485
    • (2011) J Am Soc Nephrol , vol.22 , pp. 1475-1485
    • Hickey, F.B.1    Corcoran, J.B.2    Docherty, N.G.3
  • 5
    • 54649083663 scopus 로고    scopus 로고
    • IHG-1 amplifies TGF-beta1 signaling and is increased in renal fibrosis
    • Murphy M, Docherty NG, Griffin B, et al. IHG-1 amplifies TGF-beta1 signaling and is increased in renal fibrosis. J Am Soc Nephrol 2008;19:1672-1680
    • (2008) J Am Soc Nephrol , vol.19 , pp. 1672-1680
    • Murphy, M.1    Docherty, N.G.2    Griffin, B.3
  • 6
    • 84877812701 scopus 로고    scopus 로고
    • IHG-1 must be localised to mitochondria to decrease Smad7 expression and amplify TGF-β1-induced fibrotic responses
    • Corcoran JB, McCarthy S, Griffin B, et al. IHG-1 must be localised to mitochondria to decrease Smad7 expression and amplify TGF-β1-induced fibrotic responses. Biochim Biophys Acta 2013;1833:1969-1978
    • (2013) Biochim Biophys Acta , vol.1833 , pp. 1969-1978
    • Corcoran, J.B.1    McCarthy, S.2    Griffin, B.3
  • 7
    • 84875906572 scopus 로고    scopus 로고
    • Mitochondrial dynamics in the regulation of nutrient utilization and energy expenditure
    • Liesa M, Shirihai OS. Mitochondrial dynamics in the regulation of nutrient utilization and energy expenditure. Cell Metab 2013;17:491-506
    • (2013) Cell Metab , vol.17 , pp. 491-506
    • Liesa, M.1    Shirihai, O.S.2
  • 8
    • 20044376702 scopus 로고    scopus 로고
    • The pathobiology of diabetic complications: A unifying mechanism
    • Brownlee M. The pathobiology of diabetic complications: a unifying mechanism. Diabetes 2005;54:1615-1625
    • (2005) Diabetes , vol.54 , pp. 1615-1625
    • Brownlee, M.1
  • 9
    • 65249153029 scopus 로고    scopus 로고
    • RAGE-induced cytosolic ROS promote mitochondrial superoxide generation in diabetes
    • Coughlan MT, Thorburn DR, Penfold SA, et al. RAGE-induced cytosolic ROS promote mitochondrial superoxide generation in diabetes. J Am Soc Nephrol 2009;20:742-752
    • (2009) J Am Soc Nephrol , vol.20 , pp. 742-752
    • Coughlan, M.T.1    Thorburn, D.R.2    Penfold, S.A.3
  • 10
    • 48249085391 scopus 로고    scopus 로고
    • Oxidative stress as a major culprit in kidney disease in diabetes
    • Forbes JM, Coughlan MT, Cooper ME. Oxidative stress as a major culprit in kidney disease in diabetes. Diabetes 2008;57:1446-1454
    • (2008) Diabetes , vol.57 , pp. 1446-1454
    • Forbes, J.M.1    Coughlan, M.T.2    Cooper, M.E.3
  • 11
    • 33847306780 scopus 로고    scopus 로고
    • Signaling of mitochondrial biogenesis following oxidant injury
    • Rasbach KA, Schnellmann RG. Signaling of mitochondrial biogenesis following oxidant injury. J Biol Chem 2007;282:2355-2362
    • (2007) J Biol Chem , vol.282 , pp. 2355-2362
    • Rasbach, K.A.1    Schnellmann, R.G.2
  • 12
    • 33749265862 scopus 로고    scopus 로고
    • Formation of elongated giant mitochondria in DFO-induced cellular senescence: Involvement of enhanced fusion process through modulation of Fis1
    • Yoon YS, Yoon DS, Lim IK, et al. Formation of elongated giant mitochondria in DFO-induced cellular senescence: involvement of enhanced fusion process through modulation of Fis1. J Cell Physiol 2006;209:468-480
    • (2006) J Cell Physiol , vol.209 , pp. 468-480
    • Yoon, Y.S.1    Yoon, D.S.2    Lim, I.K.3
  • 13
    • 33644552417 scopus 로고    scopus 로고
    • Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology
    • Yu T, Robotham JL, Yoon Y. Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology. Proc Natl Acad Sci U S A 2006;103:2653-2658
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 2653-2658
    • Yu, T.1    Robotham, J.L.2    Yoon, Y.3
  • 15
    • 84877075753 scopus 로고    scopus 로고
    • Downregulation of OPA3 is responsible for transforming growth factor-b-induced mitochondrial elongation and F-actin rearrangement in retinal pigment epithelial ARPE-19 cells
    • Ryu SW, Yoon J, Yim N, Choi K, Choi C. Downregulation of OPA3 is responsible for transforming growth factor-b-induced mitochondrial elongation and F-actin rearrangement in retinal pigment epithelial ARPE-19 cells. PLoS ONE 2013;8:e63495
    • (2013) PLoS ONE , vol.8 , pp. e63495
    • Ryu, S.W.1    Yoon, J.2    Yim, N.3    Choi, K.4    Choi, C.5
  • 16
    • 84864286521 scopus 로고    scopus 로고
    • Impact of high glucose and transforming growth factor-b on bioenergetic profiles in podocytes
    • Stieger N, Worthmann K, Teng B, et al. Impact of high glucose and transforming growth factor-b on bioenergetic profiles in podocytes. Metabolism 2012;61:1073-1086
    • (2012) Metabolism , vol.61 , pp. 1073-1086
    • Stieger, N.1    Worthmann, K.2    Teng, B.3
  • 17
    • 79959933148 scopus 로고    scopus 로고
    • Protection from obesity and diabetes by blockade of TGF-β/Smad3 signaling
    • Yadav H, Quijano C, Kamaraju AK, et al. Protection from obesity and diabetes by blockade of TGF-β/Smad3 signaling. Cell Metab 2011;14:67-79
    • (2011) Cell Metab , vol.14 , pp. 67-79
    • Yadav, H.1    Quijano, C.2    Kamaraju, A.K.3
  • 19
    • 84878565172 scopus 로고    scopus 로고
    • Disconnecting mitochondrial content from respiratory chain capacity in PGC-1-deficient skeletal muscle
    • Rowe GC, Patten IS, Zsengeller ZK, et al. Disconnecting mitochondrial content from respiratory chain capacity in PGC-1-deficient skeletal muscle. Cell Reports 2013;3:1449-1456
    • (2013) Cell Reports , vol.3 , pp. 1449-1456
    • Rowe, G.C.1    Patten, I.S.2    Zsengeller, Z.K.3
  • 20
    • 0035911154 scopus 로고    scopus 로고
    • Connection of the mitochondrial outer and inner membranes by Fzo1 is critical for organellar fusion
    • Fritz S, Rapaport D, Klanner E, Neupert W, Westermann B. Connection of the mitochondrial outer and inner membranes by Fzo1 is critical for organellar fusion. J Cell Biol 2001;152:683-692
    • (2001) J Cell Biol , vol.152 , pp. 683-692
    • Fritz, S.1    Rapaport, D.2    Klanner, E.3    Neupert, W.4    Westermann, B.5
  • 21
    • 0142058391 scopus 로고    scopus 로고
    • Two mitofusin proteins, mammalian homologues of FZO, with distinct functions are both required for mitochondrial fusion
    • Eura Y, Ishihara N, Yokota S, Mihara K. Two mitofusin proteins, mammalian homologues of FZO, with distinct functions are both required for mitochondrial fusion. J Biochem 2003;134:333-344
    • (2003) J Biochem , vol.134 , pp. 333-344
    • Eura, Y.1    Ishihara, N.2    Yokota, S.3    Mihara, K.4
  • 22
    • 0043092647 scopus 로고    scopus 로고
    • The mitochondrial protein hFis1 regulates mitochondrial fission in mammalian cells through an interaction with the dynamin-like protein DLP1
    • Yoon Y, Krueger EW, Oswald BJ, McNiven MA. The mitochondrial protein hFis1 regulates mitochondrial fission in mammalian cells through an interaction with the dynamin-like protein DLP1. Mol Cell Biol 2003;23:5409-5420
    • (2003) Mol Cell Biol , vol.23 , pp. 5409-5420
    • Yoon, Y.1    Krueger, E.W.2    Oswald, B.J.3    McNiven, M.A.4
  • 23
    • 10644296253 scopus 로고    scopus 로고
    • Fzo1, a protein involved in mitochondrial fusion, inhibits apoptosis
    • Sugioka R, Shimizu S, Tsujimoto Y. Fzo1, a protein involved in mitochondrial fusion, inhibits apoptosis. J Biol Chem 2004;279:52726-52734
    • (2004) J Biol Chem , vol.279 , pp. 52726-52734
    • Sugioka, R.1    Shimizu, S.2    Tsujimoto, Y.3
  • 24
    • 0033571410 scopus 로고    scopus 로고
    • Division versus fusion: Dnm1p and Fzo1p antagonistically regulate mitochondrial shape
    • Sesaki H, Jensen RE. Division versus fusion: Dnm1p and Fzo1p antagonistically regulate mitochondrial shape. J Cell Biol 1999;147:699-706
    • (1999) J Cell Biol , vol.147 , pp. 699-706
    • Sesaki, H.1    Jensen, R.E.2
  • 25
    • 68149103297 scopus 로고    scopus 로고
    • Mitofusins and OPA1 mediate sequential steps in mitochondrial membrane fusion
    • Song Z, Ghochani M, McCaffery JM, Frey TG, Chan DC. Mitofusins and OPA1 mediate sequential steps in mitochondrial membrane fusion. Mol Biol Cell 2009;20:3525-3532
    • (2009) Mol Biol Cell , vol.20 , pp. 3525-3532
    • Song, Z.1    Ghochani, M.2    McCaffery, J.M.3    Frey, T.G.4    Chan, D.C.5
  • 26
    • 84871921370 scopus 로고    scopus 로고
    • The dynamics of the mitochondrial organelle as a potential therapeutic target
    • Anne Stetler R, Leak RK, Gao Y, Chen J. The dynamics of the mitochondrial organelle as a potential therapeutic target. J Cereb Blood Flow Metab 2013;33: 22-32
    • (2013) J Cereb Blood Flow Metab , vol.33 , pp. 22-32
    • Anne Stetler, R.1    Leak, R.K.2    Gao, Y.3    Chen, J.4
  • 27
    • 79955623510 scopus 로고    scopus 로고
    • During autophagy mitochondria elongate, are spared from degradation and sustain cell viability
    • Gomes LC, Di Benedetto G, Scorrano L. During autophagy mitochondria elongate, are spared from degradation and sustain cell viability. Nat Cell Biol 2011;13:589-598
    • (2011) Nat Cell Biol , vol.13 , pp. 589-598
    • Gomes, L.C.1    Di Benedetto, G.2    Scorrano, L.3
  • 28
    • 21644455319 scopus 로고    scopus 로고
    • Activated mitofusin 2 signals mitochondrial fusion, interferes with Bax activation, and reduces susceptibility to radical induced depolarization
    • Neuspiel M, Zunino R, Gangaraju S, Rippstein P, McBride H. Activated mitofusin 2 signals mitochondrial fusion, interferes with Bax activation, and reduces susceptibility to radical induced depolarization. J Biol Chem 2005;280: 25060-25070
    • (2005) J Biol Chem , vol.280 , pp. 25060-25070
    • Neuspiel, M.1    Zunino, R.2    Gangaraju, S.3    Rippstein, P.4    McBride, H.5
  • 29
    • 38549110110 scopus 로고    scopus 로고
    • Fission and selective fusion govern mitochondrial segregation and elimination by autophagy
    • Twig G, Elorza A, Molina AJ, et al. Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. EMBO J 2008;27:433-446
    • (2008) EMBO J , vol.27 , pp. 433-446
    • Twig, G.1    Elorza, A.2    Molina, A.J.3
  • 30
    • 79952339999 scopus 로고    scopus 로고
    • Mitochondrial biogenesis in kidney disease
    • Weinberg JM. Mitochondrial biogenesis in kidney disease. J Am Soc Nephrol 2011;22:431-436
    • (2011) J Am Soc Nephrol , vol.22 , pp. 431-436
    • Weinberg, J.M.1
  • 31
    • 0036906665 scopus 로고    scopus 로고
    • Mitochondrial fusion in human cells is efficient, requires the inner membrane potential, and is mediated by mitofusins
    • Legros F, Lombès A, Frachon P, Rojo M. Mitochondrial fusion in human cells is efficient, requires the inner membrane potential, and is mediated by mitofusins. Mol Biol Cell 2002;13:4343-4354
    • (2002) Mol Biol Cell , vol.13 , pp. 4343-4354
    • Legros, F.1    Lombès, A.2    Frachon, P.3    Rojo, M.4
  • 32
    • 0033007029 scopus 로고    scopus 로고
    • Rapid measurements of intracellular calcium using a fluorescence plate reader
    • Lin K, Sadée W, Quillan JM. Rapid measurements of intracellular calcium using a fluorescence plate reader. Biotechniques 1999;26:318- 322, 324-326
    • (1999) Biotechniques , vol.26
    • Lin, K.1    Sadée, W.2    Quillan, J.M.3
  • 33
    • 0037455575 scopus 로고    scopus 로고
    • Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development
    • Chen H, Detmer SA, Ewald AJ, Griffin EE, Fraser SE, Chan DC. Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic development. J Cell Biol 2003;160:189-200
    • (2003) J Cell Biol , vol.160 , pp. 189-200
    • Chen, H.1    Detmer, S.A.2    Ewald, A.J.3    Griffin, E.E.4    Fraser, S.E.5    Chan, D.C.6
  • 35
    • 57349100367 scopus 로고    scopus 로고
    • Mitofusin 2 tethers endoplasmic reticulum to mitochondria
    • de Brito OM, Scorrano L. Mitofusin 2 tethers endoplasmic reticulum to mitochondria. Nature 2008;456:605-610
    • (2008) Nature , vol.456 , pp. 605-610
    • De Brito, O.M.1    Scorrano, L.2
  • 37
    • 78649413837 scopus 로고    scopus 로고
    • Mitochondrial fusion and fission in cell life and death
    • Westermann B. Mitochondrial fusion and fission in cell life and death. Nat Rev Mol Cell Biol 2010;11:872-884
    • (2010) Nat Rev Mol Cell Biol , vol.11 , pp. 872-884
    • Westermann, B.1
  • 38
    • 49349102894 scopus 로고    scopus 로고
    • Mitochondrial fusion, fission and autophagy as a quality control axis: The bioenergetic view
    • Twig G, Hyde B, Shirihai OS. Mitochondrial fusion, fission and autophagy as a quality control axis: the bioenergetic view. Biochim Biophys Acta 2008;1777: 1092-1097
    • (2008) Biochim Biophys Acta , vol.1777 , pp. 1092-1097
    • Twig, G.1    Hyde, B.2    Shirihai, O.S.3
  • 39
    • 70349650451 scopus 로고    scopus 로고
    • Mitochondrial networking protects beta-cells from nutrient-induced apoptosis
    • Molina AJ, Wikstrom JD, Stiles L, et al. Mitochondrial networking protects beta-cells from nutrient-induced apoptosis. Diabetes 2009;58:2303-2315
    • (2009) Diabetes , vol.58 , pp. 2303-2315
    • Molina, A.J.1    Wikstrom, J.D.2    Stiles, L.3
  • 40
    • 84863023552 scopus 로고    scopus 로고
    • Mitochondrial fission triggered by hyperglycemia is mediated by ROCK1 activation in podocytes and endothelial cells
    • Wang W, Wang Y, Long J, et al. Mitochondrial fission triggered by hyperglycemia is mediated by ROCK1 activation in podocytes and endothelial cells. Cell Metab 2012;15:186-200
    • (2012) Cell Metab , vol.15 , pp. 186-200
    • Wang, W.1    Wang, Y.2    Long, J.3
  • 41
    • 0027058552 scopus 로고
    • Correlation between mitochondrial enlargement in renal proximal tubules and microalbuminuria in rats with early streptozotocin-induced diabetes
    • Kaneda K, Iwao J, Sakata N, Takebayashi S. Correlation between mitochondrial enlargement in renal proximal tubules and microalbuminuria in rats with early streptozotocin-induced diabetes. Acta Pathol Jpn 1992;42: 855-860
    • (1992) Acta Pathol Jpn , vol.42 , pp. 855-860
    • Kaneda, K.1    Iwao, J.2    Sakata, N.3    Takebayashi, S.4
  • 42
    • 84864383669 scopus 로고    scopus 로고
    • Transgenic control of mitochondrial fission induces mitochondrial uncoupling and relieves diabetic oxidative stress
    • Galloway CA, Lee H, Nejjar S, et al. Transgenic control of mitochondrial fission induces mitochondrial uncoupling and relieves diabetic oxidative stress. Diabetes 2012;61:2093-2104
    • (2012) Diabetes , vol.61 , pp. 2093-2104
    • Galloway, C.A.1    Lee, H.2    Nejjar, S.3
  • 43
    • 0032959345 scopus 로고    scopus 로고
    • Reactive oxygen intermediates as mediators of programmed cell death in plants and animals
    • Jabs T. Reactive oxygen intermediates as mediators of programmed cell death in plants and animals. Biochem Pharmacol 1999;57:231-245
    • (1999) Biochem Pharmacol , vol.57 , pp. 231-245
    • Jabs, T.1
  • 44
    • 0242333888 scopus 로고    scopus 로고
    • Oxidative stress-induced apoptosis is mediated by ERK1/2 phosphorylation
    • Lee YJ, Cho HN, Soh JW, et al. Oxidative stress-induced apoptosis is mediated by ERK1/2 phosphorylation. Exp Cell Res 2003;291:251-266
    • (2003) Exp Cell Res , vol.291 , pp. 251-266
    • Lee, Y.J.1    Cho, H.N.2    Soh, J.W.3
  • 45
    • 0242552555 scopus 로고    scopus 로고
    • Influence of induced reactive oxygen species in p53-mediated cell fate decisions
    • Macip S, Igarashi M, Berggren P, Yu J, Lee SW, Aaronson SA. Influence of induced reactive oxygen species in p53-mediated cell fate decisions. Mol Cell Biol 2003;23:8576-8585
    • (2003) Mol Cell Biol , vol.23 , pp. 8576-8585
    • Macip, S.1    Igarashi, M.2    Berggren, P.3    Yu, J.4    Lee, S.W.5    Aaronson, S.A.6
  • 46
    • 20444417067 scopus 로고    scopus 로고
    • p38 kinase-mediated transactivation of the epidermal growth factor receptor is required for dedifferentiation of renal epithelial cells after oxidant injury
    • Zhuang S, Yan Y, Han J, Schnellmann RG. p38 kinase-mediated transactivation of the epidermal growth factor receptor is required for dedifferentiation of renal epithelial cells after oxidant injury. J Biol Chem 2005;280:21036-21042
    • (2005) J Biol Chem , vol.280 , pp. 21036-21042
    • Zhuang, S.1    Yan, Y.2    Han, J.3    Schnellmann, R.G.4
  • 47
    • 58149505555 scopus 로고    scopus 로고
    • Long-term risk of mortality and other adverse outcomes after acute kidney injury: A systematic review and meta-analysis
    • Coca SG, Yusuf B, Shlipak MG, Garg AX, Parikh CR. Long-term risk of mortality and other adverse outcomes after acute kidney injury: a systematic review and meta-analysis. Am J Kidney Dis 2009;53:961-973
    • (2009) Am J Kidney Dis , vol.53 , pp. 961-973
    • Coca, S.G.1    Yusuf, B.2    Shlipak, M.G.3    Garg, A.X.4    Parikh, C.R.5
  • 48
    • 80555157523 scopus 로고    scopus 로고
    • Cellular pathophysiology of ischemic acute kidney injury
    • Bonventre JV, Yang L. Cellular pathophysiology of ischemic acute kidney injury. J Clin Invest 2011;121:4210-4221
    • (2011) J Clin Invest , vol.121 , pp. 4210-4221
    • Bonventre, J.V.1    Yang, L.2
  • 49
    • 84856289171 scopus 로고    scopus 로고
    • Role of mitofusin 2 in the renal stress response
    • Gall JM, Wang Z, Liesa M, et al. Role of mitofusin 2 in the renal stress response. PLoS ONE 2012;7:e31074
    • (2012) PLoS ONE , vol.7 , pp. e31074
    • Gall, J.M.1    Wang, Z.2    Liesa, M.3
  • 50
    • 20444461625 scopus 로고    scopus 로고
    • The Charcot-Marie-Tooth type 2A gene product, Mfn2, up-regulates fuel oxidation through expression of OXPHOS system
    • Pich S, Bach D, Briones P, et al. The Charcot-Marie-Tooth type 2A gene product, Mfn2, up-regulates fuel oxidation through expression of OXPHOS system. Hum Mol Genet 2005;14:1405-1415
    • (2005) Hum Mol Genet , vol.14 , pp. 1405-1415
    • Pich, S.1    Bach, D.2    Briones, P.3
  • 51
    • 84859448265 scopus 로고    scopus 로고
    • Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis
    • Sebastián D, Hernández-Alvarez MI, Segalés J, et al. Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis. Proc Natl Acad Sci U S A 2012; 109:5523-5528
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. 5523-5528
    • Sebastián, D.1    Hernández-Alvarez, M.I.2    Segalés, J.3
  • 52
    • 77955280737 scopus 로고    scopus 로고
    • Mitochondrial dynamics in model organisms: What yeasts, worms and flies have taught us about fusion and fission of mitochondria
    • Westermann B. Mitochondrial dynamics in model organisms: what yeasts, worms and flies have taught us about fusion and fission of mitochondria. Semin Cell Dev Biol 2010;21:542-549
    • (2010) Semin Cell Dev Biol , vol.21 , pp. 542-549
    • Westermann, B.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.