Mitochondrial complex I deficiency leads to increased production of superoxide radicals and induction of superoxide dismutase

Journal of Clinical Investigation

Volumn 98, Issue 2, 1996, Pages 345-351

  Pitkänen, Sari ^b   Robinson, Brian H ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b HOSPITAL FOR SICK CHILDREN RESEARCH INSTITUTE   (Canada)

Author keywords

cataracts; complex I deficiency; Leigh's disease; manganese superoxide dismutase; superoxide radical

Indexed keywords

LACTIC ACID; MANGANESE SUPEROXIDE DISMUTASE; PYRUVIC ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); SUPEROXIDE; SUPEROXIDE DISMUTASE;

ARTICLE; CARDIOMYOPATHY; CATARACT; CONTROLLED STUDY; ENZYME DEFICIENCY; ENZYME INDUCTION; FIBROBLAST; GROWTH RETARDATION; HUMAN; HUMAN CELL; KIDNEY TUBULE DISORDER; LACTIC ACIDEMIA; LACTIC ACIDOSIS; LEIGH DISEASE; LIVER DISEASE; MITOCHONDRION; NORTHERN BLOTTING; OXIDATION REDUCTION STATE; PRIORITY JOURNAL;

EID: 0030056515     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI118798     Document Type: Article

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