메뉴 건너뛰기




Volumn 24, Issue 24, 2015, Pages 2925-2942

Human Induced Pluripotent Stem Cell NEUROG2 Dual Knockin Reporter Lines Generated by the CRISPR/Cas9 System

Author keywords

[No Author keywords available]

Indexed keywords

CRISPR ASSOCIATED PROTEIN; CRISPR ASSOCIATED PROTEIN 9; NEUROGENIN 2; UNCLASSIFIED DRUG; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; NERVE PROTEIN; NEUROG2 PROTEIN, HUMAN;

EID: 84983121994     PISSN: 15473287     EISSN: 15578534     Source Type: Journal    
DOI: 10.1089/scd.2015.0131     Document Type: Article
Times cited : (22)

References (78)
  • 1
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi K and S Yamanaka. (2006). Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126:663-676.
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 2
    • 36248966518 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from adult human fibroblasts by defined factors
    • Takahashi K, K Tanabe, M Ohnuki, M Narita, T Ichisaka, K Tomoda and S Yamanaka. (2007). Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131:861-872.
    • (2007) Cell , vol.131 , pp. 861-872
    • Takahashi, K.1    Tanabe, K.2    Ohnuki, M.3    Narita, M.4    Ichisaka, T.5    Tomoda, K.6    Yamanaka, S.7
  • 4
    • 0037336820 scopus 로고    scopus 로고
    • Homologous recombination in human embryonic stem cells
    • Zwaka TP and JA Thomson. (2003). Homologous recombination in human embryonic stem cells. Nat Biotechnol 21:319-321.
    • (2003) Nat Biotechnol , vol.21 , pp. 319-321
    • Zwaka, T.P.1    Thomson, J.A.2
  • 5
    • 39349097787 scopus 로고    scopus 로고
    • Targeting a GFP reporter gene to the MIXL1 locus of human embryonic stem cells identifies human primitive streak-like cells and enables isolation of primitive hematopoietic precursors
    • Davis RP, ES Ng, M Costa, AK Mossman, K Sourris, AG Elefanty and EG Stanley. (2008). Targeting a GFP reporter gene to the MIXL1 locus of human embryonic stem cells identifies human primitive streak-like cells and enables isolation of primitive hematopoietic precursors. Blood 111: 1876-1884.
    • (2008) Blood , vol.111 , pp. 1876-1884
    • Davis, R.P.1    Ng, E.S.2    Costa, M.3    Mossman, A.K.4    Sourris, K.5    Elefanty, A.G.6    Stanley, E.G.7
  • 6
    • 67649216732 scopus 로고    scopus 로고
    • Gene targeting in a HUES line of human embryonic stem cells via electroporation
    • Ruby KM and B Zheng. (2009). Gene targeting in a HUES line of human embryonic stem cells via electroporation. Stem Cells 27:1496-1506.
    • (2009) Stem Cells , vol.27 , pp. 1496-1506
    • Ruby, K.M.1    Zheng, B.2
  • 8
    • 79955548121 scopus 로고    scopus 로고
    • OLIG gene targeting in human pluripotent stem cells for motor neuron and oligodendrocyte differentiation
    • Liu Y, P Jiang andWDeng. (2011). OLIG gene targeting in human pluripotent stem cells for motor neuron and oligodendrocyte differentiation. Nat Protoc 6:640-655.
    • (2011) Nat Protoc , vol.6 , pp. 640-655
    • Liu, Y.1    Jiang, P.2    Deng, W.3
  • 11
    • 79952153009 scopus 로고    scopus 로고
    • Targeting SOX17 in human embryonic stem cells creates unique strategies for isolating and analyzing developing endoderm
    • Wang P, RT Rodriguez, J Wang, A Ghodasara and SK Kim. (2011). Targeting SOX17 in human embryonic stem cells creates unique strategies for isolating and analyzing developing endoderm. Cell Stem Cell 8:335-346.
    • (2011) Cell Stem Cell , vol.8 , pp. 335-346
    • Wang, P.1    Rodriguez, R.T.2    Wang, J.3    Ghodasara, A.4    Kim, S.K.5
  • 13
    • 84856529668 scopus 로고    scopus 로고
    • Efficient and accurate homologous recombination in hESCs and hiPSCs using helper-dependent adenoviral vectors
    • Aizawa E, Y Hirabayashi, Y Iwanaga, K Suzuki, K Sakurai, M Shimoji, K Aiba, T Wada, N Tooi, et al. (2012). Efficient and accurate homologous recombination in hESCs and hiPSCs using helper-dependent adenoviral vectors. Mol Ther 20:424-431.
    • (2012) Mol Ther , vol.20 , pp. 424-431
    • Aizawa, E.1    Hirabayashi, Y.2    Iwanaga, Y.3    Suzuki, K.4    Sakurai, K.5    Shimoji, M.6    Aiba, K.7    Wada, T.8    Tooi, N.9
  • 15
    • 84865070369 scopus 로고    scopus 로고
    • A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity
    • Jinek M, K Chylinski, I Fonfara, M Hauer, JA Doudna and E Charpentier. (2012). A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science 337:816-821.
    • (2012) Science , vol.337 , pp. 816-821
    • Jinek, M.1    Chylinski, K.2    Fonfara, I.3    Hauer, M.4    Doudna, J.A.5    Charpentier, E.6
  • 16
    • 84877707375 scopus 로고    scopus 로고
    • One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering
    • Wang H, H Yang, CS Shivalila, MM Dawlaty, AW Cheng, F Zhang and R Jaenisch. (2013). One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering. Cell 153:910-918.
    • (2013) Cell , vol.153 , pp. 910-918
    • Wang, H.1    Yang, H.2    Shivalila, C.S.3    Dawlaty, M.M.4    Cheng, A.W.5    Zhang, F.6    Jaenisch, R.7
  • 22
    • 84894081986 scopus 로고    scopus 로고
    • Generation of gene-modified cynomolgus monkey via Cas9/RNA-mediated gene targeting in one-cell embryos
    • Niu Y, B Shen, Y Cui, Y Chen, J Wang, L Wang, Y Kang, X Zhao, W Si, et al. (2014). Generation of gene-modified cynomolgus monkey via Cas9/RNA-mediated gene targeting in one-cell embryos. Cell 156:836-843.
    • (2014) Cell , vol.156 , pp. 836-843
    • Niu, Y.1    Shen, B.2    Cui, Y.3    Chen, Y.4    Wang, J.5    Wang, L.6    Kang, Y.7    Zhao, X.8    Si, W.9
  • 23
    • 11144267737 scopus 로고    scopus 로고
    • Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp red fluorescent protein
    • Shaner NC, RE Campbell, PA Steinbach, BN Giepmans, AE Palmer and RY Tsien. (2004). Improved monomeric red, orange and yellow fluorescent proteins derived from Discosoma sp. red fluorescent protein. Nat Biotechnol 22:1567-1572.
    • (2004) Nat Biotechnol , vol.22 , pp. 1567-1572
    • Shaner, N.C.1    Campbell, R.E.2    Steinbach, P.A.3    Giepmans, B.N.4    Palmer, A.E.5    Tsien, R.Y.6
  • 25
    • 84929147435 scopus 로고    scopus 로고
    • Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells
    • Chu VT, T Weber, B Wefers, W Wurst, S Sander, K Rajewsky and R Kuhn. (2015). Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells. Nat Biotechnol 33:543-548.
    • (2015) Nat Biotechnol , vol.33 , pp. 543-548
    • Chu, V.T.1    Weber, T.2    Wefers, B.3    Wurst, W.4    Sander, S.5    Rajewsky, K.6    Kuhn, R.7
  • 26
    • 84938844899 scopus 로고    scopus 로고
    • Genetic modification in human pluripotent stem cells by homologous recombination and CRISPR/Cas9 system
    • Xue H, J Wu, S Li, MS Rao and Y Liu. (2016). Genetic modification in human pluripotent stem cells by homologous recombination and CRISPR/Cas9 system. Methods Mol Biol 1307:173-190.
    • Methods Mol Biol , vol.1307 , pp. 173-190
    • Xue, H.1    Wu, J.2    Li, S.3    Rao, M.S.4    Liu, Y.5
  • 27
    • 84862908206 scopus 로고    scopus 로고
    • Chromatin insulator elements block transgene silencing in engineered human embryonic stem cell lines at a defined chromosome 13 locus
    • Macarthur CC, H Xue, D Van Hoof, PT Lieu, M Dudas, A Fontes, A Swistowski, T Touboul, R Seerke, et al. (2012). Chromatin insulator elements block transgene silencing in engineered human embryonic stem cell lines at a defined chromosome 13 locus. Stem Cells Dev 21:191-205.
    • (2012) Stem Cells Dev , vol.21 , pp. 191-205
    • MacArthur, C.C.1    Xue, H.2    Van Hoof, D.3    Lieu, P.T.4    Dudas, M.5    Fontes, A.6    Swistowski, A.7    Touboul, T.8    Seerke, R.9
  • 28
    • 34547605763 scopus 로고    scopus 로고
    • Zinc finger targeter (ZiFiT): An engineered zinc finger/target site design tool
    • Sander JD, P Zaback, JK Joung, DF Voytas and D Dobbs. (2007). Zinc finger targeter (ZiFiT): an engineered zinc finger/target site design tool. Nucleic Acids Res 35:W599-W605.
    • (2007) Nucleic Acids Res , vol.35 , pp. W599-W605
    • Sander, J.D.1    Zaback, P.2    Joung, J.K.3    Voytas, D.F.4    Dobbs, D.5
  • 30
    • 84941236834 scopus 로고    scopus 로고
    • Efficient generation of hiPSC neural lineage specific knockin reporters using the CRISPR/Cas9 and Cas9 double nickase system
    • Li S, H Xue, B Long, L Sun, T Truong and Y Liu. (2015). Efficient generation of hiPSC neural lineage specific knockin reporters using the CRISPR/Cas9 and Cas9 double nickase system. J Vis Exp e52539; DOI: 10.3791/52539.
    • (2015) J Vis Exp , pp. e52539
    • Li, S.1    Xue, H.2    Long, B.3    Sun, L.4    Truong, T.5    Liu, Y.6
  • 32
    • 79951997641 scopus 로고    scopus 로고
    • A modular cloning system for standardized assembly of multigene constructs
    • Weber E, C Engler, R Gruetzner, S Werner and S Marillonnet. (2011). A modular cloning system for standardized assembly of multigene constructs. PLoS One 6:e16765.
    • (2011) PLoS One , vol.6 , pp. e16765
    • Weber, E.1    Engler, C.2    Gruetzner, R.3    Werner, S.4    Marillonnet, S.5
  • 33
    • 65849183178 scopus 로고    scopus 로고
    • Golden gate shuffling: A one-pot DNA shuffling method based on type IIs restriction enzymes
    • Engler C, R Gruetzner, R Kandzia and S Marillonnet. (2009). Golden gate shuffling: a one-pot DNA shuffling method based on type IIs restriction enzymes. PLoS One 4:e5553.
    • (2009) PLoS One , vol.4 , pp. e5553
    • Engler, C.1    Gruetzner, R.2    Kandzia, R.3    Marillonnet, S.4
  • 37
  • 38
    • 67650562117 scopus 로고    scopus 로고
    • Xeno-free defined conditions for culture of human embryonic stem cells, neural stem cells and dopaminergic neurons derived from them
    • Swistowski A, J Peng, Y Han, AM Swistowska, MS Rao and X Zeng. (2009). Xeno-free defined conditions for culture of human embryonic stem cells, neural stem cells and dopaminergic neurons derived from them. PLoS One 4:e6233.
    • (2009) PLoS One , vol.4 , pp. e6233
    • Swistowski, A.1    Peng, J.2    Han, Y.3    Swistowska, A.M.4    Rao, M.S.5    Zeng, X.6
  • 40
    • 84896929630 scopus 로고    scopus 로고
    • Improving CRISPR-Cas nuclease specificity using truncated guide RNAs
    • Fu Y, JD Sander, D Reyon, VM Cascio and JK Joung. (2014). Improving CRISPR-Cas nuclease specificity using truncated guide RNAs. Nat Biotechnol 32:279-284.
    • (2014) Nat Biotechnol , vol.32 , pp. 279-284
    • Fu, Y.1    Sander, J.D.2    Reyon, D.3    Cascio, V.M.4    Joung, J.K.5
  • 41
    • 0036794961 scopus 로고    scopus 로고
    • Oligodendrocyte and astrocyte development in rodents: An in situ and immunohistological analysis during embryonic development
    • Liu Y, Y Wu, JC Lee, H Xue, LH Pevny, Z Kaprielian and MS Rao. (2002). Oligodendrocyte and astrocyte development in rodents: an in situ and immunohistological analysis during embryonic development. Glia 40:25-43.
    • (2002) Glia , vol.40 , pp. 25-43
    • Liu, Y.1    Wu, Y.2    Lee, J.C.3    Xue, H.4    Pevny, L.H.5    Kaprielian, Z.6    Rao, M.S.7
  • 43
    • 84925407878 scopus 로고    scopus 로고
    • Targeted genome editing in human cells using CRISPR/Cas nucleases and truncated guide RNAs
    • Fu Y, D Reyon and JK Joung. (2014). Targeted genome editing in human cells using CRISPR/Cas nucleases and truncated guide RNAs. Methods Enzymol 546:21-45.
    • (2014) Methods Enzymol , vol.546 , pp. 21-45
    • Fu, Y.1    Reyon, D.2    Joung, J.K.3
  • 44
    • 19544371373 scopus 로고    scopus 로고
    • Gene targeting in mice: Functional analysis of the mammalian genome for the twenty-first century
    • Capecchi MR. (2005). Gene targeting in mice: functional analysis of the mammalian genome for the twenty-first century. Nat Rev Genet 6:507-512.
    • (2005) Nat Rev Genet , vol.6 , pp. 507-512
    • Capecchi, M.R.1
  • 45
    • 0020396492 scopus 로고
    • Patterns of integration of DNA microinjected into cultured mammalian cells: Evidence for homologous recombination between injected plasmid DNA molecules
    • Folger KR, EA Wong, G Wahl and MR Capecchi. (1982). Patterns of integration of DNA microinjected into cultured mammalian cells: evidence for homologous recombination between injected plasmid DNA molecules. Mol Cell Biol 2:1372-1387.
    • (1982) Mol Cell Biol , vol.2 , pp. 1372-1387
    • Folger, K.R.1    Wong, E.A.2    Wahl, G.3    Capecchi, M.R.4
  • 46
    • 84896308706 scopus 로고    scopus 로고
    • Cas-OFFinder: A fast and versatile algorithm that searches for potential off-target sites of Cas9 RNA-guided endonucleases
    • Bae S, J Park and JS Kim. (2014). Cas-OFFinder: a fast and versatile algorithm that searches for potential off-target sites of Cas9 RNA-guided endonucleases. Bioinformatics 30:1473-1475.
    • (2014) Bioinformatics , vol.30 , pp. 1473-1475
    • Bae, S.1    Park, J.2    Kim, J.S.3
  • 47
  • 48
    • 84923221641 scopus 로고    scopus 로고
    • Unbiased detection of off-target cleavage by CRISPR-Cas9 and TALENs using integrase-defective lentiviral vectors
    • Wang X, Y Wang, X Wu, J Wang, Y Wang, Z Qiu, T Chang, H Huang, RJ Lin and JK Yee. (2015). Unbiased detection of off-target cleavage by CRISPR-Cas9 and TALENs using integrase-defective lentiviral vectors. Nat Biotechnol 33:175-178.
    • (2015) Nat Biotechnol , vol.33 , pp. 175-178
    • Wang, X.1    Wang, Y.2    Wu, X.3    Wang, J.4    Wang, Y.5    Qiu, Z.6    Chang, T.7    Huang, H.8    Lin, R.J.9    Yee, J.K.10
  • 50
    • 84884160273 scopus 로고    scopus 로고
    • CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering
    • Mali P, J Aach, PB Stranges, KM Esvelt, M Moosburner, S Kosuri, L Yang and GM Church. (2013). CAS9 transcriptional activators for target specificity screening and paired nickases for cooperative genome engineering. Nat Biotechnol 31:833-838.
    • (2013) Nat Biotechnol , vol.31 , pp. 833-838
    • Mali, P.1    Aach, J.2    Stranges, P.B.3    Esvelt, K.M.4    Moosburner, M.5    Kosuri, S.6    Yang, L.7    Church, G.M.8
  • 52
    • 84902210542 scopus 로고    scopus 로고
    • Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification
    • Guilinger JP, DB Thompson and DR Liu. (2014). Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification. Nat Biotechnol 32:577-582.
    • (2014) Nat Biotechnol , vol.32 , pp. 577-582
    • Guilinger, J.P.1    Thompson, D.B.2    Liu, D.R.3
  • 53
  • 54
    • 0034710920 scopus 로고    scopus 로고
    • Biochemistry, mutagenesis, and oligomerization of DsRed, a red fluorescent protein from coral
    • Baird GS, DA Zacharias and RY Tsien. (2000). Biochemistry, mutagenesis, and oligomerization of DsRed, a red fluorescent protein from coral. Proc Natl Acad Sci USA 97:11984-11989.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 11984-11989
    • Baird, G.S.1    Zacharias, D.A.2    Tsien, R.Y.3
  • 58
    • 0003073157 scopus 로고    scopus 로고
    • Identification of neurogenin, a vertebrate neuronal determination gene
    • Ma Q, C Kintner and DJ Anderson. (1996). Identification of neurogenin, a vertebrate neuronal determination gene. Cell 87:43-52.
    • (1996) Cell , vol.87 , pp. 43-52
    • Ma, Q.1    Kintner, C.2    Anderson, D.J.3
  • 59
    • 0032033009 scopus 로고    scopus 로고
    • The bHLH protein NEUROGENIN 2 is a determination factor for epibranchial placode-derived sensory neurons
    • Fode C, G Gradwohl, X Morin, A Dierich, M LeMeur, C Goridis and F Guillemot. (1998). The bHLH protein NEUROGENIN 2 is a determination factor for epibranchial placode-derived sensory neurons. Neuron 20:483-494.
    • (1998) Neuron , vol.20 , pp. 483-494
    • Fode, C.1    Gradwohl, G.2    Morin, X.3    Dierich, A.4    LeMeur, M.5    Goridis, C.6    Guillemot, F.7
  • 60
    • 0033967842 scopus 로고    scopus 로고
    • A role for neural determination genes in specifying the dorsoventral identity of telencephalic neurons
    • Fode C, Q Ma, S Casarosa, SL Ang, DJ Anderson and F Guillemot. (2000). A role for neural determination genes in specifying the dorsoventral identity of telencephalic neurons. Genes Dev 14:67-80.
    • (2000) Genes Dev , vol.14 , pp. 67-80
    • Fode, C.1    Ma, Q.2    Casarosa, S.3    Ang, S.L.4    Anderson, D.J.5    Guillemot, F.6
  • 61
    • 0035855786 scopus 로고    scopus 로고
    • Combinatorial roles of olig2 and neurogenin2 in the coordinated induction of pan-neuronal and subtypespecific properties of motoneurons
    • Mizuguchi R, M Sugimori, H Takebayashi, H Kosako, M Nagao, S Yoshida, Y Nabeshima, K Shimamura and M Nakafuku. (2001). Combinatorial roles of olig2 and neurogenin2 in the coordinated induction of pan-neuronal and subtypespecific properties of motoneurons. Neuron 31:757-771.
    • (2001) Neuron , vol.31 , pp. 757-771
    • Mizuguchi, R.1    Sugimori, M.2    Takebayashi, H.3    Kosako, H.4    Nagao, M.5    Yoshida, S.6    Nabeshima, Y.7    Shimamura, K.8    Nakafuku, M.9
  • 62
    • 0035855795 scopus 로고    scopus 로고
    • Coordinate regulation ofmotor neuron subtype identity and pan-neuronal properties by the bHLH repressor Olig2
    • Novitch BG, AI Chen and TM Jessell. (2001). Coordinate regulation ofmotor neuron subtype identity and pan-neuronal properties by the bHLH repressor Olig2. Neuron 31:773-789.
    • (2001) Neuron , vol.31 , pp. 773-789
    • Novitch, B.G.1    Chen, A.I.2    Jessell, T.M.3
  • 63
    • 0035797449 scopus 로고    scopus 로고
    • Crossregulation between Neurogenin2 and pathways specifying neuronal identity in the spinal cord
    • Scardigli R, C Schuurmans, G Gradwohl and F Guillemot. (2001). Crossregulation between Neurogenin2 and pathways specifying neuronal identity in the spinal cord. Neuron 31:203-217.
    • (2001) Neuron , vol.31 , pp. 203-217
    • Scardigli, R.1    Schuurmans, C.2    Gradwohl, G.3    Guillemot, F.4
  • 65
    • 58449121331 scopus 로고    scopus 로고
    • Involvement of Ngn2, Tbr and NeuroD proteins during postnatal olfactory bulb neurogenesis
    • Roybon L, T Deierborg, P Brundin and JY Li. (2009). Involvement of Ngn2, Tbr and NeuroD proteins during postnatal olfactory bulb neurogenesis. Eur J Neurosci 29:232-243.
    • (2009) Eur J Neurosci , vol.29 , pp. 232-243
    • Roybon, L.1    Deierborg, T.2    Brundin, P.3    Li, J.Y.4
  • 66
    • 62849111110 scopus 로고    scopus 로고
    • Neurogenin2 directs granule neuroblast production and amplification while NeuroD1 specifies neuronal fate during hippocampal neurogenesis
    • Roybon L, T Hjalt, S Stott, F Guillemot, JY Li and P Brundin. (2009). Neurogenin2 directs granule neuroblast production and amplification while NeuroD1 specifies neuronal fate during hippocampal neurogenesis. PLoS One 4:e4779.
    • (2009) PLoS One , vol.4 , pp. e4779
    • Roybon, L.1    Hjalt, T.2    Stott, S.3    Guillemot, F.4    Li, J.Y.5    Brundin, P.6
  • 67
    • 0032032016 scopus 로고    scopus 로고
    • Neurogenin1 is essential for the determination of neuronal precursors for proximal cranial sensory ganglia
    • Ma Q, Z Chen, I del Barco Barrantes, JL de la Pompa and DJ Anderson. (1998). neurogenin1 is essential for the determination of neuronal precursors for proximal cranial sensory ganglia. Neuron 20:469-482.
    • (1998) Neuron , vol.20 , pp. 469-482
    • Ma, Q.1    Chen, Z.2    Del Barco Barrantes, I.3    De La Pompa, J.L.4    Anderson, D.J.5
  • 68
    • 0037062516 scopus 로고    scopus 로고
    • Transient expression of the bHLH factor neurogenin-2 marks a subpopulation of neural crest cells biased for a sensory but not a neuronal fate
    • Zirlinger M, L Lo, J McMahon, AP McMahon and DJ Anderson. (2002). Transient expression of the bHLH factor neurogenin-2 marks a subpopulation of neural crest cells biased for a sensory but not a neuronal fate. Proc Natl Acad Sci USA 99:8084-8089.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 8084-8089
    • Zirlinger, M.1    Lo, L.2    McMahon, J.3    McMahon, A.P.4    Anderson, D.J.5
  • 69
    • 84859882919 scopus 로고    scopus 로고
    • Post-translational modification of Ngn2 differentially affects transcription of distinct targets to regulate the balance between progenitor maintenance and differentiation
    • Hindley C, F Ali, G McDowell, K Cheng, A Jones, F Guillemot and A Philpott. (2012). Post-translational modification of Ngn2 differentially affects transcription of distinct targets to regulate the balance between progenitor maintenance and differentiation. Development 139:1718-1723.
    • (2012) Development , vol.139 , pp. 1718-1723
    • Hindley, C.1    Ali, F.2    McDowell, G.3    Cheng, K.4    Jones, A.5    Guillemot, F.6    Philpott, A.7
  • 70
    • 12144271676 scopus 로고    scopus 로고
    • Olig2 and Ngn2 function in opposition to modulate gene expression in motor neuron progenitor cells
    • Lee SK, B Lee, EC Ruiz and SL Pfaff. (2005). Olig2 and Ngn2 function in opposition to modulate gene expression in motor neuron progenitor cells. Genes Dev 19:282-294.
    • (2005) Genes Dev , vol.19 , pp. 282-294
    • Lee, S.K.1    Lee, B.2    Ruiz, E.C.3    Pfaff, S.L.4
  • 71
    • 77952172670 scopus 로고    scopus 로고
    • Zinc finger genes Fezf1 and Fezf2 control neuronal differentiation by repressing Hes5 expression in the forebrain
    • Shimizu T, M Nakazawa, S Kani, YK Bae, T Shimizu, R Kageyama and M Hibi. (2010). Zinc finger genes Fezf1 and Fezf2 control neuronal differentiation by repressing Hes5 expression in the forebrain. Development 137:1875-1885.
    • (2010) Development , vol.137 , pp. 1875-1885
    • Shimizu, T.1    Nakazawa, M.2    Kani, S.3    Bae, Y.K.4    Shimizu, T.5    Kageyama, R.6    Hibi, M.7
  • 73
    • 34547890677 scopus 로고    scopus 로고
    • Functional properties of neurons derived from in vitro reprogrammed postnatal astroglia
    • Berninger B, MR Costa, U Koch, T Schroeder, B Sutor, B Grothe and M Gotz. (2007). Functional properties of neurons derived from in vitro reprogrammed postnatal astroglia. J Neurosci 27:8654-8664.
    • (2007) J Neurosci , vol.27 , pp. 8654-8664
    • Berninger, B.1    Costa, M.R.2    Koch, U.3    Schroeder, T.4    Sutor, B.5    Grothe, B.6    Gotz, M.7
  • 75
    • 84880849098 scopus 로고    scopus 로고
    • Small molecules enable neurogenin 2 to efficiently convert human fibroblasts into cholinergic neurons
    • Liu ML, T Zang, Y Zou, JC Chang, JR Gibson, KM Huber and CL Zhang. (2013). Small molecules enable neurogenin 2 to efficiently convert human fibroblasts into cholinergic neurons. Nat Commun 4:2183.
    • (2013) Nat Commun , vol.4 , pp. 2183
    • Liu, M.L.1    Zang, T.2    Zou, Y.3    Chang, J.C.4    Gibson, J.R.5    Huber, K.M.6    Zhang, C.L.7
  • 77
    • 78651235357 scopus 로고    scopus 로고
    • Grafted human embryonic progenitors expressing neurogenin-2 stimulate axonal sprouting and improve motor recovery after severe spinal cord injury
    • Perrin FE, G Boniface, C Serguera, N Lonjon, A Serre, M Prieto, J Mallet and A Privat. (2010). Grafted human embryonic progenitors expressing neurogenin-2 stimulate axonal sprouting and improve motor recovery after severe spinal cord injury. PLoS One 5:e15914.
    • (2010) PLoS One , vol.5 , pp. e15914
    • Perrin, F.E.1    Boniface, G.2    Serguera, C.3    Lonjon, N.4    Serre, A.5    Prieto, M.6    Mallet, J.7    Privat, A.8
  • 78
    • 84916219205 scopus 로고    scopus 로고
    • TALEN/CRISPR-mediated eGFP knock-in add-on at the OCT4 locus does not impact differentiation of human embryonic stem cells towards endoderm
    • Krentz NA, C Nian and FC Lynn. (2014). TALEN/CRISPR-mediated eGFP knock-in add-on at the OCT4 locus does not impact differentiation of human embryonic stem cells towards endoderm. PLoS One 9:e114275.
    • (2014) PLoS One , vol.9 , pp. e114275
    • Krentz, N.A.1    Nian, C.2    Lynn, F.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.