-
1
-
-
0022786302
-
Fatty-acid biosynthesis in man, a pathway of minor importance. Purification, optimal assay conditions, and organ distribution of fatty-acid synthase
-
Weiss L, Hoffmann GE, Schreiber R, Andres H, Fuchs E, Korber E & Kolb HJ (1986) Fatty-acid biosynthesis in man, a pathway of minor importance. Purification, optimal assay conditions, and organ distribution of fatty-acid synthase. Biol Chem Hoppe-Seyler 367, 905–912.
-
(1986)
Biol Chem Hoppe-Seyler
, vol.367
, pp. 905-912
-
-
Weiss, L.1
Hoffmann, G.E.2
Schreiber, R.3
Andres, H.4
Fuchs, E.5
Korber, E.6
Kolb, H.J.7
-
2
-
-
0012249041
-
Metabolism of neoplastic tissue. IV. A study of lipid synthesis in neoplastic tissue slices in vitro
-
Medes G, Thomas A & Weinhouse S (1953) Metabolism of neoplastic tissue. IV. A study of lipid synthesis in neoplastic tissue slices in vitro. Cancer Res 13, 27–29.
-
(1953)
Cancer Res
, vol.13
, pp. 27-29
-
-
Medes, G.1
Thomas, A.2
Weinhouse, S.3
-
3
-
-
0028301959
-
Fatty acid synthesis: a potential selective target for antineoplastic therapy
-
Kuhajda FP, Jenner K, Wood FD, Hennigar RA, Jacobs LB, Dick JD & Pasternack GR (1994) Fatty acid synthesis: a potential selective target for antineoplastic therapy. Proc Natl Acad Sci USA 91, 6379–6383.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 6379-6383
-
-
Kuhajda, F.P.1
Jenner, K.2
Wood, F.D.3
Hennigar, R.A.4
Jacobs, L.B.5
Dick, J.D.6
Pasternack, G.R.7
-
4
-
-
24044494924
-
FAS expression inversely correlates with PTEN level in prostate cancer and a PI 3-kinase inhibitor synergizes with FAS siRNA to induce apoptosis
-
Bandyopadhyay S, Pai SK, Watabe M, Gross SC, Hirota S, Hosobe S, Tsukada T, Miura K, Saito K, Markwell SJ et al. (2005) FAS expression inversely correlates with PTEN level in prostate cancer and a PI 3-kinase inhibitor synergizes with FAS siRNA to induce apoptosis. Oncogene 24, 5389–5395.
-
(2005)
Oncogene
, vol.24
, pp. 5389-5395
-
-
Bandyopadhyay, S.1
Pai, S.K.2
Watabe, M.3
Gross, S.C.4
Hirota, S.5
Hosobe, S.6
Tsukada, T.7
Miura, K.8
Saito, K.9
Markwell, S.J.10
-
5
-
-
19944374798
-
Positive feedback regulation between AKT activation and fatty acid synthase expression in ovarian carcinoma cells
-
Wang HQ, Altomare DA, Skele KL, Poulikakos PI, Kuhajda FP, Di Cristofano A & Testa JR (2005) Positive feedback regulation between AKT activation and fatty acid synthase expression in ovarian carcinoma cells. Oncogene 24, 3574–3582.
-
(2005)
Oncogene
, vol.24
, pp. 3574-3582
-
-
Wang, H.Q.1
Altomare, D.A.2
Skele, K.L.3
Poulikakos, P.I.4
Kuhajda, F.P.5
Di Cristofano, A.6
Testa, J.R.7
-
6
-
-
84858265438
-
Inhibition of fatty acid synthase attenuates CD44-associated signaling and reduces metastasis in colorectal cancer
-
Zaytseva YY, Rychahou PG, Gulhati P, Elliott VA, Mustain WC, O'Connor K, Morris AJ, Sunkara M, Weiss HL, Lee EY et al. (2012) Inhibition of fatty acid synthase attenuates CD44-associated signaling and reduces metastasis in colorectal cancer. Cancer Res 72, 1504–1517.
-
(2012)
Cancer Res
, vol.72
, pp. 1504-1517
-
-
Zaytseva, Y.Y.1
Rychahou, P.G.2
Gulhati, P.3
Elliott, V.A.4
Mustain, W.C.5
O'Connor, K.6
Morris, A.J.7
Sunkara, M.8
Weiss, H.L.9
Lee, E.Y.10
-
7
-
-
34748912615
-
Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
-
Menendez JA & Lupu R (2007) Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. Nat Rev 7, 763–777.
-
(2007)
Nat Rev
, vol.7
, pp. 763-777
-
-
Menendez, J.A.1
Lupu, R.2
-
8
-
-
84863837081
-
Lipid metabolism in cancer
-
Santos CR & Schulze A (2012) Lipid metabolism in cancer. FEBS J 279, 2610–2623.
-
(2012)
FEBS J
, vol.279
, pp. 2610-2623
-
-
Santos, C.R.1
Schulze, A.2
-
9
-
-
84881372774
-
Cellular fatty acid metabolism and cancer
-
Currie E, Schulze A, Zechner R, Walther TC & Farese RV Jr (2013) Cellular fatty acid metabolism and cancer. Cell Metab 18, 153–161.
-
(2013)
Cell Metab
, vol.18
, pp. 153-161
-
-
Currie, E.1
Schulze, A.2
Zechner, R.3
Walther, T.C.4
Farese, R.V.5
-
10
-
-
11144309582
-
Why does tumor-associated fatty acid synthase (oncogenic antigen-519) ignore dietary fatty acids?
-
Menendez JA, Colomer R & Lupu R (2005) Why does tumor-associated fatty acid synthase (oncogenic antigen-519) ignore dietary fatty acids? Med Hypotheses 64, 342–349.
-
(2005)
Med Hypotheses
, vol.64
, pp. 342-349
-
-
Menendez, J.A.1
Colomer, R.2
Lupu, R.3
-
11
-
-
0035984647
-
Going malignant: the hypoxia-cancer connection in the prostate
-
Hochachka PW, Rupert JL, Goldenberg L, Gleave M & Kozlowski P (2002) Going malignant: the hypoxia-cancer connection in the prostate. BioEssays 24, 749–757.
-
(2002)
BioEssays
, vol.24
, pp. 749-757
-
-
Hochachka, P.W.1
Rupert, J.L.2
Goldenberg, L.3
Gleave, M.4
Kozlowski, P.5
-
12
-
-
84876684375
-
Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity
-
Kidani Y, Elsaesser H, Hock MB, Vergnes L, Williams KJ, Argus JP, Marbois BN, Komisopoulou E, Wilson EB, Osborne TF et al. (2013) Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity. Nat Immunol 14, 489–499.
-
(2013)
Nat Immunol
, vol.14
, pp. 489-499
-
-
Kidani, Y.1
Elsaesser, H.2
Hock, M.B.3
Vergnes, L.4
Williams, K.J.5
Argus, J.P.6
Marbois, B.N.7
Komisopoulou, E.8
Wilson, E.B.9
Osborne, T.F.10
-
13
-
-
84922080059
-
De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells
-
Berod L, Friedrich C, Nandan A, Freitag J, Hagemann S, Harmrolfs K, Sandouk A, Hesse C, Castro CN, Bahre H et al. (2014) De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells. Nat Med 20, 1327–1333.
-
(2014)
Nat Med
, vol.20
, pp. 1327-1333
-
-
Berod, L.1
Friedrich, C.2
Nandan, A.3
Freitag, J.4
Hagemann, S.5
Harmrolfs, K.6
Sandouk, A.7
Hesse, C.8
Castro, C.N.9
Bahre, H.10
-
14
-
-
84890137621
-
T cell exit from quiescence and differentiation into Th2 cells depend on Raptor-mTORC1-mediated metabolic reprogramming
-
Yang K, Shrestha S, Zeng H, Karmaus PW, Neale G, Vogel P, Guertin DA, Lamb RF & Chi H (2013) T cell exit from quiescence and differentiation into Th2 cells depend on Raptor-mTORC1-mediated metabolic reprogramming. Immunity 39, 1043–1056.
-
(2013)
Immunity
, vol.39
, pp. 1043-1056
-
-
Yang, K.1
Shrestha, S.2
Zeng, H.3
Karmaus, P.W.4
Neale, G.5
Vogel, P.6
Guertin, D.A.7
Lamb, R.F.8
Chi, H.9
-
15
-
-
84964267895
-
Fatty acid metabolism in the regulation of T cell function
-
Lochner M, Berod L & Sparwasser T (2015) Fatty acid metabolism in the regulation of T cell function. Trends Immunol 36, 81–91.
-
(2015)
Trends Immunol
, vol.36
, pp. 81-91
-
-
Lochner, M.1
Berod, L.2
Sparwasser, T.3
-
16
-
-
84956695797
-
E2F1 mediates sustained lipogenesis and contributes to hepatic steatosis
-
Denechaud PD, Lopez-Mejia IC, Giralt A, Lai Q, Blanchet E, Delacuisine B, Nicolay BN, Dyson NJ, Bonner C, Pattou F et al. (2016) E2F1 mediates sustained lipogenesis and contributes to hepatic steatosis. J Clin Investig 126, 137–150.
-
(2016)
J Clin Investig
, vol.126
, pp. 137-150
-
-
Denechaud, P.D.1
Lopez-Mejia, I.C.2
Giralt, A.3
Lai, Q.4
Blanchet, E.5
Delacuisine, B.6
Nicolay, B.N.7
Dyson, N.J.8
Bonner, C.9
Pattou, F.10
-
17
-
-
70350236472
-
Coordination of lipid metabolism in membrane biogenesis
-
Nohturfft A & Zhang SC (2009) Coordination of lipid metabolism in membrane biogenesis. Annu Rev Cell Dev Biol 25, 539–566.
-
(2009)
Annu Rev Cell Dev Biol
, vol.25
, pp. 539-566
-
-
Nohturfft, A.1
Zhang, S.C.2
-
18
-
-
0036864411
-
Sterol regulatory element-binding proteins: transcriptional activators of lipid synthesis
-
Horton JD (2002) Sterol regulatory element-binding proteins: transcriptional activators of lipid synthesis. Biochem Soc Trans 30, 1091–1095.
-
(2002)
Biochem Soc Trans
, vol.30
, pp. 1091-1095
-
-
Horton, J.D.1
-
19
-
-
33847709027
-
SREBP in signal transduction: cholesterol metabolism and beyond
-
Bengoechea-Alonso MT & Ericsson J (2007) SREBP in signal transduction: cholesterol metabolism and beyond. Curr Opin Cell Biol 19, 215–222.
-
(2007)
Curr Opin Cell Biol
, vol.19
, pp. 215-222
-
-
Bengoechea-Alonso, M.T.1
Ericsson, J.2
-
20
-
-
0030941803
-
The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor
-
Brown MS & Goldstein JL (1997) The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell 89, 331–340.
-
(1997)
Cell
, vol.89
, pp. 331-340
-
-
Brown, M.S.1
Goldstein, J.L.2
-
21
-
-
81055140116
-
A conserved SREBP-1/phosphatidylcholine feedback circuit regulates lipogenesis in metazoans
-
Walker AK, Jacobs RL, Watts JL, Rottiers V, Jiang K, Finnegan DM, Shioda T, Hansen M, Yang F, Niebergall LJ et al. (2011) A conserved SREBP-1/phosphatidylcholine feedback circuit regulates lipogenesis in metazoans. Cell 147, 840–852.
-
(2011)
Cell
, vol.147
, pp. 840-852
-
-
Walker, A.K.1
Jacobs, R.L.2
Watts, J.L.3
Rottiers, V.4
Jiang, K.5
Finnegan, D.M.6
Shioda, T.7
Hansen, M.8
Yang, F.9
Niebergall, L.J.10
-
22
-
-
0036385719
-
Activation of fatty acid synthesis during neoplastic transformation: role of mitogen-activated protein kinase and phosphatidylinositol 3-kinase
-
Yang YA, Han WF, Morin PJ, Chrest FJ & Pizer ES (2002) Activation of fatty acid synthesis during neoplastic transformation: role of mitogen-activated protein kinase and phosphatidylinositol 3-kinase. Exp Cell Res 279, 80–90.
-
(2002)
Exp Cell Res
, vol.279
, pp. 80-90
-
-
Yang, Y.A.1
Han, W.F.2
Morin, P.J.3
Chrest, F.J.4
Pizer, E.S.5
-
23
-
-
26244464326
-
PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP
-
Porstmann T, Griffiths B, Chung YL, Delpuech O, Griffiths JR, Downward J & Schulze A (2005) PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP. Oncogene 24, 6465–6481.
-
(2005)
Oncogene
, vol.24
, pp. 6465-6481
-
-
Porstmann, T.1
Griffiths, B.2
Chung, Y.L.3
Delpuech, O.4
Griffiths, J.R.5
Downward, J.6
Schulze, A.7
-
24
-
-
50049116472
-
SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth
-
Porstmann T, Santos CR, Griffiths B, Cully M, Wu M, Leevers S, Griffiths JR, Chung YL & Schulze A (2008) SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growth. Cell Metab 8, 224–236.
-
(2008)
Cell Metab
, vol.8
, pp. 224-236
-
-
Porstmann, T.1
Santos, C.R.2
Griffiths, B.3
Cully, M.4
Wu, M.5
Leevers, S.6
Griffiths, J.R.7
Chung, Y.L.8
Schulze, A.9
-
25
-
-
77955483125
-
Activation of a metabolic gene regulatory network downstream of mTOR complex 1
-
Duvel K, Yecies JL, Menon S, Raman P, Lipovsky AI, Souza AL, Triantafellow E, Ma Q, Gorski R, Cleaver S et al. (2010) Activation of a metabolic gene regulatory network downstream of mTOR complex 1. Mol Cell 39, 171–183.
-
(2010)
Mol Cell
, vol.39
, pp. 171-183
-
-
Duvel, K.1
Yecies, J.L.2
Menon, S.3
Raman, P.4
Lipovsky, A.I.5
Souza, A.L.6
Triantafellow, E.7
Ma, Q.8
Gorski, R.9
Cleaver, S.10
-
26
-
-
79961165137
-
mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway
-
Peterson TR, Sengupta SS, Harris TE, Carmack AE, Kang SA, Balderas E, Guertin DA, Madden KL, Carpenter AE, Finck BN et al. (2011) mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway. Cell 146, 408–420.
-
(2011)
Cell
, vol.146
, pp. 408-420
-
-
Peterson, T.R.1
Sengupta, S.S.2
Harris, T.E.3
Carmack, A.E.4
Kang, S.A.5
Balderas, E.6
Guertin, D.A.7
Madden, K.L.8
Carpenter, A.E.9
Finck, B.N.10
-
27
-
-
84939497516
-
The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1
-
Han J, Li E, Chen L, Zhang Y, Wei F, Liu J, Deng H & Wang Y (2015) The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1. Nature 524, 243–246.
-
(2015)
Nature
, vol.524
, pp. 243-246
-
-
Han, J.1
Li, E.2
Chen, L.3
Zhang, Y.4
Wei, F.5
Liu, J.6
Deng, H.7
Wang, Y.8
-
28
-
-
77649264504
-
Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis
-
Li S, Brown MS & Goldstein JL (2010) Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis. Proc Natl Acad Sci USA 107, 3441–3446.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 3441-3446
-
-
Li, S.1
Brown, M.S.2
Goldstein, J.L.3
-
29
-
-
84865503043
-
Identification of Akt-independent regulation of hepatic lipogenesis by mammalian target of rapamycin (mTOR) complex 2
-
Yuan M, Pino E, Wu L, Kacergis M & Soukas AA (2012) Identification of Akt-independent regulation of hepatic lipogenesis by mammalian target of rapamycin (mTOR) complex 2. J Biol Chem 287, 29579–29588.
-
(2012)
J Biol Chem
, vol.287
, pp. 29579-29588
-
-
Yuan, M.1
Pino, E.2
Wu, L.3
Kacergis, M.4
Soukas, A.A.5
-
30
-
-
23844530704
-
Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCF(Fbw7)
-
Sundqvist A, Bengoechea-Alonso MT, Ye X, Lukiyanchuk V, Jin J, Harper JW & Ericsson J (2005) Control of lipid metabolism by phosphorylation-dependent degradation of the SREBP family of transcription factors by SCF(Fbw7). Cell Metab 1, 379–391.
-
(2005)
Cell Metab
, vol.1
, pp. 379-391
-
-
Sundqvist, A.1
Bengoechea-Alonso, M.T.2
Ye, X.3
Lukiyanchuk, V.4
Jin, J.5
Harper, J.W.6
Ericsson, J.7
-
31
-
-
79953755370
-
AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice
-
Li Y, Xu S, Mihaylova MM, Zheng B, Hou X, Jiang B, Park O, Luo Z, Lefai E, Shyy JY et al. (2011) AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell Metab 13, 376–388.
-
(2011)
Cell Metab
, vol.13
, pp. 376-388
-
-
Li, Y.1
Xu, S.2
Mihaylova, M.M.3
Zheng, B.4
Hou, X.5
Jiang, B.6
Park, O.7
Luo, Z.8
Lefai, E.9
Shyy, J.Y.10
-
32
-
-
34648828532
-
AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy
-
Hardie DG (2007) AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. Nat Rev Mol Cell Biol 8, 774–785.
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 774-785
-
-
Hardie, D.G.1
-
33
-
-
84930328718
-
Oncogenic PI3K and K-Ras stimulate de novo lipid synthesis through mTORC1 and SREBP
-
Ricoult SJ, Yecies JL, Ben-Sahra I & Manning BD (2015) Oncogenic PI3K and K-Ras stimulate de novo lipid synthesis through mTORC1 and SREBP. Oncogene. doi: 10.1038/onc.2015.179.
-
(2015)
Oncogene
-
-
Ricoult, S.J.1
Yecies, J.L.2
Ben-Sahra, I.3
Manning, B.D.4
-
34
-
-
67650088283
-
Biochemical and physiological function of stearoyl-CoA desaturase
-
Paton CM & Ntambi JM (2009) Biochemical and physiological function of stearoyl-CoA desaturase. Am J Physiol Endocrinol Metab 297, E28–E37.
-
(2009)
Am J Physiol Endocrinol Metab
, vol.297
, pp. E28-E37
-
-
Paton, C.M.1
Ntambi, J.M.2
-
35
-
-
0033563109
-
Human stearoyl-CoA desaturase: alternative transcripts generated from a single gene by usage of tandem polyadenylation sites
-
Zhang L, Ge L, Parimoo S, Stenn K & Prouty SM (1999) Human stearoyl-CoA desaturase: alternative transcripts generated from a single gene by usage of tandem polyadenylation sites. Biochem J 340 (Pt 1), 255–264.
-
(1999)
Biochem J
, vol.340
, pp. 255-264
-
-
Zhang, L.1
Ge, L.2
Parimoo, S.3
Stenn, K.4
Prouty, S.M.5
-
36
-
-
77956290719
-
Stearoyl-CoA desaturase-1: a novel key player in the mechanisms of cell proliferation, programmed cell death and transformation to cancer
-
Igal RA (2010) Stearoyl-CoA desaturase-1: a novel key player in the mechanisms of cell proliferation, programmed cell death and transformation to cancer. Carcinogenesis 31, 1509–1515.
-
(2010)
Carcinogenesis
, vol.31
, pp. 1509-1515
-
-
Igal, R.A.1
-
37
-
-
77953471622
-
Abrogation of de novo lipogenesis by stearoyl-CoA desaturase 1 inhibition interferes with oncogenic signaling and blocks prostate cancer progression in mice
-
Fritz V, Benfodda Z, Rodier G, Henriquet C, Iborra F, Avances C, Allory Y, de la Taille A, Culine S, Blancou H et al. (2010) Abrogation of de novo lipogenesis by stearoyl-CoA desaturase 1 inhibition interferes with oncogenic signaling and blocks prostate cancer progression in mice. Mol Cancer Ther 9, 1740–1754.
-
(2010)
Mol Cancer Ther
, vol.9
, pp. 1740-1754
-
-
Fritz, V.1
Benfodda, Z.2
Rodier, G.3
Henriquet, C.4
Iborra, F.5
Avances, C.6
Allory, Y.7
de la Taille, A.8
Culine, S.9
Blancou, H.10
-
38
-
-
84921605764
-
SCD1 negatively regulates autophagy-induced cell death in human hepatocellular carcinoma through inactivation of the AMPK signaling pathway
-
Huang GM, Jiang QH, Cai C, Qu M & Shen W (2015) SCD1 negatively regulates autophagy-induced cell death in human hepatocellular carcinoma through inactivation of the AMPK signaling pathway. Cancer Lett 358, 180–190.
-
(2015)
Cancer Lett
, vol.358
, pp. 180-190
-
-
Huang, G.M.1
Jiang, Q.H.2
Cai, C.3
Qu, M.4
Shen, W.5
-
39
-
-
84877096404
-
Stearoyl-CoA desaturase 1 is a novel molecular therapeutic target for clear cell renal cell carcinoma
-
von Roemeling CA, Marlow LA, Wei JJ, Cooper SJ, Caulfield TR, Wu K, Tan WW, Tun HW & Copland JA (2013) Stearoyl-CoA desaturase 1 is a novel molecular therapeutic target for clear cell renal cell carcinoma. Clin Cancer Res 19, 2368–2380.
-
(2013)
Clin Cancer Res
, vol.19
, pp. 2368-2380
-
-
von Roemeling, C.A.1
Marlow, L.A.2
Wei, J.J.3
Cooper, S.J.4
Caulfield, T.R.5
Wu, K.6
Tan, W.W.7
Tun, H.W.8
Copland, J.A.9
-
40
-
-
84871757114
-
High stearoyl-CoA desaturase 1 expression is associated with shorter survival in breast cancer patients
-
Holder AM, Gonzalez-Angulo AM, Chen H, Akcakanat A, Do KA, Fraser Symmans W, Pusztai L, Hortobagyi GN, Mills GB & Meric-Bernstam F (2013) High stearoyl-CoA desaturase 1 expression is associated with shorter survival in breast cancer patients. Breast Cancer Res Treat 137, 319–327.
-
(2013)
Breast Cancer Res Treat
, vol.137
, pp. 319-327
-
-
Holder, A.M.1
Gonzalez-Angulo, A.M.2
Chen, H.3
Akcakanat, A.4
Do, K.A.5
Fraser Symmans, W.6
Pusztai, L.7
Hortobagyi, G.N.8
Mills, G.B.9
Meric-Bernstam, F.10
-
41
-
-
54049084951
-
Inhibition of Stearoyl-CoA Desaturase 1 expression in human lung adenocarcinoma cells impairs tumorigenesis
-
Scaglia N & Igal RA (2008) Inhibition of Stearoyl-CoA Desaturase 1 expression in human lung adenocarcinoma cells impairs tumorigenesis. Int J Oncol 33, 839–850.
-
(2008)
Int J Oncol
, vol.33
, pp. 839-850
-
-
Scaglia, N.1
Igal, R.A.2
-
42
-
-
77956210076
-
Inhibition of stearoylCoA desaturase activity blocks cell cycle progression and induces programmed cell death in lung cancer cells
-
Hess D, Chisholm JW & Igal RA (2010) Inhibition of stearoylCoA desaturase activity blocks cell cycle progression and induces programmed cell death in lung cancer cells. PLoS One 5, e11394.
-
(2010)
PLoS One
, vol.5
-
-
Hess, D.1
Chisholm, J.W.2
Igal, R.A.3
-
43
-
-
79959977655
-
Stearoyl CoA desaturase (SCD) facilitates proliferation of prostate cancer cells through enhancement of androgen receptor transactivation
-
Kim SJ, Choi H, Park SS, Chang C & Kim E (2011) Stearoyl CoA desaturase (SCD) facilitates proliferation of prostate cancer cells through enhancement of androgen receptor transactivation. Mol Cells 31, 371–377.
-
(2011)
Mol Cells
, vol.31
, pp. 371-377
-
-
Kim, S.J.1
Choi, H.2
Park, S.S.3
Chang, C.4
Kim, E.5
-
44
-
-
84863388391
-
SCD1 inhibition causes cancer cell death by depleting mono-unsaturated fatty acids
-
Mason P, Liang B, Li L, Fremgen T, Murphy E, Quinn A, Madden SL, Biemann HP, Wang B, Cohen A et al. (2012) SCD1 inhibition causes cancer cell death by depleting mono-unsaturated fatty acids. PLoS One 7, e33823.
-
(2012)
PLoS One
, vol.7
-
-
Mason, P.1
Liang, B.2
Li, L.3
Fremgen, T.4
Murphy, E.5
Quinn, A.6
Madden, S.L.7
Biemann, H.P.8
Wang, B.9
Cohen, A.10
-
45
-
-
69449099939
-
Inhibition of stearoylCoA desaturase-1 inactivates acetyl-CoA carboxylase and impairs proliferation in cancer cells: role of AMPK
-
Scaglia N, Chisholm JW & Igal RA (2009) Inhibition of stearoylCoA desaturase-1 inactivates acetyl-CoA carboxylase and impairs proliferation in cancer cells: role of AMPK. PLoS One 4, e6812.
-
(2009)
PLoS One
, vol.4
-
-
Scaglia, N.1
Chisholm, J.W.2
Igal, R.A.3
-
46
-
-
81755173915
-
Cancer cell dependence on unsaturated fatty acids implicates stearoyl-CoA desaturase as a target for cancer therapy
-
Roongta UV, Pabalan JG, Wang X, Ryseck RP, Fargnoli J, Henley BJ, Yang WP, Zhu J, Madireddi MT, Lawrence RM et al. (2011) Cancer cell dependence on unsaturated fatty acids implicates stearoyl-CoA desaturase as a target for cancer therapy. Mol Cancer Res 9, 1551–1561.
-
(2011)
Mol Cancer Res
, vol.9
, pp. 1551-1561
-
-
Roongta, U.V.1
Pabalan, J.G.2
Wang, X.3
Ryseck, R.P.4
Fargnoli, J.5
Henley, B.J.6
Yang, W.P.7
Zhu, J.8
Madireddi, M.T.9
Lawrence, R.M.10
-
47
-
-
79955518028
-
Novel theranostic opportunities offered by characterization of altered membrane lipid metabolism in breast cancer progression
-
Hilvo M, Denkert C, Lehtinen L, Muller B, Brockmoller S, Seppanen-Laakso T, Budczies J, Bucher E, Yetukuri L, Castillo S et al. (2011) Novel theranostic opportunities offered by characterization of altered membrane lipid metabolism in breast cancer progression. Cancer Res 71, 3236–3245.
-
(2011)
Cancer Res
, vol.71
, pp. 3236-3245
-
-
Hilvo, M.1
Denkert, C.2
Lehtinen, L.3
Muller, B.4
Brockmoller, S.5
Seppanen-Laakso, T.6
Budczies, J.7
Bucher, E.8
Yetukuri, L.9
Castillo, S.10
-
48
-
-
84876160864
-
Human breast cancer tissues contain abundant phosphatidylcholine(36ratio1) with high stearoyl-CoA desaturase-1 expression
-
Ide Y, Waki M, Hayasaka T, Nishio T, Morita Y, Tanaka H, Sasaki T, Koizumi K, Matsunuma R, Hosokawa Y et al. (2013) Human breast cancer tissues contain abundant phosphatidylcholine(36ratio1) with high stearoyl-CoA desaturase-1 expression. PLoS One 8, e61204.
-
(2013)
PLoS One
, vol.8
-
-
Ide, Y.1
Waki, M.2
Hayasaka, T.3
Nishio, T.4
Morita, Y.5
Tanaka, H.6
Sasaki, T.7
Koizumi, K.8
Matsunuma, R.9
Hosokawa, Y.10
-
49
-
-
77649179672
-
Eicosanoids and cancer
-
Wang D & Dubois RN (2010) Eicosanoids and cancer. Nat Rev 10, 181–193.
-
(2010)
Nat Rev
, vol.10
, pp. 181-193
-
-
Wang, D.1
Dubois, R.N.2
-
50
-
-
84866463367
-
Stearoyl-CoA desaturase activity modulates the activation of epidermal growth factor receptor in human lung cancer cells
-
Nashed M, Chisholm JW & Igal RA (2012) Stearoyl-CoA desaturase activity modulates the activation of epidermal growth factor receptor in human lung cancer cells. Exp Biol Med 237, 1007–1017.
-
(2012)
Exp Biol Med
, vol.237
, pp. 1007-1017
-
-
Nashed, M.1
Chisholm, J.W.2
Igal, R.A.3
-
51
-
-
0037143752
-
Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity
-
Ntambi JM, Miyazaki M, Stoehr JP, Lan H, Kendziorski CM, Yandell BS, Song Y, Cohen P, Friedman JM & Attie AD (2002) Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity. Proc Natl Acad Sci USA 99, 11482–11486.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 11482-11486
-
-
Ntambi, J.M.1
Miyazaki, M.2
Stoehr, J.P.3
Lan, H.4
Kendziorski, C.M.5
Yandell, B.S.6
Song, Y.7
Cohen, P.8
Friedman, J.M.9
Attie, A.D.10
-
52
-
-
45449126566
-
Liver gene expression analysis reveals endoplasmic reticulum stress and metabolic dysfunction in SCD1-deficient mice fed a very low-fat diet
-
Flowers MT, Keller MP, Choi Y, Lan H, Kendziorski C, Ntambi JM & Attie AD (2008) Liver gene expression analysis reveals endoplasmic reticulum stress and metabolic dysfunction in SCD1-deficient mice fed a very low-fat diet. Physiol Genomics 33, 361–372.
-
(2008)
Physiol Genomics
, vol.33
, pp. 361-372
-
-
Flowers, M.T.1
Keller, M.P.2
Choi, Y.3
Lan, H.4
Kendziorski, C.5
Ntambi, J.M.6
Attie, A.D.7
-
53
-
-
33751159209
-
Intracellular signaling by the unfolded protein response
-
Bernales S, Papa FR & Walter P (2006) Intracellular signaling by the unfolded protein response. Annu Rev Cell Dev Biol 22, 487–508.
-
(2006)
Annu Rev Cell Dev Biol
, vol.22
, pp. 487-508
-
-
Bernales, S.1
Papa, F.R.2
Walter, P.3
-
54
-
-
34250899722
-
Signal integration in the endoplasmic reticulum unfolded protein response
-
Ron D & Walter P (2007) Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol 8, 519–529.
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 519-529
-
-
Ron, D.1
Walter, P.2
-
55
-
-
33751069967
-
Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins
-
Rutkowski DT, Arnold SM, Miller CN, Wu J, Li J, Gunnison KM, Mori K, Sadighi Akha AA, Raden D & Kaufman RJ (2006) Adaptation to ER stress is mediated by differential stabilities of pro-survival and pro-apoptotic mRNAs and proteins. PLoS Biol 4, e374.
-
(2006)
PLoS Biol
, vol.4
-
-
Rutkowski, D.T.1
Arnold, S.M.2
Miller, C.N.3
Wu, J.4
Li, J.5
Gunnison, K.M.6
Mori, K.7
Sadighi Akha, A.A.8
Raden, D.9
Kaufman, R.J.10
-
56
-
-
78650725619
-
Inhibition of stearoyl-CoA desaturase 1 expression induces CHOP-dependent cell death in human cancer cells
-
Minville-Walz M, Pierre AS, Pichon L, Bellenger S, Fevre C, Bellenger J, Tessier C, Narce M & Rialland M (2010) Inhibition of stearoyl-CoA desaturase 1 expression induces CHOP-dependent cell death in human cancer cells. PLoS One 5, e14363.
-
(2010)
PLoS One
, vol.5
-
-
Minville-Walz, M.1
Pierre, A.S.2
Pichon, L.3
Bellenger, S.4
Fevre, C.5
Bellenger, J.6
Tessier, C.7
Narce, M.8
Rialland, M.9
-
57
-
-
84877961669
-
Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumour growth
-
Griffiths B, Lewis CA, Bensaad K, Ros S, Zhang X, Ferber EC, Konisti S, Peck B, Miess H, East P et al. (2013) Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumour growth. Cancer Metab 1, 3.
-
(2013)
Cancer Metab
, vol.1
, pp. 3
-
-
Griffiths, B.1
Lewis, C.A.2
Bensaad, K.3
Ros, S.4
Zhang, X.5
Ferber, E.C.6
Konisti, S.7
Peck, B.8
Miess, H.9
East, P.10
-
58
-
-
84877731629
-
An essential requirement for the SCAP/SREBP signaling axis to protect cancer cells from lipotoxicity
-
Williams KJ, Argus JP, Zhu Y, Wilks MQ, Marbois BN, York AG, Kidani Y, Pourzia AL, Akhavan D, Lisiero DN et al. (2013) An essential requirement for the SCAP/SREBP signaling axis to protect cancer cells from lipotoxicity. Cancer Res 73, 2850–2862.
-
(2013)
Cancer Res
, vol.73
, pp. 2850-2862
-
-
Williams, K.J.1
Argus, J.P.2
Zhu, Y.3
Wilks, M.Q.4
Marbois, B.N.5
York, A.G.6
Kidani, Y.7
Pourzia, A.L.8
Akhavan, D.9
Lisiero, D.N.10
-
59
-
-
84877984661
-
Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival under tumor-like stress
-
Young RM, Ackerman D, Quinn ZL, Mancuso A, Gruber M, Liu L, Giannoukos DN, Bobrovnikova-Marjon E, Diehl JA, Keith B et al. (2013) Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival under tumor-like stress. Genes Dev 27, 1115–1131.
-
(2013)
Genes Dev
, vol.27
, pp. 1115-1131
-
-
Young, R.M.1
Ackerman, D.2
Quinn, Z.L.3
Mancuso, A.4
Gruber, M.5
Liu, L.6
Giannoukos, D.N.7
Bobrovnikova-Marjon, E.8
Diehl, J.A.9
Keith, B.10
-
61
-
-
84878464291
-
Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids
-
Kamphorst JJ, Cross JR, Fan J, de Stanchina E, Mathew R, White EP, Thompson CB & Rabinowitz JD (2013) Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids. Proc Natl Acad Sci USA 110, 8882–8887.
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, pp. 8882-8887
-
-
Kamphorst, J.J.1
Cross, J.R.2
Fan, J.3
de Stanchina, E.4
Mathew, R.5
White, E.P.6
Thompson, C.B.7
Rabinowitz, J.D.8
-
62
-
-
84943201007
-
SREBP maintains lipid biosynthesis and viability of cancer cells under lipid- and oxygen-deprived conditions and defines a gene signature associated with poor survival in glioblastoma multiforme
-
Lewis CA, Brault C, Peck B, Bensaad K, Griffiths B, Mitter R, Chakravarty P, East P, Dankworth B, Alibhai D et al. (2015) SREBP maintains lipid biosynthesis and viability of cancer cells under lipid- and oxygen-deprived conditions and defines a gene signature associated with poor survival in glioblastoma multiforme. Oncogene 34, 5128–5140.
-
(2015)
Oncogene
, vol.34
, pp. 5128-5140
-
-
Lewis, C.A.1
Brault, C.2
Peck, B.3
Bensaad, K.4
Griffiths, B.5
Mitter, R.6
Chakravarty, P.7
East, P.8
Dankworth, B.9
Alibhai, D.10
-
63
-
-
84904732950
-
Hypoxia, lipids, and cancer: surviving the harsh tumor microenvironment
-
Ackerman D & Simon MC (2014) Hypoxia, lipids, and cancer: surviving the harsh tumor microenvironment. Trends Cell Biol 24, 472–478.
-
(2014)
Trends Cell Biol
, vol.24
, pp. 472-478
-
-
Ackerman, D.1
Simon, M.C.2
-
64
-
-
84934927263
-
Wnt acylation and its functional implication in Wnt signalling regulation
-
Janda CY & Garcia KC (2015) Wnt acylation and its functional implication in Wnt signalling regulation. Biochem Soc Trans 43, 211–216.
-
(2015)
Biochem Soc Trans
, vol.43
, pp. 211-216
-
-
Janda, C.Y.1
Garcia, K.C.2
-
65
-
-
84884558970
-
Stearoyl CoA desaturase is required to produce active, lipid-modified Wnt proteins
-
Rios-Esteves J & Resh MD (2013) Stearoyl CoA desaturase is required to produce active, lipid-modified Wnt proteins. Cell Rep 4, 1072–1081.
-
(2013)
Cell Rep
, vol.4
, pp. 1072-1081
-
-
Rios-Esteves, J.1
Resh, M.D.2
-
66
-
-
84944680318
-
Unsaturated fatty acids stimulate tumor growth through stabilization of beta-catenin
-
Kim H, Rodriguez-Navas C, Kollipara RK, Kapur P, Pedrosa I, Brugarolas J, Kittler R & Ye J (2015) Unsaturated fatty acids stimulate tumor growth through stabilization of beta-catenin. Cell Rep 13, 495–503.
-
(2015)
Cell Rep
, vol.13
, pp. 495-503
-
-
Kim, H.1
Rodriguez-Navas, C.2
Kollipara, R.K.3
Kapur, P.4
Pedrosa, I.5
Brugarolas, J.6
Kittler, R.7
Ye, J.8
-
67
-
-
79958244231
-
PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation
-
Varga T, Czimmerer Z & Nagy L (2011) PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation. Biochim Biophys Acta 1812, 1007–1022.
-
(2011)
Biochim Biophys Acta
, vol.1812
, pp. 1007-1022
-
-
Varga, T.1
Czimmerer, Z.2
Nagy, L.3
-
68
-
-
78049307002
-
De novo lipogenesis protects cancer cells from free radicals and chemotherapeutics by promoting membrane lipid saturation
-
Rysman E, Brusselmans K, Scheys K, Timmermans L, Derua R, Munck S, Van Veldhoven PP, Waltregny D, Daniels VW, Machiels J et al. (2010) De novo lipogenesis protects cancer cells from free radicals and chemotherapeutics by promoting membrane lipid saturation. Cancer Res 70, 8117–8126.
-
(2010)
Cancer Res
, vol.70
, pp. 8117-8126
-
-
Rysman, E.1
Brusselmans, K.2
Scheys, K.3
Timmermans, L.4
Derua, R.5
Munck, S.6
Van Veldhoven, P.P.7
Waltregny, D.8
Daniels, V.W.9
Machiels, J.10
-
69
-
-
84892599003
-
Monounsaturated fatty acids in serum triacylglycerols are associated with response to neoadjuvant chemotherapy in breast cancer patients
-
Hilvo M, Gade S, Hyotylainen T, Nekljudova V, Seppanen-Laakso T, Sysi-Aho M, Untch M, Huober J, von Minckwitz G, Denkert C et al. (2014) Monounsaturated fatty acids in serum triacylglycerols are associated with response to neoadjuvant chemotherapy in breast cancer patients. Int J Cancer 134, 1725–1733.
-
(2014)
Int J Cancer
, vol.134
, pp. 1725-1733
-
-
Hilvo, M.1
Gade, S.2
Hyotylainen, T.3
Nekljudova, V.4
Seppanen-Laakso, T.5
Sysi-Aho, M.6
Untch, M.7
Huober, J.8
von Minckwitz, G.9
Denkert, C.10
-
70
-
-
84878396462
-
Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells
-
Commisso C, Davidson SM, Soydaner-Azeloglu RG, Parker SJ, Kamphorst JJ, Hackett S, Grabocka E, Nofal M, Drebin JA, Thompson CB et al. (2013) Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells. Nature 497, 633–637.
-
(2013)
Nature
, vol.497
, pp. 633-637
-
-
Commisso, C.1
Davidson, S.M.2
Soydaner-Azeloglu, R.G.3
Parker, S.J.4
Kamphorst, J.J.5
Hackett, S.6
Grabocka, E.7
Nofal, M.8
Drebin, J.A.9
Thompson, C.B.10
-
71
-
-
84896278325
-
Mutant ras elevates dependence on serum lipids and creates a synthetic lethality for rapamycin
-
Salloum D, Mukhopadhyay S, Tung K, Polonetskaya A & Foster DA (2014) Mutant ras elevates dependence on serum lipids and creates a synthetic lethality for rapamycin. Mol Cancer Ther 13, 733–741.
-
(2014)
Mol Cancer Ther
, vol.13
, pp. 733-741
-
-
Salloum, D.1
Mukhopadhyay, S.2
Tung, K.3
Polonetskaya, A.4
Foster, D.A.5
-
72
-
-
84938940583
-
Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors
-
Daemen A, Peterson D, Sahu N, McCord R, Du X, Liu B, Kowanetz K, Hong R, Moffat J, Gao M et al. (2015) Metabolite profiling stratifies pancreatic ductal adenocarcinomas into subtypes with distinct sensitivities to metabolic inhibitors. Proc Natl Acad Sci USA 112, E4410–E4417.
-
(2015)
Proc Natl Acad Sci USA
, vol.112
, pp. E4410-E4417
-
-
Daemen, A.1
Peterson, D.2
Sahu, N.3
McCord, R.4
Du, X.5
Liu, B.6
Kowanetz, K.7
Hong, R.8
Moffat, J.9
Gao, M.10
-
73
-
-
84904612313
-
Alteration of the lipid profile in lymphomas induced by MYC overexpression
-
Eberlin LS, Gabay M, Fan AC, Gouw AM, Tibshirani RJ, Felsher DW & Zare RN (2014) Alteration of the lipid profile in lymphomas induced by MYC overexpression. Proc Natl Acad Sci USA 111, 10450–10455.
-
(2014)
Proc Natl Acad Sci USA
, vol.111
, pp. 10450-10455
-
-
Eberlin, L.S.1
Gabay, M.2
Fan, A.C.3
Gouw, A.M.4
Tibshirani, R.J.5
Felsher, D.W.6
Zare, R.N.7
-
74
-
-
65349155747
-
Cytosolic acetyl-CoA synthetase affected tumor cell survival under hypoxia: the possible function in tumor acetyl-CoA/acetate metabolism
-
Yoshii Y, Furukawa T, Yoshii H, Mori T, Kiyono Y, Waki A, Kobayashi M, Tsujikawa T, Kudo T, Okazawa H et al. (2009) Cytosolic acetyl-CoA synthetase affected tumor cell survival under hypoxia: the possible function in tumor acetyl-CoA/acetate metabolism. Cancer Sci 100, 821–827.
-
(2009)
Cancer Sci
, vol.100
, pp. 821-827
-
-
Yoshii, Y.1
Furukawa, T.2
Yoshii, H.3
Mori, T.4
Kiyono, Y.5
Waki, A.6
Kobayashi, M.7
Tsujikawa, T.8
Kudo, T.9
Okazawa, H.10
-
75
-
-
84923148982
-
Quantitative analysis of acetyl-CoA production in hypoxic cancer cells reveals substantial contribution from acetate
-
Kamphorst JJ, Chung MK, Fan J & Rabinowitz JD (2014) Quantitative analysis of acetyl-CoA production in hypoxic cancer cells reveals substantial contribution from acetate. Cancer Metab 2, 23.
-
(2014)
Cancer Metab
, vol.2
, pp. 23
-
-
Kamphorst, J.J.1
Chung, M.K.2
Fan, J.3
Rabinowitz, J.D.4
-
76
-
-
84947648620
-
Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress
-
Schug ZT, Peck B, Jones DT, Zhang Q, Grosskurth S, Alam IS, Goodwin LM, Smethurst E, Mason S, Blyth K et al. (2015) Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress. Cancer Cell 27, 57–71.
-
(2015)
Cancer Cell
, vol.27
, pp. 57-71
-
-
Schug, Z.T.1
Peck, B.2
Jones, D.T.3
Zhang, Q.4
Grosskurth, S.5
Alam, I.S.6
Goodwin, L.M.7
Smethurst, E.8
Mason, S.9
Blyth, K.10
-
77
-
-
84919936304
-
Acetate dependence of tumors
-
Comerford SA, Huang Z, Du X, Wang Y, Cai L, Witkiewicz AK, Walters H, Tantawy MN, Fu A, Manning HC et al. (2014) Acetate dependence of tumors. Cell 159, 1591–1602.
-
(2014)
Cell
, vol.159
, pp. 1591-1602
-
-
Comerford, S.A.1
Huang, Z.2
Du, X.3
Wang, Y.4
Cai, L.5
Witkiewicz, A.K.6
Walters, H.7
Tantawy, M.N.8
Fu, A.9
Manning, H.C.10
-
78
-
-
84919903877
-
Acetate is a bioenergetic substrate for human glioblastoma and brain metastases
-
Mashimo T, Pichumani K, Vemireddy V, Hatanpaa KJ, Singh DK, Sirasanagandla S, Nannepaga S, Piccirillo SG, Kovacs Z, Foong C et al. (2014) Acetate is a bioenergetic substrate for human glioblastoma and brain metastases. Cell 159, 1603–1614.
-
(2014)
Cell
, vol.159
, pp. 1603-1614
-
-
Mashimo, T.1
Pichumani, K.2
Vemireddy, V.3
Hatanpaa, K.J.4
Singh, D.K.5
Sirasanagandla, S.6
Nannepaga, S.7
Piccirillo, S.G.8
Kovacs, Z.9
Foong, C.10
-
79
-
-
77950605484
-
Fatty acid synthase as a potential therapeutic target in cancer
-
Flavin R, Peluso S, Nguyen PL & Loda M (2010) Fatty acid synthase as a potential therapeutic target in cancer. Future Oncol 6, 551–562.
-
(2010)
Future Oncol
, vol.6
, pp. 551-562
-
-
Flavin, R.1
Peluso, S.2
Nguyen, P.L.3
Loda, M.4
-
80
-
-
0034733730
-
Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors
-
Loftus TM, Jaworsky DE, Frehywot GL, Townsend CA, Ronnett GV, Lane MD & Kuhajda FP (2000) Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors. Science 288, 2379–2381.
-
(2000)
Science
, vol.288
, pp. 2379-2381
-
-
Loftus, T.M.1
Jaworsky, D.E.2
Frehywot, G.L.3
Townsend, C.A.4
Ronnett, G.V.5
Lane, M.D.6
Kuhajda, F.P.7
-
81
-
-
84936846476
-
Crystal structure of human stearoyl-coenzyme A desaturase in complex with substrate
-
Wang H, Klein MG, Zou H, Lane W, Snell G, Levin I, Li K & Sang BC (2015) Crystal structure of human stearoyl-coenzyme A desaturase in complex with substrate. Nat Struct Mol Biol 22, 581–585.
-
(2015)
Nat Struct Mol Biol
, vol.22
, pp. 581-585
-
-
Wang, H.1
Klein, M.G.2
Zou, H.3
Lane, W.4
Snell, G.5
Levin, I.6
Li, K.7
Sang, B.C.8
|