SREBP maintains lipid biosynthesis and viability of cancer cells under lipid- and oxygen-deprived conditions and defines a gene signature associated with poor survival in glioblastoma multiforme

Oncogene

Volumn 34, Issue 40, 2015, Pages 5128-5140

  Lewis, C A ^a,e   Brault, C ^b   Peck, B ^a,f   Bensaad, K ^c   Griffiths, B ^a   Mitter, R ^a   Chakravarty, P ^a   East, P ^a   Dankworth, B ^a   Alibhai, D ^a   Harris, A L ^c   Schulze, A ^a,b,d  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d Comprehensive Cancer Center Mainfranken ^*  (Germany)

^e MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^f INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL COENZYME A DESATURASE; CHOLESTEROL; FATTY ACID; FATTY ACID BINDING PROTEIN; LIPID; OXYGEN; STEROL REGULATORY ELEMENT BINDING PROTEIN; UNSATURATED FATTY ACID; SMALL INTERFERING RNA; SREBF1 PROTEIN, HUMAN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRANSCRIPTOME;

ARTICLE; CANCER CELL; CANCER SURVIVAL; CELL FUNCTION; CELL HYPOXIA; CELL SURVIVAL; CHOLESTEROL METABOLISM; CONTROLLED STUDY; FATTY ACID METABOLISM; GENE EXPRESSION; GENETIC TRANSCRIPTION; GLIOBLASTOMA; GLIOMA STEM CELL; HUMAN; HUMAN CELL; HYPOXIC CELL; LIPID METABOLISM; LIPOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SERUM; BRAIN TUMOR; CELL LINE; DNA MICROARRAY; GENETIC TRANSFECTION; IMMUNOHISTOCHEMISTRY; METABOLISM; MORTALITY; PATHOLOGY; PHYSIOLOGY; POLYMERASE CHAIN REACTION; PROPORTIONAL HAZARDS MODEL;

BRAIN NEOPLASMS; CELL HYPOXIA; CELL LINE; CELL SURVIVAL; GLIOBLASTOMA; HUMANS; IMMUNOHISTOCHEMISTRY; LIPID METABOLISM; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLYMERASE CHAIN REACTION; PROPORTIONAL HAZARDS MODELS; RNA, SMALL INTERFERING; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRANSCRIPTOME; TRANSFECTION;

EID: 84943201007     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2014.439     Document Type: Article

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