The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1

Nature

Volumn 524, Issue 7564, 2015, Pages 243-246

  Han, Jinbo ^a   Li, Erwei ^a   Chen, Liqun ^a   Zhang, Yuanyuan ^a   Wei, Fangchao ^a   Liu, Jieyuan ^b   Deng, Haiteng ^b   Wang, Yiguo ^a  

^a Tsinghua University   (China)

^b TSINGHUA UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CREB REGULATED TRANSCRIPTION COACTIVATOR 2; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; UNCLASSIFIED DRUG; CRTC2 PROTEIN, MOUSE; MTOR PROTEIN, MOUSE; SEC23A PROTEIN, MOUSE; SEC31A PROTEIN, HUMAN; SREBF1 PROTEIN, MOUSE; TARGET OF RAPAMYCIN KINASE; TRANSCRIPTION FACTOR; VESICULAR TRANSPORT PROTEIN;

BIOACCUMULATION; ESTER; GENE EXPRESSION; GROWTH REGULATOR; HOMEOSTASIS; LIPID; MATURATION; METABOLISM; OBESITY; RODENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; INSULIN SENSITIVITY; LIPID HOMEOSTASIS; LIPID METABOLISM; LIPOGENESIS; LIVER METABOLISM; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN TRANSPORT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; ANIMAL; BINDING COMPETITION; CHEMISTRY; COATED VESICLE; DEFICIENCY; GENETICS; HOMEOSTASIS; INSULIN RESISTANCE; LIVER; MALE; METABOLISM; MOUSE MUTANT; OBESITY; PHOSPHORYLATION;

MUS;

ANIMALS; BINDING, COMPETITIVE; COP-COATED VESICLES; HOMEOSTASIS; INSULIN RESISTANCE; LIPID METABOLISM; LIPOGENESIS; LIVER; MALE; MICE; MICE, OBESE; OBESITY; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TOR SERINE-THREONINE KINASES; TRANSCRIPTION FACTORS; VESICULAR TRANSPORT PROTEINS;

EID: 84939497516     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature14557     Document Type: Article

References (29)

1. Samuel, V. T.&Shulman, G. I.Mechanisms for insulin resistance: common threads and missing links. Cell 148, 852-871 (2012
2. Perry, R. J., Samuel, V. T., Petersen, K. F.&Shulman,G. I. The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes. Nature 510, 84-91 (2014
3. Yellaturu, C. R., et al. Insulin enhances post-translational processing of nascent SREBP-1c by promoting its phosphorylation and association withCOPII vesicles. J. Biol. Chem. 284, 7518-7532 (2009
4. Goldstein, J. L., DeBose-Boyd, R. A. & Brown, M. S. Protein sensors for membrane sterols. Cell 124, 35-46 (2006
5. Horton, J. D., Goldstein, J. L. & Brown, M. S. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J. Clin. Invest. 109, 1125-1131 (2002
6. Altarejos, J. Y. & Montminy, M. CREB and the CRTC co-activators: sensors for hormonal and metabolic signals. Nature Rev. Mol. Cell Biol. 12, 141-151 (2011
7. Lamming, D. W.& Sabatini, D. M. A Central role formTOR in lipid homeostasis. Cell Metab. 18, 465-469 (2013
8. Zanetti, G., Pahuja, K. B., Studer, S., Shim, S. & Schekman, R. COPII and the regulation of protein sorting in mammals. Nature Cell Biol. 14, 20-28 (2012
9. Brown, M.S. & Goldstein, J. L. Selective versus total insulin resistance: apathogenic paradox. Cell Metab. 7, 95-96 (2008).
10. Lin, H. V. & Accili, D. Hormonal regulation of hepatic glucose production in health and disease. Cell Metab. 14, 9-19 (2011
11. Strable, M. S. & Ntambi, J. M. Genetic control of de novo lipogenesis: role in dietinduced obesity. Crit. Rev. Biochem. Mol. Biol. 45, 199-214 (2010
12. Wang, Y., et al. Targeted disruption of the CREB coactivator Crtc2 increases insulin sensitivity. Proc. Natl Acad. Sci. USA 107, 3087-3092 (2010
13. Song, Y., et al. CRTC3links catecholamine signalling to energybalance.Nature468, 933-939 (2010
14. Altarejos, J. Y., et al. The Creb1 coactivator Crtc1 is required for energy balance and fertility. Nature Med. 14, 1112-1117 (2008
15. Wang, Y., et al. Inositol-1,4,5-trisphosphate receptor regulates hepatic gluconeogenesis in fasting and diabetes. Nature 485, 128-132 (2012
16. Wang, Y., Vera, L., Fischer,W.H.& Montminy, M. TheCREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis. Nature 460, 534-537 (2009
17. Bi, X., Mancias, J. D. & Goldberg, J. Insights into COPII coat nucleation from the structure of Sec23NSar1 complexed with the active fragment of Sec31. Dev. Cell 13, 635-645 (2007
18. Peterson, T. R., et al. mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway. Cell 146, 408-420 (2011
19. Li, S., Brown, M. S. & Goldstein, J. L. Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis. Proc. Natl Acad. Sci. USA 107, 3441-3446 (2010
20. Porstmann, T., et al. SREBPactivity is regulated bymTORC1and contributes toAktdependent cell growth. Cell Metab. 8, 224-236 (2008
21. Yecies, J. L., et al. Akt stimulates hepatic SREBP1c and lipogenesis through parallel mTORC1-dependent and independent pathways. Cell Metab. 14, 21-32 (2011
22. Hsu, P. P., et al. The mTOR-regulated phosphoproteome reveals a mechanism of mTORC1-mediated inhibition of growth factor signaling. Science 332, 1317-1322 (2011
23. Khamzina, L., Veilleux, A., Bergeron, S. & Marette, A. Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance. Endocrinology 146, 1473-1481 (2005
24. Um, S. H., et al. Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature 431, 200-205 (2004
25. Shimomura, I., et al. Decreased IRS-2 and increased SREBP-1c lead to mixed insulin resistance and sensitivity in livers of lipodystrophic and ob/ob mice. Mol. Cell 6, 77-86 (2000
26. Zhao, X., et al. Regulation of lipogenesis by cyclin-dependent kinase 8-mediated control of SREBP-1. J. Clin. Invest. 122, 2417-2427 (2012
27. Li, P., et al. Adipocyte NCoR knockout decreases PPARc phosphorylation and enhances PPAR activity and insulin sensitivity. Cell 147, 815-826 (2011
28. Nohturfft, A., Yabe, D., Goldstein, J. L., Brown, M. S. & Espenshade, P. J. Regulated step in cholesterol feedback localized to budding of SCAP from ER membranes. Cell 102, 315-323 (2000
29. Schindler, A. J. & Schekman, R. In vitro reconstitution of ER-stress induced ATF6 transport in COPII vesicles. Proc. Natl Acad. Sci. USA 106, 17775-17780 (2009