Wnt acylation and its functional implication in Wnt signalling regulation

Biochemical Society Transactions

Volumn 43, Issue , 2015, Pages 211-216

  Janda, Claudia Y ^a   Garcia, K Christopher ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Acylation; Frizzled; SFRP; WIF; Wnt

Indexed keywords

FATTY ACID; FRIZZLED PROTEIN; WNT PROTEIN; CELL SURFACE RECEPTOR; FZD8 PROTEIN, HUMAN; REPRESSOR PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; WIF1 PROTEIN, HUMAN;

ACYLATION; CRYSTAL STRUCTURE; LIGAND BINDING; MOLECULAR RECOGNITION; NONHUMAN; PALMITOYLATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REGULATORY MECHANISM; REVIEW; WNT SIGNALING PATHWAY; ANIMAL; EMBRYO DEVELOPMENT; GENETICS; HUMAN; LIPOYLATION; METABOLISM;

ACYLATION; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; EMBRYONIC DEVELOPMENT; FRIZZLED RECEPTORS; HUMANS; LIPOYLATION; RECEPTORS, CELL SURFACE; REPRESSOR PROTEINS; WNT SIGNALING PATHWAY;

EID: 84934927263     PISSN: 03005127     EISSN: 14708752     Source Type: Journal    
DOI: 10.1042/BST20140249     Document Type: Review

References (45)

1. Willert, K. and Nusse, R. (2012) Wnt proteins. Cold Spring Harb. Perspect. Biol. 4, a007864 CrossRef PubMed
2. Clevers, H. and Nusse, R. (2012) Wnt/beta-catenin signaling and disease. Cell 149, 1192-1205 CrossRef PubMed
3. Cruciat, C.M. and Niehrs, C. (2013) Secreted and transmembrane wnt inhibitors and activators. Cold Spring Harb. Perspect. Biol. 5, a015081 CrossRef PubMed
4. Angers, S. and Moon, R.T. (2009) Proximal events in Wnt signal transduction. Nat. Rev. Mol. Cell. Biol. 10, 468-477 PubMed
5. Willert, K., Brown, J.D., Danenberg, E., Duncan, A.W., Weissman, I.L., Reya, T., Yates, 3rd, J.R. and Nusse, R. (2003) Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature 423, 448-452 CrossRef PubMed
6. Takada, R., Satomi, Y., Kurata, T., Ueno, N., Norioka, S., Kondoh, H., Takao, T. and Takada, S. (2006) Monounsaturated fatty acid modification of Wnt protein: its role in Wnt secretion. Dev. Cell 11, 791-801 CrossRef PubMed
7. Janda, C.Y., Waghray, D., Levin, A.M., Thomas, C. and Garcia, K.C. (2012) Structural basis of Wnt recognition by Frizzled. Science 337, 59-64 CrossRef PubMed
8. Bazan, J.F., Janda, C.Y. and Garcia, K.C. (2012) Structural architecture and functional evolution of Wnts. Dev. Cell 23, 227-232 CrossRef PubMed
9. Gao, X. and Hannoush, R.N. (2014) Single-cell imaging of Wnt palmitoylation by the acyltransferase porcupine. Nat. Chem. Biol. 10, 61-68 CrossRef PubMed
10. Bhanot, P., Brink, M., Samos, C.H., Hsieh, J.C., Wang, Y., Macke, J.P., Andrew, D., Nathans, J. and Nusse, R. (1996) A new member of the frizzled family from Drosophila functions as a Wingless receptor. Nature 382, 225-230 CrossRef PubMed
11. Dann, C.E., Hsieh, J.C., Rattner, A., Sharma, D., Nathans, J. and Leahy, D.J. (2001) Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains. Nature 412, 86-90 CrossRef PubMed
12. Chu, M.L., Ahn, V.E., Choi, H.J., Daniels, D.L., Nusse, R. and Weis, W.I. (2013) Structural studies of Wnts and identification of an LRP6 binding site. Structure 21, 1235-1242 CrossRef PubMed
13. Green, J.L., Kuntz, S.G. and Sternberg, P.W. (2008) Ror receptor tyrosine kinases: orphans no more. Trends Cell Biol. 18, 536-544 CrossRef PubMed
14. Green, J., Nusse, R. and van Amerongen, R. (2014) The role of Ryk and Ror receptor tyrosine kinases in Wnt signal transduction. Cold Spring Harb. Perspect. Biol. 6, doi: 10.1101/cshperspect.a009175 CrossRef
15. van Amerongen, R. (2012) Alternative Wnt pathways and receptors. Cold Spring Harb. Perspect. Biol. 4, doi: 10.1101/cshperspect.a007914 CrossRef
16. Liu, Y., Rubin, B., Bodine, P.V. and Billiard, J. (2008) Wnt5a induces homodimerization and activation of Ror2 receptor tyrosine kinase. J. Cell. Biochem. 105, 497-502 CrossRef PubMed
17. Mikels, A., Minami, Y. and Nusse, R. (2009) Ror2 receptor requires tyrosine kinase activity to mediate Wnt5A signaling. J. Biol. Chem. 284, 30167-30176 CrossRef PubMed
18. Yamamoto, H., Yoo, S.K., Nishita, M., Kikuchi, A. and Minami, Y. (2007) Wnt5a modulates glycogen synthase kinase 3 to induce phosphorylation of receptor tyrosine kinase Ror2. Genes Cells 12, 1215-1223 CrossRef PubMed
19. Oishi, I., Suzuki, H., Onishi, N., Takada, R., Kani, S., Ohkawara, B., Koshida, I., Suzuki, K., Yamada, G., Schwabe, G.C. et al. (2003) The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway. Genes Cells 8, 645-654 CrossRef PubMed
20. Akbarzadeh, S., Wheldon, L.M., Sweet, S.M., Talma, S., Mardakheh, F.K. and Heath, J.K. (2008) The deleted in brachydactyly B domain of ROR2 is required for receptor activation by recruitment of Src. PloS One 3, e1873 CrossRef PubMed
21. Grumolato, L., Liu, G., Mong, P., Mudbhary, R., Biswas, R., Arroyave, R., Vijayakumar, S., Economides, A.N. and Aaronson, S.A. (2010) Canonical and noncanonical Wnts use a common mechanism to activate completely unrelated coreceptors. Genes Dev. 24, 2517-2530 CrossRef PubMed
22. Kim, C. and Forrester, W.C. (2003) Functional analysis of the domains of the C elegans Ror receptor tyrosine kinase CAM-1. Dev. Biol. 264, 376-390 CrossRef PubMed
23. Billiard, J., Way, D.S., Seestaller-Wehr, L.M., Moran, R.A., Mangine, A. and Bodine, P.V. (2005) The orphan receptor tyrosine kinase Ror2 modulates canonical Wnt signaling in osteoblastic cells. Mol. Endocrinol. 19, 90-101 CrossRef PubMed
24. Green, J.L., Inoue, T. and Sternberg, P.W. (2007) The C. elegans ROR receptor tyrosine kinase, CAM-1, non-autonomously inhibits the Wnt pathway. Development 134, 4053-4062 CrossRef PubMed
25. Lin, K., Wang, S., Julius, M.A., Kitajewski, J., Moos, Jr, M. and Luyten, F.P. (1997) The cysteine-rich frizzled domain of Frzb-1 is required and sufficient for modulation of Wnt signaling. Proc. Natl. Acad. Sci. U.S.A. 94, 11196-11200 CrossRef PubMed
26. Uren, A., Reichsman, F., Anest, V., Taylor, W.G., Muraiso, K., Bottaro, D.P., Cumberledge, S. and Rubin, J.S. (2000) Secreted frizzled-related protein-1 binds directly to Wingless and is a biphasic modulator of Wnt signaling. J. Biol. Chem. 275, 4374-4382 CrossRef PubMed
27. Bhat, R.A., Stauffer, B., Komm, B.S. and Bodine, P.V. (2007) Structure-function analysis of secreted frizzled-related protein-1 for its Wnt antagonist function. J. Cell. Biochem. 102, 1519-1528 CrossRef PubMed
28. Sagara, N., Kirikoshi, H., Terasaki, H., Yasuhiko, Y., Toda, G., Shiokawa, K. and Katoh, M. (2001) FZD4S, a splicing variant of frizzled-4, encodes a soluble-type positive regulator of the WNT signaling pathway. Biochem. Biophys. Res. Commun. 282, 750-756 CrossRef PubMed
29. von Marschall, Z. and Fisher, L.W. (2010) Secreted Frizzled-related protein-2 (sFRP2) augments canonical Wnt3a-induced signaling. Biochem. Biophys. Res. Commun. 400, 299-304 CrossRef PubMed
30. Xavier, C.P., Melikova, M., Chuman, Y., Uren, A., Baljinnyam, B. and Rubin, J.S. (2014) Secreted Frizzled-related protein potentiation versus inhibition of Wnt3a/beta-catenin signaling. Cell. Signal. 26, 94-101 CrossRef PubMed
31. Mii, Y. and Taira, M. (2009) Secreted Frizzled-related proteins enhance the diffusion of Wnt ligands and expand their signalling range. Development 136, 4083-4088 CrossRef PubMed
32. Kumar, S., Zigman, M., Patel, T.R., Trageser, B., Gross, J.C., Rahm, K., Boutros, M., Gradl, D., Steinbeisser, H., Holstein, T. et al. (2014) Molecular dissection of Wnt3a-Frizzled8 interaction reveals essential and modulatory determinants of Wnt signaling activity. BMC Biol. 12, 44 CrossRef PubMed
33. Hsieh, J.C., Kodjabachian, L., Rebbert, M.L., Rattner, A., Smallwood, P.M., Samos, C.H., Nusse, R., Dawid, I.B. and Nathans, J. (1999) A new secreted protein that binds to Wnt proteins and inhibits their activities. Nature 398, 431-436 CrossRef PubMed
34. Banyai, L., Kerekes, K. and Patthy, L. (2012) Characterization of a Wnt-binding site of the WIF-domain of Wnt inhibitory factor-1. FEBS Lett. 586, 3122-3126 CrossRef PubMed
35. Surmann-Schmitt, C., Widmann, N., Dietz, U., Saeger, B., Eitzinger, N., Nakamura, Y., Rattel, M., Latham, R., Hartmann, C., von der Mark, H. et al. (2009) Wif-1 is expressed at cartilage-mesenchyme interfaces and impedes Wnt3a-mediated inhibition of chondrogenesis. J. Cell Sci. 122, 3627-3637 CrossRef PubMed
36. Malinauskas, T., Aricescu, A.R., Lu, W., Siebold, C. and Jones, E.Y. (2011) Modular mechanism of Wnt signaling inhibition by Wnt inhibitory factor1. Nat. Struct. Mol. Biol. 18, 886-893 CrossRef PubMed
37. Liepinsh, E., Banyai, L., Patthy, L. and Otting, G. (2006) NMR structure of the WIF domain of the human Wnt-inhibitory factor-1. J. Mol. Biol. 357, 942-950 CrossRef PubMed
38. Chen, B., Dodge, M.E., Tang, W., Lu, J., Ma, Z., Fan, C.W., Wei, S., Hao, W., Kilgore, J., Williams, N.S. et al. (2009) Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat. Chem. Biol. 5, 100-107 CrossRef PubMed
39. Dodge, M.E., Moon, J., Tuladhar, R., Lu, J., Jacob, L.S., Zhang, L.S., Shi, H., Wang, X., Moro, E., Mongera, A. et al. (2012) Diverse chemical scaffolds support direct inhibition of the membrane-bound O-acyltransferase porcupine. J. Biol. Chem. 287, 23246-23254 CrossRef PubMed
40. Liu, J., Pan, S., Hsieh, M.H., Ng, N., Sun, F., Wang, T., Kasibhatla, S., Schuller, A.G., Li, A.G., Cheng, D. et al. (2013) Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974. Proc. Natl. Acad. Sci. U.S.A. 110, 20224-20229 CrossRef PubMed
41. Huang, S.M., Mishina, Y.M., Liu, S., Cheung, A., Stegmeier, F., Michaud, G.A., Charlat, O., Wiellette, E., Zhang, Y., Wiessner, S. et al. (2009) Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. Nature 461, 614-620 CrossRef PubMed
42. DeAlmeida, V.I., Miao, L., Ernst, J.A., Koeppen, H., Polakis, P. and Rubinfeld, B. (2007) The soluble wnt receptor Frizzled8CRD-hFc inhibits the growth of teratocarcinomas in vivo. Cancer Res. 67, 5371-5379 CrossRef PubMed
43. Li, X., Ominsky, M.S., Warmington, K.S., Morony, S., Gong, J., Cao, J., Gao, Y., Shalhoub, V., Tipton, B., Haldankar, R. et al. (2009) Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis. J. Bone Miner. Res. 24, 578-588 CrossRef PubMed
44. Ominsky, M.S., Vlasseros, F., Jolette, J., Smith, S.Y., Stouch, B., Doellgast, G., Gong, J., Gao, Y., Cao, J., Graham, K. et al. (2010) Two doses of sclerostin antibody in cynomolgus monkeys increases bone formation, bone mineral density, and bone strength. J. Bone Miner. Res. 25, 948-959 CrossRef PubMed
45. Gurney, A., Axelrod, F., Bond, C.J., Cain, J., Chartier, C., Donigan, L., Fischer, M., Chaudhari, A., Ji, M., Kapoun, A.M. et al. (2012) Wnt pathway inhibition via the targeting of Frizzled receptors results in decreased growth and tumorigenicity of human tumors. Proc. Natl. Acad. Sci. U.S.A. 109, 11717-11722 CrossRef PubMed