Monounsaturated fatty acids in serum triacylglycerols are associated with response to neoadjuvant chemotherapy in breast cancer patients

International Journal of Cancer

Volumn 134, Issue 7, 2014, Pages 1725-1733

  Hilvo, Mika ^a   Gade, Stephan ^b   Hyötyläinen, Tuulia ^a   Nekljudova, Valentina ^b   Seppänen Laakso, Tuulikki ^a   Sysi Aho, Marko ^a   Untch, Michael ^c   Huober, Jens ^d   Von Minckwitz, Gunter ^b   Denkert, Carsten ^e   Orešič, Matej ^a   Loibl, Sibylle ^b  

^a VTT TECHNICAL RESEARCH CENTRE OF FINLAND   (Finland)

^b German Breast Group   (Germany)

^c HELIOS KLINIKUM BERLIN BUCH   (Germany)

^d UNIVERSITY OF ULM   (Germany)

^e CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

breast cancer; lipidomics; oleic acid; pathologic complete response rate; stearoyl CoA desaturase (SCD)

Indexed keywords

CAPECITABINE; CYCLOPHOSPHAMIDE; DOCETAXEL; EPIRUBICIN; ESTROGEN RECEPTOR; MONOUNSATURATED FATTY ACID; OLEIC ACID; TRASTUZUMAB; TRIACYLGLYCEROL;

ADJUVANT CHEMOTHERAPY; ARTICLE; BREAST CANCER; CANCER PATIENT; CONTROLLED STUDY; DISEASE FREE SURVIVAL; FEMALE; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; LIPID ANALYSIS; LIPIDOMICS; MAJOR CLINICAL STUDY; OVERALL SURVIVAL; PATHOLOGIC COMPLETE RESPONSE; POSTMENOPAUSE; PREMENOPAUSE; PRIORITY JOURNAL; TREATMENT RESPONSE; TRIACYLGLYCEROL BLOOD LEVEL;

BREAST CANCER; LIPIDOMICS; OLEIC ACID; PATHOLOGIC COMPLETE RESPONSE RATE; STEAROYL-COA DESATURASE (SCD);

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BREAST NEOPLASMS; CLINICAL TRIALS, PHASE III AS TOPIC; DISEASE-FREE SURVIVAL; FATTY ACIDS, MONOUNSATURATED; FEMALE; HUMANS; LIPID METABOLISM; MULTICENTER STUDIES AS TOPIC; NEOADJUVANT THERAPY; OLEIC ACID; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RECEPTORS, ESTROGEN; TRIGLYCERIDES;

EID: 84892599003     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.28491     Document Type: Article

References (34)

1. Kaufmann M, Hortobagyi GN, Goldhirsch A, et al. Recommendations from an international expert panel on the use of neoadjuvant (primary) systemic treatment of operable breast cancer: an update. J Clin Oncol 2006; 24: 1940-9.
2. Untch M, Rezai M, Loibl S, et al. Neoadjuvant treatment with trastuzumab in HER2-positive breast cancer: results from the GeparQuattro study. J Clin Oncol 2010; 28: 2024-31.
3. von Minckwitz G, Rezai M, Loibl S, et al. Capecitabine in addition to anthracycline- and taxane-based neoadjuvant treatment in patients with primary breast cancer: phase III GeparQuattro study. J Clin Oncol 2010; 28: 2015-23.
4. Hilvo M, Oresic M,. Regulation of lipid metabolism in breast cancer provides diagnostic and therapeutic opportunities. Clin Lipidol 2012; 7: 177-88.
5. Rysman E, Brusselmans K, Scheys K, et al. De novo lipogenesis protects cancer cells from free radicals and chemotherapeutics by promoting membrane lipid saturation. Cancer Res 2010; 70: 8117-26.
6. Hilvo M, Denkert C, Lehtinen L, et al. Novel theranostic opportunities offered by characterization of altered membrane lipid metabolism in breast cancer progression. Cancer Res 2011; 71: 3236-45.
7. Wood CB, Habib NA, Thompson A, et al. Increase of oleic acid in erythrocytes associated with malignancies. Br Med J (Clin Res Ed) 1985; 291: 163-5.
8. Pala V, Krogh V, Muti P, et al. Erythrocyte membrane fatty acids and subsequent breast cancer: a prospective Italian study. J Natl Cancer Inst 2001; 93: 1088-95.
9. Chajes V, Hulten K, Van Kappel AL, et al. Fatty-acid composition in serum phospholipids and risk of breast cancer: an incident case-control study in Sweden. Int J Cancer 1999; 83: 585-90.
10. Pluskal T, Castillo S, Villar-Briones A, et al. MZmine 2: modular framework for processing, visualizing, and analyzing mass spectrometry-based molecular profile data. BMC Bioinformatics 2010; 11: 395.
11. Wei S, Liu L, Zhang J, et al. Metabolomics approach for predicting response to neoadjuvant chemotherapy for breast cancer. Mol Oncol 2012; 7: 297-307.
12. Pandey M, Khatri AK, Dubey SS, et al. Erythrocyte membrane stearic to oleic acid ratio in carcinoma of the gallbladder: a preliminary study. Eur J Surg Oncol 1998; 24: 43-6.
13. Kelly SB, Miller J, Wood CB, et al. Erythrocyte stearic acid desaturation in patients with colorectal carcinoma. Dis Colon Rectum 1990; 33: 1026-30.
14. Taylor A, Manche A, Wilson I, et al. Erythrocyte fatty acid profiles in patients with bronchogenic carcinoma. Ann Clin Biochem 1987; 24 (Part 6): 604-7.
15. Apostolov K, Barker W, Catovsky D, et al. Reduction in the stearic to oleic acid ratio in leukaemic cells-a possible chemical marker of malignancy. Blut 1985; 50: 349-54.
16. Neoptolemos JP, Clayton H, Heagerty AM, et al. Dietary fat in relation to fatty acid composition of red cells and adipose tissue in colorectal cancer. Br J Cancer 1988; 58: 575-9.
17. Thomas BS, O'Dea J, Fentiman IS,. Erythrocyte membrane stearic and oleic acid ratios in breast cancer. Br J Surg 1988; 75: 1078-9.
18. von Minckwitz G, Untch M, Blohmer JU, et al. Definition and impact of pathologic complete response on prognosis after neoadjuvant chemotherapy in various intrinsic breast cancer subtypes. J Clin Oncol 2012; 30: 1796-804.
19. Mauvoisin D, Mounier C,. Hormonal and nutritional regulation of SCD1 gene expression. Biochimie 2011; 93: 78-86.
20. Scaglia N, Chisholm JW, Igal RA,. Inhibition of stearoylCoA desaturase-1 inactivates acetyl-CoA carboxylase and impairs proliferation in cancer cells: role of AMPK. PLoS One 2009; 4: e6812.
21. Luyimbazi D, Akcakanat A, McAuliffe PF, et al. Rapamycin regulates stearoyl CoA desaturase 1 expression in breast cancer. Mol Cancer Ther 2010; 9: 2770-84.
22. Fritz V, Benfodda Z, Rodier G, et al. Abrogation of de novo lipogenesis by stearoyl-CoA desaturase 1 inhibition interferes with oncogenic signaling and blocks prostate cancer progression in mice. Mol Cancer Ther 2010; 9: 1740-54.
23. Kamphorst JJ, Cross JR, Fan J, et al. Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids. Proc Natl Acad Sci USA 2013; 110: 8882-7.
24. Griffiths B, Lewis CA, Bensaad K, et al. Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth. Cancer Metab 2013; 1: 3.
25. Chajes V, Joulin V, Clavel-Chapelon F,. The fatty acid desaturation index of blood lipids, as a biomarker of hepatic stearoyl-CoA desaturase expression, is a predictive factor of breast cancer risk. Curr Opin Lipidol 2011; 22: 6-10.
26. Champ CE, Volek JS, Siglin J, et al. Weight gain, metabolic syndrome, and breast cancer recurrence: are dietary recommendations supported by the data? Int J Breast Cancer 2012; 2012: 506868.
27. Del Fabbro E, Parsons H, Warneke CL, et al. The relationship between body composition and response to neoadjuvant chemotherapy in women with operable breast cancer. Oncologist 2012; 17: 1240-5.
28. Mauvoisin D, Rocque G, Arfa O, et al. Role of the PI3-kinase/mTor pathway in the regulation of the stearoyl CoA desaturase (SCD1) gene expression by insulin in liver. J Cell Commun Signal 2007; 1: 113-25.
29. Biddinger SB, Miyazaki M, Boucher J, et al. Leptin suppresses stearoyl-CoA desaturase 1 by mechanisms independent of insulin and sterol regulatory element-binding protein-1c. Diabetes 2006; 55: 2032-41.
30. Ntambi JM, Miyazaki M, Stoehr JP, et al. Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity. Proc Natl Acad Sci USA 2002; 99: 11482-6.
31. Bryzgalova G, Lundholm L, Portwood N, et al. Mechanisms of antidiabetogenic and body weight-lowering effects of estrogen in high-fat diet-fed mice. Am J Physiol Endocrinol Metab 2008; 295: E904-E912.
32. Gao H, Bryzgalova G, Hedman E, et al. Long-term administration of estradiol decreases expression of hepatic lipogenic genes and improves insulin sensitivity in ob/ob mice: a possible mechanism is through direct regulation of signal transducer and activator of transcription 3. Mol Endocrinol 2006; 20: 1287-99.
33. Keam B, Im SA, Park S, et al. Nomogram predicting clinical outcomes in breast cancer patients treated with neoadjuvant chemotherapy. J Cancer Res Clin Oncol 2011; 137: 1301-8.
34. Colleoni M, Bagnardi V, Rotmensz N, et al. A nomogram based on the expression of Ki-67, steroid hormone receptors status and number of chemotherapy courses to predict pathological complete remission after preoperative chemotherapy for breast cancer. Eur J Cancer 2010; 46: 2216-24.