Resolution advances in cryo-EM enable application to drug discovery

Current Opinion in Structural Biology

Volumn 41, Issue , 2016, Pages 194-202

  Subramaniam, Sriram ^a   Earl, Lesley A ^a   Falconieri, Veronica ^a   Milne, Jacqueline LS ^a   Egelman, Edward H ^b  

^a NATIONAL CANCER INSTITUTE   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CAPSAZEPINE; PROTEIN P97; RESINIFERATOXIN; VANILLOID RECEPTOR 1; LIGAND;

CRYOELECTRON MICROSCOPY; DENSITY; DRUG DESIGN; DRUG DEVELOPMENT; DRUG PROTEIN BINDING; DRUG STRUCTURE; HUMAN; IMAGE QUALITY; IMAGE RECONSTRUCTION; MICROTUBULE; MOLECULAR IMAGING; MOLECULARLY TARGETED THERAPY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN STRUCTURE; REVIEW; SINGLE PARTICLE CRYOELECTRON MICROSCOPY; STRUCTURE ANALYSIS; VALIDATION STUDY; ANIMAL; METABOLISM; MOLECULAR LIBRARY; PROCEDURES; SIGNAL NOISE RATIO;

ANIMALS; CRYOELECTRON MICROSCOPY; DRUG DISCOVERY; HUMANS; LIGANDS; SIGNAL-TO-NOISE RATIO; SMALL MOLECULE LIBRARIES;

EID: 84982243228     PISSN: 0959440X     EISSN: 1879033X     Source Type: Journal    
DOI: 10.1016/j.sbi.2016.07.009     Document Type: Review

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